• Journal of Yeungnam Medical Science
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• 제25권2호
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• pp.117-123
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• 2008

Dermatomyositis is characterized by progressive, symmetric, proximal muscle weakness and a nonsuppurative inflammatory myopathy of unknown etiology involving predominantly skeletal muscles. It is also characterized by typical skin lesions. Interstitial lung disease has a poor prognosis when it is associated with dermatomyositis. Organizing pneumonia is a disease in which granulation tissue fills the lumina of terminal and respiratory bronchioles and extends into the distal airspaces. The cryptogenic nature of the process is appreciated in that organizing pneumonia patterns of injury can be seen in secondary forms of the disease (secondary organizing pneumonia). Organizing pneumonia has been reported to occur in 5~10% in dermatomyositis-polymyositis patients. Anti-histidyl tRNA synthetase antibody (anti-Jo-1) is a predictive disease marker that is reported to occur in up to 70% of patients. We describe a 49-year-old male dermatomyositis patient who presented with organizing pneumonia and was found to have negative anti-Jo-1 antibody.

• 한국콘텐츠학회논문지
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• 제18권10호
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• pp.145-157
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• 2018

본 연구에서는 국민건강보험공단 코호트를 이용하여 한국의 사망원인 1, 2, 3 위에 해당하는 질병이자 4대 중증질환에 포함되는 암, 뇌졸중, 심근경색 환자의 소득수준이 사망에 미치는 영향을 확인하고자 한다. 또한 발병 1년 이후 이차적으로 암, 심뇌혈관 질환에 발생할 위험을 확인하고자 한다. 2007년 해당 질환으로 신규 발병한 환자를 대상자로 하여 2015년까지 관찰하였고, 분석은 Cox 확률비례위험모형과 경쟁위험모형을 이용하였다. 소득수준은 2007년 발병 당시 정보를 사용하였으며, 소득분위 수 1~3/4~7/8~10으로 나눠 각각 low/mid/high로 범주화하였고 '의료급여'군은 low군으로 분석에 포함했다. 연구 결과에서 소득분위 수준에 따라 암, 뇌졸중, 심근경색이 발병한 환자의 사망 위험이나 추가 발병 위험에 차이가 있음이 나타났다. 저소득층의 초기 사망을 낮추기 위한 사회적 안전망이 필요하다는 것과 더불어 현 정책과 같이 중증질환에 대한 보편적인 보장성 강화도 지속해서 필요하다고 보인다.

• 대한한의학방제학회지
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• 제19권1호
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• pp.23-34
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• 2011

Objectives : Yiemyo-San(二妙散) is a basic oriental medicinal prescription used in basically musculoskeletal pain. Way down to posterity, Yiemyo-San has been combined with various prescriptions to treat a variety of diseases. the purpose of In this study is to investigate indications and etiology of indication using Yiemyo-San. Methodes : For prescriptions combining Yiemyo-San in Dongyeubogam(東醫寶鑑), the name of prescriptions, configuration herbs and indication were investigated and prescriptions were classified according to etiology of indication. Results : the numbers of prescriptions combining Yiemyo-San in Dongyeubogam were 45. Yiemyo-San was used frequently in musculoskeletal disease such as beriberi, amyotrophy, gout and arthritis(36%). In addition, it was applied to an internal diseases, ENT diseases and headache. it was used frequently in pathological condition due to supyeol(濕熱)(45%). Yiemyo-San was combined with various prescriptions as a primary prescription at 51% and as a secondary prescription at 49%. Conclusions : When Yiemyo-San is combined with other prescription, it may be used in various disease as well as musculoskeletal disease due to supyeol. combined with various prescriptions as a primary prescription at 51% and as a secondary prescription at 49%. Conclusions : When Yiemyo-San is combined with other prescription, it may be used in various disease as well as musculoskeletal disease due to supyeol.

• Journal of Gastric Cancer
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• 제7권4호
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• pp.237-241
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• 2007

목적: 만성 골수성 백혈병이나 말성 림프구성 백혈병에서 이차성 암의 위험은 증가하는 것으로 알려져 있다. 백혈병을 비롯한 혈액질환을 가진 환자에서 우리나라에서 가장 흔한 암 가운데 하나인 위암의 위험이 증가하는지 조사하여 혈액질환 환자를 대상으로 위암에 대한 보다 적극적인 검진이 필요한지 알아보고자 하였다. 또한 응고장애나 면역저하와 같은 수술에 관련된 위험인자가 있을 수 있는 혈액질환 환자에서 위암 수술이 안전하게 이루어질 수 있는지에 대해 조사하고자 하였다. 대상 및 방법: 지난 15년가 성모병원에서 백혈병 및 다발성 골수종, 재생불량성 빈혈로 진단받은 8,376명의 환자를 대상으로 의무기록을 후향적으로 조사하였다. 결과: 총 9예의 이차성 위암이 확인되었다. 감염이나 출혈등 수술관련 합병증은 발생하지 않았으며, 조기에 발견된 경우 재발도 관찰되지 않았다. 결론: 위암의 빈도가 일반인에 비해 크게 증가하지 않아 혈액질환 환자에서 이차성 위암의 감시를 위한 집중적인 프로그램이 따로 도입되어야 할 필요성은 없는 것으로 생각되며, 혈액질환 환자의 위암 수술에 있어 합병증도 크게 증가하지는 않는 것으로 생각된다.

• Clinical and Experimental Pediatrics
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• 제56권2호
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• pp.52-59
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• 2013

Cardiomyopathy (CMP) is a heterogeneous disease caused by a functional abnormality of the cardiac muscle. CMP is of 2 major types, dilated and hypertrophic, and is further classified as either primary or secondary. Secondary CMP is caused by extrinsic factors, including infection, ischemia, hypertension, and metabolic disorders. Primary CMP is diagnosed when the extrinsic factors of secondary CMP are absent. Furthermore, the World Health Organization, American Heart Association, and European Cardiology Association have different systems for clinically classifying primary CMP. Primary CMP is rare and associated with a family history of the disease, implying that genetic factors might affect its incidence. In addition, the incidence of CMP varies widely according to patient ethnicity. Genetic testing plays an important role in the care of patients with CMP and their families because it confirms diagnosis, determines the appropriate care for the patient, and possibly affects patient prognosis. The diagnosis and genetic identification of CMP in patients' families allow the possibility to identify novel genes that may lead to new treatments. This review focuses on the epidemiology, pathophysiology, diagnosis, and treatment of CMP, with the aim of providing pediatricians with insights that may be helpful in the early identification and management of idiopathic CMP in children.

• 성인간호학회지
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• 제29권1호
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• pp.32-40
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• 2017

Purpose: The purpose of this secondary data analysis was to identify factors influencing a relapse among patients with coronary artery disease (CAD). Methods: Of 250 participants enrolled in the original study 75 were selected as there was no relapse for more than one year following the initial treatment and 54 were selected because there was a relapse. Data were analyzed using ${\chi}^2$ test, t-test or F test to determine if there were any significant differences in the study variables relative to the status of relapse. Predictors were calculated by logistic regression. Results: Autonomy supported by healthcare providers was the significant predictor for relapse in patients with CAD. Patients with low autonomy supported by healthcare providers was 3.91 times more likely to relapse than patients with high autonomy supported. Patients with diabetes were at greater risk of recurrence. Conclusion: Secondary prevention of CAD is a major task for patients with CAD. Behavioral strategies for cardiovascular risk reduction are essential and autonomy supported by healthcare providers should be included in their strategies.

• Parasites, Hosts and Diseases
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• 제45권2호
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• pp.103-109
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• 2007

Leishmania tropica and L. major are etiologic agents of human cutaneous leishmaniasis. Delayed type hypersensitivity (DTH) is an immunologic response that has been frequently used as a correlate for protection against or sensitization to leishmania antigen. In BALB/c mice, L. tropica infection results in non-ulcerating disease, whereas L. major infection results in destructive lesions. In order to clarify the immunologic mechanisms of these 2 different outcomes, we compared the ability of these 2 leishmania species in induction of DTH response in this murine model. BALB/c mice were infected with L. major or L. tropica, and disease evolution and DTH responses were determined. The results show that the primary L. major infection can exacerbate the secondary L. major infection and is associated with DTH response. Higher doses of the primary L. major infection result in more disease exacerbation of the secondary L. major infection as well as higher DTH response. L. tropica infection induces lower DTH responses than L. major. We have previously reported that the primary L. tropica infection induces partial protection against the secondary L. major infection in BALB/c mice. Induction of lower DTH response by L. tropica suggests that the protection induced against L. major by prior L. tropica infection may be due to suppression of DTH response.

• Tuberculosis and Respiratory Diseases
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• 제69권4호
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• pp.237-242
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• 2010

Pulmonary vascular disease is a category of disorders, including pulmonary hypertension, pulmonary embolism or chronic thromboembolic pulmonary hypertension, pulmonary vasculitis, pulmonary vascular disease secondary to chronic respiratory disease, and pulmonary vascular tumor and malformations. This article reviews the recent advances in this wide spectrum of pulmonary vascular diseases.

• 식물병연구
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• 제10권4호
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• pp.209-216
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• 2004

The circular leaf spot of persimmon is occurred almost every place where persimmon is cultivated, especially the disease outbreak severely in southern part of Korea. The disease reveals unusually long incubation period after pathogen invade into leaf tissue and no practical control measure is available once the symptom has appeared. Most of the farmers just follow the suggested spray schedules calculated on the basis of weather condition of ordinary years. Therefore the damages due to circular leaf spot greatly differ year after year. In this article, we tried to describe and summarized the investigation on the circular leaf spot pathogen, Mycosphaerella nawae, related to disease outbreak such as overwintering of pathogen, inoculum formation and spread, incubation period after infection, and secondary inoculum. With the summary of these results, we suggest the disease cycle of circular leaf spot of persimmon. The pathogen overwinters in diseased leaves as mycelial form or pseudoperithecial premodium. The pseudoperitheria become matured in spring as the temperature raise and forms asci and ascospores. The maturation of pseudoperithecia are closely related to the temperatures during March and early April. The ascospores completely mature in early May and the ascospores released when the pseudoperithecia absorbed enough moisture after rainfall. The release of ascospores are diverse greatly with the variation of maturity of pseudoperithecia. Generally the spore start to release from middle of May to early of July. Duration of ascospore release is depend on the weather condition of particular year, especially amount and number of precipitation. The ascospores produced from pseudoperithecia is known to the only inoculum for circular leaf spot disease. But according to the results obtained from our investigations, the conidia formed on the lesions which incited by natural infection. This conidia are infectious to persimmon leaves and formed identical symptom as natural infection. The time of producing secondary inoculum of circular leaf spot of persimmon is considered too late to develop new disease. Generally the importance of secondary inoculum is low but the conidia produced in early September are competent to develop new disease and new infection also significantly affect to harvest of persimmon. The importance of circular leaf spot disease is recognized well to farmers. The approaches to control of the disease should be initiated on the basis of the knowledges of inoculum dynamics and ecology of disease development. The forecasting system for circular leaf spot is need to be developed.

• 한국수의병리학회:학술대회논문집
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• 한국수의병리학회 2003년도 추계학술대회초록집
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• pp.35-38
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• 2003

The parathyroid gland is probably the simplest endocrine organ in the body. The only cells of clinical significance are the parathyroid or chief cells. The primary signal that these cells listen to is calcium. Primary hyperparathyroidism is due to a parathyroid adenoma. The most common cause of hypercalcemia in veterinary medicine is hypercalcemia of malignancy associated with variety of neoplasms. Secondary hyperparathyroidism is due to a disease process, most commonly associated with renal and nutritional hyperparathyroidism. Primary and secondary hyperparathyroidism are markedly different in their clinical, laboratory, and pathogenic mechanism.