• 동국한의학연구소논문집
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• 제8권1호
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• pp.35-49
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• 1999

본 연구는 계지복령환이 고 Cholesterol 식이 생쥐의 간과 신장에 미치는 항산화 효과를 조사하였다. 실험동물은 3개의 군(정상군 대조군 실험군)으로 나누었으며 정상군은 마우스용 고형사료와 물을 제한 없이 공급하고, 대조군은 Cholestrol 고형사료(cholesterol 5g/kg)를 제한 없이 8주간 공급하면서 7, 8주에 각각 처치하였다. 실험군은 물과 Cholesterol 고형사료를 제한 없이 6주간 공급한 후 계지복령환을 2주간 음용(20cc/day)시키면서 1, 2주에 각각 처치시켰다. 대조군은 lipid peroxidation(LPO) 함량은 증가하였고 glutathion(GSH) 함량, catalase와 superoxidation dismutase(SOD)의 활성은 감소하였음을 관찰할 수 있었다. 실험군은 대조군에 비해 lipid peroxidation(LPO) 함량은 유의성있게 감소하였고 glutathion(GSH) 함량, catalase와 superoxidation dismutase(SOD)의 활성은 유의성 있게 증가하였음을 확인할 수 있었다. 이 결과들로 보아 계지복령환이 지질의 과산화를 억제하고 glutathion(GSH)과 같은 체내 항산화 물질을 증가시키는 효과가 있다고 사료된다.

• 동의생리병리학회지
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• 제17권2호
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• pp.436-442
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• 2003

In order to examine the antioxidant actions of YMJHT, the study was done through measurement of parameters such as LPO(lipidperoxidation), GSH(glutathione), SOD(superoxidation dismutase), catalase, GOT, GPT, ALP, the results were obtained as follows: For the weight changes, in the testis the group given YMJHT showed significant increase compared to the control group. In the left cerebrum, the group given YMJHT showed significant increase compared to the control group on the activities of SOD, catalase. In the right cerebrum, the group given YMJHT showed significant decrease on the content of LPO and showed significant increase on the activity of catalase. In the cerebellum, the group given YMJHT showed significant decrease on the content of LPO and showed significant increase on the activities of SOD, catalase. In the liver, the group given YMJHT showed significant decrease on the content of GSH and showed significant increase on the activity of SOD. In the kidney, the group given YMJHT showed significant decrease on the contents of GSH, GSH and showed significant increase on the activities of SOD, catalase. In the testis, the group given YMJHT showed significant decrease on the contents of LPO, GSH and showed significant increase on the activity of SOD. From above results, the antioxidant action of YMJHT is effective. And it is expected to be necessary to the study of the mechanism in the antioxidant of YMJHT.

• 동의생리병리학회지
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• 제17권2호
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• pp.356-362
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• 2003

In order to examine the antioxidant activities of SJDBT(Sibjeondaebo-tang), the study was done through measurement of parameters such as LPO(lipidperoxidation), GSH(glutathione), SOD(superoxidation dismutase), catalase, GOT, GPT, ALP. The results were obtained as follows: For the weight changes, the kidney and testis of group given SJDBT showed decrease in the weight compared to the control group, and the left cerebrum, right cerebrum, cerebellum and liver of group given SJDBT showed increase. But the changes were not significant. The left cerebrum and right cerebrum of group given SJDBT showed significant decrease in the content of LPO compared to the control group, and in the activity of SOD and catalase showed significant increase. The cerebellum of group given SJDBT showed significant decrease in the content of LPO and GSH compared to the control group, and in the activity of SOD and catalase showed significant increase. For the changes of LPO, GSH in the liver, the group given SJDBT showed significant decrease in the content of LPO and GSH compared to the control group, and in the activity of catalase showed significant increase. For the changes of LPO in the kidney, the group given SJDBT showed significant decrease in the content of LPO compared to the control group. For the changes of LPO, GSH and the activity of SOD, catalase in the testis, the group given SJDBT showed significant decrease in the content of LPO and GSH compared to the control group, and in the activity of SOD and catalase showed significant increase. From above results, the antioxidant action of SJDBT is effective. And it is expected to be necessary to the study of the mechanism in the antioxidant of SJDBT.