• Journal of the Korean Society of Earth Science Education
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• v.12 no.1
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• pp.64-81
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• 2019

The purpose of this study is to analyze elementary science gifted students' characteristics of the thinking in the problem solving process through a MEA(Model Eliciting Activity)activity. The subjects of this study are 40 elementary science gifted students who passed the first screen for the admission to the science gifted education institute in P university in 2018. The MEA activity was 'Coffee cup challenge', which is to find the best way to place cup side and bottom to save paper in a given material. Three drawings from each student and explanations of each drawing through out the design process were collected as the main data source. The data were analyzed by statistically (correlation coefficient) and qualitatively to find the relationship between; 1) the intuitive thinking and visual representation and 2) analytical thinking ability and communication skills that reflect MEA activities. In conclusion, first, intuitive thinking plays an important role in the ability of visual representation through pictures and the whole problem solving process. Second, the analytical thinking and elaboration process which are reflected through reflection on the arrangement of the drawings have a great influence on the communication skills. Therefore, this study investigated that MEA activities are useful activities to stimulate both intuitive and analytical thinking in elementary science gifted students, and to develop communication ability, by organizing their own ideas and providing learning opportunities for various solutions.

• Journal of Ginseng Research
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• v.48 no.1
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• pp.77-88
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• 2024

Background: Lung inflammation occurs in many lung diseases, but has limited effective therapeutics. Ginseng and its derivatives have anti-inflammatory effects, but their unstable physicochemical and metabolic properties hinder their application in the treatment. Panaxadiol (PD) is a stable saponin among ginsenosides. Inhalation administration may solve these issues, and the specific mechanism of action needs to be studied. Methods: A mouse model of lung inflammation induced by lipopolysaccharide (LPS), an in vitro macrophage inflammation model, and a coculture model of epithelial cells and macrophages were used to study the effects and mechanisms of inhalation delivery of PD. Pathology and molecular assessments were used to evaluate efficacy. Transcriptome sequencing was used to screen the mechanism and target. Finally, the efficacy and mechanism were verified in a human BALF cell model. Results: Inhaled PD reduced LPS-induced lung inflammation in mice in a dose-dependent manner, including inflammatory cell infiltration, lung tissue pathology, and inflammatory factor expression. Meanwhile, the dose of inhalation was much lower than that of intragastric administration under the same therapeutic effect, which may be related to its higher bioavailability and superior pharmacokinetic parameters. Using transcriptome analysis and verification by a coculture model of macrophage and epithelial cells, we found that PD may act by inhibiting TNFA/TNFAR and IL7/IL7R signaling to reduce macrophage inflammatory factor-induced epithelial apoptosis and promote proliferation. Conclusion: PD inhalation alleviates lung inflammation and pathology by inhibiting TNFA/TNFAR and IL7/IL7R signaling between macrophages and epithelial cells. PD may be a novel drug for the clinical treatment of lung inflammation.

• Spatial Information Research
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• v.20 no.2
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• pp.1-11
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• 2012

In the current construction planning and designing process, an architectural miniature model was designed to verify the interior or exterior spatial sense of a building structure, but building of the miniature model is demand much more effort and time; in addition to this it has limitation to identify interior information of the building. For a complement of it, CAD would be used in the existing planning and designing process to visualize the building information, but its visualization is not satisfactory for the 3D volume which could be easily verified with the miniature model. CAD is the specific software for designing building structures and the 3D results are usually rendered on 2D monitor screen. Therefore, there is a shortage of cognitive immersion for the 3D space. In this paper, we introduce the conversion process of BIM shape data into the Augmented Reality contents by using a series of softwares. As a result of modification on construction plan or design we reduced the cost and time to reconstruct the final visualization. We have shown that the interior or exterior information of the building structures are easily visualized with BIM shape data on augmented reality environment. Several proposed interaction methods, such as rem oval of building components, and slice-cut operation, provide the user for the effective manipulation of models on the augmented reality environment.

• Journal of Digestive Cancer Research
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• v.5 no.2
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• pp.97-104
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• 2017

Background: Cachexia is a multi-factorial syndrome presenting with chronic illness, decreases in body weight, and loss of adipose tissue and skeletal muscle, mostly in patients with advanced cancer and chronic wasting disease. Even after years of intensive researches, there remains no convincing therapy to prevent cancer cachexia. Methods: In this in vivo study, we have established C26 adenocarcinoma-induced cancer cachexia model in mice to explore the underlying core changes in cytokine, signal transduction, and muscle wasting. The ultimate aim of establishing animal model is to find optimal therapeutics to mitigate cancer cachexia. Results: We have administered C26 adenocarcinoma cells onto BALB/c mice and observed 4 weeks to assess the progression of cancer cachexia. Significant loss of weight accompanied with loss of appetite was noted. As C26 adenocarcinoma xenograft progressed, mortality was started from 3 weeks, accompanied with significant sarcopenia and decreased mice movement. Surges in TNF-α and IL-6 were noted with the commencement of cancer cachexia. Conclusion: Using C26 adenocarcinoma cancer cachexia model, we can screen the optimal therapeutics to mitigate cancer cachexia, in which agents to modulate IL-6, TNF-α, and NF-κB were essential.

• The Journal of the Convergence on Culture Technology
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• v.9 no.5
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• pp.329-334
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• 2023

This study attempted to examine the effect of corporate ESG activities perceived by college students on corporate loyalty and purchase intention. The results of the study are as follows. Looking at the average ESG activities recognized by college students, society 4.28 points, governance 4.25 points, and environment 4.12 points out of 5, and the average customer loyalty was 3.86 points when 3 points out of 5 points were median, and purchase intention was 3.84 points. Looking at the correlation between the factors of corporate ESG activities, customer loyalty, and purchase intention perceived by college students, it was confirmed that it had a static correlation coefficient. As a result of analyzing the effect of ESG activities perceived by college students on customer loyalty, the variable that significantly affects customer loyalty in [Model 1] is the major (β=.167p=).01) It was. Among the additional variables added to [Model 2], the variable that significantly affects customer loyalty is the environment (t=3.017, p<.).01), society ((t=4.365, p<.001), governance structure (t=-3.139, p<.01) was found to have a significant effect on customer loyalty. As a result of analyzing the effect of ESG activities perceived by college students on purchase intention, there was no significant effect on purchase intention in [Model 1]. Among the additional variables put into [Model 2], society (t=4.850, p<.001), governance structure (t=-3.452, p<.01) was found to have a significant effect on purchase intention.

• The Korean Journal of Applied Statistics
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• v.37 no.2
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• pp.225-237
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• 2024

In the analysis of competing risks data, some of covariates may not be fully observed for some subjects. In such cases, excluding subjects with missing covariate values from the analysis may result in biased estimates and loss of efficiency. In this paper, we studied multiple imputation and the augmented inverse probability weighting method for regression parameter estimation in the cause-specific proportional hazards model with missing covariates. The performance of estimators obtained from multiple imputation and the augmented inverse probability weighting method is evaluated by simulation studies, which show that those methods perform well. Multiple imputation and the augmented inverse probability weighting method were applied to investigate significant risk factors for the risk of death from breast cancer and from other causes for breast cancer data with missing values for tumor size obtained from the Prostate, Lung, Colorectal, and Ovarian Cancer Screen Trial Study. Under the cause-specific proportional hazards model, the methods show that race, marital status, stage, grade, and tumor size are significant risk factors for breast cancer mortality, and stage has the greatest effect on increasing the risk of breast cancer death. Age at diagnosis and tumor size have significant effects on increasing the risk of other-cause death.

• Cartoon and Animation Studies
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• s.36
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• pp.469-491
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• 2014

Webtoon has developed the method that makes it possible to express sound visually. Also we can also hear sound in webtoon through the development of web technology. It is natural that we analyze the sound that we can hear, but we can also analyze the sound that we can not hear. This study is based on 'dual code' in cognitive psychology. Cartoonists can make visual expression on the basis of auditive impression and memory, and readers can recall the sound through the process of memory and memory-retrieval. This study analyzes both audible sound and inaudable sound. Concise analysis owes the method to film sound theory. Three main factor, Volume, pitch, and tone are recognized by frequency in acoustics. On the other hand they are expressed by the thickness and site of line and image of sound source. The visual expression of in screen sound and off screen sound is related to the frame of comics. Generally the outside of frame means off sound, but some off sound is in the frame. In addition, horror comics use much sound for the effect of genre like horror film. When analyzing comics sound using this kinds of the method film sound analysis, we can find that webtoon has developed creative expression method comparing with simple ones of early comics. Especially arranging frames and expressing sound following and vertical moving are new ones in webtoon. Also types and arrangement of frame has been varied. BGM is the first in using audible sound and recently BGM composed mixing sound effect is being used. In addition, the program which makes it possible for readers to hear sound according to scroll moving. Especially horror genre raise the genre effects using this technology. Various methods of visualizing sound are being created, and the change shows that webtoon could be the model of convergence in contents.

• Journal of KIISE:Software and Applications
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• v.37 no.5
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• pp.341-353
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• 2010

Mobile Internet Device (MID) allows users to flexibly use various forms of wireless internet such as Wi-Fi, GSM, CDMA, and 3G. Using such Internet, MID users can utilize application services. MID usage is expected to grow due to the benefits of portability, Internet accessibility, and other convenience. However, it has resource constraints such as limited CPU power, small memory size, limited battery life, and small screen size. Consequently, MIDs are not capable to hold large-sized complex applications and to process a large amount of data in memory. An effective solution to remedy these limitations is to develop cloud services for the required application functionality, to deploy them on the server side, and to let MID users access the services through internet. A major concern on running cloud services for MIDs is the potential problems with low Quality of Service (QoS) due to the characteristics of MIDs. Even measuring the QoS of such services is more technically challenging than conventional quality measurements. In this paper, we first identify the characteristics of MIDs and cloud services for MIDs. Based on these observations, we derive a number of quality attributes and their metrics for measuring QoS of mobile services. A case study of applying the proposed quality model is presented to show its effectiveness and applicability.

• Horticultural Science & Technology
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• v.32 no.4
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• pp.473-483
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• 2014

In this work, the effects of shade combination, shade height and wind regime on greenhouse climate were quantified. A two-dimensional (2-D) computational fluid dynamics (CFD) model was developed based on an 11-span plastic greenhouse in eastern China for wind almost normal to the greenhouse orientation. The model was first validated with air temperature profiles measured in a compartmentalized greenhouse cultivated with mature lettuce (Lactuca sativa L., 'Yang Shan'). Next, the model was employed to investigate the effect of shade combinations on greenhouse microclimate patterns. Simulations showed similar airflow patterns in the greenhouse under different shade combinations. The temperature pattern was a consequence of convection and radiation transfer and was not significantly influenced by shade combination. The use of shade screens reduced air velocity by $0.02-0.20m{\cdot}s^{-1}$, lowered air temperature by $0.2-0.8^{\circ}C$ and raised the humidity level by 0.9-2.0% in the greenhouse. Moreover, it improved the interior climate homogeneity. The assessment of shade performance revealed that the external shade had good cooling and homogeneity performance and thus can be recommended. Furthermore, the effects of external shade height and wind regime on greenhouse climate parameters showed that external shade screens are suitable for installation within 1 m above roof level. They also demonstrated that, under external shade conditions, greenhouse temperature was reduced relative to unshaded conditions by $1.3^{\circ}C$ under a wind speed of $0.5m{\cdot}s^{-1}$, whereas it was reduced by merely $0.5^{\circ}C$ under a wind speed of $2.0m{\cdot}s^{-1}$. Therefore, external shading is more useful during periods of low wind speed.