• 제목/요약/키워드: SMRT

검색결과 48건 처리시간 0.032초

OPTHiS Identifies the Molecular Basis of the Direct Interaction between CSL and SMRT Corepressor

  • Kim, Gwang Sik;Park, Hee-Sae;Lee, Young Chul
    • Molecules and Cells
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    • 제41권9호
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    • pp.842-852
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    • 2018
  • Notch signaling is an evolutionarily conserved pathway and involves in the regulation of various cellular and developmental processes. Ligand binding releases the intracellular domain of Notch receptor (NICD), which interacts with DNA-bound CSL [CBF1/Su(H)/Lag-1] to activate transcription of target genes. In the absence of NICD binding, CSL down-regulates target gene expression through the recruitment of various corepressor proteins including SMRT/NCoR (silencing mediator of retinoid and thyroid receptors/nuclear receptor corepressor), SHARP (SMRT/HDAC1-associated repressor protein), and KyoT2. Structural and functional studies revealed the molecular basis of these interactions, in which NICD coactivator and corepressor proteins competitively bind to ${\beta}-trefoil$ domain (BTD) of CSL using a conserved ${\varphi}W{\varphi}P$ motif (${\varphi}$ denotes any hydrophobic residues). To date, there are conflicting ideas regarding the molecular mechanism of SMRT-mediated repression of CSL as to whether CSL-SMRT interaction is direct or indirect (via the bridge factor SHARP). To solve this issue, we mapped the CSL-binding region of SMRT and employed a 'one- plus two-hybrid system' to obtain CSL interaction-defective mutants for this region. We identified the CSL-interaction module of SMRT (CIMS; amino acid 1816-1846) as the molecular determinant of its direct interaction with CSL. Notably, CIMS contains a canonical ${\varphi}W{\varphi}P$ sequence (APIWRP, amino acids 1832-1837) and directly interacts with CSL-BTD in a mode similar to other BTD-binding corepressors. Finally, we showed that CSL-interaction motif, rather than SHARP-interaction motif, of SMRT is involved in transcriptional repression of NICD in a cell-based assay. These results strongly suggest that SMRT participates in CSL-mediated repression via direct binding to CSL.

도시권 지하철.전철의 운행평가 분석 (The assessment analysis of rail transit operation in Seoul metropolitan area)

  • 임강원
    • 한국경영과학회지
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    • 제1권1호
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    • pp.111-125
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    • 1976
  • This study investigates the one-year performance of the Seoul Metropolitan Rail Transit(SMRT) operation. It intends to provide a basic understanding for railway operation in Seoul Metropolitan Area and thereby for making rational transport policy. The paper is conceptually comprised of four sections; analysis of passenger travel characteristics; SMRT costing and traffic cost function: its operating characteristics in terms of finance and utilization; primary social benefits of SMRT and suggestions. In the first year of operation (1974), the average daily traffic was about 335,000, After the drastic increases of fare in both Subway and KNR rail-lines, the travel volume has been cut by almost 10 percent, though most pronounced on intra-Subway line. The spatial distribution of passengers indicates that travelers use the SMRT line mainly for uninterrupted direct travel toward the CBD. In the prospective costing, the opereting expenses are divided into three groups; those which vary directly with volume; those partially variable with volume; and those entirely unrelated to volume change, With this information, cost function was derived for varying schedules of operation. Primary social benefits of the SMRT are assessed, though preliminary. Account should be taken of the nature of common costs of the SMRT in fare-rate making, especially when much of the operating expenses are accounted for by the fixed costs such that the revenue may not readily turn into break-even. The accounting results of the one-year operation coincide reasonably well with the prospective costing estimates. According to the findings of this annd another travelers' behavior studies, managerial effort would bring more revenue gain to the SMRT than fare increase does, not to speak of greater social benefits by so doing.

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서울도시철도 신 열차제어시스템에 대한 연구 (A Study on New Train Control System of the SMRT(Seoul Metropolitan Rapid Transit Corporation))

  • 유근규;박종헌;안진성;김기춘;이상근
    • 한국철도학회:학술대회논문집
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    • 한국철도학회 2011년도 춘계학술대회 논문집
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    • pp.895-903
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    • 2011
  • The Seoul Metropolitan Rapid Transit Corporation(SMRT) is studying the New Train Control System based on Wireless Communication(CBTC System : Communication Based Train Control System) to overcome the limitations of the existing system and to deal with the switch to the new system. The SMRT's New Train Control System Based on three main elements(train position detecting, radio communication and train control) is being developed in 3 stages. Currently, the development of the train position detecting element with the RFID system and the train position detecting device and the radio communication element with RTIS and DSRC had been developed and equipped on 3 stations(Songpa~Garak Market~Munjeong, 7.3km) of Subway Line 8 in the pilot. Such a basic infrastructure of the SMRT's New Train Control System is having an efficiency test by using the real-time Train Monitoring System and Currently, the third element, the train control(ATP/ATO/ATS/Interlocking) for the study is in progress. Also, the developed system is expected to validate the performance and safety in the next three stage. This paper shows about major developments of the SMRT's New Train Control System and our future plans.

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서울특별시도시철도공사 STnF 구축과 성과 (SMRT STnF Construction and Performance)

  • 이종계;박종헌;김기춘
    • 한국철도학회:학술대회논문집
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    • 한국철도학회 2011년도 정기총회 및 추계학술대회 논문집
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    • pp.2573-2580
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    • 2011
  • SMRT(Seoul Metropolitan Rapid Transit Corporation) changed PC-oriented office system to Smart-Phone oriented mobile office system(STnF: SMRT Talk & Flash), and provided smart phone to all staffs. STnF make it possible not only voice communication between staff, but also to input and inquiry all kind of information related to work(ex: Facility maintenance, Rolling Stock management, office management, Finance, human resource etc.) based on smart phone. STnF conquers the limitation of time and space. All staffs can commute to the site directly to reduce moving time and to share information between staffs, so SMRT improve speed and reliability of work by making a quick decision and action on the spot. After introduction of STnF, within 1 year, the equipment failure ratio fell to 47%. Mobile office system reduced and level-off the step of approval. so enhanced civil customer service. Quantification and scientific movement of work make it fast evolution and development. These business improvement make it possible to put more outstanding manpower on new business and R&D project, and this contributes to company's management effectiveness.

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도시철도 실시간 모니터링 시스템 적용 사례 (Application of 5678SMRT Real-time Monitoring system)

  • 윤재관;박종헌;김기춘
    • 한국철도학회:학술대회논문집
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    • 한국철도학회 2011년도 정기총회 및 추계학술대회 논문집
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    • pp.737-747
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    • 2011
  • 5678SMRT has installed various sensor for operating conditions(field of electric, facilities, signal, communication equipment and track) and environment of Every Function Room for remotely detecting and monitoring. Installed sound sensor for analyzed after remotely heard the noise of every equipment at Every Function Room and temperature sensor for check the temperature condition of Every Function Room. Additional installed voltage sensor in signal equipment room for monitoring RF track-circuit's voltage condition. Installed displacement sensor at The Chungdam bridge's railway for measuring and monitoring track displacement caused by temperature change and Pan/Tilt camera at sub-station and drainage for remotely field monitoring. Installed sensor for each equipment's operating condition and failure at Every Function Room then periodic check of workforce turned to around-the-clock surveillance by sensor therefore improvement of operating equipment. SMRT is lots of prevent a failure by Immediately detect of precondition of equipment failure by analyzed the sensor data. If the occurrence of an failure, become detected Immediately so possibility correct diagnosis and order by remotely field check by installed camera and sound sensor at field.

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도시철도 7호선 연장 개통에 따른 경인선 수요변화 연구 (The effect of SMRT Line 7 extension on the demand of Gyongin Line)

  • 김익희;양유경
    • 한국철도학회:학술대회논문집
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    • 한국철도학회 2008년도 춘계학술대회 논문집
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    • pp.1407-1415
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    • 2008
  • Recently, there has been growing interest in Gyongin Line demand estimation, because SMRT(Seoul Metropolitan Rapid Transit Corporation) Line 7 will be extended west by 9.8km from Onsu to meet the Gyongin Line at Bupyeong-gu Office. This study was designed to estimate the change of traffic demand in Gyongin Line before and after the completion year 2011, also provide against the economic loss caused by the derived demand from Gyongin Line to SMRT Line 7. In this paper we give preliminary results for the strategic plans for traffic demand estimation and train operating plan in Gyongin Line by analyzing transport performance of Seoul metropolitan subway, and an additional study on the transportation market and the urban development plan is needed for more accurate results.

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도시철도 도면 관리에 관한 연구 -서울시 도시철도공사를 중심으로- (A study on the management of drawings of Metropolitan Rapid Transit)

  • 김미연
    • 기록학연구
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    • 제11호
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    • pp.181-214
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    • 2005
  • Metropolitan rapid transit system plays an essential role in the public transportation system of any large city, and its managing agency is usually charged with the responsibility of storing and managing the design drawings of the system. The drawings are important and historically valuable documents that must be kept permanently because they contain comprehensive data that is used to manage and maintain the system. However, no study has been performed in Korea on how well agencies are preserving and managing these records. Seoul Metropolitan Rapid Transit Corporation(SMRT) is the managing agency established by the city of Seoul to operate subway lines 5, 6, 7, and 8 more efficiently to serve its citizens. By the Act on Records Management in Public Institutions(ARMPI), SMRT should establish a records center to manage its records. Furthermore, all drawings produced by SMRT and other third party entities should be in compliance with the Act. However, SMRT, as a form of local public corporation, can establish a records center by its own way. Accordingly, the National Archives & Records Service(NARS) has very little control over SMRT. Therefore, the purpose of this study is to research and analyze the present state of storage and management of the drawings of metropolitan rapid transit in SMRT and is to find a desirable method of preservation and management for drawings of metropolitan rapid transit. In the process of the study, it was found that a records center is being considered to manage only general official documents and not to manage the drawings as required by ARMPI. SMRT does not have a records center, and the environment of management on the drawings is very poor. Although there is a plan to develop a new management system for the drawings, it will be non-compliant of ARMPI. What's happening at SMRT does not reflect the state of all other cities' metropolitan rapid transit records management systems, but the state of creation of records center of local public corporation is the almost same state as SMRT. There should be continuous education and many studies conducted in order to manage the drawings of metropolitan rapid transit efficiently by records management system. This study proposes a records center based on both professional records centers and union records centers. Although metropolitan rapid transit is constructed and managed by each local public corporation, the overall characteristics and processes of metropolitan rapid transit projects are similar in nature. In consideration of huge quantity, complexity and specialty of drawings produced and used during construction and operation of metropolitan rapid transit, and overlap of each local public corporation's effort and cost of the storage and management of the drawings, they need to be managed in a professional and united way. As an example of professional records center, there is the National Personnel Records Center(NPRC) in St. Louis, Missouri. NPRC is one of the National Archives and Records Administration's largest operations and a central repository of personnel-related records on former and present federal employees and the military. It provides extensive information to government agencies, military veterans, former federal employees, family members, as well as researchers and historians. As an example of union records center, there is the Chinese Union Dangansil. It was established by several institutions and organizations, so united management of records can be performed and human efforts and facilities can be saved. We should establish a professional and united records center which manages drawings of metropolitan rapid transit and provides service to researchers and the public as well as members of the related institutions. This study can be an impetus to improve interest on management of not only drawings of metropolitan rapid transit but also drawings of various public facilities.

시간지리학 관점에서 본 스마트워크 사례 연구 (A Case Study on Smart Work through the Lens of Time-Geography Theory)

  • 김용영
    • 경영정보학연구
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    • 제13권3호
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    • pp.99-121
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    • 2011
  • 모바일 정보기술의 발전으로 시간과 공간의 제약을 극복한 스마트워크의 시대가 열렸다. 조직에서는 똑똑한 단말기와 끊김없는 접속을 통해 스마트워크에 적합한 업무 방식과 서비스를 제공하고 있으며, 나아가 스마트워크를 활용하여 조직 활동과 조정 및 협업 프로세스를 재구성하고 있다. 이러한 활동을 통해 조직의 생산성과 성과를 극적으로 향상시키고 있으며, 스마트워크에 대한 관심도 고조되고 있다. 하지만 높은 관심에도 불구하고 스마트워크를 통해 극복된 시공간 제약조건을 체계적으로 설명하는 연구는 부족한 실정이다. 따라서 본 연구는 성공적으로 스마트워크를 구축하여 운영 중인 서울도시철도의 사례(SMRT T&F)를 시간지리학의 제약조건에 기반한 프레임워크를 통해 분석하였다. SMRT T&F 사례 분석을 통해 조직에서 시간과 공간의 제약조건을 극복하는 과정뿐 아니라 스마트워크를 성공적으로 구축하기 위해 필요한 성공 요인을 도출하였다. 또한 본 연구의 이론적 실무적 시사점을 밝히고, 향후 스마트워크 관련 연구 방안에 대해서도 제시하였다.

서울도시철도공사 터널모니터링 시스템의 운영성과와 과제 (Achievements and Tasks of the SMRT Tunnel Monitoring System(TMS))

  • 박종헌;김만화;박기환
    • 한국철도학회논문집
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    • 제15권4호
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    • pp.381-387
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    • 2012
  • 본 논문에서는 서울지하철 5~8호선에 운영 중인 터널모니터링 시스템의 운영성과를 분석 평가하고 개선방안을 제시하였다. 터널모니터링 시스템 도입으로 종래에는 열차운행이 끝나야만 가능했던 터널 내 시설물 점검이 주간에도 가능해졌다. TMS 도입으로 전에 비해 점검능력이 확대되었고, 정확성도 향상되었으며, 점검주기가 단축되었다. 인력활용 효율이 향상되어 중요 시설물에 대한 점검과 유지보수에 인력을 추가로 배치할 수 있게 되었다. 그 결과 예방정비 건수는 225% 증가하였고, 열차운행 장애는 53% 감소하였다.

도시철도 전동차량의 운행고장 데이터 분석을 통한 도어시스템 유지보수주기 결정 사례 연구 (A Case Study on Determining Doors Maintenance Intervals through Running Fault Data Analysis for Metro EMU)

  • 이덕규;김종운;이희성
    • 한국철도학회논문집
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    • 제11권3호
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    • pp.240-247
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    • 2008
  • 최근 들어 각 철도 운영기관들은 유지보수 정보 시스템을 구축하여 고장 및 유지보수 데이터를 수집하고 있다. 그 한 예로서 서울특별시도시철도공사(SMRT)에서는 전동차정보시스템(EMU-IS) 을 국내 최초로 개발하여 2000년 8월부터 본격적으로 사용을 시작하였다. 본 논문에서는 SMRT 전동차량 운영으로 EMU-IS에 모아진 운행, 정비, 고장 데이터를 분석하여 신뢰도를 평가하고 유지보수주기를 결정하는 사례를 다루었다. 그 사례로서 도어시스템의 주요 아이템에 대해 신뢰성을 시간 빛 거리 기준으로 평가하고 오버홀 주기를 결정하는 문제를 다루었다.