• Title/Summary/Keyword: Science and Technology (S&T)

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Design of closed-loop nitrogen Joule-Thomson refrigeration cycle for 67 K with sub-atmospheric device

  • Lee, C.;Lee, J.;Jeong, S.
    • Progress in Superconductivity and Cryogenics
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    • v.15 no.1
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    • pp.45-50
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    • 2013
  • Closed-loop J-T (Joule-Thomson) refrigeration cycle is advantageous compared to common open loop $N_2$ decompression system in terms of nitrogen consumption. In this study, two closed-loop pure $N_2$ J-T refrigeration systems with sub-atmospheric device for cooling High Temperature Superconductor (HTS) power cable are investigated. J-T cooling systems include 2-stage compressor, 2-stage precooling cycle, J-T valve and a cold compressor or an auxiliary vacuum pump at the room temperature. The cold compressor and the vacuum pump are installed after the J-T valve to create sub-atmospheric condition. The temperature of 67 K is possible by lowering the pressure up to 24 kPa at the cold part. The optimized hydrocarbon mixed refrigerant (MR) J-T system is applied for precooling stage. The cold head of precooling MR J-T have the temperature from 120 K to 150 K. The various characteristics of cold compressor are invstigated and applied to design parameter of the cold compressor. The Carnot efficiency of cold compressor system is calculated as 16.7% and that of vacuum pump system as 16.4%. The efficiency difference between the cold compressor system and the vacuum pump system is due to difference of enthalpy change at cryogenic temperature, enthalpy change at room temperature and different work load at the pre-cooling cycle. The efficiency of neon-nitrogen MR J-T system is also presented for comparison with the sub-atmospheric devices. These systems have several pros and cons in comparison to typical MR J-T systems such as vacuum line maintainability, system's COP and etc. In this paper, the detailed design of the subcooled $N_2$ J-T systems are examined and some practical issues of the sub-atmospheric devices are discussed.

Two Threonine Residues Required for Role of AfsKav in Controlling Morphogenesis and Avermectin Production in Streptomyces avermitilis

  • Rajkarnikar, Arishma;Kwon, Hyung-Jin;Ryu, Yeon-Woo;Suh, Joo-Won
    • Journal of Microbiology and Biotechnology
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    • v.17 no.9
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    • pp.1563-1567
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    • 2007
  • AfsKav is a eukaryotic-type serine/threonine protein kinase, required for sporulation and avermectin production in Streptomyces avermitilis. In terms of their ability to complement SJW4001 (${\Delta}afsK$-av), afsK-av mutants T165A and T168A were not functional, whereas mutants T165D and T168D retained their ability, indicating that Thr-165 and Thr-168 are the phosphorylation sites required for the role of AfsKav. Expression of the S-adenosylmethione synthetase gene promoted avermectin production in the wild-type S. avermitilis, yet not in the mutant harboring T168D or T165D, demonstrating that tandem phosphorylation on Thr-165 and Thr-168 in AfsKav is the mechanism modulating avermectin production in response to S-adenosylmethione accumulation in S. avermitilis.

HYBRIDIZATION EFFECTS IN $RT_2$ COMPOUNDS (R = Ce, Pr, Nd, Sm, Gd; T = Fe, Co, Ni)

  • Kang, Kicheon;Min, B.I.;Kang, J.S.
    • Journal of the Korean Magnetics Society
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    • v.5 no.5
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    • pp.376-379
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    • 1995
  • Employing the muffin-tin-orbital theory combined with pseudo-potential concepts, we have evaluated hybridization matrix elements between R and T sites in $RT_{2}$ compounds. The matrix elements are calculated with two parameters, the interatomic distance between R and T atoms from the crystal structure data, and the expectation values of the radial distances for the radial wave functions of the ground state charge densities, which are obtained from the linearized muffin-tin orbital band method within the local density approximation. It is found that the R 4f/T 3d hybridization matrix elements decrease with an increasing atomic number from R=Ce to Gd, and that they are smaller in $RNi_{2}$ than in $RCo_{2}$, which are consistent with trends observed in recent photoemission spectroscopy experiments. It is also found that the magnitudes of the hybridization matrix elements in $RFe_{2}$ are comparable to those in $RNi_{2}$.

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The MTHFR C677T Polymorphism and Risk of Acute Lymphoblastic Leukemia: an Updated Meta-analysis Based on 37 Case-control Studies

  • Jiang, Yuan;Hou, Jing;Zhang, Qiang;Jia, Shu-Ting;Wang, Bo-Yuan;Zhang, Ji-Hong;Tang, Wen-Ru;Luo, Ying
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.11
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    • pp.6357-6362
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    • 2013
  • Background: The C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) has been associated with acute lymphoblastic leukemia (ALL). However, results were conflicting. The aim of this study was to quantitatively summarize the evidence for the MTHFRC677T polymorphism and ALL risk. Methods: Electronic searches of PubMed and the Chinese Biomedicine database were conducted to select case-control studies containing available genotype frequencies of C677T and the odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of any association. Results: Case-control studies including 6,371 cases and 10,850 controls were identified. The meta-analysis stratified by ethnicity showed that individuals with the homozygous TT genotype had decreased risk of ALL (OR= 0.776, 95% CI: 0.687~0.877, p< 0.001) in Caucasians (OR= 0.715, 95% CI: 0.655~0.781, p= 0.000). However, results among Asians (OR=0.711, 95% CI: 0.591~1.005, p= 0.055) and others (OR=0.913, 95% CI: 0.656~1.271, p= 0. 590) did not suggest an association. A symmetric funnel plot, the Egger's test (P=0.093), and the Begg- test (P=0.072) were all suggestive of the lack of publication bias. Conclusion: This meta-analysis supports the idea that the MTHFR C677T genotype is associated with risk of ALL in Caucasians. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between the MTHFRC677T polymorphism and ALL.

Korea's Global Science & Technology(S&T) Agenda -A study on Internationalization of Industrial R&D for Korean SME- (한국의 글로벌 과학기술협력 연구 -한국 중소기업의 R&D 국제화 가속방안과 중소기업코디네이터-)

  • Lee, Sang-Yun;Yoon, Hong-Joo
    • The Journal of the Korea institute of electronic communication sciences
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    • v.7 no.4
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    • pp.693-705
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    • 2012
  • It is increasing the necessity of technology cooperation between nations, in the world, more and more. The international cooperation for the technology development have the dissipating effect of costs and risks and encourage efficient use of the knowledge and eventually help the firms better access overseas market easily. The S&T diplomacy of Korea is, at present, on international S&T cooperation to secure technologies to strengthen base of science, technology and innovation. This tendency is closely related with the governance issue in international S&T cooperation. And This international S&T cooperation is connected with the internationalization of firms. But it is getting more difficult for a firm, especially smaller firm like Korean SME to sustain the technological advantage over any significant period. The small and medium sized enterprises as Korean SME, internationalization of R&D is difficult just to think in terms of one framework with the limited accumulation of informations and experiences. So against that situation, this paper shows a new concept 'SME co-ordinator' as the role client(or player) reinforcing international S&T cooperation, sustaining the technological advantage for Korean SME. And 'SME co-ordinator' leads Korean SME to progress 'open innovation' not 'close innovation' as well as serving adequate information about appropriate partners and capable employer to help manage the international S&T cooperation for Internationalization of Industrial R&D for Korean SME.

A Single-Flux-Quantum Shift Register based on High-T$_c$ Superconducting Step-edge Josephson Junctions

  • Sung, G.Y.;Choi, C.H.;Suh, J.D.;Han, S.K.;Kang, K.Y.;Hwang, J.S.;Yoon, S.G.;Jung, K.R.;Lee, Y.H.;Kang, J.H.;Kim, Y.H.;Hahn, T.S.
    • 한국초전도학회:학술대회논문집
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    • v.9
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    • pp.133-133
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    • 1999
  • We have fabricated and tested a simple circuit of the rapid single-flux-quantum(RSFQ) four-stage shift register using a single layer high-T$_c$ superconducting (HTS) YBa$_2Cu_3O_{7-x}$ (YBCO) thin film structure with 9 step-edge Josephson junctions. The circuit includes two read superconducting quantum interference devices(SQUID) and four stages. To establish a robust HTS RSFQ device fabrication process, we have focussed the reproducible process of sharp and straight step-edge formation as well as the ratio of film thickness to step height t/h. The spread of step-edge junction parameters was measured from each13 junctions with t/h=l/3, l/2, and 2/3 at various temperatures. We have demonstrated the simplified operation of the shift register at 65 K..

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