• Korean Journal of Medicinal Crop Science
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• v.18 no.2
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• pp.79-85
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• 2010

Enhancement effect of ultrasonification process on UV-protection and skin-whitening activities using Centella asiatica L. Urban extract was investigated. Cytotoxicity of the extracts measured on human skin fibroblast cells, CCD-986sk, and then, ultrasonification associated extracts showed 5~9% lower cytotoxicity then normal crude extracts on 1.0 mg/$m{\ell}$ of highest sample concentration. The associated extrats showed highest inhibition activity of hyaluronidase on 1.0 mg/$m{\ell}$ of concentration as 54.2%. Also, the associated extract reduced expression of MMP-1 on UV-irradiated CCD-986sk cells down to 100.2% from 136.1%, and revealed high inhibitory potency on tyrosinase as 74.6% by adding 1.0 mg/$m{\ell}$ of concentration. Ultrasonification associated extract showed strong inhibition effect of melanin production on Clone M-3 cells as 84.2% by adding 1.0 mg/$m{\ell}$ of concentration. From the preliminary observations, we considered that the extracts from C. asiatica could be potent natural materials for skin-whitening and anti-aging agent, and could enhance the activities by ultrasonification process.

• Korean Journal of Acupuncture
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• v.40 no.1
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• pp.25-31
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• 2023

Strabismus is a vision disorder in which the eyes do not properly align with each other when looking at an object and it can negatively affect the quality of life. This case is a report on a strabismus patient who received Korean medicine treatment including scalp acupuncture. Scalp acupuncture, body acupuncture, and herbal medicine were performed on a patient diagnosed with strabismus and diplopia. The improvement of symptoms was evaluated by the Numeric Rating Scale (NRS), Scott and Kraft Score (SK score), and change of symptoms and progress of diplopia. NRS decreased by more than 85%, and the SK score gradually changed from -4 to 0, which means strabismus mostly recovered, and the symptom and progress of diplopia were reduced. In this study, it is considered that Korean medical treatment including scalp acupuncture is useful for strabismus patients.

• Journal of Microbiology and Biotechnology
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• v.33 no.12
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• pp.1576-1586
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• 2023

Vaccination is the most effective method for preventing the spread of the influenza virus. Cell-based influenza vaccines have been developed to overcome the disadvantages of egg-based vaccines and their production efficiency has been previously discussed. In this study, we investigated whether treatment with forskolin (FSK), an adenylyl cyclase activator, affected the output of a cell-based influenza vaccine. We found that FSK increased the propagation of three influenza virus subtypes (A/H1N1/California/4/09, A/H3N2/Mississippi/1/85, and B/Shandong/7/97) in Madin-Darby canine kidney (MDCK) cells. Interestingly, FSK suppressed the growth of MDCK cells. This effect could be a result of protein kinase A (PKA)-Src axis activation, which downregulates extracellular signal-regulated kinase (ERK)1/2 activity and delays cell cycle progression from G1 to S. This delay in cell growth might benefit the binding and entry of the influenza virus in the early stages of viral replication. In contrast, FSK dramatically upregulated ERK1/2 activity via the cAMP-PKA-Raf-1 axis at a late stage of viral replication. Thus, increased ERK1/2 activity might contribute to increased viral ribonucleoprotein export and influenza virus propagation. The increase in viral titer induced by FSK could be explained by the action of cAMP in assisting the entry and binding of the influenza virus. Therefore, FSK addition to cell culture systems could help increase the production efficiency of cell-based vaccines against the influenza virus.

• Proceedings of the Korea Society for Energy Engineering kosee Conference
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• 2002.11a
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• pp.171-184
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• 2002

Approx. 200,000 bpd vacuum residue oil is produced from oil refineries in Korea. These are supplying to use asphalt, high sulfur fuel oil, and upgrading at the residue hydro-desulfurization unit. Vacuum residue oil has high energy content, however high sulfur content and high concentration of heavy metals represent improper low grade fuel. To meet growing demand for effective utilization of vacuum residue oil from refineries, recently some of the oil refinery industries in Korea, such as SK oil refinery and LG Caltex refinery, have already proceeded feasibility study to construct 435-500 MWe IGCC power plant and hydrogen production facilities. Recently, KIER(Korea Institute of Energy Research) are studing on the Vacuum Residue gasification process using an oxygen-blown entrained-flow gasifier. The experiment runs were evaluated under the reaction temperature : 1,100~1,25$0^{\circ}C$, reaction pressure : 1~6kg/$\textrm{cm}^2$G, oxygen/V.R ratio : 0.8~0.9 and steam/V.R ratio : 0.4-0.5. Experimental results show the syngas composition(CO+H$_2$) : 85~93%, syngas flow rate : 50~110Mm$^3$/hr, heating value : 2,300~3,000 ㎉/Nm$^3$, carbon conversion : 65~92, cold gas efficiency : 60~70%. Also equilibrium modeling was used to predict the vacuum residue gasification process and the predicted values were compared reasonably well with experimental data.

• Journal of Energy Engineering
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• v.12 no.1
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• pp.49-57
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• 2003

Approx. 200.000 bpd vacuum residue oil is produced from oil refineries in Korea, and is supplied to use asphalt, high sulfur fuel oil and for upgrading at the residue hydro-desulfurization unit. Vacuum residue oil has high energy content, however its high sulfur content and high concentration of heavy metals represent improper low grade fuel. To meet growing demand for effective utilization of vacuum residue oil from refineries, recently some of the oil refinery industries in Korea, such as SK oil refinery and LG Caltex refinery, have already proceeded feasibility study to construct 435~500 MWe IGCC power plant and hydrogen production facilities. Recently, KIER (Korea Institute of Energy Research) are studying on the Vacuum Residue gasification process using an oxygen-blown entrained-flow gasifier. The experiment runs were evaluated under the reaction temperature: 1.100~l,25$0^{\circ}C$, reaction pressure: 1~6 kg/$\textrm{cm}^2$G, oxygen/V.R ratio: 0.8~0.9 and steam/V.R ratio: 0.4~0.5. Experimental results show the syngas composition (CO+H$_2$): 85~93%, syngas flow rate: 50~l10 Nm$^3$/hr, heating value: 2,300~3,000 k㎈/Nm$^3$, carbon conversion: 65~92, cold gas efficiency: 60~70%. Also equilibrium modeling was used to predict the vacuum residue gasification process and the predicted values were compared reasonably well with experimental data.

• Journal of Korean Society of Environmental Engineers
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• v.34 no.10
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• pp.678-683
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• 2012

One of alternatives to solve the global water shortages is the reuse of wastewater. The aim of this study was to evaluate whether it can be reused for industrial water from wastewater in "A" City with ultrafiltration (UF) and reverse osmosis (RO) process. The results obtained in this study were that the inorganics such as Na, Mg, Cl, Ca, Mn, $PO_4$, $SO_4$, etc. were removed with high treatment efficiency (more than 97%), respectively. However, the removal of $NH_4$-N, TN, $NO_3$-N, BOD was found to be 35.71%, 85.21%, 87.05% and 56%, respectively. The removal efficiency of nutrients was relatively low compared to other metal ions. Despite low nutrients removal, the treated wastewater is recommended to reuse, because the nutrient contents in influent from the secondary wastewater treatment plant were small amount. In addition, all other metrics in the wastewater were found to be lower amount than wastewater reuse criteria. Therefore, the wastewater treated by UF-RO could be sufficient to reuse for industrial waster.

• Explosives and Blasting
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• v.40 no.2
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• pp.25-34
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• 2022

Recently, there has been an increasing number of cases of improving constructability by using electronic detonators with precise delay time in tunnel blasting sites. This case is a case of conducting test blasting using with non-electric detonator and electronic detonator at the site of 『Seoul Metropolitan Area Express Railroad Route A Private Investment Project Section 00』 that requires careful management of vibration and noise. Although this site was designed with a non-electric detonator, it was attempted to improve the advance rate and control vibration and noise by mixing the non-electric detonator and the electronic detonator due to the decrease in the advance rate. As a result of the blasting, the target value was achieved with an advance rate of about 85% and a maximum measured value of vibration and noise is 0.215cm/sec and 73.22dB(A) which were measured below regulatory standards. As blasting works in downtown areas, it is necessary to designate measurement and management objects to continuously manage vibration and noise.

• Korean Journal of Pharmacognosy
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• v.34 no.1 s.132
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• pp.80-85
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• 2003

Water extract from Astragali Radix (AR) was tested for the safety using Ames, Bacillus subtilis Rec, and umu gene expression mutagenicity tests. Mutagenic activity in any assays we tested was not found. In Ames test, Salmonella typhimurium TA98 and TA 100 were used to identify mutagenic property, and the number of histidine revertants was measured. In the Recassay, Bacillus subtilis ${H-17(Rec^+)\;and\;M-45(Rec^-)}$ strains were used to test DNA damage activity. In the SOS umu test, Salmonella typhimurium TA1535 containing plasmid pSK1002 was used as a test strain, and we monitored the levels of umu operon expression by measuring the ${\beta}-galactosidase$ activity. From the results, there was no DNA damage and mutagenicity of AR. Hepatotoxicity of AR to female ICR mice was also monitored by the measurements of s-GOT, s-GPT, LDH activities after oral feeding for 15 days. AR was not shown any significant changes of s-GOT, s-GPT and LDH activities in mice sera.

• Korean Journal of Occupational Health Nursing
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• v.24 no.2
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• pp.76-85
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• 2015

Purpose: The purpose of this study was to identify knowledge structure of the Korean Journal of Occupational Health Nursing from 1991 to 2014. Methods: 400 articles between 1991 and 2014 were collected. 1,369 keywords as noun phrases were extracted from articles and standardized for analysis. Co-occurrence matrix was generated via a cosine similarity measure, then the network was analyzed and visualized using PFNet. Also NodeXL was applied to visualize intellectual interchanges among keywords. Results: According to the results of the content analysis and the cluster analysis of author keywords from the Korean Journal of Occupational Health Nursing articles, 7 most important research topics of the journal were 'Workers & Work-related Health Problem', 'Recognition & Preventive Health Behaviors', 'Health Promotion & Quality of Life', 'Occupational Health Nursing & Management', 'Clinical Nursing Environment', 'Caregivers and Social Support', and 'Job Satisfaction, Stress & Performance'. Newly emerging topics for 4-year period units were observed as research trends. Conclusion: Through this study, the knowledge structure of the Korean Journal of Occupational Health Nursing was identified. The network analysis of this study will be useful for identifying the knowledge structure as well as finding general view and current research trends. Furthermore, The results of this study could be utilized to seek the research direction in the Korean Journal of Occupational Health Nursing.

• International journal of advanced smart convergence
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• v.10 no.2
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• pp.79-85
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• 2021

Speech recognition technology refers to a technology in which a computer interprets the speech language spoken by a person and converts the contents into text data. This technology has recently been combined with artificial intelligence and has been used in various fields such as smartphones, set-top boxes, and smart TVs. Examples include Google Assistant, Google Home, Samsung's Bixby, Apple's Siri and SK's NUGU. Google and Daum Kakao offer free open APIs for speech recognition technologies. This paper selects three APIs that are free to use by ordinary users, and compares each recognition rate according to the three types. First, the recognition rate of "numbers" and secondly, the recognition rate of "Ga Na Da Hangul" are conducted, and finally, the experiment is conducted with the complete sentence that the author uses the most. All experiments use real voice as input through a computer microphone. Through the three experiments and results, we hope that the general public will be able to identify differences in recognition rates according to the applications currently available, helping to select APIs suitable for specific application purposes.