• Journal of Korean Neurosurgical Society
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• 제53권2호
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• pp.96-101
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• 2013

Objective : The purpose of this study was to analyze the differences of spinopelvic parameters between degenerative spondylolisthesis (DSPL) and isthmic spondylolisthesis (ISPL) patients. Methods : Thirty-four patients with DSPL and 19 patients with ISPL were included in this study. Spinopelvic parameters were evaluated on whole spine X-rays in a standing position. The following spinopelvic parameters were measured : pelvic incidence (PI), sacral slope, pelvic tilt (PT), lumbar lordosis (LL), and sagittal vertical axis from C7 plumb line (SVA). The population of patients was compared with a control population of 30 normal and asymptomatic adults. Results : There were statistically significant differences in LL (p=0.004) and SVA (p=0.005) between the DSPL and ISPL group. The LL of DSPL ($42{\pm}13^{\circ}$) was significantly lower than that of the control group ($48{\pm}11^{\circ}$; p=0.029), but that of ISPL ($55{\pm}6^{\circ}$) was significantly greater than a control group (p=0.004). The SVA of DSPL ($55{\pm}49$ mm) was greater than that of a control group (<40 mm), but that of ISPL ($21{\pm}22$ mm) was within 40 mm as that of a control group. The PT of DSPL ($24{\pm}7^{\circ}$) and ISPL ($21{\pm}7^{\circ}$) was significantly greater than that of a control group ($11{\pm}6^{\circ}$; p=0.000). Conclusion : Both symptomatic DSPL and ISPL patients had a greater PI than that of the asymptomatic control group. In conclusion, DSPL populations are likely to have global sagittal imbalance (high SVA) compared with ISPL populations because of the difference of lumbar lordosis between two groups.

• Journal of Korean Neurosurgical Society
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• 제62권5호
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• pp.567-576
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• 2019

Objective : Minimal data exist regarding non-operative management of suspected pseudarthrosis after pedicle subtraction osteotomy (PSO). This study reports radiographic and clinical outcomes of non-operative management for post-PSO pseudarthrosis at a minimum 5 years post-detection. Methods : Nineteen consecutive patients with implant breakage indicating probable pseudarthrosis after PSO surgery (13 women/six men; mean age at surgery, 58 years) without severe pain and disability were treated with non-operative management (mean follow-up, 5.8 years; range, 5-10 years). Non-operative management included medication, intermittent brace wearing and avoidance of excessive back strain. Radiographic and clinical outcomes analysis was performed. Results : Sagittal vertical axis (SVA), proximal junctional angle, thoracic kyphosis achieved by a PSO were maintained after detection of pseudarthrosis through ultimate follow-up. Lumbar lordosis and PSO angle decreased at final follow-up. There was no significant change in Oswestry Disability Index (ODI) scores and Scoliosis Research Society (SRS) total score, or subscales of pain, self-image, function, satisfaction and mental health between detection of pseudarthrosis and ultimate follow-up. SVA greater than 11 cm showed poorer ODI and SRS total score, as well as the pain, self-image, and function subscales (p<0.05). Conclusion : Non-operative management of implant failure of probable pseudarthrosis after PSO offers acceptable outcomes even at 5 years after detection of implant breakage, provided SVA is maintained. As SVA increased, outcome scores decreased in this patient population.

• Journal of Chest Surgery
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• 제38권10호
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• pp.693-698
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• 2005

배경: 발살바동류(Sinus Valsalva Aneurysm, SVA)는 드문 질환으로, 심실중격결손증과 대동맥판막 궤쇄부전 등이 흔하게 동반되는 것으로 알려져 있다 이에 대한 치료로는 여러 가지 접근 방법을 통한 수술 기법이 시도되고 있지만 국내에서의 수술 치료 후 장기적인 결과는 보고된 바가 없다. 저자들은 지난 30년간 발살바동류 및 발살바동 파열로 수술 받은 환자들의 임상 기록을 고찰하여, 발살바동류 및 발살바동 파열의 수술 후 장기 성적을 살펴보았다. 대상 및 방법: 1974년 3월부터 2002년 2월까지 연세대학교 심장혈관병원에서 SVA 및 파열로 수술을 시행한 81명을 대상으로 후향적인 조사를 시행하였는데, 환자들의 평균 나이는 $29.2\pm1l.5$세였고 남자가 49명이었다. SVA에 동반된 심장 기형으로는 VSD가 50예, 동맥관 개존증과 Bechet's병이 각각 2예, 활로 4증후군, 우심실유출로 협착 그리고 대동맥륜 확장이 각각 1예에서 있었다. 77명$(95\%)$의 환자들에서 SVA의 파열이 있었으며, 14명의 환자들에서 아급성 세균성 심내막염이 동반되어 있었다. 대동맥판막 폐쇄부전은 grade I: 8명, II: 10명, III: 9명, IV: 4명에서 발견되었다. 발살바동류는 우관상동 부위에서 66예$(81\%)$로 가장 많이 발견되었으며, 발살바동류의 파열은 우심실과의 교통이 가장 많았다(53/77). 수술은 첨포를 사용한 경우가 37예, 직접 봉합을 한 경우가 38예, 기타의 방법이 1예 있었다. 결과: 수술 사망이 1명 있었다(수술 사망률=$1.2\%$). 환자들의 추적관찰은 2명을 제외한 78명에서 가능하였는데(추적률=$97.5\%$), 평균 추적기간은 $123.3\pm80.9 (3\~330)$개월이었다. 추적 기간 중에 3명의 환자가 사망하였으며(사망률=$3.8\%$), 1명의 환자는 심부전으로, 1명의 환자는 부정맥으로 사망하였으며, 1명의 환자는 원인을 알 수 없이 사망하였다. SVA수술 후 2명의 환자에서 추적 기간 중에 완전 방실차단이 발생하였으며, SVA수술과 관련하여 재발한 경우는 없었다. Kaplan-Meier 방법에 의한 생존율은 15년과 27년에 각각 $92.5\pm3.5\%$로 매우 양호한 결과를 나타내었다. 결론: 발상바동류 및 파열의 수술 결과는 매우 양호하였으며, 장기간의 생존율도 만족할 만하였다.

• 한국안광학회지
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• 제18권2호
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• pp.165-171
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• 2013

목적: 남녀 대학생의 동공크기, 손의 반응력, 굴절이상, 교정시력, 우위안, 정지시각(static visual angle, SVA), 동적시력(kinetic visual acuity, KVA)등을 비교 분석하고, 굴절이상이 완전교정 된 상태에서 남녀 대학생의 KVA를 측정하고, 완전교정상태에 구면굴절력 ${\pm}0.50 $D를 각각 변화시켜 KVA을 측정하여 변화를 알아보고자 하였다. 방법: 안경광학과 남학생 40명, 여학생 40명을 대상으로 KVA 측정장치(KOWA AS-4A)와 손의 반응력 측정 프로그램, 자 타각적 굴절검사기기 등을 이용하여 KVA, SVA, 동공크기, 손의 반응력, 굴절이상, 교정시력, 우위안 등을 측정하였고, 양안 구면굴절력을 ${\pm}0.50$ D 변화시켜 KVA를 측정하였다. 결과: 전체 대상자의 양안 KVA는 $0.45{\pm}0.22$이고, 단안은 우안 $0.36{\pm}0.19$, 좌안 $0.34{\pm}$0.19로 양안이 단안보다 유의하게 높게 나타났다. SVA가 좋을수록 KVA가 유의하게 좋은 것으로 나타났으며, 굴절이상은 근시량이 작을수록 KVA가 좋았으나 통계적으로 유의하지 않았다. 난시에서는 -1.00 D 이하와 초과로 나눌 때 난시가 작을수록 KVA가 유의하게 좋았다. 굴절이상 교정상태에 따른 KVA는 완전교정일 때 $0.45{\pm}0.22$, 완전교정에 +0.50 D 추가할 때 $0.26{\pm}0.15$, 완전교정에 -0.50 D 추가할 때 $0.48{\pm}0.22$로 근시 교정을 강하게 할 때가 유의수준에서 KVA가 가장 높게 나타났으며, 다음으로 완전교정, 근시 저교정의 순으로 낮게 나타났다. 또한 남녀로 구별하여 비교해 볼 때도 유사한 결과를 나타냈으며 남자가 여자보다 KVA가 좋은 것으로 나타났다. KVA와 우위안 비우위안 차이는 없었다. 결론: 따라서, KVA는 원거리 SVA, 난시량, 굴절이상량과 관계가 있는 것을 알 수 있었으며, 우위안과는 관계가 없었다. KVA를 높이는 굴절이상 처방은 완전교정 또는 근시방향에서 약간 과교정 하는 것이 효과적인 것을 알 수 있었다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume I
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• pp.250-252
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• 2006

The land surface temperature (LST) can be defined as a weighted average temperature of components which constitute a pixel. The coefficients of split-window algorithm for MTSAT-1R were obtained by means of a statistical regression analysis from radiative transfer simulations using MODTRAN 4.0 for a wide range of atmospheric, satellite viewing angle (SVA) and lapse rate conditions. 6 types of atmospheric profile data imbedded in the MODTRAN 4 are used for the radiative transfer simulations. The RMSE is clearly larger on warm and humid profiles than cold and dry profiles, especially when the satellite viewing angle and lapse rate are large. The derivation of LST equations according to the atmospheric profiles clearly decreased the RMSE without regard to the SVA and lapse rate. The bias and RMSE are decreased as the more controls factors included. This preliminary result indicates that the characteristics of atmosphere, SVA and lapse rate should be included in the LST equation.

• 대한원격탐사학회지
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• 제22권5호
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• pp.385-388
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• 2006

The land surface temperature (LST) can be defined as a weighted average temperature of components which constitute a pixel. The coefficients of split-window algorithm for MTSAT-1R were obtained by means of a statistical regression analysis from radiative transfer simulations using MODTRAN 4.0 for a wide range of atmospheric, satellite viewing angle (SVA) and lapse rate conditions. 6 types of atmospheric profile data imbedded in the MODTRAN 4 are used for the radiative transfer simulations. The RMSE is clearly larger on warm and humid profiles than cold and dry profiles, especially when the satellite viewing angle and lapse rate are large. The derivation of LST equations according to the atmospheric profiles clearly decreased the RMSE without regard to the SVA and lapse rate. The bias and RMSE are decreased as the more controls factors included. This preliminary result indicates that the characteristics of atmosphere, SVA and lapse rate should be included in the LST equation.

• Journal of Korean Neurosurgical Society
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• 제65권4호
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• pp.549-557
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• 2022

Objective : This study analyzed the risk factors in patients who developed distal junctional kyphosis (DJK) after posterior cervical fusion. Methods : We retrospectively analyzed the clinical and radiographic outcomes of 64 patients, aged ≥18 years (51 and 13 male and female patients, respectively), who underwent single-staged multilevel (3-6 levels) posterior cervical fusion surgery due to multiple cervical spondylotic myelopathy. The surgeries were performed by a single spinal surgeon between January 2012 and December 2017. Demographic data, clinical outcomes, and radiological results were collected. We divided the patients into a DJK group and a non-DJK group according to the presence of DJK and investigated the risk factors by comparing the differences between the two groups. Results : Of the 64 patients, 13 developed DJK. No significant differences in clinical results were observed between the two groups before and immediately after the surgery. At the final follow-up, a higher visual analog score for neck pain was observed in the DJK group compared to the non-DJK group (p<0.01). The DJK group had a significantly lower T1 slope and a significantly higher C2-7 sagittal vertical axis (SVA) before surgery compared to the non-DJK group (p=0.03 and p<0.01, respectively). Immediately after surgery, the difference between the two groups decreased and no significant difference was observed. However, at the last follow-up, a significantly higher C2-7 SVA was observed in the DJK group (p<0.01). At the last follow up, there is no discrepancy in T1S-CL. In multiple logistic regression analysis, preoperative higher C2-7 SVA and preoperative lower T1 slope were identified as independent risk factors (p=0.03 and p<0.01, respectively). As a result, it was confirmed that DJK occurred along the process of returning to preoperative values. Conclusion : DJK can be considered to be caused by cervical misalignment due to excessive change in the surgical site in patients with low T1 slope and high C2-7 SVA before surgery. This also affects the clinical outcome after surgery. It is recommended to refrain from excessive segmental lordosis changes during multilevel cervical post fusion surgery, especially in patients with a small preoperative T1 slope and a large SVA value.

• Nuclear Medicine and Molecular Imaging
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• 제41권6호
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• pp.530-537
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• 2007

목적: 본 연구는 초기의 피질하 혈관성치매와 알쯔하이머병 환자에서 Tc-99m HMPAO 단일광자방출단층촬영술을 이용하여 국소 뇌 혈류 흐름의 특징적인 양상을 평가하고 두 질환에서의 차이를 비교하고자 하였다. 대상 및 방법: 피질하 혈관성치매 환자 16명, 알쯔하이머병 46명, 12명의 대조군이 포함되었다. 피질하 혈관성치매와 알쯔하이머병은 NINCDS-ADRDA 와 NINDS-AIREN 기준에 합당하였고, 이들의 연령, 교육연수, 한국형 간이정신상태검사 점수와 치매임상척도 점수를 일치시켰다. 세 군에서 국소 뇌혈류 흐름을 측정하고자 SPM 분석을 이용한 TG-99m HMPAO 단일 광자방출단층촬영술을 실시하였다. 피질하 혈관성치매와 알쯔하이머병에서의 단일광자방출단층촬영술 결과를 정상 대조군과 비교하였고, 이어서 두 질환 간의 차이를 비교하였다. 결과: 대조군과의 SPM분석 결과 피질하 혈관성치매에서는 우측 관자엽, 시상, 좌측 뇌섬엽, 상부 관자이랑, 양측 띠이랑, 이마엽에서 의미 있는 관류저하가 있었고, 알쯔하이머병에서는 좌측 모서리위이랑, 상부 관자이랑, 중심뒤이랑, 하부 마루소엽, 우측 뒤통수관자이랑, 양측 띠이랑에서 관류저하을 보였다(uncorrected p<0.01). 피질하 혈관성치매 환자에서 알쯔하이머병 환자에 비해 우측 해마이랑, 띠이랑, 좌측 뇌섬엽, 양측 이마소이랑 부위에 의미있는 관류저하를 보였다(uncorrected p<0.01). 결론: 본 연구는 피질하 혈관성치매와 알쯔하이머병 환자에서의 관류의 특징과 차이를 보여주었고, 이러한 결과는 질병의 초기단계에서 두 질환을 구별하는데 도움을 줄 수 있을 것으로 생각한다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2000년도 제13회 신호처리 합동 학술대회 논문집
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• pp.389-392
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• 2000

In this paper, we propose a novel post processing method of deconvolution for SAR images based on phase extension inverse filtering, which improves spatial resolution as well as effectively eliminates sidelobes with low computational complexity. It extends the bandwidth only to control the magnitude of the processed SAR data without distortions of the phase in frequency domain unlike the other techniques such as spatially variant apodization (SVA), and other deconvolution techniques. We compare the image processed by the proposed method with images processed by uniform weighting function, Hamming weighting function whose coefficient is 0.75, and SVA.

• Genomics & Informatics
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• 제10권4호
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• pp.226-233
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• 2012

Since the advent of whole-genome sequencing, transposable elements (TEs), just thought to be 'junk' DNA, have been noticed because of their numerous copies in various eukaryotic genomes. Many studies about TEs have been conducted to discover their functions in their host genomes. Based on the results of those studies, it has been generally accepted that they have a function to cause genomic and genetic variations. However, their infinite functions are not fully elucidated. Through various mechanisms, including de novo TE insertions, TE insertion-mediated deletions, and recombination events, they manipulate their host genomes. In this review, we focus on Alu, L1, human endogenous retrovirus, and short interspersed element/variable number of tandem repeats/Alu (SVA) elements and discuss how they have affected primate genomes, especially the human and chimpanzee genomes, since their divergence.