• 한국생물공학회:학술대회논문집
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• 2002.04a
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• pp.53-56
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• 2002

Mammalian cell based biosensor kits are expected to be in assessment of samples toxicity more sensitive and accurate. A recombinant fluorescent Chinese Hamster Ovary (CHO) cell line was known to be responsive to the various toxicants Specially. KFC- AlO cell line. which contain the c-fos SRE::GFP plasmid (pKFG). was found to be able to detect toxicants sensitively. A biosensor kit was developed by using an immobilized KFC-A10 cell line. Immobilized recombinant fluorescent cells within agarose, known as a representative hydrogel matrix, have been maintained in the matrix viably and have shown constant fluorescent levels for long time. Immobilized cells have shown the ability to detect the chemical toxicity in the keep of fluorescent level as the metabolism is inhibited under toxic conditions.

• International Journal of Reliability and Applications
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• v.10 no.1
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• pp.17-32
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• 2009

The aim of this work is to generalize reliability equivalence technique to apply it to a system consists of n independent and non-identical components connected in series system, that have mixing constant failure rates. We shall improve the system by using some reliability techniques: (i) reducing some failure rates; (ii) add hot reduncy components; (iii) add cold reduncy components; (iv) add cold reduncy components with imperfect switches. We start by establishing two different types of reliability equivalence factors, the survival equivalence (SRE), and mean reliability equivalence (MRE) factors. Also, we introduced some numerical results.

• Proceedings of the Korea Concrete Institute Conference
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• 1997.04a
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• pp.442-448
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• 1997

An analytical method based on the nonlinear layered finite element method is developed to simulate the load-dsflection behavior of strengthened beams. Beams considered in this study are the ones strengthened either with external steel plate or Carbon Fiber Sheets(CFS) bonded to the overlay soffit. The theoretically obtained load-deflections and strains of the strengthened beams are compared to the corresponding experimental values. Parametric studies are, then. performed using the developed model to investigate the effects of design variables on the flexural behavior of the strengthened beams. Simply supported beams under monotonically increasing loads sre considered exclusively.

• Phonetics and Speech Sciences
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• v.9 no.2
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• pp.85-94
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• 2017

Conventional speaker verification systems using time delay neural network, identity vector and probabilistic linear discriminant analysis (TDNN-Ivector-PLDA) are known to be very effective for verifying long-duration speech utterances. However, when test utterances are of short duration, duration mismatch between enrollment and test utterances significantly degrades the performance of TDNN-Ivector-PLDA systems. To compensate for the I-vector mismatch between long and short utterances, this paper proposes to use probabilistic linear discriminant analysis (PLDA) model adaptation with augmented data. A PLDA model is trained on vast amount of speech data, most of which have long duration. Then, the PLDA model is adapted with the I-vectors obtained from short-utterance data which are augmented by using vocal tract length perturbation (VTLP). In computer experiments using the NIST SRE 2008 database, the proposed method is shown to achieve significantly better performance than the conventional TDNN-Ivector-PLDA systems when there exists duration mismatch between enrollment and test utterances.

• Proceedings of the Korean Biophysical Society Conference
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• 1999.06a
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• pp.69-69
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• 1999

The human genetic disorder ataxia-telangiectasia (A-T) is a multisystem disease characterized by extreme radiosensitivity. The recent identification of the gene mutated in A-T, ATM, and the demonstration that it encodes a homologous of phosphatidylinositol 3-kinase (PI3-K), the catalytic subunit of an enzyme involved in transmitting signals from the cell surface to the nucleus, provides support for a role for this gene in signal transduction.(omitted)

• ETRI Journal
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• v.45 no.4
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• pp.678-689
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• 2023

This paper describes a novel end-to-end deep generative model-based speaker recognition system using prosodic features. The usefulness of variational autoencoders (VAE) in learning the speaker-specific prosody representations for the speaker recognition task is examined herein for the first time. The speech signal is first automatically segmented into syllable-like units using vowel onset points (VOP) and energy valleys. Prosodic features, such as the dynamics of duration, energy, and fundamental frequency (F₀), are then extracted at the syllable level and used to train/adapt a speaker-dependent VAE from a universal VAE. The initial comparative studies on VAEs and traditional autoencoders (AE) suggest that the former can efficiently learn speaker representations. Investigations on the impact of gender information in speaker recognition also point out that gender-dependent impostor banks lead to higher accuracies. Finally, the evaluation on the NIST SRE 2010 dataset demonstrates the usefulness of the proposed approach for speaker recognition.

• Journal of Korean Society for Geospatial Information Science
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• v.22 no.4
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• pp.47-52
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• 2014

Species distribution models have been widely applied in order to assess biodiversity, design reserve, manage habitat and predict climate change. However, SDMs has been used restrictively to the public and policy sectors owing to model uncertainty. Recent studies on ensemble and consensus models have been increased to reduce model uncertainty. This paper was carried out single model and multi model for Corylopsis coreana and compares two models. First, model evaluation was used AUC, kappa and TSS. TSS was the most effective method because it was easy to compare several models and convert binary maps. Second, both single and ensemble model show good performance and RF, Maxent and GBM was evaluated higher, GAM and SRE was evaluated lower relatively. Third, ensemble model tended to overestimate over single model. This problem can be solved by the suitable model selection and weighting through collaboration between field experts and modeler. Finally, we should identify causes and magnitude of model uncertainty and improve data quality and model methods in order to apply special decision-making support system and conservation planning, and when we make policy decisions using SDMs, we should recognize uncertainty and risk.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3357-3362
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• 2013

The human skeleton is the most common organ to be affected by metastatic cancer and bone metastases are a major cause of cancer morbidity. The five most frequent cancers in Malaysia among males includes prostate whereas breast cancer is among those in females, both being associated with skeletal lesions. Bone metastases weaken bone structure, causing a range of symptoms and complications thus developing skeletal-related events (SRE). Patients with SRE may require palliative radiotherapy or surgery to bone for pain, having hypercalcaemia, pathologic fractures, and spinal cord compression. These complications contribute to a decline in patient healthrelated quality of life. The multidimensional assessment of health-related quality of life for those patients is important other than considering a beneficial treatment impact on patient survival, since the side effects of treatment and disease symptoms can significantly impact health-related quality of life. Cancer treatment could contribute to significant financial implications for the healthcare system. Therefore, it is essential to assess the health-related quality of life and treatment cost, among prostate and breast cancer patients in countries like Malaysia to rationalized cost-effective way for budget allocation or utilization of health care resources, hence helping in providing more personalized treatment for cancer patients.

• BMB Reports
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• v.43 no.3
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• pp.193-198
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• 2010

In this study, we report the identification and characterization of a novel C2H2 zinc finger protein, ZNF552, from a human embryonic heart cDNA library. ZNF552 is composed of three exons and two introns and maps to chromosome 19q13.43. The cDNA of ZNF552 is 2.3 kb, encoding 407 amino acids with an amino-terminal KRAB domain and seven carboxyl-terminal C2H2 zinc finger motifs in the nucleus and cytoplasm. Northern blotting analysis indicated that a 2.3 kb transcript specific for ZNF552 was expressed in liver, lung, spleen, testis and kidney, especially with a higher level in the lung and testis in human adult tissues. Reporter gene assays showed that ZNF552 was a transcriptional repressor, and overexpression of ZNF552 in the COS-7 cells inhibited the transcriptional activities of AP-1 and SRE, which could be relieved through RNAi analysis. Deletion studies showed that the KRAB domain of ZNF552 may be involved in this inhibition.

• Journal of Oriental Neuropsychiatry
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• v.23 no.4
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• pp.133-152
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• 2012

Objectives : The purpose of this study is to investigate the effect of Sihogayonggolmoryeo-tang on the anxiety of Hwa-byung. Methods : In this randomized, double blinded, placebo-controlled study, we planned to give Sihogayonggolmoryeo-tang or controlled medication for anxiety of Hwa-byung. Hamilton Anxiety Scale (HAM-A) was measured as the 1st evaluative instrument, and Korean State-Trait Anxiety Inventory (STAI-K), Likert scale for major symptom of Hwa-byung, Hwa-Byung Scale Score, Korean Beck's Depression Inventory (BDI-K), Korean State-Trait Anger Expression Inventory (STAXI-K), Insomnia severity Index (ISI), Instrument of Oriental Medical Evaluation for Hwa-Byung, WHO Quality of Life Avvreviated (WHOQOL-BREF), genral self-Efficacy Scale (GSES), Rosenberg Self-Esteem Inventory (SRE) and Heart Rate Variability (HRV) were also measured as the 2nd evaluative instrument before treatment. Results : Clinical characteristics-vital signs and demographic characteristics showed no significant difference between both groups. The characteristics of disease-chief complaint, pattern Identification, period, etiological factor, and etc, also showed similarity of distribution in both groups. The results of Chest PA, EKG and clinicopathologic examination showed no significant difference between both groups. There were no significant difference between both groups in all valuation scales; HAM-A was measured as the first evaluative instrument, and STAI-K, Likert scale for major symptom of Hwa-byung, Hwa-Byung Scale Score, BDI-K, STAXI-K, ISI, Instrument of Oriental Medical Evaluation for Hwa-Byung, WHOQOL-BREF, GSES, SRE and HRV. Conclusions : We considered that establishment of the experimental group and controlled group was objective and worth conducting this research. In addition, this methodology is expected to be applied to the subsequent research. Further, we hope to make up for this study through various study and discussion.