• 약학회지
• /
• 제43권3호
• /
• pp.358-368
• /
• 1999

Subacute toxicity study was performed in Sprague-Dawley rats after daily dermal administration of Sangmosu (0.2, 1.0 and 5.0 g/kg) for one month. There were no clinical signs and pathological changes compared with control group. Bodyweights were not significantly changed between control and Sangmosu treatment groups. In histopathological examinations, there were some pneumonia in lung tissues at all groups of Sangmosu treatment including control, but it was not considered to be caused by Sangmosu. These results suggest that Sangmosu does not induce any significant subacute dermal toxicities in Sprague-Dawley rats.

• 약학회지
• /
• 제43권4호
• /
• pp.542-545
• /
• 1999

Primary skin irritation tests for Sangmosu were performed in male New Zealand White rabbits. In primary skin irritation test, body weights were not significantly changed and Primary Irritation Index(P.I.I) was 0.25, indicating Sangmosu as barely irritating material. These results indicate that Sangmosu was not considered to be irritant in test animals.

• 약학회지
• /
• 제43권3호
• /
• pp.351-357
• /
• 1999

Hair growth effects of Sangmosu have been evaluated in C57BL/6 mice. Animals were topically treated with Sangmosu (50 or $100{\;}{\mu}l/mouse$) for 40 days on the back of shaved area. Twenty days after treatment, hair growth effects were significantly observed in both female and male mice. There was no sex difference although 30 days after treatment female mice were shown to be more effective at the dose of $50{\;}{\mu}l/mouse$ than males. These data demonstrate that Sangmosu is very effective in hair growth effects in animals and thus it may be applicable to humans.