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Development of bioinformatics and multi-omics analyses in organoids

  • Doyeon Ha;JungHo Kong;Donghyo Kim;Kwanghwan Lee;Juhun Lee;Minhyuk Park;Hyunsoo Ahn;Youngchul Oh;Sanguk Kim
    • BMB Reports
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    • v.56 no.1
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    • pp.43-48
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    • 2023

  • Pre-clinical models are critical in gaining mechanistic and biological insights into disease progression. Recently, patient-derived organoid models have been developed to facilitate our understanding of disease development and to improve the discovery of therapeutic options by faithfully recapitulating in vivo tissues or organs. As technological developments of organoid models are rapidly growing, computational methods are gaining attention in organoid researchers to improve the ability to systematically analyze experimental results. In this review, we summarize the recent advances in organoid models to recapitulate human diseases and computational advancements to analyze experimental results from organoids.

  • https://doi.org/10.5483/BMBRep.2022-0155 인용 PDF

Pulsed-laser-diode Intermittently Pumped 2-㎛ Acousto-optic Q-switched Tm:LuAG Laser

  • Wen, Ya;Jiang, Yan;Zheng, Hao;Zhang, Hongliang;Wang, Chao;Wu, Chunting;Jin, Guangyong
    • Current Optics and Photonics
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    • v.4 no.3
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    • pp.238-246
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    • 2020

  • The heat distribution in crystals in a 2-㎛ acousto-optic Q-switched Tm:LuAG laser pumped by pulsed-laser-diode (pulsed-LD) intermittent-pumping technology was analyzed using COMSOL software. The thermal lensing effect of the Tm:LuAG crystal can be mitigated by pulsed-LD intermittent-pumping techniques. An experimental setup using this kind of approach achieved maximum output energy of 8.31 mJ, minimum pulse width of 101.9 ns, and highest peak power of 81.55 kW, reached at a Q-switched repetition rate of 200 Hz. It offers significant improvement of performance of the output laser beam, compared to pulsed-LD double-ended pumping technology at the same repetition rate.

  • https://doi.org/10.3807/COPP.2020.4.3.238 인용 PDF KSCI