• Title/Summary/Keyword: Samigangap-tang (SMGAT)

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Effect of Samhwangsasim-tang, Samigangap-tang and Bangtan-tang on Blood Pressure in Stroke Prone Spontaneously Hypertensive Rats (뇌졸중성(腦卒中性) 본태성(本態性) 고혈압(高血壓) 백서(白鼠) 모델에서 삼황사심탕(三黃瀉心湯), 사미강압탕(四味降壓湯), 방탄탕(防癱湯)의 혈압(血壓)에 미치는 영향(影響))

  • Kim, Eun-Ju;Kim, Hye-Yoom;Lee, Jae-Yun;Lee, Jun-Kyoung;Kim, Seung-Ju;Choi, Kyoung-Min;Kang, Dae-Gill
    • The Korea Journal of Herbology
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    • v.26 no.1
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    • pp.75-80
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    • 2011

  • Objectives : The aim of the present study is to investigate the hypotensive effect of Samhwangsasim-tang (SHSST), Samigangap-tang (SMGAT) and Bangtan-tang (BTT) in stroke-prone spontaneously hypertensive rats (SHR-SP). Methods : SHR-SP rats were treated with SHSST, SMGAT and BTT at dose of 200 mg/kg/day orally for 5 weeks, respectively. Results : Treatment SHR-SP rats with SMGAT significantly lowered blood pressure but not in the SHSST or BTT treat groups. On the other hand, SHSST, SMGAT and BTT ameliorated endothelium-dependent and independent vascular relaxation in the phenylephrine-precontracted aorta and carotid artery, respectively. Conclusions : These results indicated that SMGAT has an antihypertensive effect and SHSST, SMGAT and BTT improve vascular function in stroke-prone hypertensive rat model, respectively.

  • https://doi.org/10.6116/kjh.2011.26.1.075 인용 PDF KSCI