• 동의생리병리학회지
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• 제33권5호
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• pp.255-260
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• 2019

Oriental Diagnosis System(ODS) is an artificial intelligence program that utilize entered diagnosis knowledge, determine patient's disease and decide right medicine. The purpose of this study is to find a correlation between pattern Identification in Korean medicine and each sasang types(So-Yang, So-Eum and Tae-Eum) by analyzing ODS diagnosis result. Eventually our study secure availability of using ODS program at clinical training or developing diagnosis program. Subject of this study is 32 students participating in Sasang medical practice(12 subjects were So-Yang, 7 subjects were So-Eum, and 13 subjects were Tae-Eum). We analyze subject's clinical practice result reports by using ODS program and obtained result about pattern Identification. We used SPSS statistics 23 in analyzing the differences of the scores of Eight Principle Pattern Identification, Qi-Blood Pattern Identification, Bing-xie Pattern Identification, and Visceral Pattern Identification in each Sasang types (So-Yang, So-Eum, Tae-Eum). In the case of Heat-moisture, Tae-Eum showed higher score than So-Eum, but So-Yang showed no difference from the other two Sasang types(p<0.05). And in the case of Food-accumulation, Tae-Eum and So-Yang showed significantly higher score than So-Eum(p<0.05). It is hard to generalize the result because subject of this study was not enough. However, we explained correlation between pattern Identification in korean medicine and each sasang types based on quantifiable and objective evidence system. Therefore use of ODS program in student clinical practice training help to understand the relationship and correlation between different pattern Identification and will help standardization of clinical practice education.

• 한국지리정보학회지
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• 제9권2호
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• pp.54-66
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• 2006

2005년 5월 산림청에서 전국 산지를 대상으로 산사태 위험지도를 제작하였다. 본 연구는 산사태 위험지도의 정확성 검증을 위하여 2005년 8월 2~3일 전북지역에서 발생된 산사태 지역을 대상으로 부경대학교 위성정보과학과 PE&RS Lab에서 개발한 PKNU 3호 시스템으로 촬영한 영상을 이용하여 산사태 발생 지역을 추출한 후 산사태 위험지도와 중첩해서 산사태 위험지도의 정확도를 검증하였다. 또한 ArcView 3.3의 산지 지형 분석과 하계망 분석을 통해 산사태 발생 지역의 고도, 경사도, 경사방향, 하천장, 유역면적에 대한 특성을 분석하였다. 그 결과 산사태 위험지도의 등급별 단위 %량의 조정이 필요하며 산사태 위험지도 작성에 기본이 되는 산사태 위험 판정표에 대한 수정 보완이 필요하다고 사료된다.

• 동의신경정신과학회지
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• 제21권4호
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• pp.137-149
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• 2010

Objectives : The aim of this study was to describe the clinical aspects in dementia outpatients who visited oriental neuropsychiatry clinic and to analyze the efficacy of herbal medicine. Methods: We analysed medical records of dementia outpatients who visited oriental neuropsychiatry clinic of K medical center from August. 2000 to July, 2010 and matched our criteria. Results: Ninety-two subjects were selected for analysis and consisted of 77.3% dementia of Alzheimer type. 13.0% vascular dementia. and 9.8% mixed type of dementia. Herbal medicine prescribed mainly were Jowjseungchung-tang(Tiaowejshengqing-tang). Kunneo-tang(Jjannao-tang) and Chenwangbosim-dan(Tianwangbuxin-dan) for dementia of Alzheimer type, and Sunghyangjungki-san(Xjngxjangzhengqi-san) and Upung-dan (Yufeng-dan) for vascular dementia. Scores of K-DRS were not changed for some subs cales and decreased but less than natural decline of Alzheimer disease. Score on the Memory subscale in group of Kunneo-tang(Jjannao-tang) increased significantly. Conclusions : These results suggest that the herbal medicine may be effective for dementia. More prospective studies are needed to assess the efficacy and prognosis of herbal medicine for dementia. Clinical guideline is needed for systematic data accumulation.

• Journal of Gastric Cancer
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• 제10권4호
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• pp.241-246
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• 2010

Purpose: Laparoscopy-assisted gastrectomy (LAG) has become a technically feasible and safe procedure for early gastric cancer treatment. LAG is being increasingly performed in many centers; however, there have been few reports regarding LAG at low-volume centers. The aim of this study was to report our early experience with LAG in patients with gastric cancer at a low-volume center. Materials and Methods: The clinicopathologic data and surgical outcomes of 39 patients who underwent LAG for gastric cancer between April 2007 and March 2010 were retrospectively reviewed. Results: The mean age was 68.3 years. Thirty-one patients had medical co-morbidities. The mean patient ASA score was 2.0. Among the 39 patients, 4 patients underwent total gastrectomy and 35 patients underwent distal gastrectomy. The mean blood loss was 145.4 ml and the mean operative time was 259.4 minutes. The mean time-to-first flatus, first oral intake, and the postoperative hospital stay was 2.8, 3.1, and 9.3 days, respectively. The 30-day mortality rate was 0%. Postoperative complications developed in 9 patients, as follows: anastomotic leakage, 1; wound infection, 1; gastric stasis, 2; postoperative ileus, 1; pneumonia, 1; cerebral infarction, 1; chronic renal failure, 1; and postoperative psychosis, 1. Conclusions: LAG is technically feasible and can be performed safely at a low-volume center, but an experienced surgical team and careful patient selection are necessary. Furthermore, for early mastery of the learning curve for LAG, surgeons need education and training in addition to an accumulation of cases.

• 한방재활의학과학회지
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• 제21권2호
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• pp.279-288
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• 2011

Objectives : Our purpose of this study was to evaluate the association between abdominal adipose tissue and oriental obesity pattern identification. Methods : This study was performed in 78 healthy obese(BMI(body mass index)${\geq}25kg/m^2$) women in Seoul. Subjects underwent abdominal CT(computed tomography) scanning and were asked to complete the oriental obesity pattern identification questionnaire. Subjects were given written consent and this study was performed under permission of institutional review board of Kyung-hee East-west Neo medical center. Results : 1. VFA(visceral fat area) and VSR(visceral/subcutaneous adipose tissue ratio) were significantly correlated with stagnation of the liver qi(肝鬱, gan-yu)(p<0.05). But, other patterns were not significantly correlated with oriental obesity pattern identification(p>0.05). 2. We evaluated a difference of oriental obesity pattern identification score in visceral obesity group(n=34) versus non-visceral obesity group(n=44). Scores of all patterns except food accumulation(食積, shi-ji) were significantly higher in the visceral obesity group than in the non-visceral obesity group(p<0.05). Especially, there was a further significant difference in stagnation of the liver qi(肝鬱, gan-yu)(p<0.01). Conclusions : Generally, the stagnation of the liver qi(肝鬱, gan-yu) has a close relation with stress and depression. This study suggests that stress and depression might be correlated with visceral fat, and the use of oriental obesity pattern identification would be helpful for planning a treatment schedule of visceral obesity in the clinic.

• Journal of Ginseng Research
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• 제47권6호
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• pp.735-742
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• 2023

Background: Gintonin is a new material of ginseng that acts through the ginseng-derived lysophosphatidic acid (LPA) receptor ligand. The gintonin-enriched fraction (GEF) inhibits amyloid plaque accumulation in the cortex and hippocampus, improves cognitive dysfunction by increasing acetylcholine levels, and promoted hippocampal neurogenesis in an animal model of Alzheimer's disease. We evaluated the effect of the GEF on the cognitive performance of subjects with subjective memory impairment (SMI). Methods: In this eight-week, randomized, assessor- and participant-blinded, placebo-controlled study, participants with SMI were assigned to three groups receiving placebo, GEF 300 mg/day or GEF 600 mg/day. The Korean versions of the Alzheimer's Disease Assessment Scale (K-ADAS), Mini-Mental State Examination (K-MMSE), and Stroop color-word test (K-SCWT) were also evaluated along with the safety profiles. Results: One hundred thirty-six participants completed the study. After eight weeks, we analyzed intergroup differences in primary or secondary outcome score changes. When we compared the GEF group with the placebo group, we observed significant improvements in the K-ADAS and K-SCWT scores. The GEF group did not show a significant improvement in K-MMSE and BDI scores compared to the placebo group. No adverse events were observed in the gintonin and placebo groups for eight weeks. Conclusion: The GEF is safe and effective in improving subjective cognitive impairment related to both the K-ADAS and K-SCWT in this study. However, further large-scale and randomized controlled studies are warranted to secure other cognitive function tests besides the K-ADAS and K-SCWT, and to confirm the findings of the current study.

• 스마트미디어저널
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• 제12권11호
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• pp.77-85
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• 2023

COVID-19 이후 온라인을 통한 소통이 증가하여 다양한 플랫폼을 기반으로 소통을 위한 대화 텍스트 데이터가 대량으로 축적되고 있다. 텍스트 데이터로부터 유의미한 정보를 추출하기 위한 텍스트 요약에 대한 중요성이 더욱 증가함에 따라 딥러닝을 활용한 추상 요약 연구가 활발하게 이루어지고 있다. 그러나 대화 데이터는 뉴스 기사와 같은 정형화된 텍스트에 비해 누락 및 변형이 많아 대화 상황을 다양한 관점에서 고려해야 하는 특이성이 있다. 특히 어휘 생략과 동시에 내용과 관련 없는 표현 요소들이 대화의 내용을 요약하는 데 방해가 된다. 그러므로 본 연구에서는 한국어 대화 데이터의 특성을 고려하여 발화문을 재구조화하고 KoBART 기반의 사전학습된 텍스트 요약 모델을 파인 튜닝후, 요약문에서 중복 요소를 제거하는 정제 작업을 통해 대화 데이터 요약 성능을 향상시키고자 한다. 발화문을 재구조화하는 방법으로는 발화 순서에 따라 재구조화는 방법과 중심 발화자를 기준으로 재구조화하는 방법을 결합하였다. 대화문 재구조화 방법을 적용한 결과, Rouge-1 점수가 4 정도 향상되었다. 본 연구의 대화 특성을 고려한 재구조화 방법이 한국어 대화 요약 성능 향상에 유의미함을 입증하였다.

• Nutrition Research and Practice
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• 제18권1호
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• pp.46-61
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• 2024

BACKGROUND/OBJECTIVES: An increasing life expectancy in society has burdened healthcare systems substantially because of the rising prevalence of age-related metabolic diseases. This study compared the effects of animal protein hydrolysate (APH) and casein on metabolic diseases using aged mice. MATERIALS/METHODS: Eight-week-old and 50-week-old C57BL/6J mice were used as the non-aged (YC group) and aged controls (NC group), respectively. The aged mice were divided randomly into 3 groups (NC, low-APH [LP], and high-APH [HP] and fed each experimental diet for 12 weeks. In the LP and HP groups, casein in the AIN-93G diet was substituted with 16 kcal% and 24 kcal% APH, respectively. The mice were sacrificed when they were 63-week-old, and plasma and hepatic lipid, white adipose tissue weight, hepatic glucose, lipid, and antioxidant enzyme activities, immunohistochemistry staining, and mRNA expression related to the glucose metabolism on liver and muscle were analyzed. RESULTS: Supplementation of APH in aging mice resulted in a significant decrease in visceral fat (epididymal, perirenal, retroperitoneal, and mesenteric fat) compared to the negative control (NC) group. The intraperitoneal glucose tolerance test and area under the curve analysis revealed insulin resistance in the NC group, which was alleviated by APH supplementation. APH supplementation reduced hepatic gluconeogenesis and increased glucose utilization in the liver and muscle. Furthermore, APH supplementation improved hepatic steatosis by reducing the hepatic fatty acid and phosphatidate phosphatase activity while increasing the hepatic carnitine palmitoyltransferase activity. Furthermore, in the APH supplementation groups, the red blood cell (RBC) thiobarbituric acid reactive substances and hepatic H₂O₂ levels decreased, and the RBC glutathione, hepatic catalase, and glutathione peroxidase activities increased. CONCLUSIONS: APH supplementation reduced visceral fat accumulation and alleviated obesity-related metabolic diseases, including insulin resistance and hepatic steatosis, in aged mice. Therefore, high-quality animal protein APH that reduces the molecular weight and enhances the protein digestibility-corrected amino acid score has potential as a dietary supplement for healthy aging.

• 한국건설관리학회논문집
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• 제21권6호
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• pp.46-55
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• 2020

도로연장의 지속적인 증가와 공용기간이 상당히 경과한 노후 노선이 늘어남에 따라 도로포장에 대한 유지관리비용은 점차 증가하고 있어, 예방적 유지관리를 통해 비용을 최소화 하는 방안에 대한 필요성이 제기되고 있다. 예방적 유지관리를 위해서는 도로포장의 정확한 파손 예측을 통한 전략적 유지관리 계획 수립이 필요하다. 이에 본 연구에서는 고속도로 콘크리트 포장 파손 예측 모델 개발을 위해 머신러닝 분류기반 모델 중 성능이 우수한 XGBoost 기법을 사용하였다. 먼저 데이터 샘플링을 통해 데이터 불균형 문제를 해결하고 샘플링된 데이터들에 XGBoost 기법을 활용하여 예측모델을 개발하고. F1 소코어를 통해 성능을 평가하였다. 분석 결과 오버 샘플링 기법이 가장 좋은 성능 결과를 보였으며, 도로파손에 영향을 주는 주요 변수로 공용년수, ESAL, 최저 평균 최저기온 -2도 이하 일수 순으로 산정되었다. 향후 더 많은 데이터 축적 및 세밀한 데이터 전처리 작업을 통해 예측모델의 성능이 향상된다면 보다 정확한 유지보수 필요 구간의 예측이 가능해질 것으로 판단되므로 장래 고속도로 포장 유지보수 예산의 추정에 중요한 기초정보로 활용될 수 있을 것이라 기대된다.

• 한국식품위생안전성학회지
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• 제15권4호
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• pp.287-292
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• 2000

1976년과 1997년 남해안의 거제도 외포리에서 채취한 진주담치와 굴의 독력 덴 독소성분을 비교 조사하였다. 독성은 진주담치가 굴에 비하여 약 10배 정도 높았으며(1996년, 진주담치, 8,670 $\mu\textrm{g}$, 굴 860$\mu\textrm{g}$; 1997년, 진주담치 5,657 $\mu\textrm{g}$, 굴 531$\mu\textrm{g}$/100g), 독화기간도 진주담치가 굴에 비하여 길었다. 두 종류의 시료 모두 독소 주성분은 Cl 및 C2 (20~65%)와 gonyautoxin 1, 2, 3, 4 (38~78%)이었다. 그리고 독화초기에는 11$\beta$-epimer toxin(C2, GTX4)의 비율이 25~56mo1e%(1996년)와 25~80mo1e% (1997년)로 11$\alpha$-epimer toxin(Cl, GTX2)의 비율도다 높았다. 그러나 독화기간이 지남에 따라 11$\alpha$-epimer toxin의 비율이 41~57mo1e%(1996년)와 25~56mo1e%(1997년)로 11$\beta$-epimer toxin의 비율보다 높게 나타났다. 이와 같은 독소성분 조성의 변화는 패류내에서 독소가 대사되기 때문인 것으로 추측된다.