• 한국전문물리치료학회지
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• 제19권3호
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• pp.40-50
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• 2012

The purpose of this study was to investigate the effect of visual feedback on the postural control of stroke patients, by systematically varying conditions of visual feedback [eye-open condition (EO) vs. eye-closed condition (EC)], and base-support (both-side support, affected-side support, and unaffected-side support). In this study, we allocated 41 stroke patients with no damage in the cerebellum and visual cortex who can walk at least 10 meters independently, and 35 normal adults who have no experience of stroke to the control group. Both groups were asked to perform a "sit-to-stand" task three to five times, and their postural control ability was measured and compared in terms of asymmetric dependence (AD) instead of the traditional symmetric index (SI) in the literature. The results showed that although both subject groups maintained better postural control in the EO condition than in the EC condition, the patient group appeared to be more stable in EC than in EO when they were required to perform the task of the support condition given on the affected side. These results implied that visual feedback can impair stroke patients' postural control when it is combined with a specific support condition.

• 대한한의학원전학회지
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• 제22권2호
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• pp.201-229
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• 2009

In this dissertation, I will focus on the channel entry[歸經] and the effect and the treatment [效能主治] in oriental medicine texts from ancient to modern times in order to classify the medicines of the kidney. Medicines that effected the Kidney through working on any other viscera were as follows: Fossilia Ossis Mastodi(龍骨), Schizandrae Fructus(五味子), Nelumbinis Semen(蓮肉), Ostreae Testa(牡蠣), Polygalae Follium(小草), Angelicae Gigantis Radix(當歸), Albizzae Cortex(合歡), Thujae Semen(栢子仁) and Bambusae Calulis in Liquamen(竹瀝). This study was dedicated to researching the medicines related to the kidney and making efficient use of these medicines.

• 전자공학회논문지B
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• 제33B권1호
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• pp.170-177
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• 1996

본 논문은 고양이와 원숭이의 시각피질에서 보이는 특징추출경로를 모델화하여 지도화상으로부터 파선을 추출하는 파선정보추출용 뉴럴 네트워크를 제안한다. 제안하는 파선정보추출기구는 칼라입력화상을 흑백화상으로 변환한 후, 방향별 직선을 추출한다. 다음으로, 추출된 각 방향별 직선 중 추출하고자 하는 파선보다 긴 직선을 제거한 후, 파선의 성질인 연속된 짧은 직선을 찾아내어 추출한다. 제안하는 뉴럴 네트워크는 국립지리원에서 발행한 1/25,000 축척의 지도에 적용되었으며, 지도화상으로부터 성공적으로 파선 정보를 추출할 수 있음을 보였다.

• Annals of Clinical Neurophysiology
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• 제16권1호
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• pp.32-34
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• 2014

A 77-year-old man developed acute vertigo and unsteady gait. Neurological examination revealed spontaneous left-beating nystagmus in the primary position. He fell to the left when walking without support. Magnetic resonance imaging showed an acute infarction involving the right parieto-temporal lobe. Although the vertigo and unsteady gait are most often associated with vestibular disorders involving the infratentorial structures, those may occur in cerebral infarction of the parieto-temporal lobe.

• 펄프종이기술
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• 제35권4호
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• pp.68-74
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• 2003

Kenaf(Hibiscus cannabinus L.) cultivar, Tainung 2, had been grown for 152 days at the experimental farm of Jinju National University, Gajoa-dong, Jinju-si, Kyongnam, Korea. The planting, growth rate, fertilization and structural characteristics as well as the cultivation and growth characteristics of kenaf, and the product usage were investigated. The narrowest diameter at kenaf bottom was 10 mm, the widest 42 mm and the average about 28 mm, and the shortest height 150 cm, the tallest 480 cm and the average about 350 cm. The weight of a core fraction was 68.1％ and a bast fraction 31.9％. The weight ratio of core material to bast fiber was 2.31. The weight ratio of dry stem was 73.5％ and that of leaves 26.5％. The weight of dry plant produced in 1 $m^2$ was 1,467 g, and about 1,052 g of stem could be used for the commercial purpose, The application of fertilizers resulted in the increase of the growth rate of the diameter at plant bottom and the height. Bast fiber, phloem ray and cortex parenchyma cell were observed in bast, and vessel, wood fiber and ray in core.

• Korean Journal of Acupuncture
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• 제31권1호
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• pp.20-32
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• 2014

연구배경 : 침의 효과와 신경생리학적 기전에 관한 연구가 기능자기공명을 이용하여 활발히 이루어지고 있다. 좌우측 동일한 혈위에 대한 자침이 뇌 기능에 미치는 효과에 대하여 논란이 되고 있다. 그러나 동일한 혈위에 대한 좌측 또는 우측 자침이 뇌기능에 미치는 영향에 대한 연구는 부족한 점이 있다. 목적 : 본 연구의 목적은 좌우측 족삼리 자침에 의한 BOLD (blood oxygen level-dependent) 반응을 살펴보고 비교하는 것이다. 방법 : 14명의 건강한 남자를 대상으로 좌우측 족삼리에 가짜 침과 진짜 침 자극을 하였다. 좌우측 족삼리 자침이 뇌 기능에 미치는 영향을 알아보고 비교하기 위해 4가지 실험 디자인을 선택하였다. 첫째와 셋째 스캔은 우측 족삼리에, 둘째와 넷째 스캔은 좌측 족삼리에 가짜침과 진짜침 자극을 주었다. 또한, 자침은 자극기에 자침 및 자극을 주었으며, 자극기가 끝남과 동시에 발침하기를 반복하였다. 통계분석을 위해 SPM8을 이용하여 one sample T-test와 within-subject the analysis of variance (ANOVA) test 를 실시하였다. 통계 결과 좌측과 우측 족삼리 자침에 의해 BOLD 반응의 차이를 보이는 9개 영역의 ROI (regions of interest)에서 BOLD 신호를 추출하였다. 결과 : 좌측과 우측 족삼리의 자침에 의한 BOLD반응은 서로 다른 방식으로 나타났다. 좌우측 족삼리 자침에 의한 BOLD반응을 비교한 결과, 좌측 족삼리 자침은 우측 족삼리 자침에 비해 주로 해마옆 이랑 (브로드만 영역 28), 배외측 전전두 피질 (브로드만 영역 44), 시상, 소뇌정상과 기저핵의 전장에서 더 높은 활성반응이 나타났다. 좌우측 족삼리 자침에 의한 BOLD반응을 각각 조사한 결과, 우측 족삼리 자침은 주로 대뇌섬과 보조운동영역 그리고 전대상이랑 (브로드만 영역 24)에서 활성화가 나타났으며, 좌측 족삼리 자침은 주로 대뇌섬과 일차 체감각 피질 (브로드만 영역 2) 그리고 배외측 전전두 피질 (브로드만 영역 44)에서 활성화가 나타났다. 결론 : 본 연구는 기능적 자기공명영상을 이용하여 좌측과 우측의 족삼리 자침이 인간의 뇌에 미치는 영향을 알아보고 비교한 최초의 연구이다. 본 연구 결과는 좌측과 우측 족삼리 자침은 통증조절효과에 서로 다른 방식으로 영향을 미칠 수 있다는 것을 의미한다. 또한, 본 연구 결과는 좌측과 우측 자침이 뇌 신경에 미치는 영향의 차이에 대한 증거가 된다.

• 대한수의학회지
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• 제54권4호
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• pp.225-231
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• 2014

Klotho deficiency is an early event in acute kidney injury (AKI) that exacerbates acute kidney damage. The present study explored the expression of Klotho and inflammation related factors in cisplatin-induced AKI. Rats (n = 18) were treated with cisplatin intraperitoneal injection (5 mg/kg) or left untreated as controls (n = 6), then sacrificed at 5 (n = 6) and 10 days (n = 6) treatment. Five days after cisplatin injection, the serum kidney enzymes and kidney cell apoptosis were significantly increased. Moreover, the expression of Klotho was decreased when compared to the control group, especially in the cortex and outer medulla regions. In contrast, inflammation related signals including nuclear factor kappa B, tumor necrosis factor-${\alpha}$, and tumor necrosis factor-like weak inducer of apoptosis were enhanced. However, 10 days after cisplatin injection, Klotho expression was enhanced upon both IHC and Western blot analysis, with slightly recovered renal function and decreased apoptosis. Furthermore, inflammation related signals expression was decreased relative to the 5 days group. Overall, this study confirmed the opposite expression patterns between Klotho and inflammation related signals and their localization in cisplatin-induced AKI kidney.

• 사상체질의학회지
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• 제23권1호
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• pp.79-86
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• 2011

1. Objectives: Pharmacopuncture according to Sasang Constitutional Medicine is new field of constitutional medicine. We investigated safety of pharmacopunctures to develop this treatment. 2. Methods: We searched for papers in fifteen Korean oriental medical journals and four online searching portal articles. Hepatotoxicity, nephrotoxicity and general toxicity tests were investigated about one hundred thirty kinds of pharmacopunctures. 3. Results: Toxicity test about 36 kinds of 130 pharmacopunctures were investigated. 1) Hepatotoxicity and nephrotoxicity test of pharmacopunctures were searched in 11 of 38 Soeumin herbs, 8 of 36 Soyangin herbs, 5 of 44 Taeeumin herbs and 1 of 12 Taeyangin herbs. From among these herbs, toxicity was detected in Radix aconiti lateralis preparata(附子), Fructus alpiniae oxyphyllae(益智仁), Semen crotonis(巴豆), Radix bupleuri(柴胡) and Semen armeniacae amarum(杏仁) pharmacopunctures. 2) General toxicity test of pharmacopunctures were searched in 8 of 38 Soeumin herbs, 9 of 36 Soyangin herbs, 6 of 44 Taeeumin herbs and 2 of 12 Taeyangin herbs. from among thes herbs, toxicity was detected in Radix aconiti lateralis preparata(附子), Radix ginseng(人蔘), Semen crotonis(巴豆), Rhizoma seu radix notopterygii(羌活), Radix aralia cordatae(獨活), Semen armeniacae amarum(杏仁) and Radix scutellariae(黃芩) and Cortex acanthopanacis(五加皮) pharmacopunctures. 4. Conclusions: From these results, we must decide extraction method, concentration and dose carefully to use the toxic pharmacopuncture. More toxicity test and further study is needed about pharmacopuncture treatment in Sasang Constitutional Medicine.

• The Korean Journal of Physiology and Pharmacology
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• 제14권4호
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• pp.229-233
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• 2010

Amyloid precursor protein binding protein-1 (APP-BP1) binds to the carboxyl terminus of amyloid precursor protein and serves as a bipartite activation enzyme for the ubiquitin-like protein, NEDD8. Previously, it has been reported that APP-BP1 rescues the cell cycle S-M checkpoint defect in Ts41 hamster cells, that this rescue is dependent on the interaction of APP-BP1 with hUba3. The exogenous expression of APP-BP1 in neurons has been reported to cause DNA synthesis and apoptosis via a signaling pathway that is dependent on APP-BP1 binding to APP. These results suggest that APP-BP1 overexpression contributes to neurodegeneration. In the present study, we explored whether APP-BP1 expression was altered in the brains of Tg2576 mice, which is an animal model of Alzheimer's disease. APP-BP1 was found to be up-regulated in the hippocampus and cortex of 12 month-old Tg2576 mice compared to age-matched wild-type mice. In addition, APP-BP1 knockdown by siRNA treatment reduced cullin-1 neddylation in fetal neural stem cells, suggesting that APP-BP1 plays a role in cell cycle progression in the cells. Collectively, these results suggest that increased expression of APP-BP1, which has a role in cell cycle progression in neuronal cells, contributes to the pathogenesis of Alzheimer's disease.

• 대한수의학회지
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• 제23권1호
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• pp.57-67
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• 1983

The present study was carried out to observe the histopathological changes in the mammary gland of lactating rats and rabbits injected with dexamethasone. White rats were intramuscularly injected with 0.25mg, 0.5mg or 1.0mg of dexamethasone sodium phosphate (containing $9{\alpha}$-fluoro-$16{\alpha}$-methylprednisolone, 5.0mg/ml) daily for 3 to 10 days on the 3rd day after parturition and white rabbits were intramammary infused with 4mg or 20mg of dexamethasone daily for 4 days on 7th day after parturition. The histopathological changes of the mammary glands, ovaries and adrenal glands of rats and rabbits were observed with light microscope. In the mammary glands of rats, the microscopic findings encountered were decrease of the milk in the alveolar lumina, necrosis and desquamation of epithelial cells, atrophy of alveoli, proliferation of fibroblasts and thickness of alveolar walls, destruction of alveoli, presence of fat droplets within the glandular epithelial cells, infiltration of mononuclear cells and proliferation of adipose tissue, which were relative to the dose and duration of injection. Especially, in the cases of the administration of large doses or long duration, there were severe fibrosis and focal necrosis of glandular tissue. In the mammary glands of rabbits, the morphological changes were similar to those findings in the rats. The milk in the alveolar lumina was decreased gradually according to the dose and duration of injection, while milk fat concentration regarded to increase. In the histological findings of ovaries, necrosis of granulosa cellos, vacuolization and necrosis of luteal cells, atrophy and necrotic foci in the corpora lutes were observed. In the adrenal glands, hyperemia, hemorrhage, vacuolization of adrenal cortical cells, necrotic foci and atrophy of adrenal cortex were observed.