• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.10a
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• pp.5-5
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• 2019

DMZ는 살아있는 생물다양성의 보고로 지난 60여년동안 자연적으로 재생이 일어나고 환경적인 강제 보존 영향으로 높은 생태학적인 가치가 유지되고 있으며, 최근에는 남북교류에 대한 활발한 의지로 DMZ생태자원의 남북공동활용 방안에 대한 이슈가 급부상하고 있다. 이에 본 연구진은 3년전부터 DMZ에서 자생하는 식물에 대한 조사를 진행하여 총 200여종 이상의 자생식물의 표본과 추출물들을 보유하고 있으며, 이 추출물들을 활용 in vitro 와 in vivo 평가를 통해 비임상 평가에서 유효한 효과를 나타내는 후보물질들을 다수 찾아낼 수 있었다. 그 중 조팝나무(Spiraea prunifolia var. simpliciflora)는 쌍떡잎식물 장미과에 속하는 낙엽활엽관목으로 동북아시아 지역에 널리 분포되며 우리나라에서는 중부지방에 주로 서식한다고 알려져 있다. 예로부터 해열 및 소염, 신경통완화 치료등에 이용해왔다고 알려져 있으며 그 속에는 다양한 terpenoids, flavonoid 및 phenolic 화합물이 다량 함유되어 있다고 알려져 있다. 본 연구에서는 조팝나무 추출물을 이용하여 전구지방세포에서의 지방세포분화 억제 및 관련 유전자들의 활성을 확인한 후 고지방식이로 유도된 high-fat diet mouse model을 이용하여 체지방 감소 및 내장지방감소, 간 조직내의 지방량 감소등을 확인하였으며, 혈액분석을 통해 총콜레스테롤과 고중성지방등 동맥경화와 심혈관계 질환을 유도시킬수 있는 지표들에서 억제 활성도 확인하였다. 특히 내장 지방의 경우는 Micro-CT를 통해 정밀한 분석을 진행하였고, 체지방뿐만 아니라 전체 체중감소도 나타나는 것을 확인하였다. 현재 실험을 통해 적출된 간 조직과 지방조직을 이용하여 항 비만 활성의 작용기전을 지속적으로 확인하고 있으며, 이 결과는 국제적인 연구저널에 보고되어 향후 체지방 감소 또는 항 비만 치료제로 개발되는 비임상 연구자료로 활용될 계획이다. 이미 조팝나무에 대한 연구결과는 특허로 출원이 완료되어 PCT출원까지 진행중에 있으며 개별인정형 건강기능식품 개발 기업에 기술이전이 될 예정이다. 또한 원활한 원료 수급을 위해 기초단체 소속 농업기술센터와 원료 재배 및 대량 수급에 관한 논의를 마친 상태로 접경지역 근처 농가소득 증대로도 이어지는 제품화 사례이기도 하다. 이는 접경지역에서 자생하는 원료의 활성을 과학적으로 검증하여 기업과의 연계를 통해 기초시군 단체의 농가 소득과도 연계한 우수한 제품개발 사례로 향후에도 이와 같은 연구성과가 지속적으로 도출되기를 기대해본다.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.40 no.4
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• pp.383-390
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• 2014

The following conclusion was made from the 2D-QSAR model for the tyrosinase inhibitory activity according to the variation of the substituents R1 and R2 in analogues of compound 2-[(2,6-dioxocyclohexyl)methyl]cyclohexane- 1,3-dione (1-23). The best optimized 2D-QSAR model was $Obs.pI_{50}=-0.295({\pm}0.031)TDM$ $-0.120({\pm}0.014)DMZ+0.135({\pm}0.050)DMX.R_2+6.382({\pm}0.17)$, and the correlation $r^2=0.905$) of which was greater than its predictability ($q^2=0.843$). The magnitude of the effect of tyrosinase inhibitory activities was in order of TDM > $DMX.R_2{\geq}DMZ$, and it tended to increase as the hydrophobicity of substrate molecule (ClogP > 0) as well as the steric favor of substituent $R_1$ increased. The analysis of the model implies that inhibitory activity of substrate molecule will increase as $DMX.R_2$ (Dipole moment X component of $R_2$-substituent) increases, while TDM (Total Dipole Moment) and DMZ(Dipole Moment of Z-Component) decrease. As such, it is deemed feasible to conclude, that in order to increase the inhibitory effect, it would be rather desirable to replace the polar groups within the molecules with non-polar functional groups.

• Journal of Wetlands Research
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• v.6 no.3
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• pp.95-105
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• 2004

우리나라의 비무장지대는 북위 38도를 중심으로 동서로 띠 모양을 이루고 있으며 총 면적이 $907.3km^2$에 이른다. 비무장지대외곽에는 민통선이 비무장지대의 남쪽 5-20km 아래에 위치하고 있으며 이곳에는 15개의 시, 군, 98개 읍, 면이 있다. 또한 동해에서 서해로 이르는 내륙의 접경지역은 약 248km에 이르며 이곳에는 2,800여종의 동식물과 146종의 희귀 동식물이 다양하게 분포하는 우수한 생태계를 이루고 있다. 하지만 이 지역은 남북교류 및 협력의 강화로 인해 향후 남북교류와 통일을 위한 전략지역으로 활용되기 위한 방안이 논의되고 있다. 그 결과 남북접경지원법(2000)이 제정되었고 각종 개발사업의 시행이 이 지역의 우수한 생태계를 훼손하려하고 있다. 철원의 비무장지대를 비롯한 습지지역은 세계적인 희귀 철새이며 우리나라의 멸종위기종인 두루미의 서식지공간으로 활용되고 있다. 철원지방의 두루미서식지 보전을 위해 벼농사 추수 후 농경지를 그대로 유지하는 것이 중요하다. 우리나라 비무장지대의 보전을 위해 유네스코의 접경지원보전방안의 도입이 필요하다. 보전계획을 수립한 후, 보전지역 확보를 위한 자금이 조성되어야 하며, 지역주민의 참여를 유도하는 생태관광의 도입이 필요하고, DMZ를 교육 및 연구의 중심지역으로 발전시키는 방안이 강구되어야 한다. 국제사회의 주목을 받고 있는 자연생태계우수지역의 유지, 발전을 위해 정부, 학계는 같이 노력하여야 한다.

• Proceedings of the Korea Information Processing Society Conference
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• 2021.05a
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• pp.59-61
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• 2021

고성능 네트워크를 기반으로 하는 과학응용 협업연구 환경에서 대용량 데이터의 고속 전송을 위해 활용되고 있는 전용의 데이터 전송 노드는 이용률을 감안하여 연산을 위한 부수적인 목적을 위해 활용이 가능하다 본. 논문에서는 이러한 분산된 데이터 전송 노드들을 활용한 컨테이너 기반 협업연구 플랫폼의 구성 사례를 소개하고 해당 플랫폼 상에서 분산 학습을 실험하고 소요시간 측면에서 성능을 측정하여 제시한다.

• Journal of Forest and Environmental Science
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• v.37 no.3
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• pp.206-216
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• 2021

Deutzia paniculata Nakai, a rare and endemic plant, has limited distribution throughout the North and South Gyeongsang provinces of South Korea. The D. paniculata community grows mostly on the stony slopes of forests, valley edges, and rock layers at 250-960 m in altitude, where deciduous trees are dominant and high humidity is maintained. Correlation analysis of vegetation and environmental factors found that the Walter's dogwood-mulberry community was correlated with soil acidity (pH). Whilst the queritron community had correlations with distance from the valley, rock rate and slope. The natural habitat of the Palgongsan Mountain in Daegu is known to have high genetic diversity, had eight D. paniculata individuals recorded from 2014 to 2018, and 12 individuals recorded in 2020 (new individuals due to a newly created space within the herbaceous layer caused by grass mowing works), it is therefore unlikely that the community would perish unless there was an artificial disturbance. To conserve the natural habitats of D. paniculata, oppression by Sasa borealis, damage, increase in crown density of the upper layer, overexploitation, and absence of seedlings should be carefully investigated. In addition, response measures should also be established and the impact on seed fullness and the reproductive characteristics of D. paniculata recorded. To restore declined genetic diversity, individuals from high genetic diversity regions, such as Palgongsan Mountain, should be artificially transplanted.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.04a
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• pp.102-102
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• 2019

This study developed a HPLC analysis method for the determination of avicularin (AL) and quercitrin (QT) in Astilbe chinensis by HPLC. HPLC was performed on a Capcell Pak C18 MGII column ($4.6{\times}250mm$, $5{\mu}m$) with a gradient elution of 0.05% (v/v) trifluoroacetic acid (TFA) and acetonitrile at a flow rate of 1.0 mL/min at $30^{\circ}C$ and a UV detection wavelength of 254 nm. The analytical method was validated for its specificity, precision, accuracy, and linearity. The limits of detection and quantitation were AL 0.09 and 0.28 mg/mL, QT 0.03 and 0.09 mg/mL respectively. Calibration curves showed good linearity (AL r2 > 0.99990 and QT r2 > 0.99994), and the precision of analysis was satisfied (less than AL 0.59%, QT 0.63%). Recoveries of quantified compounds ranged from AL 100.57 to 102.08%, QT 99.94 to 100.64%. These results indicate that the developed HPLC method was applied successfully to the detection of AL and QT in A. chinensis.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.04a
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• pp.100-100
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• 2019

This study attempted to establish a High Performance Liquid Chromatography (HPLC) analysis method for the determination of (-)-epicatechin gallate as a part of the quality control for the development of functional cosmetic materials from Penthorum chinense Pursh extracts. HPLC was performed on a Unison US-C18 column ($4.6{\times}250mm$, $5{\mu}m$) with a gradient elution of 0.05% (v/v) trifluoroacetic acid (TFA) and methyl alcohol at a flow rate of 1.0 mL/min at $30^{\circ}C$. The analyte was detected at 280 nm. The HPLC method was performed in accordance with the International Conference on Harmonization (ICH) guideline (version 4, 2005) of analytical procedures with respect to specificity, precision, accuracy, and linearity. The limits of detection and quantitation were 0.11 and 0.33 mg/mL, respectively. Calibration curves showed good linearity (r2 > 0.9999), and the precision of analysis was satisfied (less than 0.6%). Recoveries of quantified compounds ranged from 99.51 to 101.92%. This result indicates that the established HPLC method is very useful for the determination of marker compound in P. chinense Pursh extracts.

• The Journal of the Korea institute of electronic communication sciences
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• v.13 no.4
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• pp.881-886
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• 2018

Over the last several decades, the advances in computer engineering technology have led a new paradigm of data-intensive research in the field of scientific applications. A collaborative work environment for storing, sharing and analyzing data is required for researchers of geographical distance. The Korean government supports the Research & Education network(KREONET) and the Global Science experimental Data hub Center(GSDC) to strengthen the nation's competitiveness. The KREONET has upgraded its backbone to 100Gbps to accommodate demand to transfer data fast among the global major experimental sites. This paper introduces the test result between high performance nodes reserved for big data transfer.

• Korean Journal of Ecology and Environment
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• v.48 no.1
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• pp.38-50
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• 2015

Appearance patterns of freshwater fish were investigated in the western Demilitarized Zone (DMZ) adjacent areas near Imjin River in Gyeonggi-do, Korea, of 2014. A total of 61 species belonging to 14 families were found in the river during the survey. The dominant and subdominant species were Zacco platypus (Relative abundance, 20.3%) and Zacco koreanus (12.6%), respectively. Other abundant species include Rhinogobius brunneus (9.2%), Pungtungia herzi (4.4%), Acheilognathus yamatsutae (4.4%), and Pseudogobio esocinus (4.0%). Among the residing species, 24 species (39.3%) were endemic to Korea; and 1 species, Carassius cuvieri, was non-indigenous species. Hemibarbus mylodon is a natural monument, and Lethenteron reissneri, Acheilognathus signifer, Pseudopungtungia tenuicorpa, Gobiobotia brevibarba, G. macrocephala, and G. naktongensis are endangered species in Korea. In addition, Anguilla japonica and Plecoglossus altivelis are catadromous and amphidromous species, respectively. Among the investigated sites, the lower part of Sami Stream (St. 5, 6) and Gunnarm-dam region (St. 11, 14) are particularly valuable for the conservation of species diversity, because many fish species (33~42 species) including a natural monument and several endangered species inhabit in these regions.

• Korean Journal of Plant Resources
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• v.32 no.4
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• pp.355-378
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• 2019

We investigated the flora of vascular plants in Mt. Papyeong which is located in the northern part of Paju and the border of western DMZ through 13 surveys from April 2016 to August 2019. The vascular plants of Mt. Papyeong include 410 taxa; 361 species, 9 subspecies, 36 varieties, and 4 forms from 257 genera of 91 families. Among 410 taxa, we characterize endemic species, rare and endangered plants, floristic regional indicator plants, and climate change adapted plants in Korea. Specifically, there are 9 Korean endemic plants designated by Korea National Arboretum and 6 taxa by Korean Ministry of Environment. According to IUCN evaluation, there are 13 rare and endangered plants in Mt. Papyeong. On the other hand, 2 taxa were listed in a red list suggested by Korean Ministry of Environment. The floristic regional indicator plants include 46 taxa which are composed of 2 species of IV degree, 13 taxa of III degree, 11 taxa of II degree, and 20 taxa of I degree. Also, 27 naturalized plants were identified, and the percentage of Naturalized Index (NI) and Urbanization Index (UI) were 6.58%, and 8.43%, respectively. We hope that this investigation provide a valuable data for applying the further studies on the biodiversity and strategy of conservation of environment in the DMZ and Paju areas.