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The Usefulness of Rapid Triple Test for Cardiac Marker in Forensic Paragnosis of Sudden Cardiac Death (심장표지물질 간이검사의 급성심장사 법의학적 사후진단 유용성에 관한 연구)

  • Lim, Chae-Won;Kim, Jin-Gak
    • Korean Journal of Clinical Laboratory Science
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    • v.49 no.2
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    • pp.108-113
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    • 2017
  • A sudden cardiac death (SCD) is defined as an unnatural sudden death caused by heart disease. To determine the cause of death, observation of the microscopic change in cardiac muscle tissue is suggested, rather than visual postmortem examination. However, this suggestion is time consuming to be applied in the field, is cost-ineffective, and is inconvenient. Therefore, the purpose of this study is to understand whether temporary inspection used to examine the cardiac marker (Myoglobin, CK-MB, cTn I) in postmortem blood via rapid cardiac triple test kit (which is used by clinics to diagnose patients with acute myocardial infarction) can effectively be utilized for the paragnosis of sudden, unnatural cardiac death. The results of postmortem examination and temporary investigation found that 23 groups (76.7%), among the 30 experimental groups, were assumed to be non-traumatic sudden cardiac deaths, which indicated a positive response (according to comparison with forensic autopsy); 4 groups, among the 10 control groups, were assumed to be cerebrovascular disease, which indicated a negative response; 1 group was assumed to be alcoholic and drug poisoning, indicating a positive response; and 1 group was assumed to be oxygen deficiency due to suffocation, indicating a positive response. Hence, it was found that the level of sensitivity and specificity of cardiac marker's temporary inspection showed significant result, 76.7% and 80% respectively. Given this, temporary inspection can be effectively used for the paragnosis of sudden cardiac death when the medical history, situation of the site, and postmortem interval are considered together. With the result of precedent research on time of first revelation and extinction in blood, and difference in concentration over time progress according to the characteristic of cardiac marker's (myoglobin, CK-MB, cTn I) individual material, further research on concentration of cardiac marker per each post time needs to be conducted in order to estimate time science death (which is required to identify the cause of death and investigation).

Investigation of the Effect of Calculation Method of Offset Correction Factor on the GEMS Sulfur Dioxide Retrieval Algorithm (GEMS 이산화황 산출 현업 알고리즘에서 오프셋 보정 계수 산정 방법에 대한 영향 조사)

  • Park, Jeonghyeon;Yang, Jiwon;Choi, Wonei;Kim, Serin;Lee, Hanlim
    • Korean Journal of Remote Sensing
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    • v.38 no.2
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    • pp.189-198
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    • 2022
  • In this present study, we investigated the effect of the offset correction factor calculation method on the sulfur dioxide (SO2) column density in the SO2 retrieval algorithm of the Geostationary Environment Monitoring Spectrometer (GEMS) launched in February 2020. The GEMS operational SO2 retrieval algorithm is the Differential Optical Absorption Spectroscopy (DOAS) - Principal Component Analysis (PCA) Hybrid algorithm. In the GEMS Hybrid algorithm, the offset correction process is essential to correct the absorption effect of ozone appearing in the SO2 slant column density (SCD) obtained after spectral fitting using DOAS. Since the SO2 column density may depend on the conditions for calculating the offset correction factor, it is necessary to apply an appropriate offset correction value. In this present study, the offset correction values were calculated for days with many cloud pixels and few cloud pixels, respectively. And a comparison of the SO2 column density retrieved by applying each offset correction factor to the GEMS operational SO2 retrieval algorithm was performed. When the offset correction value was calculated using radiance data of GEMS on a day with many cloud pixels was used, the standard deviation of the SO2 column density around India and the Korean Peninsula, which are the edges of the GEMS observation area, was 1.27 DU, and 0.58 DU, respectively. And around Hong Kong, where there were many cloud pixels, the SO2 standard deviation was 0.77 DU. On the other hand, when the offset correction value calculated using the GEMS data on the day with few cloud pixels was used, the standard deviation of the SO2 column density slightly decreased around India (0.72 DU), Korean Peninsula (0.38 DU), and Hong Kong (0.44 DU). We found that the SO2 retrieval was relatively stable compared to the SO2 retrieval case using the offset correction value on the day with many cloud pixels. Accordingly, to minimize the uncertainty of the GEMS SO2 retrieval algorithm and to obtain a stable retrieval, it is necessary to calculate the offset correction factor under appropriate conditions.