• Archives of Pharmacal Research
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• v.21 no.6
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• pp.629-633
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• 1998

In addition to selecting proteins for degradation by the 26S proteasome, ubiqitination appears to serve other regulatory functions, including for endosomal/lysosomal targeting, protein translocation, and enzyme modification. Currently, little is known how multiubiquitin chains are recognized by these cellular mechanisms. Within the 26S proteasome, one subunit (Mcb1/S5a) has been identified that has affinity for multiubiquitin chains and may function as a ubiquitin receptor. We recently found that a non-proteasomal protein p62 also preferentially binds multiubiquitin chains and forms a novel cytoplasmic structure "sequestosome" which serves as a storage place for ubiquitinated proteins. In the present manuscript, the role and regulation of p62 in relation to the sequestosomal function will be reviewed.

• Archives of Pharmacal Research
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• v.26 no.7
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• pp.511-515
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• 2003

Quinazolinones, 2-substituted and 3-substituted, mainly synthesized by microwave irradiation, were subjected to anti-platelet aggregation and inhibition of superoxide anion generation assays. Interestingly, 2-phenyl-4-quinazolinone (4) exhibited significant inhibitory activities toward platelet aggregation and neutrophil activation, and it might therefore serve as a prototype lead compound.

• The International Journal of Costume Culture
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• v.8 no.2
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• pp.97-104
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• 2005

In this research, the fit of basic dresses was examined, by analyzing and comparing the satisfaction of fitness of basic dresses made by the draping method on a custom-made replica body form and that of a basic dress made by the flat pattern method. Basis dresses were produced by the draping method for each 52 subjects using custom-made body forms, and another kind basic dresses for each subjects were produced by the flat pattern method using measurements of body sizes. Both basic dresses received high scores for the satisfaction of fit, but the basic dresses produced by draping method received higher scores. Thus it is expected to produce a more successful fit by draping a basic dress on a custom-made body form. Future research using more subjects might confirm these results. A more concrete analysis through using additional satisfaction tests could be conducted. For example, each subject might also serve as an evaluator to rate her satisfaction of fit wearing each of the two custom-made dresses. Finally, examining various body forms is suggested.

• Biotechnology and Bioprocess Engineering:BBE
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• v.4 no.1
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• pp.1-11
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• 1999

Considerations of partition coefficients, selectivity, biocompatibility, and waste generation are important in selection of appropriate solvents to be used for extractive recovery of products from fermentation broths. Several selection criteria can be used based upon the nature of different species present in the broth. These criteria, along with examples of specific case studies, were presented. These serve not only in screening of useful solvents, but also in pointing to the specific modes of operation of recovery-coupled bioprocesses.

• Journal of Communications and Networks
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• v.1 no.3
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• pp.201-212
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• 1999

This paper studies the rapid design and implementation of the medium access control(MAC) and related interface circuits for 802.11 wireless LANs based on the field programmed gate ar-ray(FPGA) technology. Our design is thus aimed to support both the distributed coordination function (DCF) and the point coordination function(PCF) with the aid of FPGA technology. Further-more, in an infrastructure network, some stations may serve as the access points (APs) which may function like a learning bridge. This paper will also discuss how to design for such application. The hardware of the MAC and interface may at least consist of three major parts: wireless transmission and reception processes and in-terface, host(bus) interface, and the interface to the distributed system (optional). Through the increasing popularity of FPGA de-sign, this paper presents how Complex Programmable Logic De-vices(CPLD) can be utilized for speedy design of prototypes. It also demonstrates that there is much room for low-cost hardware prototype design to accelerate the processing speed of the MAC control function and for field testing.

• Clinical and Experimental Pediatrics
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• v.57 no.10
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• pp.425-433
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• 2014

Adrenal and thyroid hormones are essential for the regulation of intrauterine homeostasis, and for the timely differentiation and maturation of fetal organs. These hormones play complex roles during fetal life, and are believed to underlie the cellular communication that coordinates maternal-fetal interactions. They serve to modulate the functional adaptation for extrauterine life during the perinatal period. The pathophysiology of systemic vasopressor-resistant hypotension is associated with low levels of circulating cortisol, a result of immaturity of hypothalamic-pituitary-adrenal axis in preterm infants under stress. Over the past few decades, studies in preterm infants have shown abnormal clinical findings that suggest adrenal or thyroid dysfunction, yet the criteria used to diagnose adrenal insufficiency in preterm infants continue to be arbitrary. In addition, although hypothyroidism is frequently observed in extremely low gestational age infants, the benefits of thyroid hormone replacement therapy remain controversial. Screening methods for congenital hypothyroidism or congenital adrenal hyperplasia in the preterm neonate are inconclusive. Thus, further understanding of fetal and perinatal adrenal and thyroid function will provide an insight into the management of adrenal and thyroid function in the preterm infant.

• 한국기계연구소 소보
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• s.17
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• pp.167-176
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• 1987

It is well known that, about 70-90% of the total drag of a ship is due to the viscous effects. Large amount of theoretical and/or experimental studies on the topic have already been performed. More studies are needed, however, to develop efficient numerical methods which are useful for practical ship design. The present study deals with the theories and numerical methods essential for understanding of real fluid characteristics. Actual ships are not considered because enough computer capacities were not available at the time. Numerical methods, however, are developed to describe complicated ship geometries, transition processes and turbulent boundary layers. The present study can serve as a good start for estimations of viscous ship resistance if an high speed computer is available.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2008.11a
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• pp.490-494
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• 2008

We simulated a forest fire which was occurred in Yangyang area on 2005 and compared a results between two different weather conditions(real weather condition and mean weather condition since 1968) using FARSITE, which is a forest fire spread simulator for preventing and predicting fire in USDA. And, we researched a problem in the transition for introducing, so we serve the basic method for prevention and attacking fire. In the result, severe weather condition on 2005 effected a forest fire behavior. The rate of spread under real weather condition was about 4 times faster than mean weather condition. Damaged area was about 10 time than mean weather condition. Therefore, Climate change will make a more sever fire season. As we will encounter to need for accurate prediction in near future, it will be necessary to predict a forest fire linked with future wether and fuel condition.

• Korean Institute of Interior Design Journal
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• no.16
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• pp.49-58
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• 1998

This paper proposes a way to design a multi-purpose hall which can serve as a culture and art space for college students and which can also accommodate college students' behaviour characteristics. The major claims made in this paper are as follows. First the hall should be located where it is easily accessible from major and minor campus facilities. Second friendliness between inside and outside of the hall should be established by providing a Gray Zone such as floor or a yard. Third lobby should have a enough space for the entrance and exit of the hall and for rest and refreshments. Fourth in addition to a fixed stage height-adjustable stage and booth should be provided in order to use the hall space for different use. Fifth in the color aspect high value and low chroma should be used to create tender and friendly atmospher and in the shape aspect a durable natural and functional design should be considered in order to create a modern atmosphere.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.20 no.44
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• pp.257-261
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• 1997

Patents often serve as leading indicators of technological change. This patenting activity reflected R&D (Research & Development) of new technology. The purpose of this study is to set up a forecasting model that anticipate the number of domestic patent applications and the number of patents granted relating to R&D inputs (R&D expenditure, R&D manpower) at the level of three industrial sectors in Korea : electrical-electronic, machinery, chemical etc. In this study, forecasting models were used trend extrapolation and a set of regressions. Both Theil's inequality coefficient and MAE(Mean Absolute Error) were utilized to test the precision of predicted value. The patent data and the R&D data were based on Indicators of Industrial Technology data throught 1980 to 1996. The major results obtained in this study are as follows (1) The regression model is more useful for forecasting the trends of the number of patent applications and patents granted than the trend extrapolation method. (2) The variance of Theil's inequality is smaller in patent applications than in patent granted.