• 제목/요약/키워드: SMR

검색결과 361건 처리시간 0.029초

단삼(丹蔘)이 뇌조직출혈 흰쥐의 혈액뇌관문 손상에 미치는 영향 (Effects of Salviae Miltiorrhizae Radix on Blood-Brain Barrier Impairment of ICH-Induced Rats)

  • 박창훈;김연섭
    • 대한본초학회지
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    • 제29권1호
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    • pp.19-26
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    • 2014
  • Objectives : This study was performed in order to evaluate the effects of Salviae Miltiorrhizae Radix (SMR) water extract against the cerebral hemorrhage and the blood-brain barrier (BBB) impairment in the intracerebral hemorrhage (ICH). Method : ICH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type IV in Sprague-Dawley rats. SMR was orally given three times every 20 hours during 3 days after the ICH induction. Hematoma volume, water content of brain tissue and volume of evans blue leakage were examined. Myeloperoxidase (MPO) positive neutrophils and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) were observed with immunofluorescence labeling and confocal microscope. Results : SMR significantly reduced the hematoma volume of the ICH-induced rat brain. SMR significantly reduced the water content of brain tissue of the ICH-induced rat brain. SMR reduced the percentage of the evans blue leakage around the hematoma on the caudate putamen compared to the ICH group, especially on the cerebral cortex. SMR significantly reduced the volume of the evans blue leakage level in the peri-hematoma regions of the ICH-induced rat brain. SMR significantly reduced MPO positive neutrophils in the peri-hematoma regions of the ICH-induced rat brain. SMR reduced the TNF-${\alpha}$ expression in peri-hematoma regions of the ICH-induced rat brain. TNF-${\alpha}$ immuno-labeled cells were coincided with MPO immuno-labeled neutrophils in peri-hematoma regions of the ICH-induced rat brain. Conclusion : These results suggest that SMR plays a protective role against the blood-brain barrier impairment in the ICH through suppression of inflammation in the rat brain tissues.

Preventing of Bone Loss in Ovariectomized Rats by Salvia miltiorrhiza Radix Root Extract

  • Park, Sung-Hye
    • Preventive Nutrition and Food Science
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    • 제10권2호
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    • pp.156-160
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    • 2005
  • Salvia miltiorrhiza Radix root extracts (SMR) was evaluated for inhibition of the progress of bone loss induced by ovariectomy (OVX) in rats. We measured body weight and bone histomorphometry in sham, OVX and SMR-administered OVX rats. From light microscopic analyses, porous or erosive appearances were observed on the surface of trabecular bone of tibia in OVX rats, whereas those of the same bone in sham rats and in SMR-administered rats were composed of fine particles. The trabecular bone area and trabecular thickness in OVX rats were decreased by $50\%$ from those in sham rats, and these decreases were completely inhibited by administration of SMR for 7 weeks. In this study, the mechanical strength in femur neck was significantly enhanced by the treatment of SMR for 7 weeks. In OVX rats, free $T_3$ was normal in all cases, whereas free $T_4$ was significantly increased. Although there was no difference between OVX and SMR-administered rat in $T_3$ levels, we have found significant difference between them in $T_4$ level. These results strongly suggest that SMR may be beneficial for preventing bone loss in OVX rats.

공사에 따른 광장형 교차로의 교통운영방안 (Proposing New Traffic Operation Method at the Large Intersection Under Consturction)

  • 박용진;김종식
    • 대한교통학회지
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    • 제21권6호
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    • pp.57-65
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    • 2003
  • 본 연구는 지하철 역사 공사가 이루어지는 교통량이 많은 광장형 교차로에서의 공사중 처리 방안을 제시하는 것으로 대부분의 지하철 역사는 혼잡한 교차로에서 위치하게 되어 기존의 복공식 교통처리방안으로 할 경우에는 공사로 인한 차선감소와 차선변경으로 인한 차량지체나 사고의 위험성이 많으며 공사가 단계별로 이루어지기 때문에 공사기간도 길어지고 공사비용도 많이 소요된다. 따라서, 본 연구에서는 충분한 공사 작업공간의 확보와 원활한 교통소통을 제공하기 위하여 현대식 로터리에 신호운영을 도입한 방식(SMR)을 사례지점인 두류네거리에 적용하여 기존의 복공식 교통처리방안과 SMR방식에 대한 효율성을 비교${\cdot}$분석하였다. 신호로 운영되는 현대식 로터리(SMR)의 도입은 공사중 교통처리방안이 기존 복공식 교통처리방식과 대등한 교통처리 효과를 나타낼 수 있으면서, 공사를 위한 공간확보 및 공사비, 공사기간 절감 효과를 기대할 수 있는 교통처리방안이다. 본 연구에서 제시된 SMR방식은 기존의 교통처리방식의 문제점인 공사기간과 공사 작업공간 협소, 교통혼잡, 교통소통을 증진시키는 새로운 운영방식으로서 향후 광장형 교차로에서 지하철공사 뿐만 아니라 공사시 교통처리 방안으로서 광범위하게 적용될 수 있다.

반사층을 이용한 FBAR(SMR)의 제조 (Fabrication of FBAR (SMR) using Reflector)

  • 이재빈;곽상현;김형준;박희대;김영식
    • 한국재료학회지
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    • 제9권12호
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    • pp.1263-1269
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    • 1999
  • 본 실험에서는 반사층(reflector)을 이용한 FBAR (Film Bulk Acoustic Resonator) 즉, SMR (Solidly Mounted Resonator) 제조에 필요한 재료들의 최적 증착 조건을 설정하여, 이를 바탕으로 제조한 SMR의 특성을 보여주었다. SMR은 상하부 전극층, 압전 박막층, 반사층, 기판으로 구성된다. 상하부 전극으로 알루미늄(Al) 금속 박막을 사용하였고 압전 박막층으로 산화아연(ZnO) 박막을 사용하였다. 실리콘(Si) 기판과 하부 전극 사이에 위치하는 반사층은 5층의 이산화규소 ($Si_2$)와 텅스텐(W) 박막으로 구성되었다. 상하부 전극은 dc 스퍼터링 방법으로 증착아였으며 반사층과 압전 박막층은 rf 스퍼터링 방법으로 증착하였다. 최적 증착 조건에서 증착된 산화아연 (ZnO) 박막은 rocking curve에서 표준편차가 $2.17^{\circ}$의 우수한 c축 우선배향성, 비저항은 $10^4\;{\Omega}cm$이상, 막 표면 거칠기(rms roughness)는 10.6${\AA}$의 특성을 나타내었다. 최적 증착 조건에서 증착된 텅스텐(W)과 이산화규소($Si_2$) 박막의 특성은 박막 거칠기 (rms roughness)가 각각 16 ${\AA}$, 33 ${\AA}$을 나타내었다. 또한 증착된 알루미늄 금속 박막의 비저항은 $5.1{\times}10^{-6}\;{\Omega}cm$이었다. 반도체 기본 공정을 이용하여 면적 $250{\times}250\;{\mu}m^2$의 SMR 소자를 만들고, 네트웍 분석기로 SMR 소자의 공진 특성을 분석하였다. 공진특성은 1.244 GHz에서 직렬공진, 1.251 GHz에서 병렬공진을 나타내었다. SMR 소자의 공진특성에서 공진기의 Q값은 1200이었다.

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SMR 회로를 이용한 소형풍력발전 시스템의 센서리스 퍼지 MPPT제어 (Sensorless Fuzzy MPPT Control for a Small-scale Wind Power Generation System with a Switched-mode Rectifier)

  • 이준민;박민기;김영석
    • 전기학회논문지
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    • 제63권7호
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    • pp.916-923
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    • 2014
  • This paper proposes a low-cost switched-mode rectifier (SMR) for a small-scale wind turbine with a permanent magnet synchronous generator (PMSG) system. Also, a sensorless Fuzzy MPPT control is realized by the proposed system. In the PMSG system with the SMR, the synchronous impedance can be replaced as the input inductor of a boost converter. Moreover, the sensorless MPPT control using the Fuzzy technique is carried out by the duty-ratio regulation of the SMR. The relation between the generating power and the duty-ratio is ruled by the chain rule. The wind turbine model is implemented by the squirrel cage induction motor and generated the variable torque when the generator speed is varied. To verify the performance of the proposed system, simulation and experimental results are executed.

EEG Asymmetry Changes by the Left and the Right SMR Brainwave of the Computer Learning Versus the Paper and Pencil Learning

  • Kwon, Hyung-Kyu;Cho, Jang-Sik
    • Journal of the Korean Data and Information Science Society
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    • 제18권4호
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    • pp.1073-1079
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    • 2007
  • The purpose of this study is to present the relationship between the computer learning and the paper and pencil learning through the math learning (simple computation and complex computation) and the cartoon learning and text learning. The canonical correlation and pairwise t-test of the SMR asymmetry brainwaves of the left and the right brain show the brainwaves with the respect to the manner in which they process information during the specified task by identifying the relative activity of the brainwaves of the left and the right brain. SMR brainwave which known as the scientific measure tool for the activity and the function of the neuronal cell were found to predict the level of the awakening to check the readiness of study preparation. Computer education as a medium of the individualized and the repetitive education shows the difference from the paper and the pencil test in the respect of the differences and the relationship of the SMR brainwave of the learning process.

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SMR을 갖는 소형풍력발전시스템의 센서리스 MPPT제어 (Sensorless MPPT Control for a Small-scale Wind Power Generation System with a Switched-mode Rectifier(SMR))

  • 허성덕;이준민;김영석
    • 전기학회논문지
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    • 제62권12호
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    • pp.1688-1693
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    • 2013
  • A small-scale wind power generation system with a switched-mode rectifier(SMR) is proposed. To simplify the converter circuit of the wind power generation system, the synchronous inductors of the permanent magnet synchronous generator(PMSG) replace the inductor for the boost converter. The sensorless maximum power point tracking(MPPT) control is carried out for the wind power generation system with the SMR. The proposed system is verified through the simulations and the experiments.

SMART-P 안전해석 전산 코드인 TASS/SMR 의 HLA 적용에 관한 연구 (A Study on the Application of TASS/SMR for SMART-P in Compliance with HLA)

  • 김희경;김희철;지성균;김현수
    • 한국정보과학회:학술대회논문집
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    • 한국정보과학회 2005년도 한국컴퓨터종합학술대회 논문집 Vol.32 No.1 (B)
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    • pp.373-375
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    • 2005
  • 본 논문에서는 최근에 각광을 받고 있는 HLA의 연구 현황을 파악하고 HLA의 기본 개념, 구성 요소, HLA를 이용한 시뮬레이션의 개발 방법 등에 대하여 조사하였다. 그리고 SMART-P 안전해석 전산코드인 TASS/SMR을 HLA에 적용하기 위한 방법에 대하여 기술하였으며 랩퍼 (Wrapper)를 사용하여 TASS/SMR을 HLA에 적용하여 보았다. 이러한 연구 결과로 TASS/SMR을 HLA에 적용, 구현하여 실행됨을 확인하였으며 그 결과로 레거시 코드를 HLA에 적용할 수 있는 방향을 제시하였다.

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단삼이 수지상 세포의 유전자 발현에 미치는 영향 (Effects of Salviae miltiorrhizae Radix Extract on Gene Expression of Dendritic cells.)

  • 강문여;김종한;최정화;박수연
    • 한방안이비인후피부과학회지
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    • 제21권3호
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    • pp.52-68
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    • 2008
  • Objectives and Methods : Salviae miltiorrhizae Radix (SMR) promotes blood circulation to remove blood stasis, cools the blood to relieve carbuncle, clears away heat from the heart and tranquilizes the mind. This study was designed to investigate the effects of SMR on immuno-potentiative action in terms of changes in the genetic profile of dendritic cells (DC) using by microarray analysis. Results and Conclusion: In this experiment, treatments with more than 250 ${\mu}g/ml$ upto 1000 ${\mu}g/ml$ of SMR elevated the proliferation rates of DC. Microscopic observations confirmed the tendency on proliferation rates. Expression levels of genes related with cellular methabolic process, cell communication, and macromolecule metabolic process were elevated by treatment with SMR in comparison of functional distribution in a Biological Process. In molecular functions, expression levels of genes related with receptor activation, nucleotide binding and nucleic acid binding were elevated. In cellular components, expression levels of genes related to cellular membrane-bound organelles were elevated. In addition, expression levels of genes related to Wnt signalling pathways and the glycerophospholipid metabolism were elevated through analysis using pathway analysis between up-and down-regulated genes in cells treated with SMR. Finally, genes related to JAK2, GRB2, CDC42, SMAD4, B2M, FOS and ESRI located the center of Protein interaction network of genes through treatment with SMR.

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Assessment of rock slope stability by slope mass rating (SMR): A case study for the gas flare site in Assalouyeh, South of Iran

  • Azarafza, Mohammad;Akgun, Haluk;Asghari-Kaljahi, Ebrahim
    • Geomechanics and Engineering
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    • 제13권4호
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    • pp.571-584
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    • 2017
  • Slope mass rating (SMR) is commonly used for the geomechanical classification of rock masses in an attempt to evaluate the stability of slopes. SMR is calculated from the $RMR_{89-basic}$ (basic rock mass rating) and from the characteristic features of discontinuities, and may be applied to slope stability analysis as well as to slope support recommendations. This study attempts to utilize the SMR classification system for slope stability analysis and to investigate the engineering geological conditions of the slopes and the slope stability analysis of the Gas Flare site in phases 6, 7 and 8 of the South Pars Gas Complex in Assalouyeh, south of Iran. After studying a total of twelve slopes, the results of the SMR classification system indicated that three slope failure modes, namely, wedge, plane and mass failure were possible along the slopes. In addition, the stability analyses conducted by a number of computer programs indicated that three of the slopes were stable, three of the slopes were unstable and the remaining six slopes were categorized as 'needs attention'classes.