• Interdisciplinary Bio Central
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• v.4 no.2
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• pp.3.1-3.7
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• 2012

Epidermal growth factor receptor (EGFR) is a member of the ErbB family (ErbB1-4) of receptor tyrosine kinases (RTKs). EGFR controls numerous physiological functions, including cell proliferation, migration, differentiation and survival. Importantly, aberrant signaling by EGFR has been linked to human cancers in which EGFR and its various ligands are frequently overexpressed or mutated. EGFR coordinates activation of multiple downstream factors and is subject of various regulatory processes as it mediates biology of the cell it resides in. Therefore, many studies have been devoted to understanding EGFR biology and targeting the protein for the goal of controlling tumor in clinical settings. Endocytic regulation of EGFR offers a promising area for targeting EGFR activity. Upon ligand binding, the activated receptor undergoes endocytosis and becomes degraded in lysosome, thereby terminating the signal. En route to lysosome, the receptor becomes engaged in activating various signaling pathways including PI-3K, MAPK and Src, and endocytosis may offer both spatial and temporal regulation of downstream target activation. Therefore, endocytosis is an important regulator of EGFR signaling, and increasing emphasis is being placed on endocytosis in terms of cancer treatment and understanding of the disease. In this review, EGFR signaling pathway and its intricate regulation by endocytosis will be discussed.

• The Korean Journal of Applied Statistics
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• v.15 no.1
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• pp.165-177
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• 2002

This poper proposes a manpower cultivation index(MCI) which can be used for evaluating how much a research project contributes for manpower cultivation. The four factors which are considered to influence the manpower cultivation are the number of participated graduate students(research assistants) , the number of graduate students who obtain master or Ph. D. degrees among the participated graduate students in the research project, the number of research papers published by participated graduate students, and the number of graduate students who get jobs. By the proposed MCI, three major research projects of KOSEF are analysed in terms of manpower cultivation. These are SRC/ERC(Science research center/Engineering research center) and RRC(Regional research center) and OBR(Objective based research) . The computed MCls show that the three major research projects enjoy satisfactory manpower cultivation to some extent.

• The Transactions of the Korean Institute of Power Electronics
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• v.23 no.1
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• pp.24-31
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• 2018

An induction heating (IH) resonant converter, as well as its coil design method, is proposed in this study to improve the heat capability of low- and high-resistance IH vessels. Conventional IH resonant converters have been designed only for heating high-resistance containers designed for IH application. Thus, the primary current in the resonant tank becomes extremely high to transfer the rated power when the converter heats the low-resistance vessel. As a result, the rated power cannot be transferred due to overcurrent flows against the rated switch current. Hence, the optimal number of coil turns and proper operating frequency to heat high- and low-resistance vessels are proposed in this study by analyzing an IH load model. Simulation and experimental results using a 2.4 kW prototype resonant converter and its IH coil validate the proposed design.

• International Journal of High-Rise Buildings
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• v.6 no.1
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• pp.33-47
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• 2017

This mixed-use Raffles City (RCH) development is located near the Qiantang River in Hangzhou, the capital of Zhejiang province, located southwest of Shanghai, China. The project incorporates retail, offices, housing, and hotel facilities and marks the site of a cultural landscape within the Quianjiang New Town Area. The project is composed of two 250-meter-tall twisting towers with a form of vibrant waves, along with a commercial podium and three stories of basement car parking. It reaches a height of 60 stories, presenting views both to and from the Qiantang River and West Lake areas, with a total floor area of almost 400,000 square meters. A composite moment frame plus concrete core structural system was adopted for the tower structures. Concrete filled steel tubular (CFT) columns together with steel reinforced concrete (SRC) beams form the outer moment frame of the towers' structure. The internal slabs and floor beams are of reinforced concrete. This paper presents the engineering design and construction of this highly complex project. Through comprehensive discussion and careful elaboration, some conclusions are reached, which serve as a reference guide for the design and construction of similar free-form, hybrid, mix-use buildings.

• The Transactions of the Korean Institute of Power Electronics
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• v.19 no.1
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• pp.57-63
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• 2014

In this paper a bidirectional DC-DC converter is proposed for renewable energy systems, eco-friendly vehicles, energy storage systems, uninterruptible power supply(UPS) systems and battery test equipments. The two-stage bidirectional converter employing a fixed-frequency series loaded resonant converter is designed to be capable of operating under zero-current-switching turn on and turn off regardless of voltage and load variation, and hence its magnetic components and EMI filters can be optimized. And efficiencies and volumes of the two-stage bidirectional converters are compared according to configuration of isolated and non-isolated parts and a two-stage topology suitable for low voltage and high current applications is proposed. A 12kW(12V, 1000A) prototype of the proposed converter has been built and tested to verify the validity of the proposed operation.

• Animal cells and systems
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• v.5 no.2
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• pp.145-151
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• 2001

p62 is a phosphotyrosine-independent ligand of the SH2 domain of $p56^{Ick}$, a T-cell specific Src family tyrosine kinase. Recently p62 has been shown to interact with a number of proteins, such as $PKC\varsigma$ and ubiquitin, and implicated in important cellular functions such as cell proliferation. Since the two p62 interacting proteins, $p56^{Ick}$ and $PKC\varsigma$, have been reported to play roles in cell death, 1 have addressed the potential role of p62 during apoptosis in Jurkat cells in this study. Herein 1 show that p62 was specifically cleaved into two peptides by a caspase-3-like activity during Fas-receptor mediated apoptosis in Jurkat cells. This cleavage generated two fragments with molecular weights of about 35 kDa that differed in subcellular localizations. The N-terminal cleaved fragment was present in the detergent-insoluble fraction whereas the C-terminal fragment was found in the detergent-soluble fraction. In addition, the C-terminal fragment appeared to be subjected to further degradation as apoptosis prolonged. Moreover, overexpression of p62 in Jurkat cells attenuated the Fas receptor mediated apoptosis, suggesting that p62 is involved in apoptotic signal transduction pathway in lymphocytes.

• Proceedings of the Korean Environmental Sciences Society Conference
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• 2020.10a
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• pp.221-221
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• 2020

Curcumin, a hydrophobic polyphenol derived from turmeric, has been used a food additive and as a herbal medicine for the treatment of various diseases. In the present study, we found the functional role of a nanosphere loaded with curcumin (CN) in the promotion of the motility of human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) during the wound closure. We found that the efficacy of hUCB-MSCs migration induced by CN was 1000-fold higher than that of curcumin powder. CN significantly increased the motility of hUCB-MSCs by activating c-Src, which is responsible for the phosphorylation of protein kinase C (PKC) and extracellular signal-regulated kinase (ERK). CN induced the expression levels of α-actinin-1, profilin-1 and filamentous-actin, as regulated by the phosphorylation of nuclear factor-kappa B during its promotion of cell migration. In a mouse skin excisional wound model, we found that transplantation of UCB-MSCs pre-treated with CN enhances wound closure, granulation, and re-epithelialization at mouse skin wound sites. These results indicate that CN is a functional agent that promotes the mobilization of UCB-MSCs for cutaneous wound repair.

• Structural Engineering and Mechanics
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• v.88 no.1
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• pp.25-42
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• 2023

This paper presents a finite element (FE) simulation of eccentrically loaded lightweight aggregate concrete-encased steel (LACES) columns with H-shaped steel sections, analytical equations are also established to estimate the columns' axial and bending moment interaction capacities. The validity of the proposed models is checked by comparing the results with experimental data. Good agreements between the test and proposed models' results are found with acceptable agreements. Moreover, design parameters, including the lightweight aggregate concrete (LWAC) strength, eccentricity, column slenderness ratio, and confinement, are studied using the FE analysis, and their efficiency factors are discussed. The results show that the ultimate axial capacity of the LACES composite columns subjected to eccentric loading is negatively affected by the increase in the columns' height, but it is positively affected by the increase of the confinement. Increasing the eccentricity and columns' height reduced the columns'stiffness. In addition, the ultimate capacity of the LACES column is significantly influenced by the LWAC strength and eccentricity, where the ultimate capacity of the LACES column is significantly increased by increasing LWAC strength, and it is remarkably decreased by increasing the eccentricity. When the eccentricity changed from zero to 70 mm, the ultimate axial capacity and stiffness decreased by 67.97% and 63.56%, respectively.

• Journal of Navigation and Port Research
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• v.48 no.2
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• pp.125-136
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• 2024

This research presents an innovative integrated ethanol solid oxide fuel cell (SOFC) system designed for applications in marine vessels. The system incorporates an exhaust gas heat recovery mechanism. The high-temperature exhaust gas produced by the SOFC is efficiently recovered through a sequential process involving a gas turbine (GT), a regenerative system, steam Rankine cycles, and a waste heat boiler (WHB). A comprehensive thermodynamic analysis of this integrated SOFC-GT-SRC-WHB system was performed. A simulation of this proposed system was conducted using Aspen Hysys V12.1, and a genetic algorithm was employed to optimize the system parameters. Thermodynamic equations based on the first and second laws of thermodynamics were utilized to assess the system's performance. Additionally, the exergy destruction within the crucial system components was examined. The system is projected to achieve an energy efficiency of 58.44% and an exergy efficiency of 29.43%. Notably, the integrated high-temperature exhaust gas recovery systems contribute significantly, generating 1129.1 kW, which accounts for 22.9% of the total power generated. Furthermore, the waste heat boiler was designed to produce 900.8 kg/h of superheated vapor at 170 ℃ and 405 kP a, serving various onboard ship purposes, such as heating fuel oil and accommodations for seafarers and equipment.

• 재활복지
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• v.17 no.4
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• pp.401-420
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• 2013

This study was performed to investigate the impact of the Neurocognitive Rehabilitation Therapy on the upper limb function recovery of patients with stroke and their abilities to perform daily activities and to provide basic data for a long-term treatment. A total of 30 patients with hemiplegia that occurred due to stroke were recruited as subjects of the present study, and 15 patients were randomly assigned to a Neurocognitive Rehabilitation Therapy group and a conventional treatment group, respectively. And, tests were performed over four weeks, five times a week, and 30 minutes a session. Manual Function Test(MFT), Fugl-Meyer Assessment Scale(FMA), and Korean-Modified Bathel Index(K-MBI) were used to measure the degree of the functional recovery before and after the experiment. According to the data of this study, in the upper limb function test, the Neurocognitive Rehabilitation Therapy group showed significant increase of the measurement values of MFT and FMA(p <.05), and when the difference between the two groups were compared, the upper limb function showed a statistically significant difference. In the daily activity performance test, only the Neurocognitive Rehabilitation Therapy group showed a significant improvement of K-MBI value(p <.05). Based on the results of the present study, it was demonstrated that the Neurocognitive Rehabilitation Therapy was effective in enhancing the upper limb functions and daily activity performance of patients with stroke.