• Clinical and Experimental Pediatrics
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• v.60 no.7
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• pp.227-231
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• 2017

Purpose: This study aimed to verify the safety of low-dose topiramate on language development in pediatric patients with migraine. Methods: Thirty newly diagnosed pediatric patients with migraine who needed topiramate were enrolled and assessed twice with standard language tests, including the Test of Language Problem Solving Abilities (TOPs), Receptive and Expressive Vocabulary Test, Urimal Test of Articulation and Phonology, and computerized speech laboratory analysis. Data were collected before treatment, and topiramate as monotherapy was sustained for at least 3 months. The mean follow-up period was $4.3{\pm}2.7months$. The mean topiramate dosage was 0.9 mg/kg/day. Results: The patient's mean age was $144.1{\pm}42.3months$ (male-to-female ratio, 9:21). The values of all the language parameters of the TOPs were not changed significantly after the topiramate treatment as follows: Determine cause, from $15.0{\pm}4.4$ to $15.4{\pm}4.8$ (P>0.05); making inference, from $17.6{\pm}5.6$ to $17.5{\pm}6.6$ (P>0.05); predicting, from $11.5{\pm}4.5$ to $12.3{\pm}4.0$ (P>0.05); and total TOPs score, from $44.1{\pm}13.4$ to $45.3{\pm}13.6$ (P>0.05). The total mean length of utterance in words during the test decreased from $44.1{\pm}13.4$ to $45.3{\pm}13.6$ (P<0.05). The Receptive and Expressive Vocabulary Test results decreased from $97.7{\pm}22.1$ to $96.3{\pm}19.9months$, and from $81.8{\pm}23.4$ to $82.3{\pm}25.4months$, respectively (P>0.05). In the articulation and phonology validation in both groups, speech pitch and energy were not significant, and all the vowel test results showed no other significant values. Conclusion: No significant difference was found in the language-speaking ability between the patients; however, the number of vocabularies used decreased. Therefore, topiramate should be used cautiously for children with migraine.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.9
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• pp.64-72
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• 2020

DELAY M9 is an ammunition used in combination with the fuse M904 and M905 of aviation drop-off ammunitions. Due to the properties of the ammunition, the performance or safety of the ammunition cannot be verified until it is used, because of its one-time function, no reproduction and is finally destroyed at the same time. Long-term storage of ammunition in use by the army is inevitable due to its operational characteristics, and a test evaluation is required to maintain and verify the performance of stored ammunition for immediate use in case of emergency. This paper estimates the reliability and shelf life of the DELAY M9 ammunition by using the test data obtained through ASRP performed from the past to the present. The result of the performance evaluation test for the currently stored DELAY M9 ammunition is analyzed, and the reliability and shelf-life of the stored ammunition are assessed by examining the number of defects according to the storage time and production year. This research result can be used to manage the stored ammunition, such as ASRP planning and evaluation test, result analysis and munition state decision.

• International Journal of Highway Engineering
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• v.12 no.2
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• pp.9-16
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• 2010

Roughness is the most important factor to maintain the road performance, and affects greatly on the design life in Jointed Plain Concrete pavements. Also, the factors the evaluate pavement‘s commonality is the three method such as functionality, safety and structural performance. In evaluating function of road, representative factors is the roughness, which has been used to determine maintenance time as key standard. As research for roughness is absence in pavement design. Applied roughness-model had a low-reliability in Korea. Therefore, it is needed to develop reliable model in road roughness. In this research, uniform specific is applied to distribute them after selecting the concrete pavements. Concrete pavement is divided by sections of 238. Total length of this sections has 281km and account for 16% of total road length in korean concrete pavements for selected sections. Considering the korean roughness-model, the evaluation of roughness is performed for the freezing index, average annual rainfall, condition for the base, the amount of traffic as well as spalling(%), cracking(%), age(year) at the selected section at the selected section. Also, additional sections is selected to evaluate various age which affects on the roughness. As a result of the analysis, it showed that spalling(%), cracking(%), age(year), and the condition of the base affected road roughness. When the correlation with the road roughness was analyzed, the reliable model for road roughness was proposed, and the ratio that can explain road roughness was R2-68.8% and P value-0 which is statistically meaningful.

• Ecology and Resilient Infrastructure
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• v.6 no.4
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• pp.304-313
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• 2019

Biopolymer based on microbial β-glucan and xanthan gum is effective for vegetation and has a function of enhancing soil strength, which can be used as soil reinforcement and stabilization materials in river embankment. The purpose of this study is to verify the vegetation effect of the surface of levee by biopolymer with seed spraying method. Mixed soils with biopolymer were used to cover the surface of embankments. The strength is higher in biopolymer-treated soil and xanthan gum based biopolymer has advantage for quality control in field scale. In addition, the vegetation of F. arundinacea and L. perenne showed various reactions with types of biopolymers. Biopolymer has a positive effect on the vegetation of them. In contrast, root growth tended to decrease in biopolymer-treated soils. The results indicate that root growth is slow down due to increasing ability to retain water in biopolymer-treated soil. In order to apply biopolymer to river embankment, it is necessary to examine the effects of biopolymers on a wide range of plant species in river embankment.

• Journal of Radiation Protection and Research
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• v.29 no.4
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• pp.263-268
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• 2004

Using the Monte Carlo simulation, a study on the lion-proportionality of the prototype phoswich detector with $2'{\times}2'$ CSI(Tl) and plastic scintillator, which was made by KAERI, has been carried. The defector response functions (DRFs) calculated by simulations were compared with the experimental measurement on the $^{137}Cs\;and\;^{60}Co$. To precisely simulate the DRF for the phoswich, the CSI(Tl) non-proportionality was calculated using the electron response and the simplified electron cascade sequence for treating the photoelectric absorption event. The resulting DRFs of $^{137}Cs\;and\;^{60}Co$ sources obtained by simulations were compared with experiments for verification. For $^{137}Cs$, gamma-ray responses simulated by MCNP5 are generally good agreement with the measured ones. But the DRF of $^{60}Co$ does not match well with the results of experiment in the energy region below second peak due to the coincidence effect of two gamma-rays (1.17 MeV and 1.33 MeV). Through the analysis of the non-proportionality of CsI(Tl) in the prototype phoswich, the improved DRFs considering non-proportionality were produced and the simulation results were verified using the experimental measurements. However, to more precisely reproduce the DRF for the phoswich, further studies in relation to the electron channeling effect and the Doppler broadening effect of a scintillator are still needed as well as considering that effect of the transfer contribution.

• Journal of Microbiology and Biotechnology
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• v.20 no.12
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• pp.1735-1743
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• 2010

The full-length genes gyrB (2,415 bp), parC (2,277 bp), and parE (1,896 bp) in Edwardsiella tarda were cloned by PCR with degenerate primers based on the sequence of the respective quinolone resistance-determining region (QRDR), followed by elongation of 5' and 3' ends using cassette ligation-mediated PCR (CLMP). Analysis of the cloned genes revealed open reading frames (ORFs) encoding proteins of 804 (GyrB), 758 (ParC), and 631 (ParE) amino acids with conserved gyrase/topoisomerase features and motifs important for enzymatic function. The ORFs were preceded by putative promoters, ribosome binding sites, and inverted repeats with the potential to form cruciform structures for binding of DNA-binding proteins. When comparing the deduced amino acid sequences of E. tarda GyrB, ParC, and ParE with those of the corresponding proteins in other bacteria, they were found to be most closely related to Escherichia coli GyrB (87.6% identity), Klebsiella pneumoniae ParC (78.8% identity), and Salmonella Typhimurium ParE (89.5% identity), respectively. The two topoisomerase genes, parC and parE, were found to be contiguous on the E. tarda chromosome. All 18 quinolone-resistant isolates obtained from Korea thus far did not contain subunit alternations apart from a substitution in GyrA (Ser83$\rightarrow$Arg). However, an alteration in the QRDR of ParC (Ser84$\rightarrow$Ile) following an amino acid substitution in GyrA (Asp87$\rightarrow$Gly) was detected in E. tarda mutants selected in vitro at $8{\mu}g/ml$ ciprofloxacin (CIP). A mutant with a GyrB (Ser464$\rightarrow$Leu) and GyrA (Asp87$\rightarrow$Gly) substitution did not show a significant increase in the minimum inhibitory concentration (MIC) of CIP. None of the in vitro mutants exhibited mutations in parE. Thus, gyrA and parC should be considered to be the primary and secondary targets, respectively, of quinolones in E. tarda.

• Journal of Korea Water Resources Association
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• v.46 no.11
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• pp.1069-1078
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• 2013

The Bangudae Petroglyphs, national treasure No. 285 is located within submerged upper districts of Sayeon dam supplying the main residential water in Ulsan. Of the many ways for the reservation of Petroglyphs located the altitude at 53~57 m, the plan that we take it out of the water lowering the water level from 60 m to 52 m has been examined mainly in case of controlling artificially the water level of the dam. In this paper, we examined expected problems from the loss of dam function and the change of water quality from water deterioration caused by the water level control of the Sayeon dam. Using the model of Vollenweider and CSTR (Continuous Stirred Tank Reactor), we analyzed the density change of BOD and COD, representative water quality index and the TP and TN, the main reason of algae growth. The result showed that the density of COD lowered a little but the density of TP and TN went up over 130% when controlling the water level from 60 m to 52 m. These changes cause a serious algae problem and if doing the water quality management as the density of TN and TP, the water quality would become worse. Water storage and supply residential water decreases, and the water quality becomes worse because of eutrophic state.

• Journal of Radiation Protection and Research
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• v.16 no.2
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• pp.41-54
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• 1991

This paper aimed to analyse dose sensitivity to the controllable parameters of indoor radon $(^{222}Rn)$ and its decay products (Rn-D) by applying the input~output linear system theory. Physical behaviors of $^{222}Rn\;&\;Rn-D$ were analyzed in terms of $(^{222}Rn)$ gas -generation, -migation and -infiltration to indoor environments, and the performance output-function, i. e. mean dose equivalent to Tracho-Bronchial (TB) lung region, was assessed to the following extented ranges of the controllable paramenters; a) the ventilation rate $constant({\lambda}_v)\;:\;0{\sim}50[h^{-l}].\;b)$ the attachment rate $constant({\lambda}_a)\;:\;0{\sim}500[h^{-l}].\;c)$ the unattached-deposition rate constant (${\lambda}^u_d)\;:\;0-50[h-l]$. A linear input-output model was reconstructed from the original models in literatures, as follows, which was modified into the matrices consisting of 111 nodal equations; a) indoor $^{222}Rn\;&\;Rn-D$ Behaviour; Jacobi-Porstendoerfer-Bruno model.

• Journal of the Korean Institute of Gas
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• v.2 no.1
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• pp.28-39
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• 1998

This study investigated the natural convection and radiation in a rectangular enclosure with ceiling vent experimentally and numerically. A heat source is located on the center of the bottom surface. The analysis was peformed a pure convection and is combination of natural convection and radiation. The shape of the considered two dimensional model is a square whose center of ceiling($30\%$) is opened. The numerical simulations are carried out for the pure natural convection case and the combined heat transfer case by using the SIMPLE algorithm. For the turbulent flow, Reynolds stresses are closed by the standard $k-{\epsilon}$ model and the wall function is used to determine the wall boundary conditions. The experiment was performed on the same geometrical shape as the computations. The radiative heat transfer is analized by the S-N discrete ordinates method. The results of pure natural convection are compared with those of combined heat transfer by the velocity vectors, stream lines, isothermal lines. The results obtained are as follows 1. Comparing the results of pure convection with those of the combined convection-radiation through the shape of stream lines, isothermal lines are similar to each other. 2. The temperature fields obtained by numerical method are compared to those obtained by experimental one, and it is found that they are showed mean relative error $8.5\%$. 3. Visualization bt smoke is similar to computational results.

• Korean Journal of Soil Science and Fertilizer
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• v.48 no.5
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• pp.428-435
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• 2015

Pedotransfer functions (PTFs) were developed for each soil horizon to estimate hydraulic characteristics of mountainous forest soils in South Korea. Twenty one dominant soil series from 8 soil catenae such as granite-originated catena and volcanic ash-originated catena were selected for the study; gravel contents of selected soils were 10% or lower. Saturated conductivity (Ks) was measured for each horizon in situ. Particle size distribution and organic matter content of each horizon were also determined. Based on correlation analysis with total data set, sand separate showed positive relationship with Ks ($r=0.24^*$) while clay separate had negative relationship with Ks ($r=-0.29^{**}$). The correlation coefficients of sand, clay, and organic matter content with Ks increased to $0.41^{**}$, $-0.67^{***}$, and $0.58^{***}$, respectively, using data from granite- or gneiss-originated catena with exception of volcanic ash-originated catena and sedimentary rock-originated catena. Determination coefficients of PTFs were 0.31 for A horizon, 0.25 for B, and 0.35 for C with all data set while those were 0.74 for A, 0.48 for B, and 0.54 for C. Organic matter was a dominant factor affecting Ks in A horizon but clay content was selected as the only factor influencing Ks in C horizon. It implies that PTFs should be developed with understanding characteristics of parent materials and horizons. Developed PTFs for granite- or gneiss-originated catena were following: A horizon: Log ($K_s{\times}10^7$) = -0.031C + 0.398OM + 3.49 B horizon: Log ($K_s{\times}10^7$) = -0.028C + 0.141OM + 4.05 C horizon: Log ($K_s{\times}10^7$) = -0.072C + 4.66 where C is clay separate (%) and OM is organic matter content ($g\;kg^{-1}$). The unit of Ks is cm $sec^{-1}$.