• 제목/요약/키워드: SNF

검색결과 167건 처리시간 0.028초

Atypical Teratoid Rhabdoid Tumour : From Tumours to Therapies

  • Richardson, Elizabeth Anne;Ho, Ben;Huang, Annie
    • Journal of Korean Neurosurgical Society
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    • 제61권3호
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    • pp.302-311
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    • 2018
  • Atypical teratoid rhabdoid tumours (ATRTs) are the most common malignant central nervous system tumours in children ${\leq}1year$ of age and represent approximately 1-2% of all pediatric brain tumours. ATRT is a primarily monogenic disease characterized by the bi-allelic loss of the SMARCB1 gene, which encodes the hSNF5 subunit of the SWI/SNF chromatin remodeling complex. Though conventional dose chemotherapy is not effective in most ATRT patients, high dose chemotherapy with autologous stem cell transplant, radiotherapy and/or intrathecal chemotherapy all show significant potential to improve patient survival. Recent epigenetic and transcriptional studies highlight three subgroups of ATRT, each with distinct clinical and molecular characteristics with corresponding therapeutic sensitivities, including epigenetic targeting, and inhibition of tyrosine kinases or growth/lineage specific pathways.

Advanced Polymer Technology of OCI -SNF for Papermaking

  • 손동진;윤지현;류정용;김봉용
    • 한국펄프종이공학회:학술대회논문집
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    • 한국펄프종이공학회 2011년도 춘계학술발표회 논문집
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    • pp.39-39
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    • 2011
  • 산림자원의 부족현상이 갈수록 심화됨에 따라, 재활용폐지를 원료로 활용하는 비율이 증가되고 있으며, 재활용 폐지의 품질도 지속적으로 악화되어 제지 환경이 점점 어려워지고 있다. 이에 최근에 개발되어 지대지, 라이너 판지등에 적용하여 강도상승 목적으로 사용중인 호프만계 폴라비닐아민에 대한 성능평가 결과를 고찰하고자한다. 호프만계 폴리비닐아민의 가장 큰 장점은 투입량을 증량하여도 종이의 Formation에 악영향을 마치지 않고 효과적으로 내절도, 파열강도등 강도적 적성이 향상되므로 응용 범위가 점차 확대되고 있다. 이와 더불어 제지환경이 점점 어려워짐에 따라, 보류 및 탈수 향상등 제지 공정개선제로 많이 사용되는 파우더 및 에멀젼의 성능 고도화가 절실히 요구되고 있으며, OCI-SNF의 개선 사례를 살펴보고자한다.

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Isolation and Characterization of New Family Genes of DNA Damage in Fission Yeast

  • Choi, In-Soon
    • 한국환경성돌연변이발암원학회지
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    • 제19권1호
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    • pp.28-33
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    • 1999
  • The SNF2 family includes proteins from a variety of species with roles I cellular processes such as transcriptional regulation, recombination and various types of DNA repair. Several proteins with unknown function are also included in this family. Here, we report the cloning and characterization of hrp 2+ gene (helicase related gene from S. pombe) which was isolated by PCR amplication using the conserved domain of SNF2 motifs within the ERCC6 gene which encodes a protein involved in DNA excision repair. The hrp2+ gene was isolated by screening with yeast S. pombe genomic library. The isolated cloned contained 6.5 kb insert DNA. Southern blot analysis confirmed that S. pombe chromosome contains the same DNA as hrp2+ gene and this gene exists as a single copy in S. pombe genome. The 4.7 kb transcript of mRNA was identified by Northern blot. To examined the transcriptional regulation of hrp2+ gene, DNA damaging agents were treated. These results indicated that the hrp2+ gene may not be directly involved in DNA replication, but may be involved in damage response pathway.

Measures for the Failure Evaluation of SNF Cladding During the Transportation

  • Noh, J.S.;Kim, H.A.;Kim, T.W.
    • 한국방사성폐기물학회:학술대회논문집
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    • 한국방사성폐기물학회 2018년도 추계학술논문요약집
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    • pp.105-106
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    • 2018
  • It is important to set up a reasonable failure criterion for cladding, because being able to determine the cladding integrity during transportation is essential for the evaluation of SNF transportation system. There are a few of measures which can be used as a failure criterion for cladding subjected to its specific failure mode. Therefore, to select and to use appropriate failure criterion measures, i.e. strain(UE), $K_{IC}$, and CSED would be a key in evaluating the cladding integrity during transportation with every aspects. In order to justify and quantify that criterion properly, various experiments for the mechanical properties of the claddings with different conditions shall be implemented, which data will enable to justify the failure criteria proposed.

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Thermal Analysis of Transportation and Storage Cask of Spent Nuclear Fuel for Forced Gas Drying Condition

  • Lim, Suk-Nam;Chae, Gyung-Sun;Han, Jae-Hyun;Park, Jae-Seok;Lee, Dong-Gyu
    • 한국방사성폐기물학회:학술대회논문집
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    • 한국방사성폐기물학회 2017년도 춘계학술논문요약집
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    • pp.153-154
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    • 2017
  • The thermal analysis of transportation and storage cask for SNF was conducted during short term loading operations for forced gas drying condition. The fuel cladding temperature in 6 regions of SNF in the cask during the short term loading operations for forced gas drying condition is shown in the Fig. 3. The thermal analysis results of calculated maximum cladding temperature in each process demonstrate that operating scenario of TFD in detailed design maintain well below the temperature limits of $400^{\circ}C$.

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An Analysis of Constraints on Pyroprocessing Technology Development in ROK Under the US Nonproliferation Policy

  • Jae Soo Ryu
    • 방사성폐기물학회지
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    • 제21권3호
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    • pp.383-395
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    • 2023
  • Since 1997, the Republic of Korea (ROK) has been developing pyro-processing (Pyro) technology to reduce the disposal burden of high-level radioactive waste by recycling spent nuclear fuel (SNF). Compared to plutonium and uranium extraction process, Korean Pyro technology has relatively excellent proliferation resistance that cannot separate pure plutonium owing to its intrinsic characteristics. Regarding Pyro technology development of ROK, the Bush administration considered that Pyro is not reprocessing under the Global Nuclear Energy Partnership, whereas the Obama administration considered that Pyro is subject to reprocessing. However, the Bush and Obama administrations did not allow ROK to conduct full Pyro activities using SNF, even though ROK had faithfully complied with international nonproliferation obligations. This is because the US nuclear nonproliferation policy to prevent the spread of sensitive technologies, such as enrichment and reprocessing, has a strong effect on ROK, unlike Japan, on a bilateral level beyond the NPT regime for non-proliferation of nuclear weapons.