• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.22 no.3
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• pp.343-348
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• 2013

In line with the advances in factory automation, various pieces of equipment are now operated in batch processes controlled by computers. However, many kinds of faults can occur in complicated and large systems, which can result in low productivity and economic loss. The reliability and safety of systems have been studied because of the difficulty of determining the severity and location of faults. Therefore, it is necessary to detect and diagnose such faults in order to guarantee the reliability and safety of the equipment. In this paper, a diagnosis method for the ball bearings of a hydraulic pump is applied using a vibration signal for the maintenance of injection molding equipment. The bearings' defects are selected as a main failure mode through a failure mode and effect analysis (FMEA). Usually, there are nonlinear and impulse components of vibration in a ball bearing with faults. For the effective fault diagnosis of a ball bearing, nonlinear diagnostic methods and time-frequency analysis are applied, in addition to the methods currently used, such as power spectrum, time series analysis, and statistical methods. As a result of this study, a failure diagnosis system is provided that is useful even for non-experts. This is a condition-based method that makes it possible to resolve problems in a timely and economical way, in contrast to the prior method, which required regular but wasteful maintenance based on the experience of expensive external experts.

• Journal of Energy Engineering
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• v.26 no.3
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• pp.71-77
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• 2017

In the event of loss of coolant accident (LOCA) and station black out (SBO) in the primary system of a nuclear reactor, the coolant water should be injected to reactor coolant system (RCS) without any intervention of operators or active components. To satisfy the requirements, hybrid safety injection tank (Hybrid SIT) was suggested by Korea Atomic Energy Research Institute (KAERI). The pressure equalizing time of Hybrid SIT is an important parameter to determine the timing of coolant injection. To predict the pressure equalizing time of the Hybrid SIT, a separate effect test facility was constructed and sensitivity tests were conducted in various conditions. The main parameter determining the pressure equalizing time was obtained from separate effect test (SET) results. The wall of condensation on the inner wall of SIT and direct contact condensation on the water surface affected to the pressure equalizing time very much. In this study, the effect of each condensation phenomena on pressure equalizing time was quantitatively analyzed from results of SET and a prediction method of pressure equalizing time was proposed.

• Journal of Dental Anesthesia and Pain Medicine
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• v.15 no.2
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• pp.63-68
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• 2015

Background: Conventional anesthetic nerve block injections into the mandibular foramen risk causing nerve damage. This study aimed to compare the efficacy and safety of the anterior technique (AT) of inferior alveolar nerve block using felypressin-propitocaine with a conventional nerve block technique (CT) using epinephrine and lidocaine for anesthesia via the mandibular foramen. Methods: Forty healthy university students with no recent dental work were recruited as subjects and assigned to two groups: right side CT or right side AT. Anesthesia was evaluated in terms of success rate, duration of action, and injection pain. These parameters were assessed at the first incisor, premolar, and molar, 60 min after injection. Chi-square and unpaired t-tests were used for statistical comparisons, with a P value of < 0.05 designating significance. Results: The two nerve block techniques generated comparable success rates for the right mandible, with rates of 65% (CT) and 60% (AT) at both the first molar and premolar, and rates of 60% (CT) and 50% (AT) at the lateral incisor. The duration of anesthesia using the CT was $233{\pm}37min$, which was approximately 40 min shorter than using the AT. This difference was statistically significant (P < 0.05). Injection pain using the AT was rated as milder compared with the CT. This difference was also statistically significant (P < 0.05). Conclusions: The AT is no less successful than the CT for inducing anesthesia, and has the added benefits of a significantly longer duration of action and significantly less pain.

• The Journal of Engineering Geology
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• v.28 no.2
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• pp.217-246
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• 2018

During the selection and characterization of target formations in the Small-scale Offshore $CO_2$ Storage Demonstration Project in the Pohang Basin, we have carefully investigated the possibility of induced earthquakes and leakage of $CO_2$ during the injection, and have designed the storage processes to minimize these effects. However, people in Pohang city have a great concern on $CO_2$-injection-intrigued seismicity, since they have greatly suffered from the 5.4 magnitude earthquake on Nov. 15, 2017. The research team of the project performed an extensive self-investigation on the safety issues, especially on the possible $CO_2$ leakage from the target formation and induced earthquakes. The target formation is 10 km apart from the epicenter of the Pohang earthquake and the depth is also quite shallow, only 750 to 800 m from the sea bottom. The project performed a pilot injection in the target formation from Jan. 12 to Mar. 12, 2017, which implies that there are no direct correlation of the Pohang earthquake on Nov. 15, 2017. In addition, the $CO_2$ injection of the storage project does not fracture rock formations, instead, the supercritical $CO_2$ fluid replaces formation water in the pore space gradually. The self-investigation results show that there is almost no chance for the injection to induce significant earthquakes unless injection lasts for a very long time to build a very high pore pressure, which can be easily monitored. The amount of injected $CO_2$ in the project was around 100 metric-tonne that is irrelevant to the Pohang earthquake. The investigation result on long-term safety also shows that the induced earthquakes or the reactivation of existing faults can be prevented successfully when the injection pressure is controlled not to demage cap-rock formation nor exceed Coulomb stresses of existing faults. The project has been performing extensive studies on critical stress for fracturing neighboring formations, reactivation stress of existing faults, well-completion processes to minimize possible leakage, transport/leakage monitoring of injected $CO_2$, and operation procedures for ensuring the storage safety. These extensive studies showed that there will be little chance in $CO_2$ leakage that affects human life. In conclusion, the Small-scale Offshore $CO_2$ Storage Demonstration Project in the Pohang Basin would not cause any induced earthquakes nor signifiant $CO_2$ leakage that people can sense. The research team will give every effort to secure the safety of the storage site.

• Environmental Analysis Health and Toxicology
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• v.24 no.2
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• pp.127-136
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• 2009

We have investigated the genotoxicity of 3 chemicals, aluminum oxide, calcium oxide, sodium tetraborate using mammalian erythrocyte with micronucleus induction. It was performed using 9 week male ICR mice. At 24 hours after treatment with 3 chemicals with oral route, mice were sacrificed and bone marrow cells were prepared for smear slides. As a result of counting the micronucleated polychromatic erythrocyte (MNPCE) of 2,000 polychromatic erythrocytes (PCE), all treatment groups did not show statistically significant increase than negative control group. And there was no clinical sign related with injection of the 3 chemicals. It was concluded that the 3 chemicals did not induce micronucleus in the bone marrow cells of ICR mice, and these results indicate that the 3 chemicals have no mutagenic potential under the condition in each studies.

• Journal of Korean Society of Disaster and Security
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• v.14 no.1
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• pp.61-72
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• 2021

There is an increasing need for water supply plan using sustainable groundwater to resolve water shortage problem caused by drought due to climate change and artificial aquifer recharge has recently emerged as an alternative. This study deals with recharge potential assessment for artificial recharge system and quantitative assessment for securing stable water and efficient agricultural water supply adapt to drought finding optimal operating condition by numerical modeling to reflect recharge scenarios considering climate condition, target water intake, injection rate, and injection duration. In order to assess recharge potential of injection well, numerical simulation was performed to predict groundwater level changes in injection and observation well respect to injection scenarios (Case 1~4) for a given total injection rate (10,000 m³). The results indicate that groundwater levels for each case are maintained for 25~42 days and optimal injection rate is 50 m³/day for Case 3 resulted in groundwater level rise less than 1 m below surface. The results also show that influential area of groundwater level rise due to injection was estimated at 113.5 m and groundwater storage and elapsed time were respectively increased by 6 times and 4 times after installation of low permeable barrier. The proposed assessment method can be contributed to sustainable agricultural water supply and stable water security for drought adaptation.

• Journal of Energy Engineering
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• v.17 no.2
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• pp.67-76
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• 2008

A thermal-hydraulic integral effect test facility, ATLAS (Advanced Thermal-hydraulic Test Loop for Accident Simulation), has been constructed at KAERI (Korea Atomic Energy Research Institute). Recently several integral effect tests for the reflood period of a LBLOCA (Large Break LOss of Coolant Accident) of the APR1400 have been performed with the ATLAS. In the APR1400 a high flow condition is changed to a low flow condition due to an fluidic device during an operation of the SIT. As the self-controlled fluidic device was not installed in the ATLAS, a set of characterization tests was performed to simulate its injection capability from the SIT for the APR1400 simulation. In the ATLAS the required SIT flow rate in the high flow condition was acquired by installing orifices with an optimized flow area to throttle the SIT discharge line and the low flow condition was achieved by changing the opening of the flow control valve in the SIT injection line. The test results showed that the safety injection systems of the ATLAS could simulate the required high and low flow rates of the SIT for the APR1400 simulation efficiently.

• Clinical and Experimental Otorhinolaryngology
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• v.11 no.4
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• pp.281-287
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• 2018

Objectives. Regenerative treatment using stem cells may serve as treatment option for empty nose syndrome (ENS), which is caused by the lack of turbinate tissue and deranged nervous system in the nasal cavity. We aimed to assess the efficacy and safety of the autologous stromal vascular fraction (SVF) in the treatment of ENS. Methods. In this prospective observational clinical study, we enrolled 10 ENS patients who volunteered to undergo treatment of ENS through the injection of autologous SVF. Data, including demographic data, pre- and postoperative Sino-Nasal Outcome Test-25 (SNOT-25) scores, overall patient satisfaction, and postoperative complications, were prospectively collected. Nasal secretion was assessed using the polyurethane foam absorption method, and the levels of biological markers were analyzed in both ENS group and control group using enzyme-linked immunosorbent assay. The SVF extracted from abdominal fat was diluted and injected into both inferior turbinates. Results. Among the 10 initial patients, one was excluded from the study. Subjective satisfaction was rated as "much improved" in two and "no change" in seven. Among the improved patients, the mean preinjection SNOT-25 score was 55.0 and the score at 6 months after injection was 19.5. However, the average SNOT-25 score of nine participants at 6 months after injection (mean${\pm}$standard deviation, $62.4{\pm}35.8$) did not differ significantly from the baseline SNOT-25 score ($70.1{\pm}24.7$, P>0.05, respectively). Among the various inflammatory markers assessed, the levels of interleukin $(IL)-1{\beta}$, IL-8, and calcitonin gene-related peptide were significantly higher in ENS patients. Compared with preinjection secretion level, the nasal secretions from SVF-treated patients showed decreased expressions of $IL-1{\beta}$ and IL-8 after injection. Conclusion. Although SVF treatment appears to decrease the inflammatory cytokine levels in the nasal mucosa, a single SVF injection was not effective in terms of symptom improvement and patient satisfaction. Further trials are needed to identify a more practical and useful regenerative treatment modality for patients with ENS.

• Journal of Energy Engineering
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• v.26 no.3
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• pp.64-70
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• 2017

The concept of Hybrid Safety Injection Tank (Hybrid SIT) proposed by the Korea Atomic Energy Research Institute (KAERI) has been introduced for the purpose of application to the Advanced Power Reactor Plus (APR+). In this study, the SBO situation of the APR+ was analyzed by using the MARS-KS code in order to evaluate whether the operation of the Hybrid SIT has an effect on the cooling performance of the Reactor Coolant System (RCS). According to the analysis, when the actuation valve on the pressure balancing line (PBL) is opened, the Hybrid SIT's pressure rises rapidly, forming equilibrium with the RCS pressure; subsequently, a flow is injected from the Hybrid SIT into the reactor vessel through the direct vessel injection (DVI) line. The analysis showed that it is possible to keep the core temperature below melting temperature during the operation of a Hybrid SIT.

• Clinical and Experimental Vaccine Research
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• v.13 no.2
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• pp.155-165
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• 2024

Purpose: Pertussis bacteria have many pathogenic and virulent antigens and severe adverse reactions have occurred when using inactivated whole-cell pertussis vaccines. Therefore, inactivated acellular pertussis (aP) vaccines and genetically detoxified recombinant pertussis (rP) vaccines are being developed. The aim of this study was to assess the safety profile of a novel rP vaccine under development in comparison to commercial diphtheria-tetanus-acellular pertussis (DTaP) vaccines. Materials and Methods: The two positive control DTaP vaccines (two- and tri-components aP vaccines) and two experimental recombinant DTaP (rDTaP) vaccine (two- and tri-components aP vaccines adsorbed to either aluminum hydroxide or purified oat beta-glucan) were used. Temperature histamine sensitization test (HIST), indirect Chinese hamster ovary (CHO) cell cluster assay, mouse-weight-gain (MWG) test, leukocytosis promoting (LP) test, and intramuscular inflammatory cytokine assay of the injection site performed for safety assessments. Results: HIST results showed absence of residual pertussis toxin (PTx) in both control and experimental DTaP vaccine groups, whereas in groups immunized with tri-components vaccines, the experimental tri-components rDTaP absorbed to alum showed an ultra-small amount of 0.0066 IU/mL. CHO cell clustering was observed from 4 IU/mL in all groups. LP tests showed that neutrophils and lymphocytes were in the normal range in all groups immunized with the two components vaccine. However, in the tri-components control DTaP vaccine group, as well as two- and tri-components rDTaP with beta-glucan group, a higher monocyte count was observed 3 days after vaccination, although less than 2 times the normal range. In the MWG test, both groups showed changes less than 20% in body temperature and body weight before the after the final immunizations. Inflammatory cytokines within the muscle at the injection site on day 3 after intramuscular injection revealed no significant response in all groups. Conclusion: There were no findings associated with residual PTx, and no significant differences in both local and systemic adverse reactions in the novel rDTaP vaccine compared to existing available DTaP vaccines. The results suggest that the novel rDTaP vaccine is safe.