• Microbiology and Biotechnology Letters
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• v.46 no.1
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• pp.18-28
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• 2018

In this study, the antioxidant activities and cytoprotective effects against oxidative stress of Lonicera japonica Thunb. 50% ethanol extract and ethyl acetate fraction were investigated. Using the 1,1-diphenyl-2-picrylhydrazyl assay, the free radical scavenging activity (FSC50) of L. japonica Thunb. 50% ethanol extract and ethyl acetate fraction was determined as 152.00 and $77.25{\mu}g/ml$, respectively. To measure the reactive oxygen species (ROS) scavenging activity, the total antioxidant capacity (OSC50) was determined by using a luminol-dependent chemiluminescence assay. The antioxidant activity of the ethyl acetate fraction ($0.33{\mu}g/ml$) was approximately four times stronger than that of the 50% ethanol extract ($1.12{\mu}g/ml$). The protective effect against $^1O_2$-induced cellular damage of human erythrocytes (${\tau}_{50}$) was 46.0 min at $10{\mu}g/ml$ of the 50% ethanol extract and 52.3 min at $1{\mu}g/ml$ of the ethyl acetate fraction. We also investigated the cytoprotective effects against oxidative stress induced by $H_2O_2$ and the intracellular ROS scavenging activity in response to UVB irradiation and found that the extract and fraction protected human skin cells from damage and reduced ROS. These results confirmed that L. japonica Thunb. was a valuable plant-derived natural antioxidant with potential for development as an antioxidative functional ingredient.

• Applied Chemistry for Engineering
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• v.30 no.1
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• pp.114-121
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• 2019

In this study, antioxidative, antibacterial and cytoprotective effects of the ethanol extract and ethylacetate fraction of Lycopus lucidus (L. lucidus) were compared and analyzed. Free radical scavenging activities ($FSC_{50}$) of the L. lucidus extract and fraction were found to be 65.1 and $64.9{\mu}g/mL$ respectively. In the $Fe^{3+}-EDTA/H_2O_2$ system, the reactive oxygen species (ROS) scavenging activities ($OSC_{50}$) for the extract and fraction were 6.6 and $6.3{\mu}g/mL$, respectively which showed excellent total antioxidant abilities. The extract showed antibacterial activity against S. aureus, while the fraction showed in all the bacteria except for A. niger. The cytoprotective effect of L. lucidus extract was compared to that of the fraction and the effect against $^1O_2$-induced cellular damage of human erythrocytes (${\tau}_{50}$) was 51.3 and 73.7 min at $50{\mu}g/mL$, respectively. For the cytoprotective effect of keratinocytes damaged by $H_2O_2$ and UVB, the extracts did not show any efficacy but showed efficacy at $1-2{\mu}g/mL$, respectively. The fraction increased the cell viability up to 85.8 and 81.9%, respectively. As a result of intracellular ROS scavenging activity, the scavenging activity was observed at $1-2{\mu}g/mL$ of the fraction. From the results comparing the physiological activities of L. lucidus extract and the fraction, the ethylacetate fraction of L. lucidus has antioxidative effect similar to that of the extract whereas superior antimicrobial and cytoprotective effects than that of the extract. Overall, the ethylacetate fraction of L. lucidus protects cells from an external stress which can be used as a potential cosmetic material.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.43 no.4
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• pp.309-320
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• 2017

In this study, the antioxidative effects and component analysis of 50% ethanol extract, ethyl acetate fraction and aglycone fraction obtained from Annona muricata leaf were investigated. Free radical scavenging activities were performed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, total antioxidant capacities were estimated using luminol-dependent chemiluminescence assay and $^1O_2$ quenching effects were estimated. Free radical scavenging activities ($FSC_{50}$) of 50% ethanol extract, ethyl acetate fraction and aglycone fraction were 45.6, 29.8 and $18.0{\mu}g/mL$, and total antioxidant capacities ($OSC_{50}$) were 4.4, 1.1 and $2.8{\mu}g/mL$, respectively. As a result of $^1O_2$ quenching experiment, ethyl acetate and aglycone fraction showed similar activities to L-ascorbic acid used as a comparative control. The cellular protective effects of 50% ethanol extract on the $^1O_2-induced$ cellular damage of human erythrocytes were exhibited at concentration-dependent ($5-50{\mu}g/mL$). TLC and HPLC were used to analyse components in the ethyl acetate fraction and aglycone fraction of Annona muricata leaf. In ethyl acetate fraction, rutin (quercetin-3-O-rutinoside), kaempferol-3-O-neohesperidoside, nicotiflorin (kaempferol-3-O-rutinoside), p-coumaric acid were identified. In aglycone fraction, kaempferol was identified. These results suggest that the extracts of Annona muricata leaf have the applicability as antioxidant cosmeceutical ingredients.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.4
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• pp.363-373
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• 2018

In recent years, parabens used as preservatives in cosmetics have become a problem of human safety. Therefore, in this study, we tried to evaluate the preservative efficacy of 1,3-butylene glycol, 1,2-hexanediol, and 1,2-pentanediol as a preservative system to replace parabens. 1,3-Butylene glycol was added to cosmetic creams at a concentration of between 5 and 25%. The preservative efficacy of 1,3-butylene glycol was determined using a M-3 challenge test, as recommended by the Personal Care Products Council (formally CTFA). The alkane diols, such as 1,2-hexanediol and 1,2-pentanediol, were assessed in a similar manner. An evaluation of the preservative efficacy of 1,3-butylene glycol revealed that it was effective against all tested microbial strains at a concentration of 25%. We also investigated the efficacy of combinations of 0.3% phenoxyethanol and 0.1% ethylhexylglycerin. Finally, we tested the alkane diols, including 1,2-hexanediol and 1,2-pentanediol, as an alternative to the preservative 0.3% phenoxyethanol. Both 1% 1,2-hexanediol and 1% 1,2-pentanediol demonstrated preservative efficacy. Taken together, our study demonstrated that the formulation of 25% 1,3-butylene glycol and 0.1% ethylhexylglycerin, 1% 1,2-hexanediol, and 1% 1,2-pentanediol had the best preservative efficacy of the compositions tested. Thus, this study suggests that the formulation is a possibility of substituting parabens preservatives, which has been used in cosmetics and has become a safety issue.

• Proceedings of the Korean Society of Computer Information Conference
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• 2024.01a
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• pp.127-130
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• 2024

본 연구는 기존 포털형 정보 서비스의 한계를 극복하고자, 이전 연구에서 제안된 연구자의 R&D 프로세스 과정에서의 협업을 지원하는 개방형 협업 지원 서비스 플랫폼을 기반으로 하여, 본 연구에서는 R&D 프로세스 중 '사전 단계'에 대한 설계와 구현을 소개한다. 우리는 R&D 프로세스를 문헌 리뷰와 연구 가설 설정 등을 수행하는 '사전 단계,' 실험과 데이터 분석 등을 수행하는 '실행 단계', 논문 작성 및 출판 등을 수행하는 '성과화 단계'로 구분하고, 이 중 '사전 단계'에 대해 프로젝트 뷰, 그룹 뷰, 문헌 뷰, 관계 뷰를 설계하고 구현하였다. 연구자는 이 플랫폼을 통해 문헌 내용 및 문헌 간 복잡한 연관성을 신속하게 파악할 수 있으며, 플랫폼은 연구자에 의해 자연스럽게 생성되는 사용자 정의 관계를 통해 향후 심층적인 문헌 네트워크 구축 및 분석이 가능해질 것으로 기대한다.

• Proceedings of the Korea Information Processing Society Conference
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• 2023.05a
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• pp.67-69
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• 2023

유연한 이동성, 쉬운 배치, 저렴한 비용 등의 장점을 가진 Unmanned Aerial Vehicle(UAV)를 이용해 Deep Neural Network(DNN) 서비스를 제공하는 기술이 연구되고 있다. 하지만 UAV 는 메모리와 컴퓨팅 능력, 배터리가 제한되어 있어 DNN 서비스의 요구사항을 만족시키기 위해서는 다수의 UAV간의 협업이 필요하다. 본 논문에서는 다수의 UAV 협업 환경에서 DNN 서비스의 처리 지연시간을 줄이기 위해 UAV 들의 작업량을 고려한 서비스 분산 처리 기법을 제안하고, 시뮬레이션을 통해 DNN 서비스 처리 지연 시간을 분석한다.

• Journal of Information Management
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• v.41 no.4
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• pp.119-140
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• 2010

Methodist church materials are classified with three types, centered on the organizations manufacturing and holding materials such as 1) 'materials of the Methodist headquarter' governing all of the Methodist churches in Korea, 2) 'materials of theological seminary libraries' holding academic study books related to theology, and 3) 'materials manufactured in individual churches'. In this manner, the Methodist church materials imply homogeneity in theme, but the materials have identity from each other, because organizations are different each other, too. By a characteristic of each organizations, to use Methodist church document done a director of each organization is demanded collaboration between the material departments of each organizations, this study intends to analysis material department operation status of three Methodist church organizations. As a result of analysis, it is necessary to perform the prior tasks, such as reconstructing organization to accomplish an original function of the Methodist headquarter, developing operation regulation classified with the Methodist church group, and constructing material management system.

• The Bulletin of The Korean Astronomical Society
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• v.42 no.2
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• pp.82.2-82.2
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• 2017

Korea Microlensing Telescope Network (KMTNet) is one of powerful tools for investigating primordial objects in the inner solar system in that it covers a large area of the sky ($2{\times}2$ degree2) with a high observational cadence. The Deep Ecliptic Patrol of the Southern sky (DEEP-South) survey has been scanning the southern sky using KMTNet for non-bulge time (45 full nights per year) [1] since 2015 for examining color, albedo, rotation, and shape of the solar system bodies. Since 2017 January, we have launched a new collaborative group between Korea Astronomy and Space Science Institute (KASI) and Seoul National University (SNU) with support from KASI to reinforce mutual collaboration among these institutes and further to enhance human resources development by utilizing the KMTNet/DEEP-South data. In particular, we focus on the detection of comets and asteroids spontaneously scanned in the DEEP-South for (1) investigating the secular changes in comet's activities and (2) analyzing precovery and recovery images of objects in the NASA's NEOWISE survey region. In this presentation, we will describe our scientific objectives and current status on using KMTNet data, which includes updating the accuracy of the world coordinate system (WCS) information, finding algorithm of solar system bodies in the image, and doing non-sidereal photometry.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.2
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• pp.56.2-56.2
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• 2010

The SPICA (SPace Infrared Telescope for Cosmology & Astrophysics) project is a next-generation astronomical mission optimized for mid- and far-infrared observation with a cryogenically cooled 3m-class telescope. Due to its high angular resolution and unprecedented sensitivity, SPICA will enable us to resolve many key issues in the present-day astronomy. As an international collaboration, KASI proposed the near-infrared instrument which is composed of two parts; (1) science observation with the capability of imaging and spectroscopy covering $0.7{\mu}m$ to $5{\mu}m$ (FPC-S) (2) fine guiding to stabilize and improve the attitude (FPC-G). Here, we introduce the science programs proposed for SPICA/FPC-S.

• Korea Science and Art Forum
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• v.37 no.3
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• pp.135-145
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• 2019

IFC(Industry Foundation Classes) is used for information exchange in BIM-based collaboration process, and it does not secure reliability of information exchange results between fields due to structural limitations. In the end, it is a realistic problem that we have to use specialized BIM software by field, and we can not secure smooth interoperability in the process of information exchange and change. This study was conducted to find ways to secure the interoperability of BIM work between architecture and structure fields by utilizing Open Source provided by software developers to solve these problems. First, through expert survey and in-depth interview, information and improvement factors required in the process of collaboration between architecture and structure were derived. Second, in order to find a solution to the improvement factors, existing studies related to Open-API and domestic and overseas APIs were investigated and analyzed. Third, Ad-On was developed to secure interoperability by using Open API, mainly BIM S/W, which is mainly used in each field. As a result of the study, the possibility of securing interoperability through the management of the design change history between fields was confirmed by using API. It is judged that the application range of API will be expanded to the construction and maintenance field in the future. Therefore, in order to increase the usability for application diffusion, further research on interface improvement through user-centered verification is needed.