• 한국동물위생학회지
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• 제31권4호
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• pp.521-532
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• 2008

The prevalence of major calf disease was investigated in 117 Holstein dairy calves in Chonnam area. All of them were moved in the College experimental farm which is operated in intensive units. clinical signs were daily examined throughout two months after the introduction of the College farm. Among calves, 92 cases(78.6%) died in the two months after the introduction in it. Outbreaks of respiratory and alimentary diseases were their main causes of their fatality. The incidence of respiratory disorders during the full period of the experiment was up to 42.8%, and the alimentary diseases were occurred 35.9% of the herd. Most of the mortality was related with respiratory(59.9%) and alimentary(52.1%) pathogens. Also calf mortality by combined infection claimed 6.6% among 100 morbidity cases. Principle pathogens to cause mortality were Pasteurella spp(44.4%), E coli(29.9%), bovine viral diarrhea virus(16.2%), IBRV(12.0%), respectively. Viruses also played as an important role in increasing calf morbidity to secondary respiratory bacterial pathogens. Pasteurella infection combined with infectious bovine rhinotracheitis virus(11 cases), parainfluenza virus type-3(9 cases), or bovine respiratory syncytial virus(7 cases) was appeared as major pattern to mortality. colibacillosis in causing enteritis was concurrently infected with BVD(19 cases), bovine coronavirus infection(14 cases), salmonellosis(5 cases), coccidiosis(5 cases) and clostridial infection(4 cases). Ninty-two cases to death were appeared to have 100% neutralizing antibodies to BCV; Among them, 73.8% had the neutralizing antibody level higher than 64. Calves with neutralizing antibodies higher than 16 to BVDV were 50%. The cases with neutralizing antibody level lower than 8 to BEFV were 89.4% that means the necessity of appropriate vaccination.

• Journal of Trauma and Injury
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• 제24권1호
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• pp.12-17
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• 2011

Purpose: A rib fracture secondary to blunt thoracic trauma continues to be an important injury with significant complications. Unfortunately, there are no definite treatment guidelines for severe multiple rib fractures. The purpose of this study was to evaluate the result of early operative stabilization and to find the risk factors of surgical fixation in patients with bilateral multiple rib fractures or flail segments. Methods: From December 2005 to December 2008, the medical records of all patients who underwent operative stabilization of ribs for severe multiple rib fractures were reviewed. We investigated patients' demographics, preoperative comorbidities, underlying lung disease, chest trauma, other associated injuries, number of surgical rib fixation, combined operations, perioperative ventilator support, and postoperative complications to find the factors affecting the mortality after surgical treatment. Results: The mean age of the 96 patients who underwent surgical stabilization for bilateral multiple rib fractures or flail segments was 56.7 years (range: 22 to 82 years), and the male-to-female ratio was 3.6:1. Among the 96 patients, 16 patients (16.7%) underwent reoperation under general or epidural anesthesia due to remaining fracture with severe displacement. The surgical mortality of severe multiple rib fractures was 8.3% (8/96), 7 of those 8 patients (87.5%) dying from acute respiratory distress syndrome or sepsis. And the other one patient expired from acute myocardial infarction. The risk factors affecting mortality were liver cirrhosis, chronic obstructive pulmonary disease, concomitant severe head or abdominal injuries, perioperative ventilator care, postoperative bleeding or pneumonia, and tracheostomy. However, age, number of fractured ribs, lung parenchymal injury, pulmonary contusion and combined operations were not significantly related to mortality. Conclusion: In the present study, surgical fixation of ribs could be carried out as a first-line therapeutic option for bilateral rib fractures or flail segments without significant complications if the risk factors associated with mortality were carefully considered. Furthermore, with a view of restoring pulmonary function, as well as chest wall configuration, early operative stabilization of the ribs is more helpful than conventional treatment for patients with severe multiple rib fractures.

• Clinical and Experimental Pediatrics
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• 제52권9호
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• pp.1048-1052
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• 2009

증식성 기관지염(plastic bronchitis)은 드문 질환으로 일반적인 점액전에 비해 크고 접착력이 있는 가지모양의 점액성 기관지 주형(cast)을 반복적으로 형성한다. 이 주형은 크기가 다양하여 자연적으로 배출되기도 하나 제거를 위해 기관지경이 필요하기도 한다. 따라서 증식성 기관지염에서 큰 기도의 폐쇄가 발생하면 생명을 위협할 수 있다. 호산구성 주형을 가진 보고된 환자 22명 중 3명이 중심 기도 폐쇄로 인해 사망에 이르렀다. 본 저자들은 아토피나 알레르기, 선천성 심장병의 병력이 없는 건강했던 소아에서 호산구성 증식성 기관지염을 진단하여 보고한다. 항생제와 스테로이드의 정주와 물리 치료를 포함한 적극적인 폐 청소와 주기적인 주형의 기관지경 제거를 시행하였으나 저산소성 뇌 손상에 이어 뇌사에 이르렀다. 본 증례와 같이 증식성 기관지염이 중심 기도를 막았을 때 생명을 위협할 수 있다. 따라서 증식성 기관지염의 증상이나 징후가 보일 경우 조기 치료가 필요하리라 생각된다.

• 분석과학
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• 제31권5호
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• pp.185-194
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• 2018

2010년 11월말 5번째 구제역이 발생하여 가축 매몰지로 인한 악취물질, 지하수, 음용수 등에 2차 환경오염 발생 가능성에 대한 문제제기 등 환경영향 저감 방안 마련이 필요하다. 본 연구의 목적은 축종별, 토성별 파일럿 규모 가축매몰지 5기를 설치하여 2012년 2월부터 2015년 2월까지 약 3년 동안 침출수를 채취하여 90 항목을 분석하였으며, 매몰사체의 유기물 분해특성, 사체관련 미량원소 특히 대사체 물질 농도변화, 사체분해정도 등을 정밀 조사하였다. 그 결과 비소, 카드뮴 등 대부분의 중금속은 검출되지 않았으며 토성에 따른 축종별 분해정도를 파악한 결과 돼지보다는 소가 더 빨리 분해되고 사질 > 식양질 > 사양질 토양 순으로 사체분해가 이루어지는 것으로 판단된다.

• 한국콘텐츠학회논문지
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• 제15권3호
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• pp.184-191
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• 2015

전립선 초음파영상은 전립선암, 전립선비대증, 전립선염을 진단하고 전립선암의 생검과 전립선비대에서 전립선 크기 확인 등을 위해서 사용된다. 전립선비대증은 노인 남성의 가장 흔한 질병 중의 하나이다. 전립선은 주변구역, 중심구역, 이행구역과 전방 섬유근 간질부분 4개 구획으로 나누어진다. 전립선비대증은 조직학적으로 전립선 이행구역에서 결절성 증식을 동반한 요도주위의 진행성 과증식이 특징으로 이 결절로 인한 요도 폐쇄를 야기함에 따라 하부요로 증상을 유발한다. 그러므로 본 연구에서는 정상 전립선 이행구역 영상과 전립선비대 이행구역 영상에 대한 컴퓨터 알고리즘을 이용하여 정량적인 분석을 하였다. GLCM을 적용하여 정상영상 60증례와 전립선비대증영상 60증례을 분석영역($50{\times}50$ 픽셀)으로 설정하고, 각 영상에서 Autocorrelation, Contrast, Cluster Prominence, Entropy, Max Probability, Sum average 6가지 파라미터를 비교하여 분석하였다. 결과적으로 Autocorrelation, Cluster Prominence, Entropy, Sum Average 4개의 파라미터에서는 병변의 질감 검출 효율이 92-98%로 높게 나왔다. 이에 전립선 이행구역의 결절성 증식 변화를 정량적인 영상분석으로 확인 할 수 있었다. 향후 전립선비대증 진단에 있어 2차적인 수단으로 가능할 것으로 기대되며, 다양한 전립선 초음파 영상에 있어 기초 자료가 될 것으로 사료된다.

• Journal of Chest Surgery
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• 제10권1호
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• pp.98-105
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• 1977

A 36 year old blindman, engineer was admitted with chief complaints of hemoptysis, recurrent sore throat, pyoderma in genital organ, uveitis and thrombophlebitis for 10 years. Above the chief complaints were remission or exacerbation during hospitalization. Physicalexamination showed that left radial, ulnar & brachial pulse was not palpable. No bruit or murmur was obtained over the mass. Neurologic examination revealed no significant finding.On admission, chest P-A showed hen egg sized round & oval compact hazy density on left upper lung field. Bronchogram revealed no pathological finding and Lt. tomogram showed well define large,ovoid mass density in the superior mediastinum. Fluoroscopy finding showed nonpulsatile on left upper lung field. Pre-op. aortography was not taken, under the impression of lung Ca. rule out .sortie aneurysm, exploratory operation was performed through the 2nd intercostal space, Lt. It was performed that the mass was ascending sortie aneurysm of saccular type. Direct aneurysmectomy with multiple figure of eight suture were done without any prosthetic graft. Post-op. control I.V.C graphy showed completely obstruction sign. Postopcontrol aortography revealed good surgical result. Final, histopathological answered non-specific sortie aneurysm, saccular type. Post-op. courses were uneventful except mild neurologic disturbance with subclavian steal syndrome and associated with both lower leg pitting edema due to inferior vena cava obstruction. After op, 3 month later, discharged to home, with big systemic problem. Behcet`s syndrome reviewed with related literatures. The coexistence of mouth and genital ulceration with hypopyon mentioned by hippocrates and described by various workers in the early part of this century was first defined as a syndrome by Behcet in 1937. In 1937 Behcet described a chronic relapsing triple symptom complex of oral ulceration, genital ulceration, and ocular inflammation. The place of the syndrome as part of a systemic disorder in now clearer, and the under lying pathology appears to be a vasculitis. The disease runs a- chronic course, blindness being the greatest disability and control nervous system involvement a cause of death. Thrombophlebitis is fairly frequent, france et al [1951] giving an incidence of 25% and Dowling [1961] 12%, superficial thrombophlebitis migrans and thrombosis of large veins, including venae cavae [Thomas, 1947: Boolukos 1960] are recorded. Little attention has been paid to arterial involvement. Mishima et al. [1961] described resection cf an aortic aneurysm in a 38 year old man with Behcet`s syndorme. Mounsey in a clinicopathological conference described a case [Brit, med. J., 1966] of ruptured aortic aneurysm in Bechcet`s syndrome treated by aorto-iliac graft. Also, Shikano and Oshima et al [1963] recorded two aneyrysm of smaller arteries. Unfrequently, aortic aneurysm was presumed to be secondary to osteomyelitis of the lumber spine, though the possible association between aortic aneurysm and Behcet`s syndrome was raised. A further case is reported here, in which ascending aortic aneurysm with Behcet`s Ds. appeared to form part of this generalized disease. This is a case report of surgical experience of Behcet`s Ds. with ascending aortic aneurysm which had nearly all the typical clinical features. Above mentioned and was reviewed with related literatures.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6227-6231
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• 2013

In the past, hepatitis B virus (HBV) infection was endemic in the general Korean population. The association of HBV infection with the occurrence of liver cancer has been well demonstrated in several epidemiologic studies. While the mortality rates of liver cancer in Korea have decreased steadily over the last decade, the presence of hepatitis B surface antigen (HBsAg) in mothers remains high at 3-4%, and 25.5% of these HBsAg positive mothers are positive for hepatitis B e antigen (HBeAg). HBV infection caused almost a quarter of hepatocellular carcinoma (HCC) cases and one-third of deaths from HCC. These aspects of HBV infection prompted the Korean government to create a vaccination program against HBV in the early 1980s. In 1995, the Communicable Disease Prevention Act (CDPA) was reformed, and the government increased the number of HBV vaccines in the National Immunization Program (NIP), driving the vaccination rate up to 95%. In 2000, the National Health Insurance Act (NHIA) was enacted, which provided increased resources for the prevention of perinatal HBV infection. Then in 2002, the Korean government, in conjunction with the Korean Medical Association (KMA), launched an HBV perinatal transmission prevention program. The prevalence of HBsAg in children had been high (4-5%) in the early 1980s, but had dropped to below 1% in 1995, and finally reached 0.2% in 2006 after the NIP had been implemented. After the success of the NIP, Korea finally obtained its first certification of achievement from the Western Pacific Regional Office of the World Health Organization (WPRO-WHO) for reaching its goal for HBV control. An age-period-cohort analysis showed a significant reduction in the liver cancer mortality rate in children and adolescents after the NIP had been implemented. In addition to its vaccination efforts, Korea launched the National Cancer Screening Program (NCSP) for 5 leading sites of cancer, including the liver, in 1999. As a consequence of this program, the 5-year liver cancer survival rate increased from 13.2% (1996-2000) to 23.3% (2003-2008). The development of both the primary and secondary prevention for liver cancer including HBV immunization and cancer screening has been of critical importance.

• 대한수의학회지
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• 제35권2호
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• pp.405-416
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• 1995

말의 뇌화연증(equine leukoencephalomalacia)과 돼지의 폐수종(porcine pulmonary edema)은 Fusarium에 오염된 옥수수로 인하여 발생되는 것으로 추정되어 왔다. 1988년에 F moniliforme에서 2차 대사산물인 fumonisin $B_1(FB_1)$이 동정되면서 오염된 옥수수와 순수 분리된 $FB_1$으로 두질병이 실험적으로 재현되었고, 말과 돼지 이외의 다른 가축에 대해서도 독성 연구가 진행되고 있다. fumonisins(FBs)는 모든 종에서 간에 독성을 나타내나 종에 따라 주요 독성 장기가 각기 다름이 밝혀지고 있다. FB의 독성 기전에 대해서는 잘 알려지지 않았으나 FB가 sphingolipid 생성과정을 차단함으로써 장기 및 혈중에 sphinganine(SA) : sphingosine(SO)를 증가시키는 것으로 알려졌다. 이는 증가된 SA : SO가 FB 독성의 진단기준이 될 수 있음을 시사하는 것이다. 최근 진행 중인 연구에 의하면, 저용량의 $FB_1$ 급식 투여가 돼지에서 혈중 입자(blood-born particle)에 대한 폐혈관 대식 세포(pulmonary intravascular macrophage)의 탐식 능력을 저하시켜, 세균 감염에 대한 감수성이 증가될 수 있음을 시사하고 있다. Fusarium 속균은 전세계적으로 생산되는 옥수수에서 발생되고 있으며, 우리나라는 사료에 사용되는 옥수수의 절대량을 수입에 의존하고 있는 점을 고려할 때, 허용기준 및 무해용량 등에 대한 관리가 절실하다. 이 논문에서는 최근 연구된 FB에 의한 가축 독성에 대하여 기술하고자 한다.

• 대한핵의학회지
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• 제26권2호
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• pp.318-326
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• 1992

Ga-67 citrate scan has been requested for detection or follow-up of inflammatory or neoplastic disease. Visualization of Ga-67 citrate in the kidneys at 48 and 72 hr post injection is usually interpreted as evidence of renal pathology. But precise mechanisms of abnormal Ga-67 uptake in kidneys were unknown. We undertook a study to determine the clinical value of Ga-67 citrate imaging of the kidneys in 68 patients with primary or secondary nephropathy confirmed by renal biopsy and 66 control patients without renal disease. Renal uptake in 48 to 72 hr images was graded as follows: Grade 0=back-ground activity:1=faint uptake greater than background;2=definite uptake, but less than lumbar vertebrae; 3=same uptake as lumbar vertebrae, but less than liver; 4=same or higher uptake than liver. The results were as follows. 1) 42 of 65 (62%) patients with noninfectious nephritis showed grade 2 or higher Ga-67 renal uptake but only 10 percent of control patients showed similar uptake. 2) In 14 patients with systemic lupus erythematosus, 8 of 9 (89%) patients with lupus nephritis exhibited marked renal uptake 3) 36 of 41 patients (88%) with combined nephrotic syndrome showed Grade 2 or higher renal uptake. 4) Renal Ga-67 uptake was correlated with clinical severity of nephrotic syndrome determined by serum albumin level, 24 hr urine protein excretion and serum lipid levels. 5) After complete remission of nephrotic syndrome, renal uptake in all 8 patients who were initially Grade 3 or 4, decreased to Grade 1 or 0. In conclusion, we think that the mechanism of renal Ga-67 uptake in nephrotic syndrome might be related to the pathogenesis of nephrotic syndrome. In systemic lupus erythematosus, Ga-67 citrate scan is useful in predicting renal involvement.

• Radiation Oncology Journal
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• 제11권2호
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• pp.403-409
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• 1993

가톨릭대학교 의과대학 성모병원 치료방사선과에서 1988년부터 1992년도까지 적절한 중추신경계 예방요법후 뇌척수액내 재발을 경험한 급성 임파구성 백혈병 환자 7명을 대상으로 간헐적인 전중추신경계 방사선조사 및 척수강내 화학요법(IIIC)을 실시하였다. 추적관찰기간은 8개월에서 41개월이었고 그 중앙값은 20개월이었다. 7명의 대상환자중 3명이 다시 뇌척수액내 재발을 경험하였고, 중추신경계 관해유지기간은 각각 8, 9, 13, 20, 34, 36개월이었다. 무병 생존기 간은 2개월에서 36개월로 그 중앙값은 11개월이었다. 생존율은 8개월에서 41개월로 그 중앙값은 28개월이었다. 5명이 치료기간중 골수재발에 따른 패혈증 및 출혈로 사망하였고, 2명의 생존자는 치료종료 10개월 및 11개월째 다시 뇌척수액내 재발을 경험하였다. 치료결과를 향상시키기 위해서는 치료중 휴식기간을 단축시키고, 치료후에도 일정기간동안 척수강내 유지화학요법을 연장하여 실시하는등 치료계획의 변형이 필요할 것으로 사료되었다.