• 대한금속재료학회지
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• 제49권7호
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• pp.570-576
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• 2011

The shape of a dendrite tip has long been approximated by a paraboloid of revolution, but many attempts have been made as well to more accurately match the dendrite tip profile using other mathematical functions: power function, 4th order polynomial, and hyperbolic function. In the present work, dendrite tip shapes were matched by parabolic function. The differences between the dendrite tip shapes of pivalic acid(PVA)-ethanol(Eth) and succinonitrile(SCN)-salol systems, characterized by anisotropic and isotropic solid-liquid interfacial properties, respectively, were quantitatively treated using shape parameters. The PVA-Eth system showed a slightly higher Z/R value than the SCN-salol system, their Z/R values lying in the range 2-4. (Z is the distance from the tip beyond which the parabolic fit starts to deviate from the profile, and R the tip radius.) ${\lambda}_P$ is the distance from the tip beyond which side branching starts to appear, and is larger in the PVA-Eth system than the SCNsalol system. ${\lambda}_P$ is different for both sides of the 2-dimensional dendrite profile. The difference of ${\lambda}_P$ between both sides of the dendrite is larger for PVA-Eth system than for SCN-salol, implying that the dendrite of PVA-Eth is less symmetric than that of SCN-salol.

• Journal of Yeungnam Medical Science
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• 제40권3호
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• pp.283-288
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• 2023

Severe chronic neutropenia is classified as severe congenital, cyclic, autoimmune, or idiopathic. However, there is a lot of uncertainty regarding the diagnosis of severe congenital neutropenia (SCN) and chronic idiopathic neutropenia, and this uncertainty affects further evaluations and treatments. A 20-year-old man presented with fever and knee abrasions after a bicycle accident. On admission, his initial absolute neutrophil count (ANC) was 30/µL. He had no medical history of persistent severe neutropenia with periodic oscillation of ANC. Although his fever resolved after appropriate antibiotic therapy, ANC remained at 80/µL. Bone marrow (BM) aspiration and biopsy were performed, and a BM smear showed myeloid maturation arrest. Moreover, genetic mutation test results showed a heterozygous missense variant in exon 4 of the neutrophil elastase ELANE: c597+1G>C (pV190-F199del). The patient was diagnosed with SCN. After discharge, we routinely checked his ANC level and monitored any signs of infection with minimum use of granulocyte colony-stimulating factor (G-CSF), considering its potential risk of leukemic transformation. Considering that SCN can be fatal, timely diagnosis and appropriate management with G-CSF are essential. We report the case of a patient with SCN caused by ELANE mutation who had atypical clinical manifestations. For a more accurate diagnosis and treatment of severe chronic neutropenia, further studies are needed to elucidate the various clinical features of ELANE.

• Journal of Veterinary Science
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• 제25권1호
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• pp.6.1-6.11
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• 2024

Background: Chronic bovine mastitis is linked to biofilm-producing Staphylococcus aureus (bp-Sa) or Staphylococcus coagulase-negative (bp-Scn). Objectives: Bp-Sa and bp-Scn were treated with intramammary preparations of either enrofloxacin HCl·2H₂O-dimethyl-sulfoxide-chitosan (enro-C/DMSO/chitosan) or enro-C alone. Their potential to inhibit and degrade biofilm formation in vitro was also assessed. Methods: Milk samples were obtained from the affected quarters in a herd. Phenotypical and genotypical identifications as biofilm-producing Staphylococcus species were carried out. Enro-C/DMSO/chitosan and enro-C alone were assessed to determine their in vitro efficacy in interfering with biofilm formation and their bactericidal effects. A prolonged eight-day treatment with a twice-daily intramammary insertion of 10 mL of enro-C/DMSO/chitosan or enro-C alone was set to evaluate the clinical and bacteriological cures on day 10 in 15 cows per group and the biofilm-inhibiting ability. Results: Fifty-seven percent of the isolates were identified as Staphylococcus spp., of which 50% were bp-Sa, 46% bp-Scn, and 4% Staphylococcus pseudintermedius. One hundred percent of the S. aureus isolated and 77% of Staphylococcus coagulase-negative were biofilm producers. In both groups, the icaA and icaD biofilm-producing genes were identified. The experimental preparation could inhibit biofilm formation, degrade mature biofilms, and have well-defined microbicidal effects on planktonic and biofilm bacteria. The respective clinical and bacteriological cure rates were 100% and 80% for enro-C/DMSO/chitosan and 41.7% and 25% for enro-C alone. Conclusions: Enro-C/DMSO/chitosan eliminates bp-Sa and bp-Scn from cases of chronic bovine mastitis.

• 한국환경과학회지
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• 제4권2호
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• pp.223-232
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• 1995

액체막의 운반체로 사용할 새로운 2개의 거대고리화합물을 합성하였다. 이들 결과들은 이 시스템을 구성하는데 있어서 이론의 응용성을 증명하여 준다. source phase의 공존이온으로서 $SCN^-$,$I^-$ 및 $Cl^-$이온을 그리고 receicing phases에서 $S_2O_3^{2-}$와 $P_2O_7^{4-}$을 이용한 액세막계로서부터 중금속 이온들에 대한 선택적 수송효율을 검토하였다. source phase의 M(II)이 $Cd(SCN)_2$$(P[SCN^-]= 0.40M)$, $Hg(SCN)_2([SCN^-]=0.40M)$, Pd(CN)$([CN^-]= 0.40M)$일때 M(II)의 수송율은 최대값을 나타낸다. 각가의 경쟁 양이온에 대한 Cd(II)이나 Pd(II)은 source phase가 00.3M-$S_2O_3^{2-}$이나 0.3M-$P_2O_7^{4-}$ 일때 가장 잘 분리된다.이 연구의 결과에서, 이 액체막계에서 효과적인 거대고리-매질수송을 하기 위해서는 두개의 규칙이 반드시 필요하다. 첫째, tiluence중으로 $M^{n+}$이온이 효과적으로 추출되고, 즉 만일 $M^{n+}$ 거대고리화합물 상호작용에 대한 logK값과 $M^{n+}$-거대고리화합물($L_1$이나 $L_2$)의 상호작용에 대한 logK값의 비가 충분히 크다면 receiving phase와 toluene의 접촉면으로부터 쉽게 중금속이온($Cd^{2+}$,$Pb^{2+}$ 및 $Hg^{2+}$)들이 떨어져 나온다. $L_1$(3,5-benzo-10,13,18,21-tetraoxa-1,7-diazabicyclo(8,5,5)eicosnan)은 $Cd^{2+}$ 과 $Pb^{2+}$ 이온과 안정한 착물을 형성한다. 그리고 $L_1$은 수용액중에서 용해하기가 매우 어렵다. 그리고 $Cd^{2+}$$L_1$나 $Pb^{2+}$$L_1$착물은 $Cd^{2+}-{(S_2O_3)}_2^{2-}$나 $Pd^{2+}-P_2O_7^{4-}$착물보다 비교적 불안정하다. 다른 한편으로 $Hg^{2+}-L_1$착물의 안정도는 $Hg^2-{2+}-(S_2O_3)_2^{2-}$이나 $Pb^{2+}-P0_2O_7^{4-}$의 그것보다 그리고 $L_2$(5,8,15,18,23,26-hexaoxa-1,12-diazabicyclo(10,8,8)octacosan)의 tuluene에 대한 분배계수는 $L_1$의 그것보다 훨씬 작다. 따라서 $Hg^{2+}$-$L_1$이나 $M^{n+}$이나 $M^{n+}-L-2(M^{2+}=Cd^{2+}, Pb^{2+}$이나 $Hg^{2+})$의 안정도수상수가 매우 큼에도 불구하고 이들 양이온의 수송량은 매우 적다.

• Environmental Engineering Research
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• 제20권1호
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• pp.65-72
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• 2015

A comparative study on response of a toxic compound thiocyanate ($SCN^-$) was carried out in continuous and fed batch moving bed reactor systems. Both systems had three sequential anaerobic, anoxic and aerobic reactors and operated at same hydraulic retention time. Feed $SCN^-$ was first increased from 600 mg/L to 1,000 mg/L for 3 days (shock 1) and then from 600 to 1,200 mg/L for 3 days (shock 2). In anaerobic continuous reactor, increase of effluent COD (chemical oxygen demand) due to shock load was only 2%, whereas in fed batch reactor it was 14%. In anoxic fed batch reactor recovery was partial in terms of $SCN^-$, phenol, COD and $NO{_3}{^-}$-N and $NO{_2}{^-}$-N removals and in continuous reactor complete recovery was possible. In both systems, inhibition was more significant on aerobic reactors than anaerobic and anoxic reactors. In aerobic reactors ammonia removal efficiency deteriorated and damage was irreversible. Present study showed that fed batch reactors showed higher substrate removal efficiency than continuous reactors during regular operation, but are more susceptible to toxic feed shock load and in nitrifying reactor damage was irreversible.

• 전자공학회논문지 IE
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• 제45권2호
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• pp.13-19
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• 2008

TLM 수치 해석법의 주요한 장점은 가장 복잡한 전송선 구조에 있어서도 해석이 용이하다는 것이다. 본 논문에서는 대칭압축노드를 이용한 TLM법을 마이크로스트립 meander 라인에 성공적으로 적용하였다. 플라나 마이크로스트립 전송선을 모델화하기 위한 대칭압축노드에 대한 상세한 기술이 제시되었고 또한 2종류의 마이크로스트립 meander 라인의 산란 파라메터 $S_{11}$과 $S_{21}$을 계산하였다. 구해진 결과로부터 TLM 해석법이 복잡한 플라나 마이크로웨이브 전송선 구조를 모델링하는데 유용한 해석법임을 보였다. 제시된 TLM 해석 결과는 고주파 영역에서 마이크로웨이브 집적 회로를 설계하는데 유용하게 사용될 수 있다.

• 식물병연구
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• 제19권3호
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• pp.216-219
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• 2013

국내에서 육성된 75개 콩 장려품종에 대하여 콩 씨스트선충 HG type 2.5에 대한 저항성을 검정하였다. 품종에 따라 콩 씨스트선충의 증식 정도는 104-624 씨스트/화분이었다. 국내 콩 장려 품종 중에서 콩 씨스트선충 HG type 2.5에 대한 저항성 품종은 없었으며, '장엽콩', '새알콩', '밀양콩', '만석콩'은 중간저항성, 33품종은 중간감수성, 나머지 38품종은 감수성으로 판정되었다. 국내에서 저항성 장려품종이 육성되기까지 콩 씨스트선충의 피해가 심한 포장에는 '장엽콩', '새알콩', '밀양콩', '만석콩'을 심도록 추천하는 것이 좋겠다.

• 대한수의학회지
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• 제41권2호
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• pp.139-146
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• 2001

This study was carry out to identify the distribution of calcium binding proteins; calbindin(CB), calretinin(CR) and parvalbumin(PA) in the suprachiasmatic nucleus(SCN) of the Korean native goat by immunohistochemical methods. The expression of substance P(SP), calcitonin gene-related peptide(CG-RP), neuropeptide Y(NPY), vasoactive intestinal polypeptide(VIP) and galanin(GAL) were also investigated. CR-immunoreactivity was found in both of the cell bodies and fibers in the SCN, which the CB-immunoreactivity was observed only in the fibers. The immunoreactivity for VIP was observed in both the cell bodies and fibers, but SP-, NPY, GAL-immunoreactivities were only found in the fibers. CGRP-immunoreactivity was not seen in cell body and fibers. These results suggest that VIP, SP, NPY and GAL play a neuromodulatory or/ and neurotransmitter roles in cooperation with CB and CR in SCN of the Korean native goat.

• Genomics & Informatics
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• 제10권2호
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• pp.110-116
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• 2012

Recent several studies have shown that the genetic variation of SCN5A is related with atrioventricular conduction block (AVB); no study has yet been published in Koreans. Therefore, to determine the AVB-associated genetic variation in Korean patients, we investigated the genetic variation of SCN5A in Korean patients with AVB and compared with normal control subjects. We enrolled 113 patients with AVB and 80 normal controls with no cardiac symptoms. DNA was isolated from the peripheral blood, and all exons (exon 2-exon 28) except the untranslated region and exon-intron boundaries of the SCN5A gene were amplified by multiplex PCR and directly sequenced using an ABI PRISM 3100 Genetic Analyzer. When a variation was discovered in genomic DNA from AVB patients, we confirmed whether the same variation existed in the control genomic DNA. In the present study, a total of 7 genetic variations were detected in 113 AVB patients. Of the 7 variations, 5 (G87A-A29A, intervening sequence 9-3C>A, A1673G-H558R, G3578A-R1193Q, and T5457C-D1819D) have been reported in previous studies, and 2 (C48G-F16L and G3048A-T1016T) were novel variations that have not been reported. The 2 newly discovered variations were not found in the 80 normal controls. In addition, G298S, G514C, P1008S, G1406R, and D1595N, identified in other ethnic populations, were not detected in this study. We found 2 novel genetic variations in the SCN5A gene in Korean patients with AVB. However, further functional study might be needed.

• Bulletin of the Korean Chemical Society
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• 제21권3호
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• pp.339-341
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• 2000