• 한국작물학회지
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• 제35권6호
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• pp.532-538
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• 1990

본 연구는 유전 배경과 초형이 다른 추파소맥 4품종을 공시하였으며, 이들 품종들의 조합배열을 감안하여 단교배 6조합, 3원교배 6조합 및 복교배 3조합을 생산하여 각 교잡방법 및 품종교잡 배열순서에 관한 효율성을 비교 분석하여 교잡육종의 기초자료를 제공하고 신품종 육성의 효율성을 높이고자 시행하였던 바 그 결과를 요약하면, 1. 교배양식간 비교에 있어서 복교잡에서 가장 빠른 출수를 보였으며 종실수량도 20.3g으로서 가장 많았는데 3원교배 및 단교배 순으로 감소하였는데, 친품종들이 가장 적은 주당수량을 보였다. 2. 주당수량과 수량구성요소에 대한 4$\times$4 단교배 Diallel 분석은 GCA와 SCA에서 각각 조합능력의 차가 인정되었으며, 또한 SCA 효과중 평균 우성편차도 역시 모든 형질에서 차가 있었다. 주당수량의 GCA효과는 그루밀과 Bezostaya 1이 가장 높았으며, 이들 품종들이 실제 주당수량이 가장 많았다. 3. F$_1$의 SCA효과는 (은파밀/Bezostaya 1)조합에서 4.22로가장 높았고, (그루밀/은파밀) 조합에서 2.00으로 가장 낮았다. 4. 3조합의 F$_1$ 복교잡종중에서 (Lancota/은파밀//그루밀/Bezostaya 1) 조합이 주당수량 24.5g으로서 가장 많았고, 이러한 복교잡에 이용된 단교잡종(그루밀/은파밀)과 (Lancota/Bezostaya 1)의 복교잡에 직접 발현되지 않고 이들간의 염색체 교환방법에 의하여 결합되어 (그루밀/Lancota), (그루밀/Bezostaya 1), (은파밀/Lancota) 및 (은파밀/Bezostaya 1)의 조합이 발현되었으며, 이들의 단교배 F$_1$들의 평균 수량도 많고 SCA 효과도 높았다. 5. 3원교잡 F$_1$의 6조합중에서(Lan./Bez.//은파밀) 조합에서 21.3g으로 가장 높은 수량을 보였는데, 이들의 염색체의 상호 교환 결합에 의하여(Lancota/은파밀)과 (Bezostaya 1/은파밀) 조합이 SCA효과가 가장 컸고 평균 종실수량도 다른 3원교잡의 경우보다 많았다.

• 대한본초학회지
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• 제28권4호
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• pp.7-16
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• 2013

Objectives : Brassica campestris var narinosa (BCN), Canavalia gladiata DC semen (CGD) and their combinational prescription (BCN+CGD) have been use to demonstrate to regulate hematopoiesis. In the current study, we investigated whether Brassica campestris var narinosa, Canavalia gladiata DC semen and their combinational prescription is related to hemato-potentiating function using Sca-$1^+$ hematopoietic stem cells (Sca-$1^+HSCs$) as a testing system. Methods : Sca-$1^+HSCs$ isolated from femur in C57bl/6 mice with leukopenia and thrombocytopenia induced by cyclophosphamide (CTX). Then, Real-time PCR was performed to measure the mRNA expression, ELISA and haematopoiesis-related gene (EPO, TPO, IL-3, SCF, c-kit, GM-CSF), the phosphorylation of JAK2, GATA-1 and STAT-5a/b were observed by western blot, and the numbers of $CD117^+/Sca-1^+$ cell and the number of granulocyte erythrocyte monocyte macrophage colony-forming units (CFU-GEMM) and erythroid burst forming units (BFU-E), semisolid clonogenic assay was performed. Result : When Sca-$1^+HSCs$ were treated with Brassica campestris var narinosa, Canavalia gladiata DC semen and their combinational prescription with rIL-3/rSCF, the expression of haematopoiesis-related (EPO, TPO, IL-3, SCF, c-kit, and GM-CSF) were significantly increased at the levels of mRNA as well as production in Sca-$1^+HSCs$. Additionally, CGS enhanced phosphorylation of JAK2, GATA-1, and signal transducer and activator of transcription-5a/b (STAT-5a/b) in Sca-$1^+HSCs$. Furthermore, their combinational prescription (BCN+CGD) significantly enhanced the growth rate of granulocyte erythrocyte monocyte macrophage colony-forming units (CFU-GEMM) and erythroid burst forming units (BFU-E) in vitro. Conclusion : These result suggest that Brassica campestris var narinosa (BCN) and Canavalia gladiata DC have hematopoietic enhancement via hematopoietic cytokine-mediated JAK2/GATA-1/STAT-5a/b pathway, and their combinational prescription (BCN+CGD) has superior hematopoietic enhancement to those of individual extracts.

• Molecules and Cells
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• 제24권3호
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• pp.338-342
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• 2007

Spinocerebellar ataxias (SCAs) are caused by expansion of (CAG)n triplet repeats. These repeats occur as polymorphic forms in general population; however, beyond a threshold size they become pathogenic. The sizes and distributions of repeats at the SCA1, SCA2, SCA3, SCA7 and DRPLA loci were assessed by molecular analysis of 124 unrelated ataxia patients and 44 controls, and the association of larger normal (LN) alleles with disease prevalence was evaluated. Triplet repeat expansions in the disease range were detected in 8% (10/124) of the cases, with the majority having expansion at the SCA1 locus. Normal allele ranges in the cohort studied were similar to the Caucasian and North Indian populations but differed from the Korean and Japanese populations at various loci. The percentage of individuals with LN alleles at the SCA1 and SCA2 loci was higher than reported in Indians, Japanese and Caucasians. LN alleles showed a good correlation with the incidence of SCA1, indicating that SCA1 is the most prevalent ataxia in our population. The majority of cases with clinical symptoms of SCA could not be diagnosed by established CAG repeat criteria, suggesting that there may be an alternative basis for disease pathogenesis: (i) Repeats lower than the normal range may also result in abnormal phenotypes (ii) LN alleles at different loci in the same individual may contribute to symptoms (iii) Exogenous factors may play a role in triggering disease symptoms in individuals with LN alleles (iv) Triplet repeats may reach the disease range in the brain but not in the blood.

• 한국산림과학회지
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• 제96권6호
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• pp.644-651
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• 2007

본 연구는 교토의정서 제 2차 공약기간(2013~2017년) 이후 교섭에 있어서 국가별 탄소배출 흡수 인벤토리에 유력하게 포함될 전망인 HWP 탄소축적 변화량 및 배출량을 평가하기 위하여 우리나라 HWP 생산 수입 수출량에 대한 FAO통계와 국내통계를 적용하여 비교 추정하였다. 그 결과, 2005년 현재 HWP 탄소축적 변화량은 FAO 통계 적용의 경우 축적변화 접근법(SCA)이 1.434 Tg C, 대기유출입 접근법(AFA)이 -1.330 Tg C, 생산 접근법(PA)이 0.597 Tg C, 국내통계 적용은 SCA가 1.246 Tg C, AFA가 -1.520 Tg C, PA가 0.444 Tg C로 추정되었다. HWP으로 부터의 $CO_2$ 배출량 흡수량은 FAO통계 적용의 경우 SCA가 $-5,258Gg\;CO_2$ (흡수), AFA가 $4,877Gg\;CO_2$ (배출), PA가 $-2,189Gg\;CO_2$ (흡수), 국내통계 적용은 SCA가 $-4,569Gg\;CO_2$ (흡수), AFA가 $5,573Gg\;CO_2$ (배출), PA가 $-1,628Gg\;CO_2$ (흡수)로 FAO통계 적용이 국내통계 적용보다 모든 방법별 HWP 탄소축적 변화량 및 배출량 추정에서 유리한 것으로 나타났다.

• 한국인터넷방송통신학회논문지
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• 제14권1호
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• pp.85-91
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• 2014

본 논문은 16-QAM 신호 전송시 시분산 채널에서 발생되는 진폭과 위상 찌그러짐에 의한 부호간 간섭을 경감시키기 위한 적응 등화 알고리즘인 VSDA (Variable stepsize Square contour Decision directed Algorithm)의 성능에 관한 것이다. 기존 SCA 에서는 송신 신호의 2차 통계치인 Constellation Dependent Constant를 이용하여 수신 신호의 진폭과 위상을 보상하지만, VSDA에서는 constellation matching을 위한 distance adjusted approach 개념과 decision directed 비용 함수를 부가하여 수렴 성능을 더욱 개선시킨 것이다. 논문에서는 컴퓨터 시뮬레이션을 통하여 VSDA와 SCA의 등화 성능을 비교하였으며, 이를 위한 성능 지수로는 등화기 출력 신호 성상도, 잔류 isi양, 최대 찌그러짐 및 MSE를 사용하였다. 성능의 비교 결과 수렴 속도에서는 VSDA 알고리즘이 SCA보다 훨씬 개선되었지만, 모든 성능 지수는 유사함을 알 수 있었다.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.79-79
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• 2017

Grain Sorghum varieties grown in Korea have low productivity and are constrained by the fact that farmers' choice of improved varieties is limited. Hybrid cultivars have been demonstrated to be more productive and food security than pure line varieties. However, There's no available hybrid cultivars and never planted before in Korea. This study was, therefore, conducted to determine combining ability of Korean landrace varieties and cultivar, the level of heterosis of experimental hybrids depending on environments. Two cytoplasmic male-sterile lines were crossed with six male-fertile lines in accordance with North Carolina II mating scheme to generate 12 experimental hybrids. The hybrids were evaluated in replicated row-column alpha designs at two sites in Texas and South Korea under on-season production conditions. For each trait, general combining ability (GCA) and specific combining ability (SCA) effects were estimated using the line-tester method of analysis. Results indicated significant differences among genotypes for both grain yield potential and secondary traits. Hybrids were predominant for grain yield, and displayed up to 127% heterosis of A03017 ${\times}$ Sodamchal in Korea. Positive GCA for yield was observed for Donganme, Hwanggeumchal and Jungmo4002 in Korea. Among them Jungmo4002 and Donganme had highly positive for yield (227.90 and 84.90 kg ha-1), while it showed negative GCA for yield in College station (-40.90, -189.60 kg ha-1). ATx630 ${\times}$ Sodamchal had the greatest SCA for yield (468.10 kg/ha) in College station but at South Korea its SCA effect was -302.40 kg/ha. A similar trend was observed, followed by A03017 ${\times}$ Donganme (SCA effect = 215 kg ha-1 at College station vs. -44.20 kg ha-1 at South Korea). At South Korea the greatest positive SCA effect for grain was observed in ATx630 ${\times}$ Jungmo4002 as 322.20 kg/ha. Both GCA and SCA effects significantly interacted with site effects demonstrating the need for region adaptation of potential cultivars and test for developing Korea suitable cultivar.

• Molecules and Cells
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• 제19권1호
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• pp.23-30
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• 2005

Spinocerebellar ataxia type 1 (SCA1) is an autosomal-dominant neurodegenerative disorder caused by expansion of the polyglutamine tract in the SCA1 gene product, ataxin-1. Using d2EGFP, a short-lived enhanced green fluorescent protein, we investigated whether polyglutamine-expanded ataxin-1 affects the function of the proteasome, a cellular multicatalytic protease that degrades most misfolded proteins and regulatory proteins. In Western blot analysis and immunofluorescence experiments, d2EGFP was less degraded in HEK 293T cells transfected with ataxin-1(82Q) than in cells transfected with lacZ or empty vector controls. To test whether the stability of the d2EGFP protein was due to aggregation of ataxin-1, we constructed a plasmid carrying $ataxin-1-{\Delta}114$, lacking the self-association region (SAR), and examined degradation of the d2EGFP. Both the level of $ataxin-1-{\Delta}114$ aggregates and the amount of d2EGFP were drastically reduced in cells containing $ataxin-1-{\Delta}114$. Furthermore, d2EGFP localization experiments showed that polyglutamine-expanded ataxin-1 inhibited the general function of the proteasome activity. Taken together, these results demonstrate that polyglutamine-expanded ataxin-1 decreases the activity of the proteasome, implying that a disturbance in the ubiquitin-proteasome pathway is directly involved in the development of spinocerebellar ataxia type1.

• Korean Journal of Acupuncture
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• 제19권2호
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• pp.79-85
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• 2002

Objective : In 1983 Autosomal dominent spinocerebellar ataxia(ADCA) has been classified to four types by a useful clinical features according to Harding. Since 1993 ADCA referred to as SCA by molecular genetic characteristics. We focused on the improvement of clinical symptoms in SCA patient through oriental medical treatment. Methods ＆ Results : The assessment included neurophysiological examination and clinical symptoms. For example slow saccade, gaze limitation, upward and lateral, nystagmus, truncal and gait ataxia. The patient(M/30) was clinically charaterized by ocular abnormalities, trunkal and gait ataxia and the MRI showed atrophy of cerebellar vermis. The patient was taken both common acupuncture and Dong-Si venepuncture on Hwasan with herbal medicine. Before the treatment Rt. ocular movement were slowed and a significant eye fixation was observed always in abduction and intermittently presented trunkal and gait ataxia. During the treatment trunkal and gait ataxia has not been presented and ocular obnomalities changed to normal state. This case suggests the possibility of oriental medical treatment on SCA but further observation is needed on this patient.

• Journal of Korean Neurosurgical Society
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• 제62권1호
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• pp.114-122
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• 2019

Objective : Silent corticotroph adenomas (SCA) are endocrine-inactive pituitary adenomas with positive immunohistochemistry staining for adrenocorticotropic hormone (ACTH). We investigated whether SCA-associated clinical profiles were more aggressive than hormonally negative adenomas (HNA). Methods : Among 627 patients with pathologically proven endocrine-inactive pituitary adenomas between 2004 and 2013, positive immunohistochemistry revealed 55 SCAs and 411 HNAs. Surgical outcomes and radiological and endocrinological characteristics were compared. Results : Strong female predominance was observed in the SCA group (p<0.001). Cavernous sinus invasion was identified in 22 (40%) SCA patients and 72 (17.6%) HNA patients (p<0.001). There were no differences in ACTH or cortisol levels between the two groups. The incidence of preoperative hypopituitarism and postoperative hormonal outcome did not differ between two groups. Total resection was achieved in 35 patients (63.7%) with SCA and 332 patients (80.8%) with HNA (p=0.007). When tumors were completely removed, recurrence rates were not statistically different between two groups (p=0.60). When complete resection was not achieved, tumors regrew from these remnants in seven patients (35.0%) with SCA and 12 patients (15.2%) with HNA (p=0.05). Conclusion : Total surgical resection for SCA is often challenging as these tumors frequently invade a cavernous sinus. Early remnant tumor intervention is justified, because untreated residual pituitary tumors regrow when patients were followed up for a long time. Prophylactic radiotherapy is not warranted for completely resected SCAs as tumor recurrence is uncommon.

• 한국과학교육학회지
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• 제27권7호
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• pp.631-638
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• 2007

이 연구에서는 물리적 비유를 사용한 학생 중심 비유 수업의 효과를 학생들의 개념 이해와 응용, 개념 이해 및 응용의 파지, 과학 수업 환경에 대한 인식, 비유 수업에 대한 인식 측면에서 조사하였다. 서울시에 소재한 중학교에서 1학년 6학급(208명)을 선정하여 통제 집단, 교사 중심 비유(TCA) 집단, 학생 중심 비유(SCA) 집단에 배치하고, '물질의 세 가지 상태' 및 '분자의 운동'에 대해서 8차시 동안 수업을 실시하였다. 연구 결과, 개념 이해, 개념 및 응용의 파지, 과학 수업 환경에 대한 인식에서 SCA 집단의 점수는 다른 집단들보다 유의미하게 높았다. 개념 응용에서도 SCA 집단의 점수가 다른 집단들보다 높았으나, SCA 집단과 통제 집단 간에만 유의미한 점수 차이가 있었다. TCA 집단은 응용의 파지에서만 통제 집단보다 학생들의 점수가 높았다. 또한, SCA 집단의 학생들은 TCA 집단에서보다 비유 수업에 대해 긍정적으로 인식하고 있었다. 이에 대한 교육적 함의를 논의했다.