• Molecules and Cells
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• 제42권3호
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• pp.237-244
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• 2019

Understanding the mechanisms of cancer drug resistance is a critical challenge in cancer therapy. For many cancer drugs, various resistance mechanisms have been identified such as target alteration, alternative signaling pathways, epithelial-mesenchymal transition, and epigenetic modulation. Resistance may arise via multiple mechanisms even for a single drug, making it necessary to investigate multiple independent models for comprehensive understanding and therapeutic application. In particular, we hypothesize that different resistance processes result in distinct gene expression changes. Here, we present a web-based database, CDRgator (Cancer Drug Resistance navigator) for comparative analysis of gene expression signatures of cancer drug resistance. Resistance signatures were extracted from two different types of datasets. First, resistance signatures were extracted from transcriptomic profiles of cancer cells or patient samples and their resistance-induced counterparts for >30 cancer drugs. Second, drug resistance group signatures were also extracted from two large-scale drug sensitivity datasets representing ~1,000 cancer cell lines. All the datasets are available for download, and are conveniently accessible based on drug class and cancer type, along with analytic features such as clustering analysis, multidimensional scaling, and pathway analysis. CDRgator allows meta-analysis of independent resistance models for more comprehensive understanding of drug-resistance mechanisms that is difficult to accomplish with individual datasets alone (database URL: http://cdrgator.ewha.ac.kr).

• 산업경영시스템학회지
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• 제41권4호
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• pp.42-49
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• 2018

Pilot Aptitude Research Equipment (PARE) is a simulator developed to measure or research pilot aptitude and train for student pilots. Design of an ergonomic PARE operation console is required to operate the equipment effectively. This study carried out five steps : (S1) operator questionnaire survey, (S2) anthropometric design formula development, (S3) usability evaluation, (S4) improvement design, and (S5) validation considering both Physical User Interface (PUI) and Graphic User Interface (GUI) of PARE operation console. The operator questionnaire surveyed needs for each PUI and GUI part of the console from two PARE actual operators. In terms of PUI, the anthropometric design formula was developed by using design variables, body dimensions, target population characteristics, and reference posture related to the PARE console. In terms of GUI, the usability evaluation was conducted by three usability testing experts with a 7-point scale (1 : very low, 4 : neutral, 7 : very high) on GUI of the PARE operation console by seven usability criteria. The improved PARE operation console was designed to reflect the optimal values of design variables calculated from design formula, the results from usability testing, and the operator's needs. The improvement effect was observed by 20 people who had experience with the PARE operation console. As a result of the validation, monitor visibility and cockpit visibility for the improved PUI design and visibility and efficiency for the improved GUI design were significantly increased by more than 90% respectively. The improved design of the PARE operation console in this study can contribute to enhance operation performance of the PARE.

• 전기전자학회논문지
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• 제22권4호
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• pp.1056-1061
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• 2018

본 연구에서는 건물 외벽 태양광 발전 통합 시스템(BIPV: Building Integrated Photovoltaic System)용 컬러 유리의 구조를 제안하고 이를 구현하기 위한 공정 기술을 개발하였다. 굴절률 값이 다른 두 종류의 산화 금속 박막을 집적함으로써 투과도가 우수하면서도 서로 다른 컬러를 구현할 수 있음을 파동광학에 기반한 전산모사를 통해서 확인하였다. 선택된 구조를 구현하기 위해 RF Magnetron 증착 방법을 통해 목표로 하는 두께를 균일하게 얻을 수 있는 공정을 개발하였다. 실험 시편에 대한 광학적 분석을 전산모사 결과와 비교하여 분석한 결과, 원하는 컬러 유리를 랩 스케일에서 안정적으로 구현할 수 있음을 알 수 있었으며, 상온에서 일주일 이상의 안정성을 갖는 것을 확인하였다. 이러한 기술은 BIPV 건축물을 구축하는 데에 유용할 것으로 기대된다.

• Parasites, Hosts and Diseases
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• 제56권6호
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• pp.625-632
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• 2018

Malaria remains one of the leading health burdens in the developing world, especially in several sub-Saharan Africa countries; and Uganda has some of the highest recorded measures of malaria transmission intensity in the world. It is evident that the prevalence of malaria infection, the incidence of disease, and mortality from severe malaria remain very high in Uganda. Although the recent stable political and economic situation in the last few decades in Uganda supported for a fairly good appreciation of malaria control, the declines in infection, morbidity, and mortality are not sufficient to interrupt transmission and this country is among the top 4 countries with cases of malaria, especially among children under 5 years of age. In fact, Uganda, which is endemic in over 95% of the country, is a representative of challenges facing malaria control in Africa. In this study, we evaluated an active case detection program in 6 randomly selected villages, Uganda. This program covered a potential target population of 5,017 individuals. Our team screened 12,257 samples of malaria by active case detection, every 4 months, from February 2015 to January 2017 in the 6 villages (a total of 6 times). This study assessed the perceptions and practices on malaria control in Kiyuni Parish of Kyankwanzi district, Uganda. Our study presents that the incidence of malaria is sustained high despite efforts to scale-up and improve the use of LLINs and access to ACDs, based on the average incidence confirmed by RDTs.

• 대한통합의학회지
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• 제7권3호
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• pp.61-69
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• 2019

Purpose : The purpose of this study was to investigate the effects of Straight leg lifts (SLL) and double leg lowering (DLL) exercise on abdominal muscle activity, visual analog scale (VAS), and flexibility in patients with chronic low back pain (LBP). Methods : A total of 30 LBP patients were divided into two groups: those with SLL exercise group 15 (male=8, female=7) and those with DLL exercise group 15 (male=7, female=8). Before the intervention, the abdominal muscle activity, VAS, and flexibility were measured. After 4 weeks of intervention, the above variables were measured in the same way. The SLL exercise bends the leg $45^{\circ}$ in the supine position, and the DLL exercise was performed as opposed to SLL. At this time, the pressure biofeedback unit (PBU) was placed behind the lumbar to reduce the instability of the pelvis and muscles. The subjects were instructed to use the PBU to maintain the target pressure determined (40 mmHg) during the exercise. Results : The external oblique (EO), internal oblique (IO), and transverse abdominis (TrA) were significantly different in the SLL and DLL group, and EO, IO, and TrA activity improved more significantly increased in the DLL than SLL group (p<.05). The results on the VAS and flexibility were significantly different both group (p<.05). However, there was no significant difference between the groups (p>.05). Conclusion : SLL and DLL exercises in patients with LBP were able to confirm the increased activity of the abdominal muscles, decreased pain, and increased flexibility of the waist. In addition, DLL exercise is more effective in patients with LBP in terms of muscle activity.

• Journal of Korean Neurosurgical Society
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• 제62권1호
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• pp.27-34
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• 2019

Objective : Stent-assisted coil embolization of intracranial wide-necked aneurysm requires long-term postoperative antiplatelet therapy to prevent in-stent thrombosis. This study aimed to demonstrate results of temporary stent placement for coiling wide necked small intracranial aneurysms, which eliminated need for antiplatelet agents, and to discuss its feasibility and safety. Methods : Data of 156 patients who underwent stent-assisted coil embolization between 2011 and 2014 were retrospectively analyzed. Thirteen cases of temporary stent-assisted coil embolization were included, and their clinical and radiological results were evaluated. Results : The aneurysms treated were all unruptured except one case. All of them had wide neck with mean dome-to-neck ratio of 0.96 and were small-sized aneurysms with mean maximal diameter of 4.2 mm. There was no technical failure in retrieval of stent after completion of embolization of the target aneurysm. Immediate angiography revealed 11 complete and two partial embolization (one residual neck and one residual aneurysm). Two cases encountered thrombosis complication, and they were managed without neurological sequelae. The mean follow-up period was 43 months, angiographic follow-up revealed two cases with minor recurrence, and clinical outcome was good with modified Rankin scale score of 0. Conclusion : Temporary stent-assisted coil embolization of small wide-necked intracranial aneurysm using fully retrievable stent appears safe and effective. Further application and evaluation of this technique in more cases with larger size aneurysm is warranted.

• 한국물환경학회지
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• 제35권1호
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• pp.35-42
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• 2019

Urbanization has led to extreme changes in land use on urban watersheds. Most cities are becoming residential, commercial and industrial areas, making infiltration and storage of rainfall less favorable. The demand for LID (Low Impact Development) technology is increasing in order to mitigate this water cycle distortion and return to existing hydrological conditions. The LID technique is effective in reducing runoff by permeating the urban impervious area. However, considering the limit of the installation area and the financial requirement of the installation, there is not much research on the linkage of each LID component technology for optimum efficiency according to the appropriate scale. In this study, the effects of the LID facilities applied to the target site were simulated using the SWMM model, suggesting the optimal linkage method considering interconnectivity, and applying the effects as an existing installation of individual facilities. The water balance at the time of application of the LID technology, short-term and long-term rainfall event were compared. Also, the individual application and the linkage application were compared with each other. If each component technology has sufficient processing size, then linkage application is more effective than individual application.

• 환경영향평가
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• 제30권2호
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• pp.132-139
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• 2021

과산소산(peroxy-acid)을 산화제로 사용하여 현장 오염토양내 존재하는 다환방향족탄화수소의 산화분해 효과를 알아보기 위하여 실험실 규모의 연구를 진행하였다. 대상 토양의 토성은 19.2 %의 토양 유기물을 포함한 pH 6.8의 사양토(sandy loam)로 확인되었으며 토양 내 다환방향족탄화수소 중 벤조(a)피렌(benzo(a)pyrene)의 농도가 평균 2.23 mg/kg으로 국내 토양환경보전법의 1 지역 우려 기준치의 3배 정도 높게 나타났다. 따라서 벤조(a)피렌 오염 토양에 대하여 유기산과 과산화수소를 이용한 과산소산 산화(peroxy-acid oxidation)처리에 의한 토양내 벤조(a)피렌의 농도 저감효과를 유기산의 종류와 유기산 및 과산화수소의 농도조건별로 평가하였다. 선정된 유기산 중 프로피온산(propionic acid)의 산화 효과가 가장 큰 것으로 확인되었으며 토양 중 벤조(a)피렌의 농도를 최종적으로 1 지역 우려 기준치 이하로 저감하였다.

• 한국물환경학회지
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• 제35권5호
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• pp.409-417
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• 2019

In this study, a $480m^3/day$ pilot device was constructed through laboratory experiments based on the Ministry of Environment manual. The purpose of this study was to analyze the characteristics of CSO treatment and backwashing characteristics by applying the pilot device to the field. The purpose of this study was to acquire the basic data necessary for the design and operation management of the real scale filtration type non-point pollution control system. The filtration was conducted while maintaining the linear velocity of 20m/hour. The CSO treatment efficiencies of the pilot devices were 0.4-76.1%(mean 49.0 %), SS 51.4-91.6%(mean 77.8%), COD 22.2-59.4% (mean 38.3%) and TP 14.5-52.6%(mean 38.1%),respectively. The correlation coefficient between SS and the turbidity of influent water was 0.90, higher than that of CSO. To operate the treatment system effectively, the turbidity can be easily measured in real time as the monitoring item is the most appropriate because SS is the main target substance of the non-point source. As a result of analyzing the adsorbent treatment characteristics of PP filter material applied to this pilot device, the average particle diameter range of influent was $4.6-40.1{\mu}m$(mean $21.2{\mu}m$) and the treated water was $0.9-24.5{\mu}m$(mean $6.4{\mu}m$), respectively. Particles of approximately 10m or less are leached out, and so it is necessary to compensate for the raw water containing micro particulate matter.

• Current Optics and Photonics
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• 제5권3호
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• pp.270-277
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• 2021

The adaptive sparse representation (ASR) can effectively combine the structure information of a sample dictionary and the sparsity of coding coefficients. This algorithm can effectively consider the correlation between training samples and convert between sparse representation-based classifier (SRC) and collaborative representation classification (CRC) under different training samples. Unlike SRC and CRC which use fixed norm constraints, ASR can adaptively adjust the constraints based on the correlation between different training samples, seeking a balance between l₁ and l₂ norm, greatly strengthening the robustness and adaptability of the classification algorithm. The correlation coefficients (CC) can better identify the pixels with strong correlation. Therefore, this article proposes a hyperspectral image classification method called correlation coefficients and adaptive sparse representation (CCASR), based on ASR and CC. This method is divided into three steps. In the first step, we determine the pixel to be measured and calculate the CC value between the pixel to be tested and various training samples. Then we represent the pixel using ASR and calculate the reconstruction error corresponding to each category. Finally, the target pixels are classified according to the reconstruction error and the CC value. In this article, a new hyperspectral image classification method is proposed by fusing CC and ASR. The method in this paper is verified through two sets of experimental data. In the hyperspectral image (Indian Pines), the overall accuracy of CCASR has reached 0.9596. In the hyperspectral images taken by HIS-300, the classification results show that the classification accuracy of the proposed method achieves 0.9354, which is better than other commonly used methods.