• Structural Engineering and Mechanics
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• 제47권4호
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• pp.471-493
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• 2013

This paper presents a framework for seismic damage evaluation for Algerian buildings adapted from HAZUS approach (Hazard-United States). Capacity and fragility curves were adapted to fit the Algerian building typologies (Reinforced Concrete structures, Confined or Non-Confined Masonry, etc). For prediction purposes, it aims to estimate the damages and potential losses that may be generated by a given earthquake in a prone area or country. Its efficiency is validated by comparing the estimated and observed damages in Boumerd$\grave{e}$s city, in the aftermath of Boumerd$\grave{e}$s earthquake (Algeria: May $21^{st}$ 2003; $M_w$ = 6.8). For this purpose, observed damages reported for almost 3,700 buildings are compared to the theoretical predictions obtained under two distinct modelling of the seismic hazard. In one hand, the site response spectrum is built according to real accelerometric records obtained during the main shock. In the other hand, the effective Algerian seismic code response spectrum (RPA 99) in use by the time of the earthquake is considered; it required the prior fitting of Boumerd$\grave{e}$s site PGA (Peak Ground Acceleration) provided by Ambraseys' attenuation relationship.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2009년도 춘계학술대회 논문집
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• pp.119-122
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• 2009

본 연구에서는 2차원 초음속 공동유동에서 발생하는 압력진동을 제어하기 위하여 수치해석적 연구를 수행하였다. 본 계산에서는 압력진동을 제어하기 위하여 보조공동의 형상을 변화시켰으며, 유동의 마하 수를 1.50, 1.83 그리고 2.50로 변화시켰다. 그 결과, 보조공동은 압력진동을 상당히 감소시켰으며, 압력진동의 제어효과는 유동의 마하수와 보조공동의 상세형상에 크게 의존함을 알았다.

• Archives of Pharmacal Research
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• 제12권4호
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• pp.282-288
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• 1989

This study was investigated the effects of imipramine (IMI) and electroconvulsive shock (ECS), which are used as antidepressant therapy, on the central $\beta_1$or $\beta_2$ adrenergic receptor in anesthetized rats. The resting blood pressure and heart rate decreased in reserpinized group (5 mg/kg i. p., 24 hr before), but not in order 4 groups i. e. acute IMI (20 mg/kg i. p.. 3-5 hr before), chronic IMI (Same dose, twice a day for 14 days), siggle ECS (sinusoidal 20 Hz, 120 V for 2 sec) and repeated ECS (same condition, daily for 12 days). The increase of heart rate and hypotension evoked by 1 or 3 $\mu$g intracerebroventricular (i. c. v.) administration of (+) dobutamine, $\beta_2$-agonist, 1 or 3 $\mu$g i. c. v. was significantly attenuated in repeated ECS or reserpine treatment. And, the diminuation of pulse pressure of salbutamol also reduced by repeated ECS. These results suggest that IMI or ECS result in attenuation on tachycardia by (+) dobutamine or on hypotension by salbutamol, presumably by which the central $\beta_1$ or $\beta_2$receptor sensitivity may be suppressed, repectively.

• 대한기계학회논문집A
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• 제33권8호
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• pp.819-825
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• 2009

An open frame structure is fastened by bolt joints for strength and shock attenuation. Therefore the full finite element model of an open frame structure should be properly modeled including bolt joints for strength analysis of the frames and joint assemblies which are operated under multi-loading conditions such as driving, drop, inertia and torsional loads. Then the joints and frames must satisfy the specified allowable strength constraints. Because the full finite element model has a large number of elements to perform strength analysis, a detailed fine bolt analysis seems to be very expensive. Therefore bolts of the full finite element model are approximately modeled by coupling method to constrain degree of freedoms between adjacent nodes. However, the coupling method can exaggerate stress results at the constrained nodes. Thus a detailed bolt analysis and a theoretical/experiential formula of bolts for a worst bolt joint are performed using reaction force applied both bolt and bolt joint. Finally, the results from the two methods are compared and discussed to verify the safety of the open frame structure.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.523-528
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• 2008

An open frame structure is fastened by bolt joints for strength and shock attenuation. Therefore the full finite element model of an open frame structure should be properly modeled including bolt joints for strength analysis of the frames and joint assemblies which are operated under multi-loading conditions such as driving, drop, inertia and torsional loads. Then the joints and frames must satisfy the specified allowable strength constraints. Because the full finite element model has a large number of elements to perform strength analysis, a detailed fine bolt analysis seems to be very expensive. Therefore bolts of the full finite element model are approximately modeled by constraints equations to constrain degree of freedoms between adjacent nodes. However, the constraints equation method can exaggerate stress results at the constrained nodes. Thus a detailed bolt analysis and a theoretical/experiential formula of bolts for a worst bolt joint are performed using reaction force applied both bolt and bolt joint. Finally, the results from the two methods are compared and discussed to verify the safety of the open frame structure.

• The Korean Journal of Physiology and Pharmacology
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• 제24권3호
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• pp.241-248
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• 2020

Luminespib (AUY922), a heat shock proteins 90 inhibitor, has anti-neoplastic and antitumor effects. However, it is not clear whether AUY922 affects events in vascular diseases. We investigated the effects of AUY922 on the platelet-derived growth factor (PDGF)-BB-stimulated proliferation and migration of vascular smooth muscle cells (VSMC). VSMC viability was detected using the XTT (2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide) reagent. To detect the attenuating effects of AUY922 on PDGF-BB-induced VSMCs migration in vitro, we performed the Boyden chamber and scratch wound healing assays. To identify AUY922-mediated changes in the signaling pathway, the phosphorylation of protein kinase B (Akt) and extracellular signal-regulated kinase (ERK) 1/2 was analyzed by immunoblotting. The inhibitory effects of AUY922 on migration and proliferation ex vivo were tested using an aortic ring assay. AUY922 was not cytotoxic at concentrations up to 5 nM. PDGF-BB-induced VSMC proliferation, migration, and sprout outgrowth were significantly decreased by AUY922 in a dose-dependent manner. AUY922 significantly reduced the PDGF-BB-stimulated phosphorylation of Akt and ERK1/2. Furthermore, PD98059 (a selective ERK1/2 inhibitor) and LY294002 (a selective Akt inhibitor) decreased VSMC migration and proliferation by inhibiting phosphorylation of Akt and ERK1/2. Greater attenuation of PDGF-BB-induced cell viability and migration was observed upon treatment with PD98059 or LY294002 in combination with AUY922. AUY922 showed anti-proliferation and anti-migration effects towards PDGF-BB-induced VSMCs by regulating the phosphorylation of ERK1/2 and Akt. Thus, AUY922 is a candidate for the treatment of atherosclerosis and restenosis.

• 한국터널지하공간학회 논문집
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• 제6권1호
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• pp.25-40
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• 2004

밀장전한 암반발파공에서 화약폭발로 전파되는 초음속 충격파는 암반중에 전파되면서 차자로 저음속 충격파, 소성파, 탄성파로 변화된다. 이 연구는 발파압력파의 최대압력 도달시간 산정에 중점을 두었고 연계된 논문 I (the companion paper)에서는 최대 발파업력 산정에 중점을 두었다. 이 연구에서 최대압력 도달시간을 화약밀도, 단열지수, 폭광파속도, 감쇠지수, 동적항복강도, 소성파속도, 암반밀도, 탄성파속도, Hugoniot 상수의 함수식으로 유도하였다 최대합력 도달시간에 대한 매개변수분석 결과 암반특성치가 화약특성치보다 더 크게 영향을 미쳤다. 최대압력 도달시간의 확률분포는 화약과 암반 특성치의 확률분포로부터 Rosenblueth 확률모델로 조합하여 산출되었다. 화약과 암반특성의 불확정성이 발파진동의 불확정성에 미치는 영향을 수치해석으로 분석하였다. 불확정성 분석결괴 화약특성보다 암반특성의 불확정성이 발파진동에 더 크게 영향을 미쳤다. 수치해석 분석결괴 최대 발파양력과 최대양력 도달시간의 바인 하중재하율이 발파진동에 큰 영향을 미쳤다. 또한 화약특성보다 암반특성이 하중재하율에 더 크게 영향을 미쳤다.

• 한국운동역학회지
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• 제21권1호
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• pp.1-7
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• 2011

The purpose of this study was to investigate changes in kinetic and kinematic variables associated with an increase in upper body weight. Eighteen healthy male university students($175.96{\pm}4.19\;cm$, $70.79{\pm}8.26\;kg$) participated. Eight motion analysis cameras(Qualysis Oqus 500) and 2 force AMTI platforms(Advanced Mechanical Technologies Inc. OR6-7, US) were used to record motion and forces during the drop landing at a frequency of 120 Hz and 1200 Hz, respectively. QTM software(Qualisys Track Manager) was used to record the data, and the variables were analyzed with Visual 3D and Matlab 2009. For the drop landing, a box of $4{\times}2{\times}0.46\;m$ was constructed from wood. Knee and ankle maximum flexion angle, knee flexion angle, knee and ankle angle at landing, time for maximum ankle flexion after landing, and time for maximum knee flexion after landing were calculated. There was a significant change in the time for maximum and minimum ground force reaction and the time for maximum dorsal flexion after landing(p<.05) with increasing weight. There was no significant change for the hip, knee, and ankle ROM, whereas there was an increase in the angle ROM as the weight increased, in the order of ankle, knee, and hip ROM. This result shows that the ankle joint ROM increased with increasing weight for shock attenuation during the drop landing. There was a trend for greater ankle ROM than knee ROM, but there was no clear change in the ROM of the hip joint with increasing weight. In conclusion, this study shows the importance of ankle joint flexibility and strength for safe drop landing.

• BMB Reports
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• 제49권5호
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• pp.276-281
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• 2016

Corosolic acid (CA), a triterpenoid compound isolated from Lagerstroemia speciosa L. (Banaba) leaves, exerts anti-inflammatory effects by regulating phosphorylation of interleukin receptor- associated kinase (IRAK)-2 via the NF-κB cascade. However, the protective effect of CA against endotoxic shock has not been reported. LPS (200 ng/mL, 30 min) induced phosphorylation of IRAK-1 and treatment with CA (10 μM) significantly attenuated this effect. In addition, CA also reduced protein levels of NLRP3 and ASC which are the main components of the inflammasome in BMDMs. LPS-induced inflammasome assembly through activation of IRAK-1 was down-regulated by CA challenge. Treatment with Bay11-7082, an inhibitor of IκB-α, had no effect on CA-mediated inhibition of IRAK-1 activation, indicating that CA-mediated attenuation of IRAK-1 phosphorylation was independent of NF-κB signaling. These results demonstrate that CA ameliorates acute inflammation in mouse BMDMs and CA may be useful as a pharmacological agent to prevent acute inflammation.

• 천문학회보
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• 제36권2호
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• pp.103.1-103.1
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• 2011

Recent observations by Hinode show weakly-attenuated coronal loop oscillations in the presence of background flow (Ofman & Wang 2008, A&A, 482, L9). We study the vertical kink oscillations in solar coronal loops, considering field aligned flows inside the loops as well as surrounding the loops environment. The two dimensional numerical model of straight slab is used to explore the excitation and attenuation of the impulsively triggered fast magnetosonic standing kink waves. A full set of time dependent ideal magnetohydrodynamics equations is solved numerically taking into account the value of flow of the order of observed flows detected by SOT/Hinode. We find that relaxing the assumption of the limited flows within the loops enhances the damping rate of the fundamental mode of the standing kink waves by 2 - 3 % as compared to flow pattern which is basically localized within the loops. We further notice that extending the flow pattern beyond the loop thickness also enhances the strength of the shock associated with slow magnetoacoustic waves, recognized as an addition feature detected in the numerical simulation. The wider out-flow pattern destroys the oscillation patterns early as compared to narrower flow pattern, in other words we can say that it affects the durability of the oscillation. However, for the typical coronal loops parameters we find that the observed durability periods of the SOT/Hinode observation can be achieved with an out-flow Gaussian patterns for which half-width is not greater than factor 2.0 of the loop-half-width. explain a possible relation between electric current structure and sigmoid observed in a preflare phase.