• Biomolecules & Therapeutics
• /
• 제31권3호
• /
• pp.350-358
• /
• 2023

Hand-foot-and-mouth disease (HFMD) is a viral infectious disease that occurs in children under 5 years of age. Its main causes are coxsackievirus (CV) and enterovirus (EV). Since there are no efficient therapeutics for HFMD, vaccines are effective in preventing the disease. To develop broad coverage against CV and EV, the development of a bivalent vaccine form is needed. The Mongolian gerbil is an efficient and suitable animal model of EV71 C4a and CVA16 infection used to investigate vaccine efficacy following direct immunization. In this study, Mongolian gerbils were immunized with a bivalent inactivated EV71 C4a and inactivated CVA16 vaccine to test their effectiveness against viral infection. Bivalent vaccine immunization resulted in increased Ag-specific IgG antibody production; specifically, EV71 C4a-specific IgG was increased with medium and high doses and CVA16-specific IgG was increased with all doses of immunization. When gene expression of T cell-biased cytokines was analysed, Th1, Th2, and Th17 responses were found to be highly activated in the high-dose immunization group. Moreover, bivalent vaccine immunization mitigated paralytic signs and increased the survival rate following lethal viral challenges. When the viral RNA content was determined from various organs, all three doses of bivalent vaccine immunization were found to significantly decrease viral amplification. Upon histologic examination, EV71 C4a and CVA16 induced tissue damage to the heart and muscle. However, bivalent vaccine immunization alleviated this in a dose-dependent manner. These results suggest that the bivalent inactivated EV71 C4a/CVA16 vaccine could be a safe and effective candidate HFMD vaccine.

• Korean Journal of Culture and Social Issue
• /
• 제23권4호
• /
• pp.605-634
• /
• 2017

The purpose of this study was to investigate families' responses and attitudes and the experiences of Korean LGBT individuals after revealing their sexual identity and sexual orientation and to determine how families' attitudes affected the mental health of these individuals. For this purpose, in-depth interviews were performed with 12 male and female LGBT participants, ranging from 19-30 years of age, who resided in Seoul and metropolitan areas, and reported coming out to or being outed by their families. One-to-one interviews were carried out using semi-structured questions, and the data from the interviews were analyzed using consensual qualitative research (CQR). Most of the families had very negative responses and attitudes to the participants coming out and exhibited rejection or avoidant attitudes; only a few of the families responded with receptive attitudes. As a result, the LGBT participants reacted with friction and coping behaviors, such as persuasion, participation in professional counseling, abandonment or avoidance, and running away from home. Most of the effects of the families' attitudes on the participants were negative psychological effects, such as anger, sadness, a sense of alienation, depression, anxiety, fear, trauma, helplessness, lowered self-esteem, alcohol dependence, and suicidal ideation and attempt, while receptive attitudes provided a sense of stability. For all participants, they reported that they were more likely to be hurt by their families' negative attitudes than by social attitudes. This study is significant because it provides framework for specifying families' attitudes and LGBT individuals' experiences after coming out in Korean society. It also outlines LGBT individuals' coping behaviors, psychological difficulties, and the process of coming out and provides suggestions for individuals to overcome. The results are expected to help counselors create practical strategies to better understand LGBT individuals and the psychological difficulties they may experience and provide proper interventions while counseling both the individual and the family.

• Journal of the Korean Applied Science and Technology
• /
• 제40권3호
• /
• pp.374-384
• /
• 2023

Universities that previously targeted in 20s have recently diversified their operation methods, founding purposes, and target. With a significant decrease in the school-age population relative to the number of universities, universities are making their best efforts to secure new students and minimize student attrition. In this study, an online survey was conducted to empirically examine the effects of motivation for major selection and sense of belonging on learning persistence intention among students in beauty-related departments at 2-year and 4-year general universities and cyber universities. The collected data from 119 students at general universities and 113 students at cyber universities were analyzed using SPSS 28. The key findings can be summarized as follows: For general universities, motivation for major selection did not have a significant effect on learning persistence intention, but sense of belonging had a significant positive effect. Additionally, an interaction effect was observed, indicating that as the sense of belonging increased, extrinsic motivation significantly increased learning persistence intention. For cyber universities, intrinsic motivation and sense of belonging among motivations for major selection had a significant positive effect on learning persistence intention, while the moderating effect of sense of belonging in the relationship between motivation for major selection and learning persistence intention was not significant. In summary, for general universities, the factor that influenced students' learning persistence intention was a sense of belonging to the university, while for cyber universities, intrinsic motivation played a significant role. These findings are expected to provide meaningful insights and data for universities to develop effective policies for preventing student attrition.

• Journal of Korea Entertainment Industry Association
• /
• 제13권4호
• /
• pp.241-253
• /
• 2019

The purpose of this study was to examine the phenomena that occurred when the students were practicing flip-learning lessons and to present the good points and the unsatisfactory points to improve the students' learning pleasure. Therefore, it is aimed to provide the basic data and the advantages and disadvantages which are needed to apply the flip learning method which is newly emerging recently to the university instruction. The method of this study was a questionnaire survey to understand the perception of flip learning. Based on the results of this study, the following conclusions are presented. First, the experience of flip learning instruction was first encountered by 50% of college students. Second, the students showed a very low tendency in practicing the flip learning instruction(video watching) the instructor intended. Third, college students have a habit of learning that they are not ready for pre-study of the subject. Fourth, the perception of flip learning lesson through the provision of video was highly positive. Fifthly, flip learning lessons have the advantage of being able to learn regardless of the time and place that they have, but they are not actively involved if they are not actually reflected in the test or grades. In conclusion, it was found that college students became accustomed to the incentive-style lessons due to the application of various learning techniques from elementary school age, making it difficult to participate in voluntary learning.

• Women's Studies Review
• /
• 제29권2호
• /
• pp.139-173
• /
• 2012

This paper examines the delayed situations for gender equality in South Korean, Japanese, and Taiwanese families despite the challenge to the gender division of labor in modern society, and to analyze the contradiction between the notions of gender equality and the experiences women face in East Asia countries. Using EASS data, we analyze the effective difference over the division of household labor according to women's age and length of school time, attitude for gender division of labor, couple's labor time, and family network. In South Korea and Taiwan, men's actual ratio of household division is higher than Japanese men's. On the other hand, Japanese women's ratio of household division is the highest in spite of their progressive attitude for gender equality. It is due to the difference of women's working time among the countries. In South Korea and Taiwan, women tend to work in full time job, so that they seem to inevitably reduce the time for household labor. The family characteristics have an effect on the women's ratio of household division in Taiwan, and the feature of women's employment does in South Korea. The high percentage of three-generation household contributes to the reduction of housework burden in Taiwan. In South Korea, the higher women's education levels, the higher the women's ratio of household division. Women's weakened bargaining power for household labor is due to the relatively low level of high-educated women's economic participation in South Korea. This paper reveals the effective factors on the gender division of household labor. We propose the necessity of the macro-level analysis as well as the analysis of the personal and conjugal feature.

• Korean Journal of Forensic Psychology
• /
• 제12권1호
• /
• pp.35-51
• /
• 2021

People's belief in free will is important in determining the causes and responsibilities of human behavior. Over the past decades, there has been debate about belief in free will in the fields of neuroscience, philosophy, ethics, and criminal law. The Free Will and Determinism Scale (FAD-Plus; Paulhus & Carey, 2011) is a test tool that measures the components related to the belief in an individual's free will. This study conducted a confirmatory factor analysis of 1,000 ordinary people of various age groups and socio-economic backgrounds based on previous studies that conducted an exploratory factor analysis (Study 1). The author has secured the reliability and validity of a number of measures. Furthermore, it was examined how the sub-item of the FAD-Plus scale, 'belief in free will,' was related to correspondence bias and locus of control (Study 2). As a result of analyzing a total of 83 subjects, high belief in free will had a positive correlation with punishment judgment for negative behavior and internal attribution, but there was no significant relationship in reward judgment for positive behavior. Based on the study results, it was proven that the FAD-Plus is valid for the general public as well, and the relationship between belief in free will, attribution bias, locus of control and behavior judgment was examined. The limitations of this study, policy implications, and research directions are discussed.

• Journal of Dental Rehabilitation and Applied Science
• /
• 제39권1호
• /
• pp.1-8
• /
• 2023

Purpose: The purpose of this study is to analyze the prognostic factors related to tooth loss after 5 years of periodontal surgery in periodontal disease patients. Materials and Methods: From January to December 2017, 22 patients and 124 teeth who underwent periodontal treatment through periodontal surgery were targeted. At the time of treatment, the measured values were evaluated after recording the maximum probing depth, average periodontal probing depth, number of root, furcation involvement, pulp vitality, and prosthesis state on the day of periodontal surgery. Based on the initial records at the time of visit, patient-related factors were gender, age, smoking, tooth loss due to periodontal disease at the time of first visit, diabetes, and maintenance period. The influence of each factor on tooth loss was evaluated. Results: As a result of examining the influence of tooth-related factors on tooth loss, the maximum probing depth depth (P: 0.000), bone loss (P: 0.021) was found to have a significant effect on tooth loss. Conclusion: As a result of examining the influence of patient-related factors on tooth loss, any variables had no significant effect. Bone loss, maximum probing depth acted as statistically significant prognostic factors for tooth loss in patients who underwent periodontal surgery.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
• /
• 제8권3호
• /
• pp.357-365
• /
• 2018

In the 21st century, as the emergence of the age of creative economy is expected, interest in the cultivation of creative talents required in society around the world is newly rising. Sustainable development education should not be limited to school education, but should be promoted and supported at all social education sites for the purpose of lifelong education. Therefore, the purpose of this paper is to consider the relationship between the possibility of formal and informal learning and the development of capacity in higher education. Exploratory and qualitative research based on intensive groups was designed using several groups of formal and informal learning settings. In China, the creation of a creative economy is set as a major national policy direction for the new government. What is required for talented people in the creative economy era and how to educate them is becoming a major policy issue. The development of core competencies requires multiple contexts based on cognitive non-cognitive disposition. By combining the formal and informal learning environment within higher education for the purpose of a new learning culture, it can provide a variety of situations and improve competency development. While this study can identify aspects of formal and informal learning settings, the interdependencies between them are still difficult to grasp. However, practical implications can be seen clearly. In other words, based on the results, you can point out key aspects of competency acquisition that can be a key element in the higher education environment. As a result, this study analyzed implications for formal and informal learning environments for new ways of developing core competencies in higher education.

• Journal of agricultural medicine and community health
• /
• 제48권2호
• /
• pp.91-102
• /
• 2023

Objective: This study aimed to evaluate the effects of a digital group reminiscence program on elderly patients with mild dementia who were registered with Day Care Centers. Methods: The study was conducted with elderly patients with mild dementia in Day Care Centers in D city. The patients were randomly assigned to either the experimental group or the control group and were assessed for cognitive function, depression, and ego integrity using pre-test and post-test designs. A digital group reminiscence program was applied to the experimental group. Data was collected from July 5 to September 17, 2021, using questionnaires in three sessions. Results: The pre-test cognitive function score was 12.00 in the experimental group and 11.09 in the control group. The post-test cognitive function score was 19.20 in the experimental group and 14.42 in the control group. The later cognitive function score was 18.00 in the experimental group and 13.31 in the control group. The pre-test depression score was 8.32 in the experimental group and 9.91 in the control group. The post-test depression score was 6.05 in the experimental group and 8.82 in the control group. The later depression score was 6.94 in the experimental group and 9.02 in the control group. The pre-test ego integrity score was 41.39 in the experimental group and 39.55 in the control group. The post-test ego integrity score was 57.95 in the experimental group and 51.41 in the control group. The later ego integrity score was 55.88 in the experimental group and 42.15 in the control group. Cognitive function, depression, and ego integrity showed significant differences according to group (p<.05), time (p<.001), and interaction between group and time (p<.01). Conclusion: The digital group reminiscence program was found to be effective in improving cognitive function and ego integrity and reducing depression in elderly patients with mild dementia. Further research is needed to explore the effects of repetitive digital group recall programs based on the progress, course, age, and communication level of dementia.

• 한국체육학회지인문사회과학편
• /
• 제55권5호
• /
• pp.619-633
• /
• 2016

In March 26th, 2016, two major sport organizations of South Korea, Korean Olympic Committee and the Korean Council of Sports for All, have merged with the ultimate goal of improving health and wellness among Korean people through sport and physical activity participation. Integration of sport system intended to shift the paradigm from "old" to "new", and can be a catalyzer to promote Korea as a developed nation with the delivery of quality sport. This study critically reviewed the Canadian Sport for Life-Long-Term Athlete Development (CS4L-LTAD) which serves as a platform to integrate and operate sport organizations in Canada, and discussed the feasibility and adaptability of CS4L-LTAD in the Korean context. This study also introduced Integrated Model for Korea Sport System developed based on the CS4L-LTAD framework, and addressed key strategies that will drive to the successful implementation of the model. The Integrated Model for Korea Sport System offers ways to improve the quality of sport and physical activity for all Koreans by linking sport, recreation, physical education, and health, and by aligning programs and services across different settings: school, elite, and community sports. The recent restructure and redesign of Korea sport system will play vital roles in promoting the overall welfare of all Koreans, regardless of one's sex, age, disability, and sociodemographic status by providing inclusive, ethical, and holistic framework that is appropriate for the Korea sport system.