• Journal of Nutrition and Health
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• v.53 no.1
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• pp.1-12
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• 2020

Purpose: Diabetic nephropathy is one of the most important diabetic complications prompted by chronic hyperglycemia, characterized by glomerulosclerosis, tubular fibrosis, and it eventually causes kidney failure. Nobiletin is a polymethoxyflavone present in tangerine and other citrus peels, and has anti-cancer and anti-inflammatory effects. This study investigated the effects of nobiletin on glomerular fibrosis through inhibition of the transforming growth factor (TGF)-β1-Src-caveolin-1 pathway. Methods: Human renal mesangial cells (HRMC) were incubated in media containing 33 mM glucose with or without 1-20 uM nobiletin for 3 day. The cellular expression levels of fibrogenic collagen IV, fibronectin, connective tissue growth factor (CTGF), TGF-β1, Src and caveolin-1 were all examined. In addition, TGF-β1, Src and caveolin-1 proteins were screened to reveal the relationship among TGF-β1-Src-caveolin-1 signaling in glomerular fibrosis. Results: High glucose promoted the production of collagen IV, fibronectin and CTGF in HRMC, which was inhibited in a dose dependent manner by 1-20 uM nobiletin. The Western blot data showed that high glucose elevated the expression of TGF-β1, Src, caveolin-1 and Rho GTPase. When nobiletin was treated to the HRMC exposed to high glucose, the expression of TGF-β1-Src-caveolin-1 was dampened. Finally, TGF-β1-Src-caveolin-1 signaling pathway was activated in high glucose-exposed HRMC, and such activation was encumbered by nobiletin. Conclusion: These result demonstrated that nobiletin blunted high glucose-induced extracellular matrix accumulation via inhibition of the TGF-β1-Src-caveolin-1 related intracellular signaling pathway. Nobiletin may be a potent renoprotective agent to counteract diabetes-associated glomerular fibrosis that leads to kidney failure.

• Journal of the Korean GEO-environmental Society
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• v.14 no.1
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• pp.23-32
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• 2013

Currently, the west coast has focused on large-scale investment and development, such as harbor construction work and land reclamation projects, with soft ground grouting issues being the major concern. In addition, grouting for soft ground reinforcement is definitely considered that construction purpose, soil condition, construction situation, and construction costs. The SRC method, which is a high pressure injection method, can easily produce well-distributed strength regardless of soil characteristics and is environmentally friendly. Therefore in this study, the SRC method was applied to marine clay on the west coast where located Jeongok-ri, Seosin-myeon, Hwaseong-si, Gyeonggi-do, Korea as well as estimated of the ground reinforcement and the application on the site. The results of the application on the site by SRC method indicated age 28 day strength is $14,700{\sim}31,800kN/m^2$ which is satisfied the criterion of unconfined compressive strength that more than $5,333kN/m^2$. Therefore the result that the SRC method constructed marine clay on the west coast indicated the outstanding strength as well as excellent durability.

• Proceedings of the Korean Information Science Society Conference
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• 2011.06d
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• pp.241-242
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• 2011

SRC 프로토콜은 BCDCP 클러스터 라우팅 기법과 페어와이즈 키와 디지털서명을 이용한 키 분배 프로토콜을 결합한 클러스터링 기반 보안 프로토콜이며, 초기 키 생성 및 분배, 주기적인 키 재 생성, 센서 추가 및 센서 단계로 구성되어 있다. 본 논문에서는 SRC 프로토콜의 한계점인 페어와이즈 키의 선분배를 이용한 보안방법의 개선과 에너지 사용량을 개선하기 위한 초기 키 생성 및 분배단계를 분리하여 초기 키 생성 단계와 분배단계를 제시한다.

• Steel and Composite Structures
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• v.19 no.6
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• pp.1561-1580
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• 2015

No significant improvement has been observed on the seismic performance of the ordinary steel reinforced concrete (SRC) columns compared with the reinforced concrete (RC) columns mainly because I, H or core cross-shaped steel cannot provide sufficient confinement for core concrete. Two improved SRC columns by constructing with new-type section steel were put forward on this background: a cross-shaped steel whose flanges are in contact with concrete cover by extending the geometry of webs, and a rotated cross-shaped steel whose webs coincide with diagonal line of the column's section. The advantages of new-type SRC columns have been proved theoretically and experimentally, while construction measures and seismic behavior remain unclear when the new-type columns are joined onto SRC beams. Seismic behavior of SRC joints with new-type section steel were experimentally investigated by testing 5 specimens subjected to low reversed cyclic loading, mainly including the failure patterns, hysteretic loops, skeleton curves, energy dissipation capacity, strength and stiffness degradation and ductility. Effects of steel shape, load angel and construction measures on seismic behavior of joints were also analyzed. The test results indicate that the new-type joints display shear failure pattern under seismic loading, and steel and concrete of core region could bear larger load and tend to be stable although the specimens are close to failure. The hysteretic curves of new-type joints are plumper whose equivalent viscous damping coefficients and ductility factors are over 0.38 and 3.2 respectively, and this illustrates the energy dissipation capacity and deformation ability of new-type SRC joints are better than that of ordinary ones with shear failure. Bearing capacity and ductility of new-type joints are superior when the diagonal cross-shaped steel is contained and beams are orthogonal to columns, and the two construction measures proposed have little effect on the seismic behavior of joints.

• 한국방재학회:학술대회논문집
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• 2009.02b
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• pp.67.2-67.2
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• 2009

• Proceedings of the Korean Society of Embryo Transfer Conference
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• 2003.10a
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• pp.66-66
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• 2003

• Proceedings of the Korean Information Science Society Conference
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• 2011.06a
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• pp.458-461
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• 2011

본 논문에서는 요주의 인물 식별 시스템의 서브시스템으로 SRC 기반의 실시간 정면 얼굴 탐지 시스템을 제안한다. 제안된 시스템은 개선된 피부색 탐지기를 통해 실시간으로 입력되는 영상의 이미지로부터 얼굴 탐지 범위를 축소하고, 단계형 분류기를 통해 얼굴 여부를 빠른 속도로 탐지함으로써 실시간 탐지가 가능케 하였다. 또한 최근 얼굴 인식 분야에서 성공적인 업적을 보여주고 있는 신호 처리 분야의 SRC를 이용하여 정면 얼굴, 비정면 얼굴, 그리고 비얼굴을 분류하여 정면 얼굴만을 출력함으로써 정면 얼굴 탐지율을 높힌다. 공인된 벤치마킹 데이터인 FEI Face Database을 사용하여 제안된 SRC 기반의 정면 얼굴 탐지 시스템의 성능을 실험적으로 평가한다.

• Proceedings of the Korea Concrete Institute Conference
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• 2005.05a
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• pp.423-426
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• 2005

Steel reinforced concrete (SRC) columns, which are widely employed in high-rise buildings, exhibit particular time-dependent behavior due to creep and shrinkage of the concrete, and this behavior may cause problems related to serviceability and structural stability. SRC columns also exhibit a time-dependent, cross-sectional relative humidity distribution that differs from reinforced concrete (RC) columns, due to the presence of an inner steel plate, which interferes with the moisture diffusion of concrete. This differential moisture distribution of SRC columns may reduce the drying shrinkage and the drying creep as contrasted with RC columns. Therefore, we propose that the differential moisture distribution be taken into account to accurately predict SRC column shortening.

• YAKHAK HOEJI
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• v.52 no.5
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• pp.370-375
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• 2008

In this study, the anti-allergic activity and mechanim of Salviae radix (SR) were investigated. The ethanol extract of SR showed significant inhibitory effect on degranulation from antigen-stimulated mast cells and it also inhibited the expression and secretion of TNF-${\alpha}$ and IL-4 in antigen-stimulated RBL-2H3 cells. In the mast cell-mediated local animal allergy model, it suppressed the passive cutaneous anaphylaxis in a dose-dependent manner. As its mechanism of action, SR inhibited the activating phosphorylation of Syk, a downstream signaling molecule of Src-family kinase, for the activation of mast cells. The results of the study indicate that the anti-allergic activity of SR is mediated by the inhibition of Src-family kinase in mast cells.

• Steel and Composite Structures
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• v.20 no.2
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• pp.295-316
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• 2016

This paper presents the results of experimental investigation, numerical calculation and theoretical analysis on axial compression ratio limit values for steel reinforced concrete (SRC) special shaped columns. 17 specimens were firstly intensively carried out to investigate the hysteretic behavior of SRC special shaped columns subjected to a constant axial load and cyclic reversed loads. Two theories were used to calculate the limits of axial compression ratio for all the specimens, including the balanced failure theory and superposition theory. It was found that the results of balanced failure theory by numerical integration method cannot conform the reality of test results, while the calculation results by employing the superposition theory can agree well with the test results. On the basis of superposition theory, the design limit values of axial compression ratio under different seismic grades were proposed for SRC special shaped columns.