• 제목/요약/키워드: SEER

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African American Race and Low Income Neighborhoods Decrease Cause Specific Survival of Endometrial Cancer: A SEER Analysis

  • Cheung, Min Rex
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권4호
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    • pp.2567-2570
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    • 2013
  • Background: This study analyzed Surveillance, Epidemiology and End Results (SEER) data to assess if socio-economic factors (SEFs) impact on endometrial cancer survival. Materials and Methods: Endometrial cancer patients treated from 2004-2007 were included in this study. SEER cause specific survival (CSS) data were used as end points. The areas under the receiver operating characteristic (ROC) curve were computed for predictors. Time to event data were analyzed with Kaplan-Meier method. Univariate and multivariate analyses were used to identify independent risk factors. Results: This study included 64,710 patients. The mean follow up time (S.D.) was 28.2 (20.8) months. SEER staging (ROC area of 0.81) was the best pretreatment predictor of CSS. Histology, grade, race/ethnicity and county level family income were also significant pretreatment predictors. African American race and low income neighborhoods decreased the CSS by 20% and 3% respectively at 5 years. Conclusions: This study has found significant endometrial survival disparities due to SEFs. Future studies should focus on eliminating socio-economic barriers to good outcomes.

Receiver Operating Characteristic Curve Analysis of SEER Medulloblastoma and Primitive Neuroectodermal Tumor (PNET) Outcome Data: Identification and Optimization of Predictive Models

  • Cheung, Min Rex
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권16호
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    • pp.6781-6785
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    • 2014
  • Purpose: This study used receiver operating characteristic curves to analyze Surveillance, Epidemiology and End Results (SEER) medulloblastoma (MB) and primitive neuroectodermal tumor (PNET) outcome data. The aim of this study was to identify and optimize predictive outcome models. Materials and Methods: Patients diagnosed from 1973 to 2009 were selected for analysis of socio-economic, staging and treatment factors available in the SEER database for MB and PNET. For the risk modeling, each factor was fitted by a generalized linear model to predict the outcome (brain cancer specific death, yes/no). The area under the receiver operating characteristic curve (ROC) was computed. Similar strata were combined to construct the most parsimonious models. A Monte Carlo algorithm was used to estimate the modeling errors. Results: There were 3,702 patients included in this study. The mean follow up time (S.D.) was 73.7 (86.2) months. Some 40% of the patients were female and the mean (S.D.) age was 16.5 (16.6) years. There were more adult MB/PNET patients listed from SEER data than pediatric and young adult patients. Only 12% of patients were staged. The SEER staging has the highest ROC (S.D.) area of 0.55 (0.05) among the factors tested. We simplified the 3-layered risk levels (local, regional, distant) to a simpler non-metastatic (I and II) versus metastatic (III) model. The ROC area (S.D.) of the 2-tiered model was 0.57 (0.04). Conclusions: ROC analysis optimized the most predictive SEER staging model. The high under staging rate may have prevented patients from selecting definitive radiotherapy after surgery.

부분부하 조건에서 히트펌프의 운전변수 최적화를 통한 냉방계절성능(SEER) 향상에 관한 실험적 연구 (An Experimental Study on the Performance Improvement of the Seasonal Energy Efficiency Ratio(SEER) of a Heat Pump by Optimizing Operating Parameters under Partial Load Conditions)

  • 최성경;이상헌;김선재;김용찬
    • 설비공학논문집
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    • 제29권3호
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    • pp.111-118
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    • 2017
  • Performance factors such as the EER(Energy Efficiency Ratio) and the COP (Coefficient of Performance) are being replaced by seasonal energy efficiency factors, like the SEER (Seasonal EER) and the SCOP (Seasonal COP) to evaluate the performance of a heat pump by the time of the year. Seasonal performance factors, such as the CSPF (Cooling Seasonal Performance Factor) and the HSPF (Heating Seasonal Performance Factor) are used to describe the heat pump's performance during the cool and hot seasons. In this study, the optimization of all heat pump's operating parameters was experimentally conducted to enhance the SEER based on the EU standard (EN 14825). Moreover, the SEER was improved by the compressor frequency, as well as indoor and outdoor fan speeds. In addition, the performance characteristics of the heat pump were studied under partial load conditions. As a result, the SEER was enhanced by 17% when the compressor frequency was optimized. An additional 2% improvement was achievable with the optimization of indoor and outdoor fan speeds.

Analysis of SEER Adenosquamous Carcinoma Data to Identify Cause Specific Survival Predictors and Socioeconomic Disparities

  • Cheung, Rex
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권1호
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    • pp.347-352
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    • 2016
  • Background: This study used receiver operating characteristic curve to analyze Surveillance, Epidemiology and End Results (SEER) adenosquamous carcinoma data to identify predictive models and potential disparities in outcome. Materials and Methods: This study analyzed socio-economic, staging and treatment factors available in the SEER database for adenosquamous carcinoma. For the risk modeling, each factor was fitted by a generalized linear model to predict the cause specific survival. An area under the receiver operating characteristic curve (ROC) was computed. Similar strata were combined to construct the most parsimonious models. Results: A total of 20,712 patients diagnosed from 1973 to 2009 were included in this study. The mean follow up time (S.D.) was 54.2 (78.4) months. Some 2/3 of the patients were female. The mean (S.D.) age was 63 (13.8) years. SEER stage was the most predictive factor of outcome (ROC area of 0.71). 13.9% of the patients were un-staged and had risk of cause specific death of 61.3% that was higher than the 45.3% risk for the regional disease and lower than the 70.3% for metastatic disease. Sex, site, radiotherapy, and surgery had ROC areas of about 0.55-0.65. Rural residence and race contributed to socioeconomic disparity for treatment outcome. Radiotherapy was underused even with localized and regional stages when the intent was curative. This under use was most pronounced in older patients. Conclusions: Anatomic stage was predictive and useful in treatment selection. Under-staging may have contributed to poor outcome.

Analysis of SEER Glassy Cell Carcinoma Data: Underuse of Radiotherapy and Predicators of Cause Specific Survival

  • Cheung, Rex
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권1호
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    • pp.353-356
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    • 2016
  • Background: This study used receiver operating characteristic curve to analyze Surveillance, Epidemiology and End Results (SEER) for glassy cell carcinoma data to identify predictive models and potential disparities in outcome. Materials and Methods: This study analyzed socio-economic, staging and treatment factors. For risk modeling, each factor was fitted by a generalized linear model to predict the cause specific survival. Area under the receiver operating characteristic curves (ROCs) were computed. Similar strata were combined to construct the most parsimonious models. A random sampling algorithm was used to estimate modeling errors. Risk of glassy cell carcinoma death was computed for the predictors for comparison. Results: There were 79 patients included in this study. The mean follow up time (S.D.) was 37 (32.8) months. Female patients outnumbered males 4:1. The mean (S.D.) age was 54.4 (19.8) years. SEER stage was the most predictive factor of outcome (ROC area of 0.69). The risks of cause specific death were, respectively, 9.4% for localized, 16.7% for regional, 35% for the un-staged/others category, and 60% for distant disease. After optimization, separation between the regional and unstaged/others category was removed with a higher ROC area of 0.72. Several socio-economic factors had small but measurable effects on outcome. Radiotherapy had not been used in 90% of patients with regional disease. Conclusions: Optimized SEER stage was predictive and useful in treatment selection. Underuse of radiotherapy may have contributed to poor outcome.

Using SEER Data to Quantify Effects of Low Income Neighborhoods on Cause Specific Survival of Skin Melanoma

  • Cheung, Min Rex
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권5호
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    • pp.3219-3221
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    • 2013
  • Background: This study used receiver operating characteristic (ROC) curves to screen Surveillance, Epidemiology and End Results (SEER) skin melanoma data to identify and quantify the effects of socioeconomic factors on cause specific survival. Methods: 'SEER cause-specific death classification' used as the outcome variable. The area under the ROC curve was to select best pretreatment predictors for further multivariate analysis with socioeconomic factors. Race and other socioeconomic factors including rural-urban residence, county level % college graduate and county level family income were used as predictors. Univariate and multivariate analyses were performed to identify and quantify the independent socioeconomic predictors. Results: This study included 49,999 parients. The mean follow up time (SD) was 59.4 (17.1) months. SEER staging (ROC area of 0.08) was the most predictive foctor. Race, lower county family income, rural residence, and lower county education attainment were significant univariates, but rural residence was not significant under multivariate analysis. Living in poor neighborhoods was associated with a 2-4% disadvantage in actuarial cause specific survival. Conclusions: Racial and socioeconomic factors have a significant impact on the survival of melanoma patients. This generates the hypothesis that ensuring access to cancer care may eliminate these outcome disparities.

CiteSeer 말뭉치를 이용한 과학기술 문헌의 주제 분석 (Topic Analysis of Science and Technology Articles using CiteSeer Corpus)

  • 정한민;강인수;성원경
    • 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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    • 제14권5호
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    • pp.507-511
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    • 2008
  • 과학기술 분야는 매우 빠른 발전 속도를 보이며 세부 분야 간 융 복합 현상이 빈번하게 일어나는 특징을 가지고 있다. 과학기술정보 말뭉치로부터 상기 특성을 분석해 내는 작업은 연구 주제 추이를 분석하고 주제 간 연관 관계를 파악하기 위해 필요하다. 본 연구는 과학기술 분야 - 특히 정보기술(Information Technology) 분야 - 에서 광범위하게 활용되고 있는 Citeseer 말뭉치로부터 추출된 주제를 이용하여 다양한 주제 분석을 수행하는 방안을 보이는 것을 목표로 한다. 특히, 연구개발 전주기 지원 시스템인 OntoFrame에서 주제가 어떠한 역할을 할 수 있는지 사례를 통해 실증하고자 한다.

Racial and Social Economic Factors Impact on the Cause Specific Survival of Pancreatic Cancer: A SEER Survey

  • Cheung, Rex
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권1호
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    • pp.159-163
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    • 2013
  • Background: This study used Surveillance, Epidemiology and End Results (SEER) pancreatic cancer data to identify predictive models and potential socio-economic disparities in pancreatic cancer outcome. Materials and Methods: For risk modeling, Kaplan Meier method was used for cause specific survival analysis. The Kolmogorov-Smirnov's test was used to compare survival curves. The Cox proportional hazard method was applied for multivariate analysis. The area under the ROC curve was computed for predictors of absolute risk of death, optimized to improve efficiency. Results: This study included 58,747 patients. The mean follow up time (S.D.) was 7.6 (10.6) months. SEER stage and grade were strongly predictive univariates. Sex, race, and three socio-economic factors (county level family income, rural-urban residence status, and county level education attainment) were independent multivariate predictors. Racial and socio-economic factors were associated with about 2% difference in absolute cause specific survival. Conclusions: This study s found significant effects of socio-economic factors on pancreas cancer outcome. These data may generate hypotheses for trials to eliminate these outcome disparities.

에어컨의 냉방기간 에너지 효율 산출을 위한 실험적 연구 (Experimental Study on the Cooling seasonal Performance Factor of Room Air-conditioner)

  • 이홍원;문정호;배영돈;박종철
    • 설비공학논문집
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    • 제4권3호
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    • pp.204-216
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    • 1992
  • In most cases, EER(Energy Efficiency Ratio) is available to present energy efficiency of air-conditioners. But, EER is not adapt to measure energy efficiency at actual life environment because it is based on fixed temperature and humidity contditions. To overcome this disadvantage, there is need to introduce SEER(Seasonal Energy Efficiency Ratio) established at time varient temperature and humidity conditions. In this paper, SEER measurement method and conditions based on actual life environment of the country is introduced, and discussed SEER value about two air-conditioner type, that is, non inverter air-conditioner and inverter air-conditioner. As a result of, inverter air-conditioner was superior to non inverter air-conditioner at cooling seasonal energy efficiency.

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바이패스방식을 이용한 용량가변 스크롤 압축기에 관한 연구 (A study on the Modulated Scroll Compressor by Bypass Method)

  • 김철환;신동구;박홍희
    • 유체기계공업학회:학술대회논문집
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    • 유체기계공업학회 2003년도 유체기계 연구개발 발표회 논문집
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    • pp.693-696
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    • 2003
  • Hermetic Compressor circulates refrigerant with constant flow rate regardless of operation condition. so, at the operating condition requiring low cooling capacity, too much refrigerant flow deteriorates seasonal energy efficiency ratio(SEER). In this reason, modulated compressor is needed to improve SEER. Among many types of modulated compressor, non-inverter type modulated compressor is required for its low cost and easy to development. In the modulated scroll compressor by bypass method, EER steeply decreases for many loss like re-compression, changes of volume ratio, decrease of motor efficiency by torque variation. So. the range of modulation ratio for optimized SEER must be selected accompany with air conditioner set development.

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