• Journal of Yeungnam Medical Science
• /
• v.33 no.1
• /
• pp.64-67
• /
• 2016

We report on a 64-year-old man with leptomeningeal metastasis (LM) from an epidermal growth factor receptor (EGFR)-mutated adenocarcinoma of the lung. He was treated with paclitaxel, cisplatin. After completion of chemotherapy, he complained of headache, nausea, and vomiting. EGFR-mutated tumor cells were identified from the cerebrospinal fluid (CSF). Second-line therapy with gefitinib, methotrexate was started. After receiving gefitinib for 4 weeks, he had no more headaches or vomiting. Eleven months after initiation of gefitinib, he developed headache and nausea. Chest computed tomography showed aggravation of bone metastasis. Third-line therapy was started with gemcitabine and carboplatin. Two weeks later, he experienced disorientation. After a fourth relapse within the central nervous system, the therapy was switched to erlotinib and significant improvement of LM was achieved. This case shows that LM can be diagnosed by detecting EGFR mutation in CSF and EGFR tyrosine kinase inhibitors are effective for LM from EGFR mutant non-small cell lung cancer.

• Clinical and Experimental Reproductive Medicine
• /
• v.47 no.2
• /
• pp.108-113
• /
• 2020

Objective: Endometrial fibrosis, the primary pathological feature of intrauterine adhesion, may lead to disruption of endometrial tissue structure, menstrual abnormalities, infertility, and recurrent pregnancy loss. At present, no ideal therapeutic strategy exists for this fibrotic disease. Eupatilin, a major pharmacologically active flavone from Artemisia, has been previously reported to act as a potent inducer of dedifferentiation of fibrotic tissue in the liver and lung. However, the effects of eupatilin on endometrial fibrosis have not yet been investigated. In this study, we present the first report on the impact of eupatilin treatment on transforming growth factor beta (TGF-β)-induced endometrial fibrosis. Methods: The efficacy of eupatilin on TGF-β-induced endometrial fibrosis was assessed by examining changes in morphology and the expression levels of fibrosis markers using immunofluorescence staining and quantitative real-time reverse-transcription polymerase chain reaction. Results: Eupatilin treatment significantly reduced the fibrotic activity of TGF-β-induced endometrial fibrosis in Ishikawa cells, which displayed more circular shapes and formed more colonies. Additionally, the effects of eupatilin on fibrotic markers including alpha-smooth muscle actin, hypoxia-inducible factor 1 alpha, collagen type I alpha 1 chain, and matrix metalloproteinase-2, were evaluated in TGF-β-induced endometrial fibrosis. The expression of these markers was highly upregulated by TGF-β pretreatment and recovered to the levels of control cells in response to eupatilin treatment. Conclusion: Our findings suggest that suppression of TGF-β-induced signaling by eupatilin might be an effective therapeutic strategy for the treatment of endometrial fibrosis.

• Journal of Mechanical Science and Technology
• /
• v.18 no.6
• /
• pp.955-960
• /
• 2004

Some characteristics of the eigenvalue sensitivities have been found for beams in the paper. For cantilever beams and simply supported beams, the sensitivities of the eigenvalues to the stiffness correction factor of one element are equal and opposite to the sensitivities to the mass correction factor of the symmetrically positioned element. For beams with other boundary conditions, however, the relationship does not hold. The relationship has been proven analytically for simply supported beams.

• Journal of Korean Academy of Nursing
• /
• v.27 no.2
• /
• pp.377-388
• /
• 1997

This study was done to develop a eating behavior scale for high school girls using Stunkard and Messick(1985)'s three factors(dietary restraint disinhibition, hunger) as a conceptual framework and to test the validity and reliability of the scale. The subjects were 202 high school girls. The convenience sample is consist of 96 normal weight and 106 obese girls. Data were collected between October 28 and November 25 in 1996 and analyzed using the SPSS package. The new 32-item scale measuring these factors is presented 1. Three stable factors emerged and these contributed 45.7% of the variance in the total score. All 32 items loaded above .35 on each factor, 2. Factor 1 was named disinhibition(14 items), factor 2 was named cognitive restraint of eating(10 items), factor 3 was named hunger(8 items). Comparison of factor Ⅰ, factor Ⅱ, factor Ⅲ between normal subjects and obese subjects showed that there was a significant difference in factor Ⅱ & Ⅲ, not in factor Ⅰ. 3. Cronbach's alpha coefficient for internal consistancy was .9393 for total 32 items and .8820, .8652, .8490 for three dimensions of eating behavior in high school girls. Recommendations are suggested below : 1. Replication study with appropriate age groups be done to test validity and reliability, 2. The present developed scale must be a reliable measure of eating behavior and should have utility in further study on how effective nursing intervention related to different kind of groups such as disinhibition group and cognitive restraint of eating group. 3. To extend validity of the scale, further study is needs using more larger subjects which is consists of dieters and free eaters.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.23 no.6
• /
• pp.886-897
• /
• 1999

Fitness of clothes becomes a major concern in apparel industry. But girls had difficulties to buy ready-made clothes of good fit. To solve this problem it is necessary to classify girls' lower body Into several kinds of somatotypes and to develop dress form. The purposes of this study was to classify lower body types of middle-high school an provide the dress forms based on the analysis of their lower body types. The subjects for anthropometric measurement were 402 middle-high school girls of 13 to 15 year-old. The result of factor analysis indicated that 5 factors were extracted from anthropometric measurments through factor analysis and those factors comprise 71% of total variance. 4 clusters were categorized using 5 factor scores by cluster analysis 4 lower body dress forms for middle-high school girls were made of gypsum mould. By the analysis of more photograph three dimensional characteristics of somatotype and overlapped cross-section diagrams were analyzed.

• Journal of Electrical Engineering and Technology
• /
• v.12 no.1
• /
• pp.478-485
• /
• 2017

Urban DC railways have played an important role in urban transportation, and railway operation and energy management have been emphasized to be important to achieve maximum efficiency from existing infrastructure. Fast, accurate DC railway power flow analysis is required to operate a DC railway efficiently, and this paper proposes a novel methodology to analyze the DC railway power network by implementing the participation factor (PF). The PF concept consists of a correlation between the vehicle and the substation, as explained using zones based on the position of the vehicles running on the route. Then, the DC railway powerflow is calculated using the PF concept. Finally, the usability of the proposed method was validated via case studies with actual railway operation data, and we discuss some of the advantages of the suggested methodology.

• International Journal of Fluid Machinery and Systems
• /
• v.5 no.3
• /
• pp.126-133
• /
• 2012

The transfer matrix and unsteady cavitation characteristics, cavitation compliance and mass flow gain factor, of cavitating inducer were evaluated by CFD using commercial software. Quasi-steady values of cavitation compliance and mass flow gain factor were obtained first by using steady calculations at various flow rate and inlet cavitation number. Then unsteady calculations were made to determine the transfer matrix and the cavitation characteristics. The results are compared with experiments to show the validity of calculations.

• Journal of Advanced Marine Engineering and Technology
• /
• v.29 no.3
• /
• pp.281-289
• /
• 2005

An experimental study on the heat transfer and friction characteristics of a fully developed turbulent air flow in a square channel with $45^{\circ}$ inclined ribs on one, two, and four walls is reported. Tests were performed for Reynolds number ranging from 7,600 to 24,900. The pitch-to-rib height ratio, p/e, was kept at 8 and rib height-to-channel hydraulic diameter ratio, $e/D_h$, was kept at 0.0667. The heat transfer coefficient and friction factor values were enhanced with the increase in the number of ribbed walls. Results of this investigation could be used in various applications of internal channel turbulent flows involving different number of roughened walls.

• Archives of Pharmacal Research
• /
• v.26 no.8
• /
• pp.649-652
• /
• 2003

Polymeric nanoparticles composed of polystyrene (PS) as core and poly(methacrylic acid) (PMA) as corona were prepared by the dispersion copolymerization. The potential of the nanoparticles as carriers for recombinant human epidermal growth factor (EGF) was investigated. The nanoparticles showed monodispersity and good water-dispersibility. The loading content of EGF to the nanoparticles was very high due to electrostatic interaction between EGF and nanoparticles. EGF was released as a pseudo-zero order pattern after initial burst effect. The nanoparticles were sufficient for A431 cells proliferation.

• Geomechanics and Engineering
• /
• v.13 no.3
• /
• pp.517-533
• /
• 2017

In this paper, with a graphical approach, a series of stability charts for homogeneous slopes with benches are presented based on the upper bound limit analysis theory and strength reduction technique. The objective function of the slope safety factor $F_s$ is optimized by the nonlinear sequential quadratic programming, and a substantial number of examples are illustrated to use the stability charts for homogeneous slopes with benches driven by only the action of the soil weight. These charts can be applied to quick and accurate estimations of the stability status of homogeneous slopes with benches. Moreover, the failure modes and the formula for safety factor Fs of homogeneous slopes with benches are provided to illustrate the stability analysis of slopes with benches, which is validated by samples.