• Title/Summary/Keyword: Saururus Chinensis

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Rhizoctonia Black Stem Rot of Saururi Herba Caused by Rhizoctoia solani (Rhizoctonia solani에 의한 삼백초 검은줄기썩음병(가칭))

  • 이기열
    • Korean Journal Plant Pathology
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    • v.14 no.2
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    • pp.184-185
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    • 1998

  • Rhizoctonia stem rot of Saururui herba [Saururus chinensis (Lour) Baill] was observed during plantations from 1996 to 1997 in Chungbuk area. Infected plant showed damping-off and stem rot at soil line. The causal fungus of stem rot isolated from the infected plant was identified as Rhizoctonia solani according to the criteria based on the cultural and morphological characteristics. The stem rot of Saururi herba caused by Rhizoctonia solani was first described in Korea, and the name the“Rhizoctonia black stem rot”is proposed.

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Inhibition of NF-IL6 Activity by Manassantin B, a Dilignan Isolated from Saururus chinensis, in Phorbol Myristate Acetate-stimulated U937 Promonocytic Cells

  • Son, Kyung-No;Song, In-Sung;Shin, Yong-Hyun;Pai, Tong-Kun;Chung, Dae-Kyun;Baek, Nam-In;Lee, Jung Joon;Kim, Jiyoung
    • Molecules and Cells
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    • v.20 no.1
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    • pp.105-111
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    • 2005

  • Mannasantin B, a dilignan structurally related to manssantin A, is an inhibitor of NF-${\kappa}B$ transactivation. In the present study, we found that it inhibited PMA-induced expression of IL-$1{\beta}$, IL-$1{\beta}$ mRNA, and IL-$1{\beta}$ promoter activity in U937 cells with $IC_{50}$ values of about 50 nM. It also inhibited NF-IL6- and NF-${\kappa}B$-induced activation of IL-$1{\beta}$, with $IC_{50}$ values of 78 nM and $1.6{\mu}M$, respectively, revealing a potent inhibitory effect on NF-IL6. Electrophoretic mobility shift assays showed that manassantin B had an inhibitory effect on DNA binding by NF-IL6, but not by NF-${\kappa}B$. Further analysis revealed that transactivation by NF-IL6 was also inhibited. Our results indicate that manassantin B suppresses expression of IL-$1{\beta}$ in promonocytic cells by inhibiting not only NF-${\kappa}B$ but also NF-IL6 activity. Furthermore, our observations suggest that manassantin B may be clinically useful as a potent inhibitor of NF-IL6 activity.

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