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Naloxone Postconditioning Alleviates Rat Myocardial Ischemia Reperfusion Injury by Inhibiting JNK Activity

  • Xia, Anzhou;Xue, Zhi;Wang, Wei;Zhang, Tan;Wei, Tiantian;Sha, Xingzhi;Ding, Yixun;Zhou, Weidong
    • The Korean Journal of Physiology and Pharmacology
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    • v.18 no.1
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    • pp.67-72
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    • 2014
  • To investigate the alteration of c-Jun N-terminal kinase (JNK) activity after myocardial ischemia reperfusion injury (MIRI) and further explore the effect of naloxone postconditioning on MIRI. Forty male Sprague Dawley rats were randomly divided into five groups: sham operation (sham, n=8); ischemia reperfusion (IR, n=8); IR+naloxone 0.5 mg/kg (Nal L, n=8); IR+naloxone 1.0 mg/kg (Nal M, n=8); IR+naloxone 2.0 mg/kg (Nal H, n=8). Pathological changes of myocardial tissue were visualized by HE staining. The expression of p-JNK, and the apoptosis of cardiomyocytes were investigated with Western blotting and the TUNEL assay, respectively. Irregular arrangement and aberrant structure of myocardial fibers, cardiomyocytes with granular or vacuolar degeneration, and inflammatory cells infiltrating the myocardial interstitial regions characterized MIRI in the IR group. Signs of myocardial injury and inflammatory infiltration were less prominent in the Nal-treated groups. The expression of p-JNK in the sham group and in all Nal-treated groups was significantly lower than that in the IR group (p<0.01). The apoptosis index of cardiomyocytes in the IR group was significantly higher than in the sham group (p<0.01). The apoptosis indices of cardiomyocytes in all Nal-treated groups were significantly reduced to 55.4%, 26.2%, and 27.6%, respectively, of the IR group (p<0.01). This study revealed that Naloxone postconditioning before reperfusion inhibits p-JNK expression and decreases cell apoptosis, thus alleviating MIRI.

A 1.8 V 40-MS/sec 10-bit 0.18-㎛ CMOS Pipelined ADC using a Bootstrapped Switch with Constant Resistance

  • Eo, Ji-Hun;Kim, Sang-Hun;Kim, Mun-Gyu;Jang, Young-Chan
    • Journal of information and communication convergence engineering
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    • v.10 no.1
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    • pp.85-90
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    • 2012
  • A 40-MS/sec 10-bit pipelined analog to digital converter (ADC) with a 1.2 Vpp differential input signal is proposed. The implemented pipelined ADC consists of eight stages of 1.5 bit/stage, one stage of 2 bit/stage, a digital error correction block, band-gap reference circuit & reference driver, and clock generator. The 1.5 bit/stage consists of a sub-ADC, digital to analog (DAC), and gain stage, and the 2.0 bit/stage consists of only a 2-bit sub-ADC. A bootstrapped switch with a constant resistance is proposed to improve the linearity of the input switch. It reduces the maximum VGS variation of the conventional bootstrapped switch by 67%. The proposed bootstrapped switch is used in the first 1.5 bit/stage instead of a sample-hold amplifier (SHA). This results in the reduction of the hardware and power consumption. It also increases the input bandwidth and dynamic performance. A reference voltage for the ADC is driven by using an on-chip reference driver without an external reference. A digital error correction with a redundancy is also used to compensate for analog noise such as an input offset voltage of a comparator and a gain error of a gain stage. The proposed pipelined ADC is implemented by using a 0.18-${\mu}m$ 1- poly 5-metal CMOS process with a 1.8 V supply. The total area including a power decoupling capacitor and the power consumption are 0.95 $mm^2$ and 51.5 mW, respectively. The signal-to-noise and distortion ratio (SNDR) is 56.15 dB at the Nyquist frequency, resulting in an effective number of bits (ENOB) of 9.03 bits.

Design and Implementation of Stream Cipher based on SHACAL-2 Superior in the Confidentiality and Integrity (기밀성과 무결성이 우수한 SHACAL-2 기반 스트림 암호 설계 및 구현)

  • Kim, Gil Ho;Cho, Gyeong Yeon
    • Journal of Korea Multimedia Society
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    • v.16 no.12
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    • pp.1427-1438
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    • 2013
  • We have developed a 128-bit stream cipher algorithm composed of the 5-stage pipeline, capable of real-time processing, confidentiality and integrity. The developed stream cipher is a stream cipher algorithm that makes the final 128-bit ciphers through a whitening process after making the ASR 277 bit and SHACAL-2 and applying them to the CFB mode. We have verified the hardware performance of the proposed stream cipher algorithm with Modelsim 6.5d and Quartus II 12.0, and the result shows that the hardware runs at 33.34Mhz(4.27Gbps) at worst case. According to the result, the new cipher algorithm has fully satisfied the speed requirement of wireless Internet and sensor networks, and DRM environment. Therefore, the proposed algorithm with satisfaction of both confidentiality and integrity provides a very useful ideas.

ANALYSIS OF FLOW RESPONSE CHANCE ON A DAM CATCHMENT DUE TO GLOBAL WARMING

  • Shin, Sha-Chul;Koh, Deuk-Koo
    • Water for future
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    • v.35 no.5
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    • pp.31-43
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    • 2002
  • This study describes results of numerical simulations on river flow response due to global warming. Forecasts of changes in climatic conditions are required to estimate the hydrologic effects of increasing trace gas concentratrions in the atmosphere. However, reliable forecasts of regional climate change are unavailable. In there absense various approaches to the development of scenarios of furture climatic conditions are used. The approach in this study is to prescribe climatic changes for a river basin in a simplified manner. As a rule, such scenarios apecify air temperature increases from $0^{\circ}C$ to $4.0^{\circ}C$ and precipitation change (increase or decrease) in the range of 0% to 15%. On the basis of acceptable supposition of warming scenarios, furute daily stream flow is simulated using rainfall-runoff model in the Andong Dam basin. The numerical experiments have quantitatively revealed the change of discharge at 2010, 2020, 2030 and 1050 for each warming scenarios and compared it with the results for a non-worming scenario.

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Application of Normalized Difference Vegetation Index for Drought Detection in Korea (우리 나라에서의 가뭄 발생 지역 판별을 위한 식생지수(NDVI)의 적용성에 관한 연구)

  • Shin, Sha-Chul;Kim, Chul-Joon
    • Journal of Korea Water Resources Association
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    • v.36 no.5
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    • pp.839-849
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    • 2003
  • Drought is one of the major environmental disasters. Weather data, particularity rainfall, are currently the primary source of information widely used for drought monitoring. However, weather data are often from a very sparse meteorological network, incomplete and/or not always available in good time to enable relatively accurate and timely drought detection. Data from remote sensing platforms can be used to complements weather data in drought. Therefore, data obtained from the Advanced Very High Resolution Radiometer(AVHRR) sensor on board the NOAA polar-orbiting satellites have been studied as a tool for drought monitoring. The normalized difference vegetation index(NDVI)-based vegetation condition index(VCI) were used in this study These indices showed their excellent ability to detect vegetation stress due to drought. The results clearly show that temporal and spatial characteristics of drought in Korea can be detected and mapped by the VCI index.

Drought Detection and Estimation of Water Deficit using NDVI (NDVI를 이용한 가뭄지역 검출 및 부족수분량 산정)

  • Shin, Sha-Chul;Jeong, Soo;Kim, Kyung-Tak;Kim, Joo-Hun;Park, Jung-Sool
    • Journal of the Korean Association of Geographic Information Studies
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    • v.9 no.2
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    • pp.102-114
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    • 2006
  • This study aims to develop a method to analyze droughts in Nakdong river area. Satellite imagery can be applied to droughts monitoring because it can afford periodic data for large area for long time. In this study, supposing that evapotranspiration and NDVI are closely related to each other, we presented a method to estimate evapotranspiration in large area with NDVI from MODIS data and temperature. For the final analysis of droughts, water deficit is calculated by climatological water balance using the distribution of evapotranspiration and precipitation. As the results of this study, we improved the usability of satellite imagery, especially in drought analysis.

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Estimation of Areal Evapotranspiration Using NDVI and Temperature Data (NDVI와 기온자료를 이용한 광역증발산량의 추정)

  • Shin, Sha-Chul;An, Tae-Young
    • Journal of the Korean Association of Geographic Information Studies
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    • v.7 no.3
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    • pp.79-89
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    • 2004
  • Remote sensing technique is a probable means to estimate distribution of actual evapotranspiration in connection with regional characteristics of vegetation and landuse. The factors controlling evapotranspiration from ground surface are air temperature, humidity, wind, radiation, soil moisture and so on. Not only the vegetation influences directly the evapotranspiration, but also these factors strongly influences the vegetation growth at the area. Therefore, it can be expected that evapotranspiration is highly correlated to vegetation condition. The normalized difference vegetation index (NDVI) showed excellent ability to get the vegetation information. The NDVI is obtained using NOAA/AVHRR have been studied as a tool for vegetation monitoring. In this paper, a simple method to estimate actual avapotranspiration is proposed based on vegetation and meteorological data.

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A Novel Method for Time-Interleaved Subranging ADC 8bit 80MS/s in 0.18um CMOS (새로운 방법의 채널 시간 공유 Subraning ADC 8bit 80MS/s 0.18um CMOS)

  • Park, Ki-Chul;Kim, Kang-Jik;Cho, Seong-Ik
    • Journal of the Institute of Electronics Engineers of Korea SC
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    • v.46 no.1
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    • pp.76-81
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    • 2009
  • A novel design method of time-interleaved subranging ADC is presented. We use the bisection method to let only half of comparators in typical subranging ADC working in every clock cycle. Thus, we are able to reduce the number of comparators by half. It is possible to reduce the die size. An example of 8-bit time-interleaved subranging ADC operates at 40MHz sampling rate and 1.8V supply voltage is demonstrated. The power consumption of the proposed circuit is only 10mV with SPECTRE simulation. Compared with the typical subranging ADC, our bisection method is able to reduce up to 40% in die size.

A 12b 100 MS/s Three-Step Hybrid Pipeline ADC Based on Time-Interleaved SAR ADCs

  • Park, Jun-Sang;An, Tai-Ji;Cho, Suk-Hee;Kim, Yong-Min;Ahn, Gil-Cho;Roh, Ji-Hyun;Lee, Mun-Kyo;Nah, Sun-Phil;Lee, Seung-Hoon
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.14 no.2
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    • pp.189-197
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    • 2014
  • This work proposes a 12b 100 MS/s $0.11{\mu}m$ CMOS three-step hybrid pipeline ADC for high-speed communication and mobile display systems requiring high resolution, low power, and small size. The first stage based on time-interleaved dual-channel SAR ADCs properly handles the Nyquist-rate input without a dedicated SHA. An input sampling clock for each SAR ADC is synchronized to a reference clock to minimize a sampling-time mismatch between the channels. Only one residue amplifier is employed and shared in the proposed ADC for the first-stage SAR ADCs as well as the MDAC of back-end pipeline stages. The shared amplifier, in particular, reduces performance degradation caused by offset and gain mismatches between two channels of the SAR ADCs. Two separate reference voltages relieve a reference disturbance due to the different operating frequencies of the front-end SAR ADCs and the back-end pipeline stages. The prototype ADC in a $0.11{\mu}m$ CMOS shows the measured DNL and INL within 0.38 LSB and 1.21 LSB, respectively. The ADC occupies an active die area of $1.34mm^2$ and consumes 25.3 mW with a maximum SNDR and SFDR of 60.2 dB and 69.5 dB, respectively, at 1.1 V and 100 MS/s.

UTrustDisk: An Efficient Data Protection Scheme for Building Trusted USB Flash Disk

  • Cheng, Yong;Ma, Jun;Ren, Jiangchun;Mei, Songzhu;Wang, Zhiying
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.11 no.4
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    • pp.2276-2291
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    • 2017
  • Data protection of removable storage devices is an important issue in information security. Unfortunately, most existing data protection mechanisms are aimed at protecting computer platform which is not suitable for ultra-low-power devices. To protect the flash disk appropriately and efficiently, we propose a trust based USB flash disk, named UTrustDisk. The data protection technologies in UTrustDisk include data authentication protocol, data confidentiality protection and data leakage prevention. Usually, the data integrity protection scheme is the bottleneck in the whole system and we accelerate it by WH universal hash function and speculative caching. The speculative caching will cache the potential hot chunks for reducing the memory bandwidth pollution. We adopt the symmetric encryption algorithm to protect data confidentiality. Before mounting the UTrustDisk, we will run a trusted virtual domain based lightweight virtual machine for preventing information leakage. Besides, we prove formally that UTrustDisk can prevent sensitive data from leaking out. Experimental results show that our scheme's average writing throughput is 44.8% higher than that of NH scheme, and 316% higher than that of SHA-1 scheme. And the success rate of speculative caching mechanism is up to 94.5% since the access pattern is usually sequential.