• The Transactions of the Korean Institute of Electrical Engineers D
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• v.50 no.4
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• pp.201-207
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• 2001

This paper describes an automated detection algorithm of ST-T episodes using global curvature which can connect the isoelectric level in ECG and can eliminate not only the slope of ST segment, but also difference of the baseline and global curve. This above method of baseline correction is very faster than the classical baseline correction methods. The optimal values of parameters for baseline correction were found as the value having the highest detection rate of ST episode. The features as input of backpropagation Neural Network were extracted from the whole ST segment. The European ST-T database was used as training and test data. Finally, ST elevation, ST depression and normal ST were classified. The average ST episode sensitivity and predictivity were 85.42%, 80.29%, respectively. This result shows the high speed and reliability in ST episode detection. In conclusion, the proposed method showed the possibility in various applications for the Holter system.

• Genomics & Informatics
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• v.16 no.4
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• pp.28.1-28.6
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• 2018

Due to the increasing interest in synonymous codons, several codon bias-related terms were introduced. As one measure of them, the tRNA adaptation index (tAI) was invented about a decade ago. The tAI is a measure of translational efficiency for a gene and is calculated based on the abundance of intracellular tRNA and the binding strength between a codon and a tRNA. The index has been widely used in various fields of molecular evolution, genetics, and pharmacology. Afterwards, an improved version of the index, named specific tRNA adaptation index (stAI), was developed by adapting tRNA copy numbers in species. Although a subsequently developed webserver (stAIcalc) provided tools that calculated stAI values, it was not available to access pre-calculated values. In addition to about 100 species in stAIcalc, we calculated stAI values for whole coding sequences in 148 species. To enable easy access to this index, we constructed a novel web database, named STADIUM (Species-specific tRNA adaptive index compendium). STADIUM provides not only the stAI value of each gene but also statistics based on pathway-based classification. The database is expected to help researchers who have interests in codon optimality and the role of synonymous codons. STADIUM is freely available at http://stadium.pmrc.re.kr.

• The Journal of the Korea Contents Association
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• v.11 no.3
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• pp.271-280
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• 2011

Heart Rate Variability (HRV) analysis is a convenient tool to assess Myocardial Ischemia (MI). The analysis methods of HRV can be divided into time domain and frequency domain analysis. This paper uses wavelet transform as frequency domain analysis in contrast to time domain analysis in short term HRV analysis. ST-T and normal episodes are collected from the European ST-T database and the MIT-BIH Normal Sinus Rhythm database, respectively. An episode can be divided into several segments, each of which is formed by 32 successive RR intervals. Eighteen HRV features are extracted from each segment by the time and frequency domain analysis. To diagnose MI, the Neural Network with Weighted Fuzzy Membership functions (NEWFM) is used with the extracted 18 features. The results show that the average accuracy from time and frequency domain features is 75.29% and 80.93%, respectively.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.10
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• pp.2223-2230
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• 2011

ECG is used to diagnose heart diseases such as myocardial ischemia, arrhythmia and myocardial infarction. Particularly, myocardial ischemia causes the shape change of the ST segment, this change is transient and may occur without symptoms. So it is important to detect the transient change of ST segment through long term monitoring. ST segment classification algorithm for making diagnosis myocardial ischemia is presented in this paper. The first step in the ST segment shape classification process is to detect R wave point and feature points based adaptive threshold and window. And then, the suggested algorithm detects the ST level change, To classify the ST segment shape, the suggested algorithm uses the slope values of the four points between the S and T wave. The ECG data in the European ST-T database were used to verify the performance of the developed algorithm. The best correct rate was 99.40% and the worst correct rate was 68.48%.

• Proceedings of the Korea Information Processing Society Conference
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• 2008.11a
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• pp.19-22
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• 2008

최근 서구화된 식생활 패턴과 흡연, 비만 등의 원인으로 인해 심근경색, 협심증과 같은 심근허혈(myocardial ischemia) 질환이 급증하고 있다. 이 논문에서는 심전도 신호로부터 허혈성 심장 질환 진단을 위해 출현 패턴 마이닝을 이용하여 심근경색 및 협심증의 진단 신호인 ischemia beat를 분류 하였다. 또한 기존의 출현 패턴 마이닝에 빠른 패턴 탐사와 저장 공간의 효율성을 고려하여 Apriori-T 빈발 패턴 탐사 알고리즘을 출현 패턴 생성이 가능하도록 확장하였다. PhysioNet의 ST-T 데이터베이스로부터 138개의 대조군(정상)과 ischemia beat 데이터에 제안된 분류 알고리즘을 실험한 결과 최소 75% 및 최대 95%의 예측 정확도를 보였다.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2003.05a
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• pp.128-133
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• 2003

본 연구에서는 심전도 신호의 전처리 과정에서 원신호의 왜곡을 최소화하여 기저선을 제거 할 수 있는 웨이브렛 모함수를 결정하기 위하여, European S-T T database의 심전도 신호에 다양한 웨이브렛 모함수를 적용하여 기저선을 제거하였으며 제거효율을 평가하기 위하여 SNR과 RSE를 계산하였다. 실험결과 가장 우수했던 웨이브렛 모함수는 db8(diff: 27.12), coif5(diff: 25.32), sym7(diff: 25.13)이었으며, diff(meanSNR-meanRSE)의 값이 23미만으로는 심전도의 진단 파라미터까지 왜곡시키므로 사용할 수 없다는 것을 알 수 있었다.

• Journal of Biomedical Engineering Research
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• v.19 no.3
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• pp.269-278
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• 1998

This paper describes a development of efficient stress ECG signal analysis algorithm. The algorithm consists of wavelet adaptive filter(WAF), QRS detector and ST segment detector. The WAF consists of a wavelet transform and an adaptive filter. The wavelet transform decomposed the ECG signal into seven levels using wavelet function for each high frequency bank and low frequency bank. The adaptive filter used the signal of the seventh lowest frequency band among the wavelet transformed signals as primary input. For detection of QRS complex, we made summed signals that are composed of high frequency bands including frequency component of QRS complex and applied the adaptive threshold method changing the amplitude of threshold according to RR interval. For evaluation of the performance of the WAF, we used two baseline wandering elimination filters including a standard filter and a general adaptive filter. WAF showed a better performance than compared filters in the noise elimination characteristics and signal distortion. For evaluation of WAF showed a better performance than compared filters in the noise elimination characteristics and signal distortion. For evaluation of results of QRS complex detection, we compared our algorithm with existing algorithms using MIT/BIH database. Our algorithm using summed signals showed the accuracy of 99.67% and the higher performance of QRS detection than existing algorithms. Also, we used European ST-T database and patient data to evaluate measurement of the ST segment and could measure the ST segment adaptively according to change of heart rate.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.2
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• pp.450-460
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• 2017

T wave is cardiac parameters that represent ventricular repolarization, it is very important to diagnose arrhythmia. Several methods for detecting T wave have been proposed, such as frequency analysis and non-linear approach. However, detection accuracy is at the lower level. This is because of the overlap of the P wave and T wave depending on the heart condition. We propose T wave detection algorithm based on target area extraction through QRS cancellation and moving average. For this purpose, we detected Q, R, S wave from noise-free ECG(electrocardiogram) signal through the preprocessing method. And then we extracted P, T target area by applying decision rule for four PAC(premature atrial contraction) pattern another arrhythmia through moving average and detected T wave using RT interval and threshold of RR interval. The performance of T wave detection is evaluated by using 48 record of MIT-BIH arrhythmia database. The achieved scores indicate the average detection rate of 95.32%.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.5075-5079
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• 2012

Purpose: The results of recent published studies focusing on IL-8 polymorphism in colorectal cancer susceptibility have often been inconsistent. We therefore carried out a meta-analysis based on independent studies to assess the association. Methods: Nine case-control studies with 7,003 individuals (3,019 cases and 3,984 controls) were included in this meta-analysis through searching the databases of PubMed, Excerpta Medica Database (EMBASE), and Chinese Biomedical Literature Database (CBM; Chinese) (up to Aug 1st, 2012). The odds ratio (OR) and 95% confidence interval (95%CI) were used to assess the strength of the association. Meta-analysis was conducted in a fixed/random effect model. Results: No obvious associations were found for all genetic models when all studies were pooled into the meta-analysis (for A vs. T: OR = 1.084, 95% CI = 0.971-1.209, P = 0.019; for TA vs. TT: OR = 1.18, 95% CI = 0.943-1.475, P = 0.001; for AA vs. TT: OR = 1.155, 95% CI = 0.916-1.456, P = 0.014; for AA+TA vs. TT: OR = 1.170, 95% CI =0.953-1.437, P = 0.001; for AA vs. TT+TA: OR = 1.044, 95% CI = 0.886-1.230, P = 0.097). In the subgroup analyses by ethnicity (Caucasian) and source of controls (population based), also no significant associations were found for all genetic models. Conclusions: Result suggests that the IL-8-251T>A polymorphism is not associated with colorectal cancer risk. Because of the limitations of this meta-analysis, this finding demands further investigation.

• Asian-Australasian Journal of Animal Sciences
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• v.27 no.5
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• pp.616-627
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• 2014

The Lanyu is a miniature pig breed indigenous to Lanyu Island, Taiwan. It is distantly related to Asian and European pig breeds. It has been inbred to generate two breeds and crossed with Landrace and Duroc to produce two hybrids for laboratory use. Selecting sets of informative genetic markers to track the genetic qualities of laboratory animals and stud stock is an important function of genetic databases. For more than two decades, Lanyu derived breeds of common ancestry and crossbreeds have been used to examine the effectiveness of genetic marker selection and optimal approaches for individual assignment. In this paper, these pigs and the following breeds: Berkshire, Duroc, Landrace and Yorkshire, Meishan and Taoyuan, TLRI Black Pig No. 1, and Kaohsiung Animal Propagation Station Black pig are studied to build a genetic reference database. Nineteen microsatellite markers (loci) provide information on genetic variation and differentiation among studied breeds. High differentiation index ($F_{ST}$) and Cavalli-Sforza chord distances give genetic differentiation among breeds, including Lanyu's inbred populations. Inbreeding values ($F_{IS}$) show that Lanyu and its derived inbred breeds have significant loss of heterozygosity. Individual assignment testing of 352 animals was done with different numbers of microsatellite markers in this study. The testing assigned 99% of the animals successfully into their correct reference populations based on 9 to 14 markers ranking D-scores, allelic number, expected heterozygosity ($H_E$) or $F_{ST}$, respectively. All miss-assigned individuals came from close lineage Lanyu breeds. To improve individual assignment among close lineage breeds, microsatellite markers selected from Lanyu populations with high polymorphic, heterozygosity, $F_{ST}$ and D-scores were used. Only 6 to 8 markers ranking $H_E$, $F_{ST}$ or allelic number were required to obtain 99% assignment accuracy. This result suggests empirical examination of assignment-error rates is required if discernible levels of co-ancestry exist. In the reference group, optimum assignment accuracy was achievable achieved through a combination of different markers by ranking the heterozygosity, $F_{ST}$ and allelic number of close lineage populations.