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Purity assignment of 17α-hydroxyprogesterone by mass balance method to establish traceability in measurement

  • Lee, Hwa Shim;Park, Su Jin
    • Analytical Science and Technology
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    • v.32 no.6
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    • pp.225-232
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    • 2019
  • Traceability establishment in chemical measurements is a like a linkage established through an unbroken chain from the measured results to the international system (SI) of units. The primary process for traceability establishment is the purity assignment of a target material to be measured. In this study, we studied the purity assignment of 17α-hydroxyprogesterone (17-OHP). The presence of 17-OHP is indicative of congenital adrenal hyperplasia (CAH) and it builds up due to the deficiency of 21-hydroxylase and 11β-hydroxylase enzyme in the human blood. The purity assignment of 17-OHP was performed by the mass balance method, in which the impurities are categorized into four classes: total related structural impurities, water, residual organic solvents, and nonvolatiles/inorganics. The total related structural impurities were characterized by HPLC-UV; water content was determined by Karl-Fisher coulometer; and the total residual solvents and nonvolatiles/inorganics were determined by TGA. The purity of 17-OHP from a commercial manufacturer was calculated as 993.30 mg/g, and the expanded uncertainty was 0.58 mg/g. The proposed method was validated by uncertainty evaluation and comparing with the actual value of purity.

Combination Procedure for Seismic Correlation Coefficient in Fragility Curves of Multiple Components (다중기기 취약도곡선의 지진상관계수 조합 절차)

  • Kim, Jung Han;Kim, Si Young;Choi, In-Kil
    • Journal of the Earthquake Engineering Society of Korea
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    • v.24 no.3
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    • pp.141-148
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    • 2020
  • For the important safety system, two or more units of identical equipment or redundant components with similar function were installed to prevent abnormal failure. If the failure probability of such equipment is independent, this redundancy could increase the system safety remarkably. However, if the failure of each component is highly correlated by installing in a structure or experiencing an earthquake event, the expected redundancy effect will decrease. Therefore, the seismic correlation of the equipment should be evaluated quantitatively for the seismic probabilistic safety assessment. The correlation effect can be explained in the procedure of constructing fragility curves. In this study, several methodologies to quantify the seismic correlation in the failure probability calculation for multiple components were reviewed and two possible ways considering the realistic situation were selected. Simple examples were tested to check the applicability of these methods. The conversion method between these two methods was suggested to render the evaluation using the advantages of each method possible.

Isolation and Physiological Characterization of a New Algicidal Virus Infecting the Harmful Dinoflagellate Heterocapsa pygmaea

  • Kim, JinJoo;Kim, Chang-Hoon;Takano, Yoshihito;Jang, In-Kwon;Kim, Si Wouk;Choi, Tae-Jin
    • The Plant Pathology Journal
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    • v.28 no.4
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    • pp.433-438
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    • 2012
  • Dinoflagellates are considered one of the most abundant and diverse groups of marine microplankton and viruses are recognized as one of the significant factors affecting the plankton dynamics. Here, we report basic characteristics of a new dinoflagellate-infecting virus, Heterocapsa pygmaea DNA virus (HpygDNAV) which infects a toxic dinoflagellate, H. pygmaea. HpygDNAV is a polyhedral large virus (ca. 160-170 nm in diameter) propagating in its host's cytoplasm. Because of the virion size, appearance in thin sections, and propagation characteristics, HpygDNAV is assumed to harbor a large double-stranded DNA genome; i.e., HpygDNAV is most likely a nucleocytoplasmic large DNA virus (NCLDV) belonging to the family Phycodnaviridae. Its infectivity is strain-specific, rather than species-specific, as is the case for other algal viruses. The burst size and latent period are estimated to be roughly 100-250 infectious units $cell^{-1}$ and < 96 h, respectively.

Assessment and Classification of Meteorological Drought Severity in North Korea (북한의 지역별 기상학적 가뭄의 평가와 유형분류)

  • Yoo, Seung-Hwan;Nam, Won-Ho;Jang, Min-Won;Choi, Jin-Yong
    • Journal of The Korean Society of Agricultural Engineers
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    • v.50 no.4
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    • pp.3-15
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    • 2008
  • North Korea is one of the most vulnerable countries of the world for drought but still it is difficult to find scientific researches for understanding of the drought characteristics. This study analyzed the temporal and spatial distribution of meterological drought severity and classified the drought development types in North Korea. All eleven drought indices were tested such as seasonal rainfall, PDS, SPI and so on, and then drew the drought risk map by each indicator using frequency analysis and GIS(Geographic Information Systems) for twenty one meteorological stations. In addition meteorological drought characteristics in North Korea was classified to six patterns on Si/Gun administrative units using cluster analysis on the drought indicators. The cluster III has the strongly drought-resistant area due to sufficient rainfall and the cluster V was considered as the most drought-vulnerable area, Pungsan and Sinpo, because of the severest drought condition for eight drought indicators. The results of this study are expected to be provided for the basic understanding of regionalized drought severity and characteristics confronting the risk of drought from climate variations in North Korea.

An Evaluation of Heat Transfer Characteristics of Individualized Fin Type Using Large Scale Model (확대모델을 이용한 특성화된 핀형상의 열전달평가)

  • 윤점열;강희찬;이관수;김무환
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.8 no.1
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    • pp.166-175
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    • 1996
  • In recent years, air-conditioning units designed with higher efficiency and more compactness are required due to emphasis on energy efficiency in home electrical appliances. This trend in the air-conditioning industries has accelerated the development of improved heat exchanger with a better performance in heat transfer aspects. In this study, experiments were performed to investigate the shape and configuration of fins affecting on the performance of the conventional fin-and-tube type heat exchanger equipped in a commercial air conditioners. The geometry similtude method was employed to measure the heat transfer coefficient and pressure drop. Experimental results show that this method is very useful to analyze the heat transfer characteristics of the fin-and-tube type heat exchanger. It is also found that the slit fin has better performance than the conventional fin type in the air conditioners. The present results indicate that heat transfer from the fin si influenced by the parameters such as the forming area of the slit fin, the type of interrupted surfaces like a louver or slit, slit patterns and slit raised direction, and it also affects the overall heat exchanger performance.

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Synthesis and Characterization of Poly(arylene-ethynylene)s with Ferrocene Unit by Reaction of 1,1'-Bis(ethynyldimethylsilyl)ferrocene and Aromatic Dihalides

  • Lee, In-Sook;Lee, Chong-Gu;Kwak, Young-Woo;Gal, Yeong-Soon
    • Bulletin of the Korean Chemical Society
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    • v.30 no.2
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    • pp.309-314
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    • 2009
  • New poly(arylene-ethynylene)s with silicon-containing ferrocene moiety in the polymer main chain were synthesized via the C-C bond forming reactions of 1,1´-bis(ethynyldimethylsilyl)ferrocene and various aromatic dihalides in high yields. The aromatic dihalides include 1,4-dibromobenzene, 4,4´-dibromobiphenyl, 9,10-dibromoanthracene, 2,5-dibromopyridine, 2,5-dibromothiophene, and 2,6-diiodo-4-nitroaniline. The polymer structures and properties were characterized by such instrumental methods as NMR $(^1H-,\;^{13}C-,\;and\;^{29}Si-)$, IR, UV-visible spectroscopies and TGA/DSC. The spectral data indicated that the present polymers have the regular alternating structure of 1,1´-bis(ethynyldimethylsilyl)ferrocenylene and arylene units. The resulting polymers were completely soluble in such organic solvents as methylene chloride, chloroform, benzene, chlorobenzene, and THF. The thermal behaviors of the resulting polymers were examined.

Synthesis of Silicone Surfactant for Antifoamer (저기포성 실리콘 계면활성제의 합성)

  • Jeong, Noh-Hee;Son, Hyun-Gu
    • Journal of the Korean Applied Science and Technology
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    • v.25 no.2
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    • pp.115-122
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    • 2008
  • The hydrosilylation is an addition reaction of Si-H bond to unsaturated double bonds, which provides a convenient mechanism to synthesize poly(dimethylsiloxane-co-methylsiloxane)copolymer having siloxy units in polymer backbone. In this study, Poly(dimethylsiloxane-co-methylsiloxane) copolymer was synthesized through the polymerization reaction of cyclopentasiloxane with poly(methyl-hydrogen) siloxane. Silicone-hydrogen functional group of the poly(dimethylsiloxane-co-methylsiloxane) copolymer was substituted to the alkyl groups by hydrosilylation. And their structure was analyzed with FT-IR, H-NMR and GPC instruments, respectively. Surface tension of the synthetic compounds is increased from 22dyne/cm to 25dyne/cm according to increase additional EO moles. The cmc which was evaluated by surface tension was ranged $10^{-5}$ to $10^{-4}mol/L$ and it was decreased according to increase of dimethyl siloxyl content. HLB number of these surfactants was evaluated 9.5 to 11.5 range. These silicone surfactants is applied to self-emulsifier defoamer and personal care products as surface tension depressant, emulsifier, foam control agent.

Study on Vocabulary Relating to the Housing Cultures in Jeju Dialect: Around Seongeup folk village, Seogwipo-si (제주도 방언의 주거 문화 관련 어휘 연구 -서귀포시 성읍민속마을을 대상으로-)

  • Kim, Sun-Ja
    • Korean Linguistics
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    • v.80
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    • pp.49-85
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    • 2018
  • The purpose of this study is to research and systematize Jeju dialectal words about Jeju traditional housing culture and study them on the basis of lexical semantics. Vocabularies related to the names of the traditional thatched-roof house and its partial names, thatching, supplementary facilities, housing culture, etc. were categorized after recording in an ethnographic way from Seongeup folk village which is Important Folklore Material no.188, and studied them linguistically. Informants are fore people who were born and bred in Seongeup-ri and they are over 70. They have a lot of experiences building thatched-roof houses from a young age. There are 9 different categories - the kind of the house, partial names, exterior space, materials, tools, words about actions, doers, units, and folklore. Some new words related to Jeju traditional housing, which had not been in the list of Korean dictionary, could be introduced as a result of the study. For example, rice which are made when doing earth work is called Heukppap and adzes used to sharpen stones are called Dolchagui. The finding of These new words hopefully contribute to the promotion of Korean language as well as enrich vocabulary on housing. Furthermore, the collected vocabularies and oral materials could be used as important educational materials to comprehend Jeju traditional housing culture.

Traffic Congestion Management on Urban Roads using Vehicular Ad-hoc Network-based V2V and V2I Communications (차량 애드혹 네트워크 기반 V2V와 V2I 통신을 사용한 시내 도로에서의 교통 체증 관리)

  • Ryu, Minwoo;Cha, Si-Ho
    • Journal of Korea Society of Digital Industry and Information Management
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    • v.18 no.2
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    • pp.9-16
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    • 2022
  • The nodes constituting the vehicle ad hoc network (VANET) are vehicles moving along the road and road side units (RSUs) installed around the road. The vehicle ad hoc network is used to collect the status, speed, and location information of vehicles driving on the road, and to communicate with vehicles, vehicles, and RSUs. Today, as the number of vehicles continues to increase, urban roads are suffering from traffic jams, which cause various problems such as time, fuel, and the environment. In this paper, we propose a method to solve traffic congestion problems on urban roads and demonstrate that the method can be applied to solve traffic congestion problems through performance evaluation using two typical protocols of vehicle ad hoc networks, AODV and GPSR. The performance evaluation used ns-2 simulator, and the average number of traffic jams and the waiting time due to the average traffic congestion were measured. Through this, we demonstrate that the vehicle ad hoc-based traffic congestion management technique proposed in this paper can be applied to urban roads in smart cities.

Dynamic Traffic Light Control Scheme Based on VANET to Support Smooth Traffic Flow at Intersections (교차로에서 원활한 교통 흐름 지원을 위한 VANET 기반 동적인 교통 신호등 제어 기법)

  • Cha, Si-Ho;Lee, Jongeon;Ryu, Minwoo
    • Journal of Korea Society of Digital Industry and Information Management
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    • v.18 no.4
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    • pp.23-30
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    • 2022
  • Recently, traffic congestion and environmental pollution have occurred due to population concentration and vehicle increase in large cities. Various studies are being conducted to solve these problems. Most of the traffic congestion in cities is caused by traffic signals at intersections. This paper proposes a dynamic traffic light control (DTLC) scheme to support safe vehicle operation and smooth traffic flow using real-time traffic information based on VANET. DTLC receives instantaneous speed and directional information of each vehicle through road side units (RSUs) to obtain the density and average speed of vehicles for each direction. RSUs deliver this information to traffic light controllers (TLCs), which utilize it to dynamically control traffic lights at intersections. To demonstrate the validity of DTLC, simulations were performed on average driving speed and average waiting time using the ns-2 simulator. Simulation results show that DTLC can provide smooth traffic flow by increasing average driving speed at dense intersections and reducing average waiting time.