• 전력전자학회:학술대회논문집
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• 전력전자학회 2011년도 전력전자학술대회
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• pp.338-339
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• 2011

본 논문에서는 SRC를 이용한 고효율 차량탑재형 충전기를 제안한다. 제안한 컨버터는 앞단의 부스트컨버터가 역률보상과 동시에 배터리의 전압 전류 제어를 수행하고 후단의 SRC를 고정듀티와 고정주파수로 동작시켜 전 부하영역에서 스위치와 다이오드의 ZCS 턴온 턴오프가 가능하다. 3.3kW의 시작품으로 부터 CC-CV 충전을 통한 제안한 방식의 타당성을 검증한다.

• 한국공간구조학회지
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• 제12권3호
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• pp.13-17
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• 2012

• Archives of Pharmacal Research
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• 제29권11호
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• pp.1006-1017
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• 2006

A series of 3-(substituted-benylidene)-1, 3-dihydro- indolin-2-one, 3-(substituted-benylidene)-1, 3-dihydro- indolin-2-thione and 2, 2'-dithiobis 3-(substituted-benylidene)-1, 3-dihydro-indole derivatives was investigated as inhibitor of $p60^{c-Src}$tyrosine kinase by performing receptor docking studies and inhibitory activity toward tyrosine phosphorylation. Some compounds were shown to be docked at the site, where the selective inhibitor PP1 [1-tert-Butyl-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidine-4-yl-amine] was embedded at the enzyme active site. Evaluation of all compounds for the interactions with the parameters of lowest binding energy levels, capability of hydrogen bond formations and superimposibility on enzyme active site by docking studies, it can be assumed that 3-(substituted-benzylidene)-1, 3-dihydro-indolin-2-one and thione derivatives have better interaction with enzyme active site then 2, 2'-dithiobis 3-(substituted-benzylidene)-1, 3-dihydro indole derivatives. The test results for the inhibitory activity against tyrosine kinase by Elisa method revealed that 3-(substituted-benylidene)-1, 3-dihydro- indolin-2-thione derivatives have more activity then 3-(substituted-benylidene)-1, 3-dihydro- indolin-2-one derivatives.

• 정보보호학회논문지
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• 제21권6호
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• pp.183-190
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• 2011

감시카메라 환경에서 군중의 비정상 집단행동 탐지란 감시카메라로부터 유입되는 영상에서 다중 객체가 위험에 처한 상황을 신속하고 정확하게 탐지하는 분야를 말한다. 본 논문에서는 CCTV 등과 같은 감시카메라 환경에서 움직임 벡터와 SVDD를 이용하여 집단내의 비정상 상황을 탐지하는 프로토타입 시스템을 제안한다. 제안된 시스템은 H.264 압축과정에서의 움직임 벡터 정보를 이용하여 영상내의 움직임 정보를 추출 표현하였으며, 비정상 집단행동의 판별 문제를 실용적 차원의 단일 클래스 분류 문제로 재해석하여 단일 클래스 SVM의 대표적 모델인 SVDD를 탐지기로 설계하였다. 제안된 시스템은 H.264 압축 과정에서 얻어지는 움직임 벡터를 이용함으로써, 실시간성을 보장하며 SVDD의 점증적 갱신 학습 능력으로 인하여 비정상 집단행동 데이터베이스의 변화에도 능동적으로 적응할 수 있다. 공개적으로 사용 가능한 벤치마크 데이터 셋인 PETS 2009와 UMN을 이용하여 본 논문에서 제안한 비정상 집단행동 탐지 시스템의 성능을 실험적으로 검증한다.

• The Korean Journal of Physiology and Pharmacology
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• 제20권3호
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• pp.253-259
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• 2016

Previously, we found that KTH-13 isolated from the butanol fraction of Cordyceps bassiana (Cb-BF) displayed anti-cancer activity. To improve its antiproliferative activity and production yield, we employed a total synthetic approach and derivatized KTH-13 to obtain chemical analogs. In this study, one KTH-13 derivative, 4-(tert-butyl)-2,6-bis(1-phenylethyl)phenol (KTH-13-t-Bu), was selected to test its anti-cancer activity. KTH-13-t-Bu diminished the proliferation of C6 glioma, MDA-MB-231, LoVo, and HCT-15 cells. KTH-13-t-Bu induced morphological changes in C6 glioma cells in a dose-dependent manner. KTH-13-t-Bu also increased the level of early apoptotic cells stained with annexin V-FITC. Furthermore, KTH-13-t-Bu increased the levels of cleaved caspase-3 and -9. In contrast, KTH-13-t-Bu upregulated the levels of pro- and cleaved forms of caspase-3, -8, and -9 and Bcl- 2. Phospho-STAT3, phospho-Src, and phospho-AKT levels were also diminished by KTH13-t-Bu treatment. Therefore, these results strongly suggest that KTH-13-t-Bu can be considered a novel anti-cancer drug displaying pro-apoptotic activity.

• 한국동물학회지
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• 제35권1호
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• pp.17-22
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• 1992

The three yolk polypeptides have been isolated and partially characterized. Their molecular weights of YPI, YP2, and YP3 were 48, 000, 47, 000, and 46, 000, respectivelv, as judged by SDS-polyacrvlamide gel electrophoresis. They have different digestion products upon in situ peptide mapping by limited proteolysis. Two-dimensional gel electrophoresis showed that their isoelectric points were heterogeneous from 5.92 to 6.54. And thew showed three different antigen-antibody reactions when each polvpeptides is reacted with antisera made to a mixture of all of three. These data reported here indicate that the yolk proteins are consisted of distinctive polypeptides in Drosophlla sp. (robusta species group).

• Journal of Biosystems Engineering
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• 제35권1호
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• pp.37-45
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• 2010

Since SRC (Short-term Rotation Coppice) such as poplar and willow can be harvested in three years, they are known to be a potential forest biomass as fuel for a power plant. The production system including transplanting and harvesting is, however, necessary to be mechanized because such a biomass should be handled in a massive volumetric size. A pull-type stem-cutting transplanter was developed in the research as the first step to realize the production of SRC. A needle-like transplanting device pushes a stem-cutting into the prepared soil bed by a pneumatic cylinder, and another device firms soil around a stem-cutting transplanted. Since this is an intermittent operation, it was necessary to develop a zero horizontal velocity mechanism which enabled only the transplanting needle part to continue a zero horizontal movement relative to the ground during the transplanting operation even when the tractor kept moving forward. The 2-row transplanter can transplant stem-cuttings at the rate of 6.5 seconds per row without missing a single attempt. The planting depth and distance were well maintained and controlled. Their CVs were between 2.1~3.4% and 0.87~1.7% for the depth and the distance, respectively. Although, the transplanted stem-cuttings tended to lean outward from the back-view and forward from the side view, they were planted within the range of $3^{\circ}$ from the upright position.

• International Journal of Oral Biology
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• 제39권3호
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• pp.131-136
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• 2014

Porphyromonas gingivalis is one of the most important periodontal pathogens and has been to known to invade various types of cells, including endothelial cells. The present study investigated the mechanisms involved in the internalization of P. gingivalis in human umbilical vein endothelial cells (HUVEC). P. gingivalis internalization was reduced by clathrin and lipid raft inhibitors, as well as a siRNA knockdown of caveolin-1, a principal molecule of lipid raft-related caveolae. The internalization was also reduced by perturbation of actin rearrangement, while microtubule polymerization was not required. Furthermore, we found that Src kinases are critical for the internalization of P. gingivalis into HUVEC, while neither Rho family GTPases nor phosphatidylinositol 3-kinase are required. Taken together, this study indicated that P. gingivalis internalization into endothelial cells involves clathrin and lipid rafts and requires actin rearrangement associated with Src kinase activation.

• 동의생리병리학회지
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• 제35권5호
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• pp.177-184
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• 2021

The root bark of Morus alba L. (MA) used in traditional oriental medicine for the treatment of pulmonary diseases exerts various pharmacological activities including anticancer effects. In the current study, we investigated the effects of MA on the migration and invasion of colorectal carcinoma cells. Results from a transwell assay showed that the methylene chloride extract of MA (MEMA) suppressed the migration and invasion of HCT116 human colorectal carcinoma cells in a concentration-dependent manner. MEMA reduced both mRNA and protein levels of matrix metalloproteinase (MMP)-9, but did not suppress the expression of MMP-2 in HCT116 cells. As a molecular mechanism, MEMA inhibited the phosphorylation of mitogen-activated protein kinases (MAPKs), including ERK, JNK and p38, in a dose-dependent manner. In addition, MEMA dephosphorylated both Src and signal transducer and activator of transcription 3 (STAT3) in HCT116 cells. Taken together, we demonstrate that MEMA suppressed the migration and invasion capacity of HCT116 human colorectal cancer cells by downregulation of MMP-9 and inactivation of both MAPKs and Src/STAT3 signaling pathway.

• 한국강구조학회 논문집
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• 제29권2호
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• pp.147-158
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• 2017

본 연구에서는 볼트조립 앵글을 적용한 선조립 합성기둥(이하 PSRC 합성기둥)의 압축성능을 연구하였다. 2/3 축소비율의 PSRC 기둥실험체 4개와 기존 SRC 기둥실험체 2개에 대하여 중심축 압축실험을 수행하였다. 횡보강재의 수직간격 및 단면형상과 앵글의 단면형상을 실험변수로 고려하였다. 실험결과, PSRC 기둥실험체는 기존 SRC 기둥실험체와 비교하여 비슷한 압축하중 재하능력 및 변형능력을 발휘하였다. PSRC 합성기둥의 경우, 횡방향 강판의 좁은 횡보강 간격과 Z형 단면의 강판이 압축강도 및 변형능력 향상에 효과적인 것으로 나타났다. 또한 PSRC 합성기둥은 현행설계기준에 의한 공칭 압축강도보다 큰 압축하중 재하능력을 나타내었다. 실험체들에 대한 수치해석결과는 피복 콘크리트 탈락으로 인한 하중감소를 제외하고 초기강성 및 하중재하능력을 비교적 잘 예측하였다.