• 제목/요약/키워드: Science and Technology Park

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CJ-11668, A new selective and potent COX-2 inhibitor, reduces inflamation, fever and pain in animal models

  • Kim, Seong-Woo;Park, Hyun-Jung;Kim, Young-Gi;Yeon, Kyu-Jeong;Ryu, Hyung-Chul;Park, Sang-Wook;Kim, Jong-Hoon;Ko, Dong-Hyun;Chae, Myeong-Yun
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.94.2-94.2
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    • 2003

  • CJ-11668 is a new potent and selective COX-2 inhibitor. CJ-11668 showed COX-2 inhibition (IC50) of 65nM and selectivity ratio (COX-l/COX-2) of 770 in the cell based assay. In the human whole blood assay, CJ-11668 showed COX-2 inhibition (IC50) of 370nM and selectivity ratio (COX-l/COX-2), 135. The treatment of CJ-11668 (5 mg/kg, p.o) produced a significant inhibition (35%) of inflamed rat paw volume in the carrageenan-induced acute inflammation. CJ-11668 also suppressed the PGE2 level (69% inhibition, 1 mg/kg, p.o) in the zymosan-induced mouse air pouch model after 3 hrs. (omitted)

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