• Clinical and Experimental Pediatrics
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• v.57 no.7
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• pp.329-332
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• 2014

3-methylcrotonyl-coenzyme A carboxylase (3MCC) deficiency is an autosomal recessive disorder in which leucine catabolism is hampered, leading to increased urinary excretion of 3-methylcrotonylglycine. In addition, 3-hydroxyisovalerylcarnitine levels increase in the blood, and the elevated levels form the basis of neonatal screening. 3MCC deficiency symptoms are variable, ranging from neonatal onset with severe neurological abnormality to a normal, asymptomatic phenotype. Although 3MCC deficiency was previously considered to be rare, it has been found to be one of the most common metabolic disorders in newborns after the neonatal screening test using tandem mass spectrometry was introduced. Additionally, asymptomatic 3MCC deficient mothers have been identified due to abnormal results of unaffected baby's neonatal screening test. Some of the 3MCC-deficient mothers show symptoms such as fatigue, myopathy, or metabolic crisis with febrile illnesses. In the current study, we identified an asymptomatic 3MCC deficient mother when she showed abnormal results during a neonatal screening test of a healthy infant.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.13 no.4
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• pp.29-42
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• 2005

The passenger security screening is a mandatory procedure for boarding the aircraft according to ICAO standard as well as national law of each country. The enhanced threat of terrorism have had the security procedure strengthened since 9/11 events. However the effectiveness of passenger screening is not satisfactory and the service level for passenger is getting worse because of tightened security measurements. This research studied the responsibility issue for the enhancement of the effectiveness and service quality in passenger security screening. The study concluded that a desirable responsibility assignment for passenger screening is to the airport authority at normal time and to the government authority at the time of high threat.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2006.11a
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• pp.365-368
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• 2006

The implementation of a screening procedure for removing non-conforming products has become a common practice especially in high-tech manufacturing industries. Screening procedures involve a measurement on the quality characteristic of interest since decisions regarding the conformance to specifications are usually made on the basis of the realization of measurement. A significant variability in measurement procedures may result in the misclassification of an outgoing product (that is, falsely accepting defectives or falsely rejecting conforming items), which may lead to wrong interpretation on product quality, It may thus be necessary to consider the impacts of misclassification errors due to measurement variability when designing screening procedures. Along this line, this article investigates the design of screening procedures based on the assessment of misclassification errors. The main objective is to determine the screening limits on measured values so that two types of misclassification errors may properly be compromised.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1969-1974
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• 2013

The objective of this study was to determine the knowledge and associated factors regarding colorectal cancer screening among university students in Malaysia. The questionnaire consisted of three parts: socio-demographic characteristics, lifestyle practice and knowledge of colorectal screening. A cross-sectional study was conducted among 300 students ($21.3{\pm}1.4$ years old). The majority of the participants were Malay with a monthly family income of less than 5,000 Ringgit Malaysia (equal to 1,700 USD) (67.0% and 76.0%, respectively). Regarding their lifestyle practices, the majority were non-smokers and had never consumed alcohol (83.7%, and 88.0%, respectively). The majority of the participants had no knowledge of digital rectal examination, colonoscopy, barium enema and fecal occult blood screening (63.3%, 60.7%, 74.0% and 62.3%, respectively). Univariate and multivariate analysis revealed that their age and the discipline which the students were studying significantly influenced their level of knowledge about colorectal screening. The present study results indicate that education campaigns about colorectal cancer should be promoted.

• 한국디지털정책학회:학술대회논문집
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• 2004.05a
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• pp.195-204
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• 2004

Due to growth of diversified media, content screening is the definite procedures. The procedures of screening varies from country by country in various reasons. Therefore, reason of conducting such study is to compare & contrast screening process by countries. In order to clarify definition of terms that measures screening, "censorship" means "legislative filtering process prior to public appearance". In contrary "Rating and/or Classification" is defined opposite of it. After defining these terms, Screening is dignified into two distinctive measures, which are "legislative intereference" and "voluntary notification". Those two measures are again sub-categorized into eight distinctive operational definition. Utilizing those distinctive measures, our study has concluded as US, Japan and some laissez-faire countries use "voluntary notification" systems but in contrast China and Brunei use "legislative filtering" system.? Korea and Australia uses unique combination of both system. In order for Korea to adopt "voluntary notification system", legislative intereference must be weaken and develop strong "voluntary notification" system.

• Journal of Korean Society for Quality Management
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• v.36 no.4
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• pp.77-86
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• 2008

Due to the rapid growth in automated testing and manufacturing systems, screening inspection becomes very attractive. In this paper, we investigate the effects of limited capacity on screening inspection using a surrogate variable. The model is developed under the assumption that the reprocessed and nonreprocessed items are produced by the same manufacturing process and therefore their quality characteristics are independently and identically distributed. Profit models are constructed which involve four price/cost components; selling price, cost incurred by imperfect quality, reprocessing and quality inspection costs. Methods of finding the optimal screening limits are presented, and a numerical example is given. Sensitivity analyses are also performed to study the effect of a process standard deviation on this model.

• The Korean Journal of Ceramics
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• v.5 no.4
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• pp.386-389
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• 1999

Effect of high voltage screening was examined on mechanical strength of titania ceramics with two different surface roughness. Roughly finished sample showed degraded mechanical strength meaning that the introduced flaw played the role of starting point of mechanical fracture. On such sample, electrically weak parts were eliminated by applying a screening field. Mechanical strength measurement on survived parts revealed that after screening the Weibull plots bended to become a convex curve while plots at high strength region were almost the same. This result means that relatively low mechanical strength parts were eliminated by the electrical method. As a result the Weibull modulus calculated from all the data increased, demonstrating the effect of high voltage screening on titania ceramics containing fracture controlling surface flaws. Roles of the surface flaw such as a common weak spot for both failures are disscussed in relation to the electric field concentration similar to that of mechanical stress.

• Korean Journal of Bronchoesophagology
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• v.7 no.2
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• pp.168-173
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• 2001

Background and Objectives： The introduction of highly sensitive imaging techniques has made it possible to detect many non-palpable nodules, or“incidentaloma”in the thyroid. Discovery of these lesions raises concerns about their malignancy, but the optimal strategy for managing these lesions has not been clearly established. This study was designed to evaluate the usefulness of ultrasonographic exam with new diagnostic criteria and presume the value of mass screening for thyroid cancer. Materials and Methods : Mass screening for thyroid cancer were carried out in conjunction with mass screening for breast cancer. The subjects were 630 women aged 30 years or over. Thyroid glands were examined with 10 MHz transducer ultrasonography by one radiologist. Needle aspiration biopsy were performed when suspicious of malignancy under the new diagnostic criteria. Results and Conclusion : The new ultrasonographic criteria to diagnose thyroid cancer provided useful information and ensured more accurate evaluation. 7 cases of thyroid cancer were discovered and successfully managed. It should be further demonstrated that there is sufficient value of mass screening for thyroid cancer to perform it independently despite early cancer detection.

• Genomics & Informatics
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• v.5 no.1
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• pp.24-29
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• 2007

Computational virtual screening has become an essential platform of drug discovery for the efficient identification of active candidates. Moleculardocking, a key technology of receptor-centric virtual screening, is commonly used to predict the binding affinities of chemical compounds on target receptors. Despite the advancement and extensive application of these methods, substantial improvement is still required to increase their accuracy and time-efficiency. Here, we evaluate several advanced structure-based virtual screening approaches for elucidating the rank-order activity of chemical libraries, and the quantitative structureactivity relationship (QSAR). Our results show that the ensemble-average free energy estimation, including implicit solvation energy terms, significantly improves the hit enrichment of the virtual screening. We also demonstrate that the assignment of quantum mechanical-polarized (QM-polarized) partial charges to docked ligands contributes to the reproduction of the crystal pose of ligands in the docking and scoring procedure.

• Journal of Korea Association of Health Promotion
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• v.1 no.1
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• pp.7-8
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• 2003

The health screening and promotion is an emerging field of clinical preventiemedicine and is proved to be effective for reduction of diseaseprevalence, particularly life-style related diseases in aged population. However, the goal of perodic health screening can be achieved by a reliable health screening that largely depond on the quality of tests. Various tests including ultrasonography, endoscopy, CT and automated blood analyzers are used in health screening. Thesescreening tests are usually sensitive, but not specific to the presence of diseases. It meams the tests produce more false positive results, that demand eztra-expenses for the confirmation of disease. Promising screening tests should be sensitive as well as specific. However, it is not easy to maintain the quality of laboratory tests, because it is affected by various factors, such as instruments, reagents, laboratory methods and human factors. This review focuses on internal and external quality control of laboratory tests and quality management of health screening services to obtain reliable test results.