• Title/Summary/Keyword: Scale-up

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Research on the Dispersion Stability and Scale up of Carbon Slurry Fuel (카본슬러리 연료의 분산안정성 개선 및 scale up 제조 연구)

  • Cho, Min-Ho;Yang, Mun-Kyu;Lee, Ik-Mo;Cho, Joon-Hyun;Kwon, Tae-Soo;Jeong, Byung-Hun;Han, Jeong-Sik
    • Journal of the Korean Society of Propulsion Engineers
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    • v.13 no.3
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    • pp.34-40
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    • 2009
  • For the preparation of carbon-slurry fuel, the effects of process parameters on the carbon dispersion stability in the liquid fuel have been investigated. The dispersion stability of carbon-slurry fuels could be monitored by measurements of particle size and carbon contents in the different positions, and observation of dispersion states after centrifuging. Through the application of various additives, it was found that NB463S84 based on polyolefin succinimde showed the best dispersion and longest stability life of carbon-slurry fuel. Also, PIBSI (polyisobutenyl succimide) with the similar functional groups to NB463S84 was effectively synthesized and same dispersion stability was verified by application to carbon-slurry fuel. Finally, the possibility of practical use of carbon-slurry fuels was confirmed by application of the mixing conditions obtained from g scale to kg scale preparation.

Application of Scale-Up Criterion of Constant Oxygen Mass Transfer Coefficient ($k_La$) for Production of Itaconic Acid in a 50 L Pilot-Scale Fermentor by Fungal Cells of Aspergillus terreus

  • Shin, Woo-Shik;Lee, Dohoon;Kim, Sangyong;Jeong, Yong-Seob;Chun, Gie-Taek
    • Journal of Microbiology and Biotechnology
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    • v.23 no.10
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    • pp.1445-1453
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    • 2013
  • The scale-up criterion of constant oxygen mass transfer coefficient ($k_La$) was applied for the production of itaconic acid (IA) in a 50 L pilot-scale fermentor by the fungal cells of Aspergillus terreus. Various operating conditions were examined to collect as many $k_La$ data as possible by adjusting the stirring speed and aeration rate in both 5 L and 50 L fermentor systems. In the fermentations performed with the 5 L fermentor, the highest IA production was obtained under the operating conditions of 200 rpm and 1.5 vvm. Accordingly, we intended to find out parallel agitation and aeration rates in the 50 L fermentor system, under which the $k_La$ value measured was almost identical to that ($0.02sec^{-1}$) of the 5 L system. The conditions of 180 rpm and 0.5 vvm in the 50 L system turned out to be optimal for providing almost the same volumetric amount of dissolved oxygen (DO) into the fermentor, without causing shear damage to the producing cells due to excessive agitation. Practically identical fermentation physiologies were observed in both fermentations performed under those respective operating conditions, as demonstrated by nearly the same values of volumetric ($Q_p$) and specific ($q_p$) IA production rates, IA production yield ($Y_{p/s}$), and specific growth rate (${\mu}$). Specifically, the negligible difference of the specific growth rate (${\mu}$) between the two cultures (i.e., $0.029h^{-1}$ vs. $0.031h^{-1}$) was notable, considering the fact that ${\mu}$ normally has a significant influence on $q_p$ in the biosynthesis of secondary metabolites such as itaconic acid.

Clinical Comparison of Posterolateral Fusion with Posterior Lumbar Interbody Fusion

  • Kim, Chang-Hyun;Gill, Seung-Bae;Jung, Myeng-Hun;Jang, Yeun-Kyu;Kim, Seong-Su
    • Journal of Korean Neurosurgical Society
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    • v.40 no.2
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    • pp.84-89
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    • 2006
  • Objective : The purpose of this study is to compare the outcomes of two methods for stabilization and fusion : Postero-Lateral Fusion [PLF, pedicle screw fixation with bone graft] and Posterior Lumbar Interbody Fusion [PLIF, cage insertion] for spinal stenosis and recurred disc herniation except degenerative spondylolisthesis. Methods : Seventy one patients who underwent PLF [n=36] or PLIF [n=35] between 1997 and 2001 were evaluated prospectively. These two groups were compared for the change of interbody space, the range of segmental angle, the angle of lumbar motion, and clinical outcomes by Prolo scale. Results : The mean follow-up period was 32.6 months. The PLIF group showed statistically significant increase of the interbody space after surgery. However, the difference in the change of interbody space between two groups was insignificant [P value=0.05]. The range of segmental angle was better in the PLIF group, but the difference in the change of segmental angle was not statistically significant [P value=0.0l7]. Angle of lumbar motion was similar in the two groups. Changes of Prolo economic scale were not statistically significant [P value=0.193]. The PLIF group showed statistically significant improvement in Prolo functional scale [P value=0.003]. In Prolo economic and functional scale, there were statistically significant relationships between follow-up duration [P value<0.001]. change of interbody space [P value<0.001], and range of segmental angle [P value<0.001]. Conclusion : Results of this study indicate that PLIF is superior to PLF in interbody space augmentation and clinical outcomes by Prolo functional scale. Analysis of clinical outcomes showed significant relationships among various factors [fusion type, follow-up duration, change of interbody space, and range of segmental angle]. Therefore, the authors recommend instrumented PLIF to offer better clinical outcomes in patients who needed instrumented lumbar fusion for spinal stenosis and recurred disc herniation.

Research on the Dispersion Stability and Scale up of Carbon Slurry Fuel (카본슬러리 연료의 분산안정성 개선 및 scale up 제조연구)

  • Jo, Min-Ho;Yang, Mun-Kyu;Lee, Ik-Mo;Cho, Joon-Hyun;Kwon, Tae-Soo;Jeong, Byung-Hun;Han, Jeong-Sik
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • 2008.11a
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    • pp.459-462
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    • 2008
  • In manufacture of slurry fuel, the effects of process parameters on the carbon dispersion stability have been investigated. The particle size and contents of the carbon slurry taken from 3 (top, medium, bottom) positions in fuel reservoir were analyzed to estimate the dispersion of the carbon in Jet A-1. Through the application of various additives, it was found that NB463S84 additive showed the best dispersion and stability of carbon at accelerated gravity condition. The mixer performance was compared by the observation of height change of carbon-containing layer and measurement of particle sizes at the same conditions. Application of the mixing conditions obtained from the lab-scale to bench scale manufacture confirmed the practical feasibility of our research.

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Comparative Analysis of the Performance of SIFT and SURF (SIFT 와 SURF 알고리즘의 성능적 비교 분석)

  • Lee, Yong-Hwan;Park, Je-Ho;Kim, Youngseop
    • Journal of the Semiconductor & Display Technology
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    • v.12 no.3
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    • pp.59-64
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    • 2013
  • Accurate and robust image registration is important task in many applications such as image retrieval and computer vision. To perform the image registration, essential required steps are needed in the process: feature detection, extraction, matching, and reconstruction of image. In the process of these function, feature extraction not only plays a key role, but also have a big effect on its performance. There are two representative algorithms for extracting image features, which are scale invariant feature transform (SIFT) and speeded up robust feature (SURF). In this paper, we present and evaluate two methods, focusing on comparative analysis of the performance. Experiments for accurate and robust feature detection are shown on various environments such like scale changes, rotation and affine transformation. Experimental trials revealed that SURF algorithm exhibited a significant result in both extracting feature points and matching time, compared to SIFT method.

Catechol-Chitosan Hydrogel: Scale-up Synthesis and Self-Healing Properties (카테콜-키토산 하이드로겔의 대용량 합성과 자가 치유 특성 분석)

  • Choi, Hoe Young;Ko, Haye Min
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2022.11a
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    • pp.251-252
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    • 2022
  • Chemical crosslinking is the most widely used method for hydrogel preparations. We prepared a hydrogel using chitosan catechol/polyvinyl alcohol and sodium tetraborate decahydrate (Na2B4O7·10H2O). The formation of hydrogels often presents inconsistent results and issues according to the reaction scale. Therefore, we measured and analyzed the self-healing property and viscoelasticity of hydrogels attributed to scale-up synthesis using a rheometer.

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Mass Production of Aphicidal Beauveria bassiana SFB-205 Supernatant with the Parameter of Chitinase

  • Kim, Jae-Su;Je, Yeon-Ho;Yu, Yong-Man
    • Journal of Microbiology and Biotechnology
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    • v.21 no.6
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    • pp.604-612
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    • 2011
  • Beauveria bassiana SFB-205 supernatant can effectively control cotton aphid populations, which is closely associated with its chitinase activity. The present work extends to optimizing a culture medium to produce more efficacious supernatant in flask conditions, followed by scale-up in 7 L, 300 L and 1.2 KL fermentors with the parameter of chitinase. In flask conditions, a combination of soluble starch and yeast extract produced the greatest amount of chitinase (5.1 units/ml) and its supernatant had the highest aphicidal activity. An optimal quantitative combination of the two substrates, estimated by a response surface method, enabled the supernatant to have 15.7 units/ml of chitinase activity and 3.7 ml/l of median lethal concentration ($LC_{50}$) of toxicity against cotton aphid adults in laboratory conditions. In the scale-up conditions, overall supernatant had 25-28 units/ml of chitinase activity. Decrease in pH and limitation of dissolved oxygen (DO) during cultures were significantly related to the yield of chitinase. These results suggest that the substrate-dependent chitinase production can be background information for optimizing a culture medium, and pH and DO are critical factors in maximizing the production in scale-up conditions.

Concurrent Validity of the Functional Gait Assessment, Berg Balance Scale, and Timed Up and Go Test in Patients With Stroke (뇌졸중 환자에 대한 기능적 보행평가, 버그 균형척도, 일어나 걸어가기 검사의 동시 타당도)

  • Won, Jong-Im;Kim, Ki-Song
    • Physical Therapy Korea
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    • v.18 no.2
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    • pp.43-51
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    • 2011
  • Balance is a complex motor skill that depends on interactions between multiple sensorimotor processes and environmental and functional contexts. Many rehabilitation specialists believe that balance assessment under multitask conditions may be a more sensitive indicator of balance problems and falls than balance assessment in a single-task context. Functional Gait Assessment has many tasks that allow for testing under multitask conditions. The purpose of this study was to determine the concurrent validity between the Functional Gait Assessment (FGA), Berg Balance Scale (BBS), and Timed "Up & Go" Test (TUG) in patients with stroke. One hundred and five participants with at least 3 months post stroke and able to walk at least 6 m with or without a mono cane, participated in this study. Concurrent validity between the FGA, BBS, and TUG was assessed using Spearman rank order correlation. The FGA correlated with the BBS (r=.80, p<.01) and TUG (r=-.77, p<.01). The good and moderate correlation between the FGA, BBS, and TUG establishes the concurrent validity of the FGA in patients with stroke. These measures provide clinicians with valuable information about patients' functional balance capabilities.

Citric Acid Production and Scale-up in Dual Hollow Fiber Bioreactor (이중실관 생물 반응기에서의 구연산 생산과 Scale-up)

  • 장호남;지동진;심상준
    • Membrane Journal
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    • v.2 no.2
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    • pp.122-128
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    • 1992
  • A study on the citric acid production was performed in various size dual hollow fiber bioreactors with immobilized Aspergillus niger (KCTC 1232). The final dry cell mass density reached 300g/l based on the space volume available for cell growth. Under air and oxygen aeration the volumethe productivity reached 0.63 and 1.02g/l.h, which cormsponded to 10 and 16 fold over those of batch fermentation, respectively. The initial pH of the medium was a critical factor and the lower value resulted in higher citric acid yield. The increase in the feeding rate of medium or the number of reactor unit resulted in the improvement of the productivity due to higher consumption rate of substrate.

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Efficient Multi-scalable Network for Single Image Super Resolution

  • Alao, Honnang;Kim, Jin-Sung;Kim, Tae Sung;Lee, Kyujoong
    • Journal of Multimedia Information System
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    • v.8 no.2
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    • pp.101-110
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    • 2021
  • In computer vision, single-image super resolution has been an area of research for a significant period. Traditional techniques involve interpolation-based methods such as Nearest-neighbor, Bilinear, and Bicubic for image restoration. Although implementations of convolutional neural networks have provided outstanding results in recent years, efficiency and single model multi-scalability have been its challenges. Furthermore, previous works haven't placed enough emphasis on real-number scalability. Interpolation-based techniques, however, have no limit in terms of scalability as they are able to upscale images to any desired size. In this paper, we propose a convolutional neural network possessing the advantages of the interpolation-based techniques, which is also efficient, deeming it suitable in practical implementations. It consists of convolutional layers applied on the low-resolution space, post-up-sampling along the end hidden layers, and additional layers on high-resolution space. Up-sampling is applied on a multiple channeled feature map via bicubic interpolation using a single model. Experiments on architectural structure, layer reduction, and real-number scale training are executed with results proving efficient amongst multi-scale learning (including scale multi-path-learning) based models.