• Archives of Pharmacal Research
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• 제22권1호
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• pp.35-43
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• 1999

Overstimulation of both kainate (KA) and N-methyl-D-aspartate (NMDA) receptors has been reported to induce excitatoxicity which can be characterized by neuronal damage and formation of reactive oxygen free radicals. Neuroprotective effect of melatonin against KA-induced excitotoxicity have been documented in vitro and in vivo. It is, however, not clear whether melationin is also neuroportective against excitotoxicity mediated by NMDA receptors. In the present work, we tested the in vivo protective effects of striatally infused melatonin against the oxidative stress and neuronal damage induced by the injection of KA and NMDA receptors into the rat striatum. Melatonin implants consisting of 22-gauge stainless-steel cannule with melatonin fused inside the tip were placed bilaterally in the rat brain one week prior to intrastriatal injection of glutamate receptor subtype agonists. Melatonin showed protective effects against the elevation of lipid peroxidation induced by either KA or NMDA and recovered Cu, Zn-superoxide dismutase activities reduced by both KA and NMDA into the control level. Melatonin also clearly blocked both KA- and NMDA-receptor mediated neuronal damage assessed by the determination of choline acetyltransferase activity in striatal monogenages and by microscopic observation of rat brain section stained with cresyl violet. The protective effects of melatonin are comparable to those of DNQX and MK801 which are the KA- and NMDA-receptor antagonist, respectively. It is suggested that melatonin could protect against striatal oxidative damages mediated by glutamate receptors, both non-NMDA and NMDA receptors.

• Steel and Composite Structures
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• 제17권2호
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• pp.199-213
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• 2014

The damage characters of scarf repaired composite laminates subjected to low-velocity impact with various energy levels at different locations are studied experimentally. The results are compared with those of the original laminates which have no initial damage and don't need repair. The impact load-time history of the specimens, the velocity-time curves of the impactor, the post impact compressive strength of the specimens and the C-scan photographs of the damaged regions are obtained. The delamination threshold load and damage character of the specimen section at impact point are also studied. The results have shown that the impact response of a repaired composite laminate is sensitive to the location of the impact. The impact load and the delamination threshold load have shown different characters for specimens with different impact locations. The debonding characters of the adhesive and compressive strength after impact of the specimens are also influenced by impact locations.

• 한국구조물진단유지관리공학회 논문집
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• 제13권1호통권53호
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• pp.115-124
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• 2009

본 연구에서는 구조물에 발생하는 변상 진전 특성을 수치 해석적으로 평가할 수 있는 기법을 새롭게 개발하기 위한 연구를 수행한 것이다. 이를 위해서, 변상발생 메커니즘을 토대로 하여, 인장균열 발생 후, 휨압축에 의한 압축손상까지를 해석에 반영하였다. 특히 인장균열이 발생하고나서 압축손상이 발생하기까지의 해석 단계를 위해서는, 등가소성힌지길이 개념을 새롭게 도입하여, 균열의 진전을 해석하게 된다. 등가소성힌지 길이개념을 도입함으로써, 균열발생단면에 대한 단면력, 즉, 축력과 모멘트를 균열폭과 관계지어 균열폭의 확장을 추적해 나가게 된다.

• 수산경영론집
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• 제42권1호
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• pp.19-35
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• 2011

This paper tries to show the appropriate estimation method of oil pollution damage for mariculture fisheries. The International Oil Pollution Fund 1992(also known as the IOPC Fund 1992) has made up the Claims Manual to assist claimants by giving a general overview of the Fund's obligation to pay compensation. Section III of the Manual provides more specific information to assist claimants in presenting their claims concerning about economic losses in the fisheries, mariculture and fish processing sectors. The paper tries to suggest reform proposals for current etimation method of damages of maricluture fisheries contaminated by oil spillover using the population biology of living resources charaterized with age distribution.

• 마이크로전자및패키징학회지
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• 제22권1호
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• pp.27-34
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• 2015

The correlation between crack propagation and localized recrystallization are compared in a series of cross section analyses on thermal cycled edgebond and underfilm material applied wafer level chip scale package (WLCSP) components with a baseline of no-material applied WLCSP components. The results show that the crack propagation distribution and recrystallization region correlation can explain potential degradation mechanisms and support the damage accumulation history in a more efficient way. Edgebond material applied components show a shift of damage accumulation to a more localized region, thus potentially accelerated the degradation during thermal cycling. Underfilm material applied components triggered more solder joints for a more wider distribution of damage accumulation resulting in a slightly improved thermal cycling performance compared to no-material applied components. Using an analysis on localized distribution of recrystallized areas inside the solder joint showed potential value as a new analytical approach.

• Interaction and multiscale mechanics
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• 제3권4호
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• pp.321-331
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• 2010

A new technique is proposed for bridge structural damage detection based on spatial wavelet analysis of the time history obtained from vehicle body moving over the bridge, which is different from traditional detection techniques based on the bridge response. A simply-supported Bernoulli-Euler beam subjected to a moving spring-mass unit is established, with the crack in the beam simulated by modeling the cracked section as a rotational spring connecting two undamaged beam segments, and the equations of motion for the system is derived. By using the transfer matrix method, the natural frequencies and mode shapes of the cracked beam are determined. The responses of the beam and the moving spring-mass unit are obtained by modal decomposition theory. The continuous wavelet transform is calculated on the displacement time histories of the sprung-mass. The case study result shows that the damage location can be accurately determined and the method is effective.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1992년도 춘계학술대회 논문집
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• pp.306-312
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• 1992

The prevention of roll breakage in hot rolling process is improtant to reduce maintenance cost and production loss. Rolling conditions such as the roll force and torque have been intensively studied to overcome the roll breakage. in the present work, a model for life prediction of work rolls under working condition was developed and discussed. The model consists of stress analysis, crack propagation, wear and fatigue calculation model. Roll life can be predicted by stress, crack depth and fatigue damage calculated from this model. The reliability of stress analysis is backed up by the FEM analysis. From the result of simulation using by pressent model, although the fatigue damage of back up roll reachs 80% of practical limit, that of workroll was less than 40%. In edge section of workroll stress amplification is found by wear and bender effect. We can judge that workroll failures are not due to fatigue damage, crack propagation by bending stress but stress amplification by wear and bender in present working condition.

• Nuclear Engineering and Technology
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• 제53권10호
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• pp.3158-3163
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• 2021

Chromium material is commonly used for fusion plasma facing applications because of the low neutron activation property. The Monte Carlo method is one of the useful ways to investigate the ion-target interactions. In this study, Chromium target irradiated by protons was investigated using Monte Carlo based simulation tools. In this context, the calculations of radiation damage on Chromium material irradiated with protons at 17.9 and 22.3 MeV energies were carried out using GEANT4 and SRIM codes. Besides, the cross sections for proton interaction with Chromium target were calculated by the TALYS 1.9 code using CTM + FGM, BSFGM, and GSFM level densities. As a result, GEANT4, SRIM and TALYS 1.9 codes provide a suitable tool for the predictions of radiation damage and cross cross section with proton irradiation.

• Earthquakes and Structures
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• 제26권4호
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• pp.269-283
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• 2024

When a reinforced concrete (RC) structure is exposed to a corrosive environment for an extended period of time, the material qualities deteriorate, resulting in a loss in seismic performance. Engineered Cementitious Composites (ECC) have been used to reinforce the corroded RC structure, which can achieve reinforcement effectiveness for a small change in cross-section size. In this work, finite element models of unjacketed RC pier and ECC jacketed pier were established and verified by experimental tests, with the buckling effect of longitudinal reinforcement considered. Compared with the unjacketed pier, the displacement of the pier top of the ECC jacketed pier was reduced by about 9.52% under earthquake action. In the case of moderate and major earthquakes, the probability of exceedance of ECC jacketed pier is significantly reduced. For the case of rare earthquake loading, with the ECC jacket, the e of the pier experiencing serious damage and complete damage states is reduced by 10.29% and 29.78%, respectively.

• 한국구조물진단유지관리공학회 논문집
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• 제23권5호
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• pp.84-95
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• 2019

본 논문은 5경간 라멘형 교량의 지진취약도 분석을 위한 해석적 연구이다. 연구를 위하여 한국에서 공용중인 교각 높이 72m의 교량을 선정하였으며 범용 구조해석 프로그램인 OpenSEES를 이용하여 비선형시간이력해석을 실시하였다. 비선형시간이력해석은 총 50개의 지진을 사용하였으며, 지진파의 최대지반가속도를 0.1g에서 2.0g까지 0.1g 간격으로 증가시켜 다양한 강도 범위의 지진파를 고려하였다. 또한 단면해석을 통해 각 교각의 항복변위와 극한변위를 산출하였으며 시간이력해석 결과 및 단면해석 결과를 바탕으로 Barbat 등이제시한 손상상태 정의에 따라 대상교량의 손상상태를 분류하였다. 해석결과 0.731g의 지진이 교축방향으로 작용하였을 때 P1교각에서 Extensive Damage가 발생하는 것으로 예측되었다. 또한 지진위험도 평가결과를 국내 내진설계 기준에 적용한 결과 구조물의 기능을 수행할 수 없는 Extensive Damage가 발생할 확률은 4,800년 주기 지진에서 약 4.2%로 대상교량은 충분한 내진성능을 확보하고 있을 것으로 예상된다.