• 대한치과보철학회지
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• 제46권1호
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• pp.83-91
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• 2008

문제제기 : 2007년 4월 '노인장기요양보험법'이 국회를 통과하였고 노인수발행위에 치과의사의 참여가 확정되어 2008년 7월부터 법이 시행되면서, 고령화가 급속이 진행되고 있는 한국사회에서 치과분야가 담당해야 할 역할은 커질 수밖에 없다. 목적 : 본 논문은 한국의 두 노인시설에 대한 설문조사를 바탕으로 일본의 노인요양보험법과 비교를 통해 앞으로 시행되는 노인장기요양법의 구강위생서비스의 역할 및 방향을 수립하는데 기여하고자 한다. 연구재료 및 방법 : 2005년 한국의 두 노인요양시설에서 책임 있는 직무자 또는 실제 간호의 내용을 파악하고 있는 분을 대상으로 15개 항목의 설문조사를 시행하였다. 결과 : 두 시설 모두 각각의 특징을 살려 매우 기능을 잘 하고 있었으나, 구강위생 및 이에 대한 직원의 인지도는 낮았으며 정기적인 진료나 관리는 소홀했다. 고찰 : 일본에서는 2000년 노인요양보험이 도입 후 체계화된 방법론을 기초로 시행되고 있다. 현재 '노인장기요양' 법안에 치과의사 참여가 보장된 것과 관련하여 앞으로 치과의사의 적극적인 참여가 필요하고, 시설 및 재택 방문 진료가 가능하도록 하는 법정비용을 통해 치과분야의 진료영역을 넓힐 수 있는 움직임이 필요하다고 볼 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2093-2097
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• 2016

Background: HCV is a major global health problem. IL-27 is a member of the IL-6/IL-12 cytokine family with a broad range of anti-inflammatory properties. Recent studies highlighted the effect of a SNP in the IL-27 promoter region on modulating the progression of infectious diseases and individual responses to therapy. Aim of the work: The present study investigated the potential role of (-964 A/G) SNP in the promoter region of IL-27p28 gene (alleles rs153109) on the outcome of HCV infection among genotype 4a infected patients. Materials and Methods: HCV genotyping confirmed that all of the HCV-infected patients had genotype 4a infection. Genomic DNA was extracted from 111 patients with chronic HCV infection, 42 spontaneous resolvers (SR) and 16 healthy controls. IL- 27p28.rs153109 genotyping was assessed using PCR-RFLP then confirmed by DNA sequencing. Results: The frequency of IL-27-p28.rs153109AA, AG, and GG genotypes among chronically infected subjects were 74.8 %, 25.2%, and 0% while among the SR, they were 57.1%, 35.7%, and 7.14%, respectively. Our data show the unique presence of G/G genotype in the SR group (3 patients; 7.14%). Moreover, the "G" allele frequencies among chronic and resolved subjects were 12.6% and 25.0%, respectively (p=0.0136). Importantly, subjects with the GG genotype were more likely to clear their HCV infection than those with the AA genotype (p=0.0118). Conclusions: HCV genotype 4a subjects with the IL-27-p28.rs153109 A/G and G/G genotype were more likely to clear their HCV infection. Therefore, we propose IL- 27p28.rs153109SNPas a genetic biomarker for predicting HCV infection outcome.

• 한국응용과학기술학회지
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• 제25권4호
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• pp.539-555
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• 2008

It is well understood that developing new drugs is one of the highest value-added businesses in a country; however, the current governments' spending in pharmaceutical research and development(R&D) is minimal in Korea. This paper suggests that different governmental bodies should take in charge of different stages of the R&D process in order to maximize the use of limited government research funding. First, during the initial phase of the drug development, including clinical trials, the Ministry of Education, Science and Technology is the most appropriate governmental organization to support the research. For later procedures such as supporting the industries for exporting developed drugs, legislative approvals, and building infrastructure for future clinical trials should be supported by the Ministry of Knowledge and Economy and the Ministry of Health and Welfare along with the Korea Food and Drug Administration(KFDA). The KFDA, which is the main governmental agency approving newly developed drugs in the market, will need to take a crucial responsibility in the initial phase of the pharmaceutical R&D by guiding the industries with timely and proper information. As a first step, it is recommended to set up and operate a center for supporting new drugs, so that the industries can facilitate the development of marketable drugs which meet customers' needs. Later, in order to expedite the process of exporting and getting approvals of the newly developed drugs from foreign countries, it is necessary to develop new approval system, which includes introduction of the Good Manufacturing Practice (GMP), mandatory validation system, and education program for supporting expertise. Lastly, the KFDA needs to take an active role in developing Korean pharmaceutical industries by communicating with other foreign governments with regards to the globalization of the Korean pharmaceutical industries. For example, as a follow up after the Free Trade Agreement(FTA), active discussion on GLP of Mutual Recognition Agreement(MRA) with the United States of America, should be seriously considered.

• Journal of Nutrition and Health
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• 제35권5호
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• pp.544-557
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• 2002

This study was performed to evaluate the quality of nutrient intakes of the hemodialysis patients (26 men and 23 women) according to the socioeconomic status by 3-day dietary recall in Daejeon city and Chungnam area, Korea. Mean age of the subjects was 50.7 yrs and BMI was 22.0 $\pm$ 0.4 kg/$m^2$. Education level was divided into two groups ($\leq$ 9 years： LE group, 9 years： HE group), and monthly family income level was divided into three groups (< 500,000 won: LI group, 500,000-1,499,999 won: MI group, $\geq$ 1,500,000 won : HI group). The data were analyzed by Student t-test and Oneway ANOVA using SPSS 9.0 version at p < 0.05 level. Intakes of energy, carbohydrates, cholesterol, potassium, thiamin and riboflavin were significantly higher in HE group than in LE group (p < 0.05). Intakes of all the nutrients except protein and phosphorus were less than Korean RDA, and INQs (Index of Nutritional Quality) of most nutrients were lower than 1.0 but cholesterol, phosphorus. thiamin and niacin being over 1.0 in HE group. MAR (Mean adequacy ratio) of all the nutrients (e.g., energy, protein, calcium, phosphorus, iron, vitamin A, vitamin C, thiamin, riboflavin and niacin) was significantly higher in HE group (0.61 $\pm$ 0.04) than in LE group (0.48 $\pm$ 0.03) at p = 0.036. Intakes of energy, protein (total, animal and plant), fat, cholesterol, potassium, calcium, phosphorus, iron, vitamin A, thiamin and riboflavin were also significantly higher in HI group than in LI and MI group (p < 0.05). Daily intakes of most nutrients were less than Korean RDA except protein ed phosphorus in HI poop, and INQs of thiamin, niacin and phosphorus were higher than 1.0, while those of calcium, iron, vitamin A and riboflavin were lower than 1.0. MAR of energy and 9 nutrients was significantly higher in HI group (0.70 $\pm$ 0.04) than in LI group (0. 56 0.04) and MI poop (0.47 $\pm$ 0.03) at p = 0.000. In conclusion, quality of nutrient intakes, especially energy and protein, was significantly influenced by socioeconomic status such as education and monthly income (p < 0.05). This result suggests that it would be very helpful to develop nutritional education programs considering hemodialysis patients' education levels, and to improve public supports (e.g., medical insurance system, low-rate lease system of dialysis equipments, etc.) focusing on the patients' family income levels f3r their better nutrition and health.

• 한국산학기술학회논문지
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• 제16권10호
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• pp.6627-6640
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• 2015

본 연구는 제조업 남성 근로자들의 신체부위별 근골격계질환 자각증상 호소율을 알아보고 그의 관련요인을 파악하고자 제조업에 종사하고 있는 생산직 남성 근로자 856명을 대상으로 자기기입식 설문조사를 통해 이루어졌다. 연구결과, 조사대상자의 신체부위별 근골격계질환 자각증상 호소율을 보면 어깨부위 61.2%, 허리부위 55.4%, 목 부위 55.3%, 다리/발 부위 38.6%, 손/손목/손가락부위 32.2%, 팔/팔꿈치부위 26.9%의 순위였다. 로지스틱회귀분석 결과 신체부위별 자각증상 관련요인을 보면, 목 부위는 결혼상태, 주관적인 건강상태, 흡연여부, 커피음용여부, 직무스트레스가 유의한 관련성이 있는 요인으로 나타났으며, 어깨부위는 근무경력, 교대근무여부, 업무상 질병으로 인한 외래진료여부, 직무스트레스가 유의한 관련성이 있는 요인으로 나타났다. 팔/팔꿈치부위는 수면시간, 업무상 질병으로 인한 결근여부, 직무스트레스가 유의한 관련성이 있는 요인으로 나타났으며, 손/손목/손가락 부위는 연령, 흡연여부, 커피음용여부, 주당근무시간, 직급, 근무경력, 업무상 질병으로 인한 외래진료여부, 직무스트레스가 유의한 관련성이 있는 요인으로 나타났다. 허리 부위는 학력, BMI, 수면시간, 직급, 근무경력, 업무상 질병으로 인한 외래진료여부, 직무스트레스가 유의한 관련성이 있는 요인으로 나타났으며, 다리/발 부위는 결혼상태, 직급, 근무경력, 업무상 질병으로 인한 입원경험여부, 직무스트레스가 유의한 관련성이 있는 요인으로 나타났다.

• 한국산학기술학회논문지
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• 제13권1호
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• pp.201-210
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• 2012

본 연구는 노인들의 ADL, IADL 및 우울수준을 알아보고, ADL, IADL과 우울수준과의 관련성을 검토하고자 농촌지역 노인 412명(남자 191명, 여자 221명)을 대상으로 2010년 4월 1일부터 6월 30일까지의 기간 동안에 표준화된 무기명식 면접조사용 설문지를 사용하여 면접조사를 실시하였다. 연구결과, 조사대상자의 ADL의 분포는 정상범위노인군 94.7%, 기능장애노인군 5.3%이었으며, IADL의 분포는 정상범위노인군 87.4%, 기능장애노인군 12.6%이었다. 우울수준의 분포는 정상군 59.0%, 우울군 41.0%이었다. 조사대상자의 우울군의 분포는 ADL이 정상범위노인군에서 38.2%, 기능장애노인군에서 90.9%로 기능장애노인군에서 유의하게 높았으며, IADL이 정상범위노인군에서 35.8%, 기능장애노인군에서 76.9%로 기능장애노인군에서 유의하게 높았다. 다른 변수를 통제한 다변량 모델에서의 로지스틱 회귀분석 결과 우울수준에 대한 위험비는 ADL에서 정상범위노인군보다 기능장애노인군에서 23.21배(95% CI=4.38~123.05) 높았고, IADL에서 정상범위노인군보다 기능장애노인군에서 7.76배(95% CI=2.99~20.08) 높은 것으로 나타났다. 결론적으로, 농촌지역 노인들의 ADL과 IADL이 기능장애노인군인 경우 정상군에 비해 우울상태로 되는 위험비가 높아졌다. 따라서 향후 노인들의 우울을 예방하기 위한 대책의 하나로 개인의 ADL 및 IADL과 같은 신체적 기능을 더욱 건강하게 유지 증진시킬 수 있는 방안을 모색할 필요가 있다고 생각된다.

• The Journal of Korean Physical Therapy
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• 제14권4호
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• pp.172-182
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• 2002

Objectives: We did research in the cause of the Pitchers' injury and their recovery process to make a detailed injury list for the purpose of finding the cause of the Korean professional pitchers' injury and its classification. We drew the conclusion through the results as following. Methods: We posed a question to the 80 pitchers playing in the first team of the eight Korean professional baseball team and analyzed the 62 pieces of question paper except the paper having a mistake. We used SAS/PC statistical package in analyzing the data. Results: In the frequency of the pitchers' shoulder injury in the last three years, the injured of all the players were 61.3$\%$ and the injury free players were 28.7$\%$. The cause of the injury was 45.2$\%$ wrong pitching motion, which was the highest value. For the shape of a pain when injured, the reverberation ache feeling when he is hit in the weight commanded an absolute majority as 19.4$\%$. Those who had muscular pain were 17.7$\%$, which was felt mostly at the pitching motion. The most trouble name of the injured shoulder was bicepstendinitis as 16.1$\%$ while the injury of shoulder joint was the lowest as 1.6$\%$. As the most widely used treatment, 25.8 percent of all the players had taken an electronical thraphy after injury. 14.5 percent of the players who had an injury to the shoulder told that they have an operation and 85 percent of them didn't. As a sort of the operation, a repairing of labrum was 44.4 percent, which is the highest value and the 77.8 percent pitchers are performing a normal pitching through rehabilitation after the operation and 22.2 percent of them are undergoing rehabilitation training. Conclusion: The research have shown that the main cause of the injury, concerning the Korean professional pitchers throwing lots of ball in both matches and practices, is overuse syndrome, bad mechanism, muscle weakness and instability of balance. I think that the role of trainer, physical therapy, and team physician taking charge of the players' injury must learn physical test method by heart exactly to check up the state of the injury definitely at the initial phase. Moreover, when the cause of the injury part after a close examination is discovered, the scientific and good surgery is essential to the rehabilitation success and making a classification of shoulder instability is useful to make a operation plan as well as the players' rehabilitation, treatment.

• 응용통계연구
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• 제22권3호
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• pp.595-606
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• 2009

이중구간중도절단된 자료의 생존함수를 비교하기 위한 두 검정법을 소개하고 한국인 암 예방연구 (Jee 등, 2005) 자료에 적용하여 당뇨병 잠복시간의 분포를 성별과 연령에 따라 비교하였다. Kim 등 (2006)의 검정법을 이중구간중도절단된 자료로 확장한 검정법은 위험집합의 크기에만 의존하는 가중값을 사용하기 때문에 대용량 자료의 분석에서 Sun (2006)의 검정법보다 계산 시간을 대폭 줄일 수 있으며, 이산형 생존자료뿐만 아니라 연속형 생존자료에도 적용가능한 장점이 있다. 당뇨병의 잠복시간이 성별에 따라 매우 유의하게 달랐으며 여자의 잠복시간이 남자보다 긴 것으로 나타났다. 4개 연령그룹 간 당뇨병의 잠복시간도 성별에 관계 없이 매우 유의하게 달랐으며 여자의 경우가 남자의 경우보다 그 차이가 훨씬 더 유의했다. 한편, 소표본 모의실험을 통해 제안한 검정법과 Sun (2006)의 검정법의 검정력을 비교하였으며 제안한 검정법의 검정력이 Sun (2006)의 검정법보다 더 좋은 것으로 나타났다.

• Journal of Preventive Medicine and Public Health
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• 제42권3호
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• pp.190-198
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• 2009

Objectives : The objective of this study is to estimate the economic costs of cancer on society. Methods : We estimated the economic burden of people with cancer in South Korea. To perform the analysis, we reviewed the records of people who were cancer patients and those who were newly diagnosed with cancer. The data was compiled from the National Health Insurance Corporation, which included the insurance claims database, a list of cancer patients, a database that records the cancer rates, the Korea Central Cancer Registry Center s cancer patient registry database and the Korea National Statistical Office s causes of death database. We classified the costs as related to cancer into direct costs and indirect costs, and we estimated each cost. Direct costs included both medical and non-medical care expenses and the indirect costs consisted of morbidity, mortality and the caregiver's time costs. Results : The total economic costs of cancer in South Korea stood at 14.1 trillion won in 2005. The largest amount of the cost 7.4 trillion won, was the mortality costs. Following this were the morbidity costs (3.2 trillion won), the medical care costs (2.2 trillion won), the non-medical care costs (1.1 trillion won) and the costs related to the caregiver's time (100 billion won). As a result, the economic cost of cancer to South Korea is estimated to be between 11.6 trillion won to 14.1 trillion won for the year 2005. Conclusions : We need to reduce the cancer burden through encouraging people to undergo early screening for cancer and curing it in the early stage of cancer, as well as implementing policies to actively prevent cancer.

• Journal of Preventive Medicine and Public Health
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• 제36권2호
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• pp.179-186
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• 2003

Objectives : To compare the quality improvement of the abstracts of original articles, according to the revised manuscript format, of the Korean Journal of Preventive Medicine (Korean J Pre Med) was adopted in 1999. Methods : A total 63 abstracts for 1997, and 49 for 2001, were selected as the original articles from the Kor J Pre Med. This study was carried out by the separate-sample pretest-posttest design. The quality of the abstracts was measured by a checklist of Narine' evaluation criteria, and the other information related to the articles were also surveyed by e-mail and fax or telephone using a self-made Questionnaire, From the response rate, a total of 62 abstracts for 1997 and 49 for 2901 were finally analyzed. Results : The mean number of words in an abstract decreased from 285 in 1997, to 250 by 2001. The mean number of key words per abstract decreased from 3.9 in 1997, to 3.6 by 2001. The mean number of inappropriate usage of key words per abstract, by the MeSH standard, decreased from 1.9 in 1997, to 0.4 by 2001 Also, the overall mean score of abstract quality increased from 0.54 in 1997 to 0.61 by 2001. The range of scores for the abstract quality was better in 2001 ($0.40{\sim}0.77$) than in 1997 ($0.20{\sim}0.81$). From the multiple regression analyses of the 1997 and 2001 databases, the intervention of the manuscript format's revision, and the number of English words to the quality score of the .abstract, were the only statistically significant factors, Conclusions : In conclusion, the quality of abstracts in the Kor J Pre Med has improved since the revised manuscript format was adopted in 1999. The Korean Society for Preventive Medicine will continuously recommend proposals for more informative abstracts in their journal, and will evaluate the abstracts' content with quality criteria. Future studies should address these issues, and compare the quality of abstracts between different international and domestic journals.