• Title/Summary/Keyword: Scale-up process

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Characterization of Secondary Exposure to Chemicals and Indoor Air Quality in Fire Station (소방서 실내공간의 화학적 유해인자 2차노출과 실내공기질 특성)

  • Kim, Soo Jin;Ham, Seunghon;Jeon, Jeong Seok;Kim, Won
    • Fire Science and Engineering
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    • v.33 no.4
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    • pp.140-151
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    • 2019
  • It is to assess the indoor air quality of the chemical hazardous materials exposed to the fire after firefighters returned to the fire scene. The research subject randomly selected four fire stations located in Seoul, Korea. Two fire stations were set up as control groups after the return of the firefighting activities at the actual fire scene, and two other fire stations were set up as control groups to measure the air quality of the room at normal levels regardless of the action. We conducted 24-hour monitoring for all fire accidents that occurred in Seoul Metropolitan using fire safety map computer system. Also, indoor air quality was measured immediately after homecoming if the experiment group was to be dispatched due to an accident of intermediate or larger scale. 11 hazardous substance items such as fine dust, formaldehyde, volatile organic compounds, PAH, VCM, acidity, asbestos, CO2, NO2, O3 were measured according to the process test method. Three of 11 types of harmful substances exceeded domestic and foreign standards, and one of them was found to be close to foreign standards. In particular, total volatile organic compounds, carbon dioxide and sulfuric acids were 2.5 times, 2.2 times and 1.1 times higher than the standard. Also, for formaldehyde and sulfuric acid, it was measured higher in the control group than in the case group. This findings could be used in policies to improve indoor air quality in the fire station of the Seoul Metropolitan Government.

Impacts of wave and tidal forcing on 3D nearshore processes on natural beaches. Part I: Flow and turbulence fields

  • Bakhtyar, R.;Dastgheib, A.;Roelvink, D.;Barry, D.A.
    • Ocean Systems Engineering
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    • v.6 no.1
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    • pp.23-60
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    • 2016
  • The major objective of this study was to develop further understanding of 3D nearshore hydrodynamics under a variety of wave and tidal forcing conditions. The main tool used was a comprehensive 3D numerical model - combining the flow module of Delft3D with the WAVE solver of XBeach - of nearshore hydro- and morphodynamics that can simulate flow, sediment transport, and morphological evolution. Surf-swash zone hydrodynamics were modeled using the 3D Navier-Stokes equations, combined with various turbulence models (${\kappa}-{\varepsilon}$, ${\kappa}-L$, ATM and H-LES). Sediment transport and resulting foreshore profile changes were approximated using different sediment transport relations that consider both bed- and suspended-load transport of non-cohesive sediments. The numerical set-up was tested against field data, with good agreement found. Different numerical experiments under a range of bed characteristics and incident wave and tidal conditions were run to test the model's capability to reproduce 3D flow, wave propagation, sediment transport and morphodynamics in the nearshore at the field scale. The results were interpreted according to existing understanding of surf and swash zone processes. Our numerical experiments confirm that the angle between the crest line of the approaching wave and the shoreline defines the direction and strength of the longshore current, while the longshore current velocity varies across the nearshore zone. The model simulates the undertow, hydraulic cell and rip-current patterns generated by radiation stresses and longshore variability in wave heights. Numerical results show that a non-uniform seabed is crucial for generation of rip currents in the nearshore (when bed slope is uniform, rips are not generated). Increasing the wave height increases the peaks of eddy viscosity and TKE (turbulent kinetic energy), while increasing the tidal amplitude reduces these peaks. Wave and tide interaction has most striking effects on the foreshore profile with the formation of the intertidal bar. High values of eddy viscosity, TKE and wave set-up are spread offshore for coarser grain sizes. Beach profile steepness modifies the nearshore circulation pattern, significantly enhancing the vertical component of the flow. The local recirculation within the longshore current in the inshore region causes a transient offshore shift and strengthening of the longshore current. Overall, the analysis shows that, with reasonable hypotheses, it is possible to simulate the nearshore hydrodynamics subjected to oceanic forcing, consistent with existing understanding of this area. Part II of this work presents 3D nearshore morphodynamics induced by the tides and waves.

A Study of Evaluation Indices for Selecting Castle Remains Maintenance and Restoration Sections (성곽유적의 정비복원(整備復元) 대상구간 선정을 위한 평가지표 연구)

  • Kim, Hong-Gon;Choi, Key-Soo
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.30 no.1
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    • pp.1-13
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    • 2012
  • Most of all Castle Remains in Korea were built on an axis of development with a scale of great magnitude. Because of its characteristics, the restoration and conservation plans should be phased in over medium and long term. There is no standards for evaluating the value of Castle Remains to set up the restoration and conservation sections. Some plans were set up through the value evaluation of its Castle Remains but those plans didn't have Evaluation System and different weight depending on different environment between Sanseong(mountain fortress) and Eupsung(fortress built in villages). To solve the limitation of Evaluation System of Castle Remains, this study try to approach in the Evaluation System methodology for selecting restoration sections. The results of its study follow below. First, this study drew the Evaluation Indices for selecting restoration sections of Castle Remains. There are three kinds of Elements(upper Index) and nine kinds of Evaluations(low Index). Second, Calculation of weight index by index on the questionnaire survey from expers through the relative importance analysis of AHP. Third, This study suggests the specific Evaluation System according to types; Sanseong(mountain fortress) and Eupsung(fortress built in villages);. Therefore, this study suggests standards to select the priority list for the restoration and conservation plan process and it can be used one of important standards in future plans.

Suspension of Sediment over Swash Zone (Swash대역에서의 해빈표사 부유거동에 관한 연구)

  • Cho, Yong Jun;Kim, Kwon Soo;Ryu, Ha Sang
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.28 no.1B
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    • pp.95-109
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    • 2008
  • We numerically analyzed the nonlinear shoaling, a plunging breaker and its accompanying energetic suspension of sediment at a bed, and a redistribution of suspended sediments by a down rush of preceding waves and the following plunger using SPH with a Gaussian kernel function, Lagrangian Dynamic Smagorinsky model (LDS), Van Rijn's pick up function. In that process, we came to the conclusion that the conventional model for the tractive force at a bottom like a quadratic law can not accurately describe the rapidly accelerating flow over a swash zone, and propose new methodology to accurately estimate the bottom tractive force. Using newly proposed wave model in this study, we can successfully duplicate severely deformed water surface profile, free falling water particles, a queuing splash after the landing of water particles on the free surface and a wave finger due to the structured vortex on a rear side of wave crest (Narayanaswamy and Dalrymple, 2002), a circulation of suspended sediments over a swash zone, net transfer of sediments clouds suspended over a swash zone toward the offshore, which so far have been regarded very difficult features to mimic in the computational fluid mechanics.

A Data-based Sales Forecasting Support System for New Businesses (데이터기반의 신규 사업 매출추정방법 연구: 지능형 사업평가 시스템을 중심으로)

  • Jun, Seung-Pyo;Sung, Tae-Eung;Choi, San
    • Journal of Intelligence and Information Systems
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    • v.23 no.1
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    • pp.1-22
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    • 2017
  • Analysis of future business or investment opportunities, such as business feasibility analysis and company or technology valuation, necessitate objective estimation on the relevant market and expected sales. While there are various ways to classify the estimation methods of these new sales or market size, they can be broadly divided into top-down and bottom-up approaches by benchmark references. Both methods, however, require a lot of resources and time. Therefore, we propose a data-based intelligent demand forecasting system to support evaluation of new business. This study focuses on analogical forecasting, one of the traditional quantitative forecasting methods, to develop sales forecasting intelligence systems for new businesses. Instead of simply estimating sales for a few years, we hereby propose a method of estimating the sales of new businesses by using the initial sales and the sales growth rate of similar companies. To demonstrate the appropriateness of this method, it is examined whether the sales performance of recently established companies in the same industry category in Korea can be utilized as a reference variable for the analogical forecasting. In this study, we examined whether the phenomenon of "mean reversion" was observed in the sales of start-up companies in order to identify errors in estimating sales of new businesses based on industry sales growth rate and whether the differences in business environment resulting from the different timing of business launch affects growth rate. We also conducted analyses of variance (ANOVA) and latent growth model (LGM) to identify differences in sales growth rates by industry category. Based on the results, we proposed industry-specific range and linear forecasting models. This study analyzed the sales of only 150,000 start-up companies in Korea in the last 10 years, and identified that the average growth rate of start-ups in Korea is higher than the industry average in the first few years, but it shortly shows the phenomenon of mean-reversion. In addition, although the start-up founding juncture affects the sales growth rate, it is not high significantly and the sales growth rate can be different according to the industry classification. Utilizing both this phenomenon and the performance of start-up companies in relevant industries, we have proposed two models of new business sales based on the sales growth rate. The method proposed in this study makes it possible to objectively and quickly estimate the sales of new business by industry, and it is expected to provide reference information to judge whether sales estimated by other methods (top-down/bottom-up approach) pass the bounds from ordinary cases in relevant industry. In particular, the results of this study can be practically used as useful reference information for business feasibility analysis or technical valuation for entering new business. When using the existing top-down method, it can be used to set the range of market size or market share. As well, when using the bottom-up method, the estimation period may be set in accordance of the mean reverting period information for the growth rate. The two models proposed in this study will enable rapid and objective sales estimation of new businesses, and are expected to improve the efficiency of business feasibility analysis and technology valuation process by developing intelligent information system. In academic perspectives, it is a very important discovery that the phenomenon of 'mean reversion' is found among start-up companies out of general small-and-medium enterprises (SMEs) as well as stable companies such as listed companies. In particular, there exists the significance of this study in that over the large-scale data the mean reverting phenomenon of the start-up firms' sales growth rate is different from that of the listed companies, and that there is a difference in each industry. If a linear model, which is useful for estimating the sales of a specific company, is highly likely to be utilized in practical aspects, it can be explained that the range model, which can be used for the estimation method of the sales of the unspecified firms, is highly likely to be used in political aspects. It implies that when analyzing the business activities and performance of a specific industry group or enterprise group there is political usability in that the range model enables to provide references and compare them by data based start-up sales forecasting system.

INTRINSIC NMR ISOTOPE SHIFTS OF CYCLOOCTANONE AT LOW TEMPERATURE (저온에서의 싸이클로옥타논에 대한 고유동위원소 효과)

  • Jung, Miewon
    • Analytical Science and Technology
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    • v.7 no.2
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    • pp.213-224
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    • 1994
  • Several isotopomers of cyclooctanone were prepared by selective deuterium substitution. Intrinsic isotope effects on $^{13}C$ NMR chemical shifts of these isotopomers were investigated systematically at low temperature. These istope effects were discussed in relation to the preferred boat-chair conformation of cyclooctanone. Deuterium isotope effects on NMR chemical shifts have been known for a long time. Especially in a conformationally mobile molecule, isotope perturbation could affect NMR signals through a combination of isotope effects on equilibria and intrinsic effects. The distinction between intrinsic and nonintrinsic effects is quite difficult at ambient temperature due to involvement of both equilibrium and intrinsic isotope effects. However if equilibria between possible conformers of cyclooctanone are slowed down enough on the NMR time scale by lowering temperature, it should be possible to measure intrinsic isotope shifts from the separated signals at low temperature. $^{13}C$ NMR has been successfully utilized in the study on molecular conformation in solution when one deals with stable conformers or molecules were rapid interconversion occurs at ambient temperature. The study of dynamic processes in general requires analysis of spectra at several temperature. Anet et al. did $^1H$ NMR study of cyclooctanone at low temperature to freeze out a stable conformation, but were not able initially to deduce which conformation was stable because of the complexity of alkyl region in the $^1H$ NMR spectrum. They also reported the $^1H$ and $^{13}C$ NMR spectra of the $C_9-C_{16}$ cycloalkanones with changing temperature from $-80^{\circ}C$ to $-170^{\circ}C$, but they did not report a variable temperature $^{13}C$ NMR study of cyclooctanone. For the analysis of the intrinsic isotope effect with relation to cylooctanone conformation, $^{13}C$ NMR spectra are obtained in the present work at low temperatures (up to $-150^{\circ}C$) in order to find the chemical shifts at the temperature at which the dynamic process can be "frozen-out" on the NMR time scale and cyclooctanone can be observed as a stable conformation. Both the ring inversion and pseudorotational processes must be "frozen-out" in order to see separate resonances for all eight carbons in cyclooctanone. In contrast to $^1H$ spectra, slowing down just the ring inversion process has no apparent effects on the $^{13}C$ spectra because exchange of environments within the pairs of methylene carbons can still occur by the pseudorotational process. Several isotopomers of cyclooctanone were prepared by selective deuterium substitution (fig. 1) : complete deuterium labeling at C-2 and C-8 positions gave cyclooctanone-2, 2, 8, $8-D_4$ : complete labeling at C-2 and C-7 positions afforded the 2, 2, 7, $7-D_4$ isotopomer : di-deuteration at C-3 gave the 3, $3-D_2$ isotopomer : mono-deuteration provided cyclooctanone-2-D, 4-D and 5-D isotopomers : and partial deuteration on the C-2 and C-8 position, with a chiral and difunctional case catalyst, gave the trans-2, $8-D_2$ isotopomer. These isotopomer were investigated systematically in relation with cyclooctanone conformation and intrinsic isotope effects on $^{13}C$ NMR chemical shifts at low temperature. The determination of the intrinsic effects could help in the analysis of the more complex effects at higher temperature. For quantitative analysis of intrinsic isotope effects, the $^{13}C$ NMR spectrum has been obtained for a mixture of the labeled and unlabeled compounds because the signal separations are very small.

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Comparison of work measures for some physician services in Obstetrics & Gynecology (산부인과 의사의 일부 서비스 진료업무량 측정방법 비교에 관한 연구)

  • Hur, Yeong-Joo;Sohn, Myong-Sei;Park, Eun-Cheol;Kang, Hyung-Gon;Kim, Han-Joong
    • Journal of Preventive Medicine and Public Health
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    • v.28 no.3 s.51
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    • pp.623-639
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    • 1995
  • We have never seen any method to cope basically with complicated situation and problems around medical reimbursement rates here in Korea since 1977 witnessed by the beginning of medical insurance. By the way researchers concerned are beginning to propose some kinds of innovative and detailed ideas to government these days. They are Diagnosis-related group(DRG) and Resource-based .elative value scale(RBRVS). In the light of this situation it is so encouraging that our government can come up with that and move. In case of RBRVS research we have already been reaching even to the level of reviewing and revising methodology for its further development after naive pilot study on internal medicine and general surgery last year. However there might be something different conditions between USA and Korea to apply the same Dr. Hsiao's method and it must be vital to check so called' total work approach' compared with 'intra-service work approach' before expanding to the whole medical fields. According to the' Intra-service approach', the physician's work is supposed to be divided into three sub-works by the name of intraservice work, pre, and post service work. These sub-works, again should be merged together to be the pre-postwork subset through some statistical methods of the estimation process applied by Dr. Hsiao's methodology in RBRVS development later on. But in this paper that estimation process was not taken because we could have real values for all of those surveyed items related to just one specialty, OB & GY. Instead, We used some statistical comparison procedures relevant to demographic characteristics, reliability & validity and correlation analysis with American RVU(Relative value unit) between the total work and merged total work from intraservice work approach. The unit of analysis was individual physicians of OB & GY and 300 physicians were selected for each approach through statistical sampling method based on national population of OB & GY physicians in Korea. And also with the thankful help of Advisory Committee under Korean Association of OB & GY, questionnaires were made and mailed to the subjects, two times. As a result there were not any statistically significant differences in demographic characteristics between the two approaches except for the variable 'Response time for the questionnaires', but in other sections of comparisons, response rate, representative values, reliability & validity test, correlation analysis with American RVU, all showed 'Total approach' was not only more rational and statistically meaningful than 'Intra-service approach' but also had considerable merits. But we are not absolutely sure about this paper's robustness. Because of some limitations, we'd rather like to suggest further researches should be followed. In that sense the first thing would be a research for the influence of doctor's characteristics, especially 'frequency' on the rating of work and the way to define total work more clearly.

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Lactulose Production Using Immobilized Cells Including Thermostable Cellobiose 2-epimerase (열내성 Cellobiose 2-epimerase를 발현하는 대장균의 고정화담체를 이용한 락툴로오스의 생산방법)

  • Park, Ah-Reum;Koo, Bong-Seong;Kim, Jin-Sook;Kim, Eun-Jeong;Lee, Hyeon-Cheol
    • Microbiology and Biotechnology Letters
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    • v.44 no.4
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    • pp.504-511
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    • 2016
  • Lactulose, a synthetic disaccharide, has received increasing interest because of its role as a prebiotic that can increase the proliferation of Bifidobacterium and Lactobacillus spp. and enhance the absorption of calcium and magnesium. While the industrial production of lactulose is still mainly achieved by the chemical isomerization of lactose in alkaline media, this process has drawbacks including the need to remove catalysts and by-products, as well as high energy requirements. Recently, the use of cellobiose 2-epimerase (CE) has been considered an interesting alternative for industrial lactulose production. In this study, to develop a process for enzymatic lactulose production using CE, we screened improved mutant enzymes ($CS-H^RC^E$) from a library generated by an error-prone PCR technique. The thermostability of one mutant was enhanced, conferring stability up to $75^{\circ}C$, and its lactulose conversion yield was increased by 1.3-fold compared with that of wild-type CE. Using a recombinant Escherichia coli strain harboring a CS35 $H^RC^E$-expressing plasmid, we prepared cell beads immobilized on a Ca-alginate substrate and optimized their reaction conditions. In a batch reaction with 200 g/l lactose solution and the immobilized cell beads, lactose was converted into lactulose with a conversion yield of 43% in 2 h. In a repeated 38-plex batch reaction, the immobilized cell beads were relatively stable, and 80% of the original enzyme activity was retained after 4 cycles. In conclusion, we developed a reasonable method for lactulose production by immobilizing cells expressing thermostable CE. Further development is required to apply this approach at an industrial scale.

A Study on Control of Access to Internal Network Information and Authority Set Up Management for Client by Class (제한된 내부 네트워크 정보 접근제어와 계층별 클라이언트 권한설정 관리에 관한 연구)

  • Seo, Woo-Seok;Park, Jae-Pyo;Jun, Moon-Seog
    • The Journal of the Korea institute of electronic communication sciences
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    • v.7 no.2
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    • pp.287-293
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    • 2012
  • It has been only few years that various contents information subject for information processing system has been remarkably increased in online. If we say the year 2000 is the technology based year when deluge of information and data such as real time sharing, the time since after 2000 until 2011 has been a period plentiful of application based functions and solutions. Also, as the applicable range of these information process systems extends, individual information effluence has been social issues twice in 2009 and 2010. Thus now there are continuous efforts made to develop technologies to secure and protect information. However, the range problem has been extended from the illegal access from outside to the legal access from internal user and damages by agents hidden in internal information process system and client system. Therefore, this study discusses the necessity for the studies on efficiency based information security by control of access to internal information and authority setting for administrator and internal users. Based on the result of this study, it provides data that can be used from SOHO class network to large scale for information security method.

Job Analysis for IT Security Workers in Defense Industry through DACUM Process (DACUM 기법을 이용한 방위산업체 정보통신보안실무자 직무분석)

  • Woo, Kwang Jea;Song, Hae-Deok
    • Convergence Security Journal
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    • v.14 no.4
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    • pp.73-84
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    • 2014
  • As the society turns into more of an information an technology centric society, the importance of information security is being increased these days. Recently, as the number of leaking accidents of personal information and valuable industrial technology is on the rise, every field of industry endeavors to come up with a security solution. In particular, since defense industry is a field where it establishes national defense power that is essential of national security, it requires higher standards of security solutions than any other ordinary fields of industry. According to Defense Industry Security Work Instructions, defense industry firms from security organizations and employ a security worker corresponding to the firm's scale and conditions. In an environment where essential information and technology are stored and managed in information and communication system or storing media, the duty and role of IT security workers are crucial. However, there is a shortage of systematic analysis on the work of IT security workers and development of curriculum to enhance their professionalism. Thus DACUM process, a job analysis technique, was used to identify IT Security workers' duties and responsibilities and verify the validity and credibility of the deducted results from the survey. The findings of this study will help in development of IT security duty in defense industry and can be used as baseline data for the development of curriculum and amendments of related regulations.