• Molecular & Cellular Toxicology
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• v.5 no.2
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• pp.126-132
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• 2009

The usage and types of chemicals are advancing, specializing, large-scaled increasing, and new chemical exposed workers are concerning to occupational disease. The generation of reactive oxygen in the body from carcinogen, mutation and DNA damage in cancer is protected by natural antioxidants (phytochemicals) with antimutagenic effect. There were many reports of ginsenoside Rb$_1$, Rg$_1$ grievances of the genetic mutation to suppress the effect confirm the genetic toxicity test with chromosomal aberration test and the Comet (SCGE) assay confirmed the suppression effect occurring chromosomal DNA damage. We had wanted to evaluate the compatibility and sensitivity between the chromosomal aberration (CA) test and the Comet assay. We used the CA test and Comet assay to evaluate the anti-genotoxicity of ginsenoside Rb$_1$ and Rg$_1$, in CHO-K1 (Chinese hamster ovary fibroblast) cell in vitro, composed negative control (solvent), positive control (benzo[a]pyrene), test group (carcinogen+variety concentration of ginsenoside) group. The positive control was benzo[a]pyrene (50 $\mu$M), well-known carcinogen, and the negative control was the 1 % DMSO solvent. The test group was a variety concentration of ginsenoside Rb$_1$, Rg$_1$ with 10$^{-8}$%, 10$^{-6}$%, 10$^{-4}$%, 10$^{-2}$%, 1%, 10%. In chromo-somal aberration test, we measured the number of cells with abnormally structured chromosome. In Comet assay, the Olive tail moment (OTM) and Tail length (TL) values were measured. The ratio of cell proliferation was increased 8.3% in 10$^{-8}$%, 10$^{-6}$%, 10$^{-4}$%, 10$^{-2}$%, 1%, 10% Rb$_1$ treated groups, and increased 10.4% in 10$^{-10}$%, 10$^{-8}$%, 10$^{-6}$%, 10$^{-4}$%, 10$^{-2}$%, 1% Rg$_1$ treated groups. In the CA test, the number of chromosomal aberration was decreased all the Rb$_1$ and Rg$_1$ treated groups. In the Comet assay, the OTM values were decreased in all the Rb$_1$ and Rg$_1$ treated groups. To evaluate the compatibility between CA and Comet assay, we compared the reducing ratio of chromosomal abnormalities with its OTM values, it was identified the antimutagenicity of ginsenoside, but it was more sensitive the CA test than the Comet assay. Ginsenoside Rb$_1$ and Rg$_1$ significantly decrease the number of cells with chromosomal aberration, and decrease the extent of DNA migration. Therefore, ginsenoside Rb$_1$, Rg$_1$ are thought as an antioxidant phytochemicals to protect mutagenicity. The in vitro Comet assay seems to be less sensitive than the in vitro chromosomal aberration test.

• Journal of the Korean Home Economics Association
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• v.42 no.9
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• pp.149-160
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• 2004

This study investigated the effectiveness of traffic safety education by integrated activities on children's traffic safety knowledge. Subjects were 55 kindergarten children aged 5 years old. The subjects were divided into experimental and control groups. Traffic safety education by integrated activities were applied in the experimental group for 6 weeks. The traffic safety knowledge test was administered to the experimental and control groups for pre-test and post-test analyses. ANCOVA was carried out for both groups to verify the hypothesis of this study. There were statistically significant differences of the children's traffic safety knowledge score including walking, bike, and automobile between the experimental and control groups. To conclude, traffic safety education by integrated activities was very effective to increase children's traffic safety knowledge.

• Journal of Auto-vehicle Safety Association
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• v.12 no.4
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• pp.7-12
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• 2020

Recently, automobile industries have developed ADAS, smart cars, connected cars, automated driving systems, which use a variety of sensor systems - ultrasonics, cameras, lidars and radars - and communication systems. It is necessary to examine the electromagnetic immunity of vehicles equipped with the sensor systems due to the fact that the normal operation of those systems is very important to the safety of the vehicles. The electromagnetic immunity tests are carried out in an electromagnetic semi anechoic chamber, which is cut off from the outside. It is difficult to create test environments in which the camera sensor systems of vehicles work properly in the test chamber. In this study, test jigs were designed and tested and as a result they are shown to be effective to create test environments for electromagnetic immunity tests of vehicles equipped with camera sensors. We also proposed additional safety standards for immunity tests of vehicles with camera systems that currently do not exist.

• Journal of Auto-vehicle Safety Association
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• v.12 no.4
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• pp.48-53
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• 2020

This paper describes in work which is currently underway to the minimum safety performance requirements and test methods of V2V based on IEEE 802.11p in vehicle level like below. - The ranges and positions at static and driving condition of vehicle for BSM (Basic safety message) - Various road conditions such as straight road, crossroad, slope-way Based on this study, We will define the minimum safety performance requirements and test methods of V2V in vehicle considering various road conditions.

• Journal of Auto-vehicle Safety Association
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• v.14 no.3
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• pp.77-82
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• 2022

The Korea's automobile safety standards consist of standards for automobiles, automated vehicles, two-wheeled vehicles and auto parts, and there are 157 articles. In connection with the safety standards, the implementation rules stipulated for detailed test methods and procedures are composed of the main body, asterisks and annexes, and have a rather complicated structure. In addition, the test items in the asterisk are specified with the same or similar name as the test items in other asterisks. In this study, the structure of these implementation rules is simplified and the same test items are integrated. This is expected to increase the user's understanding of laws and regulations and efficiency.

• Journal of the Korean Applied Science and Technology
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• v.38 no.6
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• pp.1587-1595
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• 2021

The purpose of this study was to investigate the patient safety motivation, patient safety management attitude, and patient safety management behavior and to identify the factors affecting patient safety management behavior of targeted new nurses. Subjects were 127 nurses and data were collected by questionnaires from September 11 to September 30, 2020. Data were analyzed using t-test, ANOVA, Scheffe's test, Pearson correlation coefficients and multiple regression analysis. Patient safety motivation was positive correlated with patient safety management attitude, and patient safety management behavior. Patient safety management attitude was positive correlated with patient safety management behavior. Patient safety motivation, patient safety management attitude and safety education experience were main factors that affect safety management behavior. These results suggest to develop educational program and application that include patient safety motivation, patient safety management attitude in order to improve patient safety management behavior of new nurses.

• Nuclear Engineering and Technology
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• v.53 no.8
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• pp.2477-2487
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• 2021

To improve safety analysis technology for a nuclear reactor containment considering an interaction between a reactor coolant system (RCS) and containment, this study aims at an experimental investigation on the integrated simulation of the RCS and containment, with an integral effect test facility, ATLAS-CUBE. For a realistic simulation of a pressure and temperature (P/T) transient, the containment simulation vessel was designed to preserve a volumetric scale equivalently to the RCS volume scale of ATLAS. Three test cases for a steam line break (SLB) transient were conducted with variation of the initial condition of the passive heat sink or the steam flow direction. The test results indicated a stratified behavior of the steam-gas mixture in the containment following a high-temperature steam injection in prior to the spray injection. The test case with a reduced heat transfer on the passive heat sink showed a faster increase of the P/T inside the containment. The effect of the steam flow direction was also investigated with respect to a multi-dimensional distribution of the local heat transfer on the passive heat sink. The integral effect test data obtained in this study will contribute to validating the evaluation methodology for mass and energy (M/E) and P/T transient of the containment.

• Environmental Analysis Health and Toxicology
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• v.21 no.4 s.55
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• pp.317-322
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• 2006

We have investigated the genotoxicity of 1,2,4-trimethylbenzene using Ames reverse mutation test. In Ames reverse mutation test, 1,2,4-trimethylbenzene treatment at the dose of 100, 50, 25, 12.5, $6.25{\mu}g/plate$ did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537 and in Escherichia coli WP2uvrA with and without metabolic activation. These results indicate that 1,2,4-trimethylbenzene has no mutagenic potential under the rendition in this study.

• International Journal of Safety
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• v.7 no.1
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• pp.30-34
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• 2008

For the purpose of establishing basic design standards for the manufacture of wheelchairs, a dummy for an ISO-standard wheelchair was modeled for use with a manufactured wheelchair, and the safety and performance of the wheelchair were examined through numerical simulations.

• Nuclear Engineering and Technology
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• v.23 no.2
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• pp.174-182
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• 1991

Effects of human error relevant to the periodic test are incorporated in the evaluations of the unavailability and optimal test interval of a safety system. Two types of possible human error with respect to the test and maintenance are considered. One is the possibility that a good safety system is inadvertently left in a bad state after test（Type A human error) and the other is the possibility that a bad safety system is undetected upon the test（Type B human error). An event tree model is developed for the steady-state unavailability of a safety system in order to determine the effects of human errors on the system unavailability and the optimal test interval. A reliability analysis of the Safety Injection System (SIS) was peformed to evaluate the effects of human error on the SIS unavailability. Results of various sensitivity analyses show that ; (1) the steady-state unavailability of the safety system increases as the probabilities of both types of human error increase and it is far more sensitive to Type A human error, (2) the optimal test interval increases slightly as the probability of Type A human error increases but it decreases as the probability of Type B human error increases, and (3) provided that the test interval of the safety injction pump is kept unchanged, the unavailability of SIS increases significantly as the probability of Type A human error increases but slightly as the probability of Type B human error increases. Therefore, to obtain the realistic result of reliability analysis, one should take shorter test interval (not optimal test interval) so that the unavailability of SIS can be maintained at the same level irrespective of human error. Since Type A human error during test & maintenance influeces greatly on the system unavailability, special efforts to reduce the possibility of Type A human error are essential in the course of test & maintenance.