• Journal of Pharmaceutical Investigation
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• v.38 no.4
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• pp.241-247
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• 2008

Paclitaxel is a taxane diterpene amide, which was first extracted from the stem bark of the western yew, Taxus brevifolia. This natural product has proven to be useful in the treatment of a variety of human neoplastic disorders, including ovarian cancer, breast and lung cancer. Paclitaxel is a highly hydrophobic drug that is poorly soluble in water. It is mainly given by intravenous administration. Therefore, The pharmaceutical formulation of paclitaxel ($Taxol^{(R)}$; Bristol-Myers Squibb) contains 50% $Cremophor^{(R)}$ EL and 50% dehydrated ethanol. However the ethanol/Cremophor EL vehicle required to solubilize paclitaxel in $Taxol^{(R)}$ has a pharmacological and pharmaceutical problems. To overcome these problems, new formulations for paclitaxel that do not require solubilization by $Cremophor^{(R)}$ EL are currently being developed. Therefore this study utilized a supercritical fluid antisolvent (SAS) process for cremophor-free formulation. To select hydrophilic polymers that require solubilization for paclitaxel, we evaluated polymers and the ratio of paclitaxel/polymers. HP-${\beta}$-CD was used as a hydrophilic polymer in the preparation of the paclitaxel solid dispersion. Although solubility of paclitaxel by polymers was increased, physical stability of solution after paclitaxel/polymer powder soluble in saline was unstable. To overcome this problem, we investigated the use of surfactants. At 1/20/40 of paclitaxel/hydrophilic polymer/ surfactant weight ratio, about 10 mg/mL of paclitaxel can be solubilized in this system. Compared with the solubility of paclitaxel in water ($1\;{\mu}g/mL$), the paclitaxel solid dispersion prepared by SAS process increased the solubility of paclitaxel by near 10,000 folds. The physicochemical properties was also evaluated. The particle size distribution, melting point and amophorization and shape of the powder particles were fully characterized by particle size distribution analyzer, DSC, SEM and XRD. In summary, through the SAS process, uniform nano-scale paclitaxel solid dispersion powders were obtained with excellent results compared with $Taxol^{(R)}$ for the physicochemical properties, solubility and pharmacokinetic behavior.

• Journal of Oriental Neuropsychiatry
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• v.9 no.2
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• pp.97-109
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• 1998

This study was designed and undertaken to identify objectively the degree and relationship of anxiety, depression, & anger which are chief essential elements of emotional status in Hwabyung patients.The subjects in this study were 35 Hwabyung patients and 40 Non-Hwabyung persons, and for the assessment of anxiety, depression, & anger. We used Zung's Self-Rating Anxiety Scale(SAS), Zung's Self-Rating Depression Scale(SDS) & State-Trait Anger Expression Inventory(STAXI).The results of this study are as follows:1. There were significant differences in the 18 items of SAS among 20 items between Hwabyung patients and the control group(p＜0.05 respectively).2. There were significant differences in the 13 items of SDS among 20 items between Hwabyung patients and the control group(p＜0.05 respectively).3. There were significant differences in the mean scores of SAS and SDS between Hwabyung patients and the control group(p＜0.001 respectively).4. There were significant differences in the mean scores of State Anger, Trait Anger, Trait Anger/Temperament, Anger-in & Anger-out counted by STAXI between Hwabyung patients and the control group (p＜0.001, p＜0.01, p＜0.001, p＜0.001, p＜0.05 respectively).5. There were significant relationships between State Anger & Anxiety, Anger-out & Trait Anger/Temperament, Depression & Anxiety(r=.43, r=.37, r=.64).

• Journal of the Korean Society for Aviation and Aeronautics
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• v.15 no.4
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• pp.9-16
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• 2007

Tilt rotor aircraft can take off and land vertically and cruise faster than any other helicopter. A scaled flight demonstration model of a tilt rotor aircraft has been developed by KARI. Because the flight characteristics of tilt rotor are not well known, the developed scaled model would be helpful to evaluate flight control algorithm of a full scale aircraft. The tethered hover test has been performed in order to improve hover flight characteristics of tilt rotor aircraft prior to flight test of the small scaled model. During the tethered hover test, the performance of rotor speed governor, rate SAS (Stability Augmentation System) and control surface mixers have been evaluated. We expect that the results of real flight hover test would be quite same as tethered hover test. Therefore the tethered hover test results will reduce the risk of flight test properly by fixing some of hidden problems which might occur during the flight test. This paper presents the results of tethered hover test in detail and shows how it could be final ground test before flight test. The control mixer gain and rate SAS feedback gains were modified in order to get higher controllability and stability during the tethered hover flight. The rotor governor showed that it could keep rotor RPM constant with very small deviation even during severe pilot collective input change. The tethered hover test results gave pilot and engineers confirmation and experience about the scheduled flight test.

• Journal of the Korean Professional Engineers Association
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• v.18 no.3
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• pp.28-35
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• 1985

As the paper industry consumes much water in process and discharge wastewater containing suspended solid and COD(chemical oxygen demand), relevant law against this discharge has been set up to limit the total containment of COD in discharge. This study has been carried out to improve the treatment method for the soluble COD in wastewater produced during the process of paste-board production, which is made of semichemical pulp and waste paper. Applicated methods are, O$_2$AS : O$_2$ activated sludge process DAS : Deep well activated sludge process SAS : standard activated sludge process and proper combination of DAS and SAS 1) As a result of this experiment, we get the following conclusion between in COD sludge loading "X" and COD removable rate in the process of treating waste-water. COD removable rate(％)=(0.778+0.0146/X)${\times}$100(％)……(7) 2) In case that the COD sludge loading is high, it has been cleared out that the COD removable rate shall become low due to unknown unsoluble substances contained in the process. Meanwhile, to increase the efficiency rate of treatment, it is thought to be necessary, to provide long-time contacts with activated sludge. 3) Once the COD of original waste-water and the target COD of treated water are decided, COD sludge loading is obtained from equation(7), and capacity of aeration tank in the effective systems such as O$_2$AS, DAS, to bet the required COD removable rate can be decided. Therefore the choice among SAS, O$_2$AS, DAS methods is made in consideration of required COD removable rate and allowable installation area. 4) In the sedimentation tank with sludge bulking, it is possible to increase the COD removable rate by 3～7％ but still there exist many obstacles to manage this operation.

• Smart Structures and Systems
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• v.20 no.2
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• pp.175-180
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• 2017

The load-carrying capacity and structural behavior of concrete-filled steel tube (CFST) structures is highly influenced by the grouting compactness in the steel tube. Due to the invisibility of the grout in the steel tube, monitoring of the grouting progress in such a structure is still a challenge. This paper develops an active sensing approach with combined piezoceramic-based smart aggregates (SA) and piezoceramic patches to monitor the grouting compactness of CFST bridge structure. A small-scale steel specimen was designed and fabricated to simulate CFST bridge structure in this research. Before casting, four SAs and two piezoceramic patches were installed in the pre-determined locations of the specimen. In the active sensing approach, selected SAs were utilized as actuators to generate designed stress waves, which were detected by other SAs or piezoceramic patch sensors. Since concrete functions as a wave conduit, the stress wave response can be only detected when the wave path between the actuator and the sensor is filled with concrete. For the sake of monitoring the grouting progress, the steel tube specimen was grouted in four stages, and each stage held three days for cement drying. Experimental results show that the received sensor signals in time domain clearly indicate the change of the signal amplitude before and after the wave path is filled with concrete. Further, a wavelet packet-based energy index matrix (WPEIM) was developed to compute signal energy of the received signals. The computed signal energies of the sensors shown in the WPEIM demonstrate the feasibility of the proposed method in the monitoring of the grouting progress.

• Nuclear Engineering and Technology
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• v.38 no.6
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• pp.575-584
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• 2006

As the development of total management systems for sites along with site environmental information is becoming standard, the system known as the Site Information and Total Environmental database management System (SITES) has been developed over the last two years. The first result was a database management system for storing data obtained from facilities, and a site characterization in addition to an environmental assessment of a site. The SITES database is designed to be effective and practical for use with facility management and safety assessment in relation to Geographic Information Systems. SITES is a total management program, which includes its database, its data analysis system required for site characterization, a safety assessment modeling system and an environment monitoring system. It can contribute to the institutional management of the facility and to its safety reassessment. SITES is composed of two main modules: the SITES Database module (SDM) and the Monitoring & Assessment (M&A) module [1]. The M&A module is subdivided into two sub-modules: the Safety Assessment System (SAS) and the Site Environmental Monitoring System (SEMS). SAS controls the data (input and output) from the SITES DB for the site safety assessment, whereas SEMS controls the data obtained from the records of the measuring sensors and facilities. The on-line site and environmental monitoring data is managed in SEMS. The present paper introduces the procedure and function of the M&A modules.

• Journal of Acupuncture Research
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• v.20 no.1
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• pp.144-158
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• 2003

This study was carried out to investigate what kinds of statistical techniques have been used to analyze data from oriental medicine research, For study, 551 original articles which used statistical techniques in their data analysis were selected form the articles published in The journal of Korean Acupuncture & Moxibustion Society(JKAMS) between 1984 to 2002. among them, 122 articles used descriptive statistics while 429 articles used inferential statistics for data analysis. For that 429 articles, t-test (189 articles), analysis fo variance (111 articles), chi-square test (14 articles), correlation (10 articles), regression analysis (4 articles), factor analysis(5 articles), or nonparametric test (23 articles) were chose to analyze the data. Nonparametric approach has substantial power in case data do not meet the assumption of normality. This method is not only easy to use ut also provides measures of the statistical variation of nominal and ordinal scale. This study shows that more and more recent papers use nonparametric test compared to the old articles. nine different statistical software or packages (SAS, SPSS, Statview, Minitab, Sigma plot, ISP, Graphpad prism, Excel, Access) have been used in the articles published JKMAS. High level statistical techniques such as SAS, SPSS, and Statview are user friendly and used most for acupuncture and Moxibustion research. Including tables and plots in an article facilitates understanding family process data from a descriptive standpoint, minimized erroneous statistical conclusions, and clarifies theoretically important relationships among variables. Table and plots have been used 500 and 233 articles, respectively. A computer procedure is proposed and illustrated with statistical packages using SAS, SPSS, Statview and ISP.

• Journal of Korean Society of Forest Science
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• v.82 no.2
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• pp.207-219
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• 1993

The study was conducted to discuss the theory and practical application of point sampling method using Spiegel Relaskop that can reduce time and expenses with efficiency in field work for stand inventory. An example of the analysis for real data was given to help practical foresters easily compute basal area, number of trees and volume per hectare even though the theory of point sampling technique is relatively difficult. Also, a SAS program for personal computer and the handling methods of pocket calculator were provided to easily use the point sampling technique in data analysis.

• Journal of dental hygiene science
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• v.12 no.3
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• pp.287-294
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• 2012

The aim of this study was to investigate the effect of standardized oral health care program by dental hygiene school students. Target population was 100 University students who attended standardized oral health care program by a dental hygiene school students. Present study was conducted during first and second semester in 2011 at E dental hygiene school. We analysed students' oral health related knowledge, attitude, behavior, and self-oral hygiene care ability after the program. Univariate analysis, Chi-square test and paired t-test were conducted using SAS version 9.2. University students' who attended standardized oral health care program by dental hygiene school students oral health related knowledge, attitude, behavior, and self oral-hygiene care ability were significantly improved whether they have attended oral health related lectures or not(p<.05). It is recommended provide standardized oral health care program to university students by dental hygiene school students to promote their oral health related knowledge, attitude, behavior, and self-oral hygiene care ability.

• Journal of the Korean Data and Information Science Society
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• v.10 no.2
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• pp.485-500
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• 1999

The systematic forecast of interest rates with liberalization was on the rise to important problems in the money market. Liberalization and globalization of the money market produced a seriously change as a compatition among the money market. Profits of an organ of monetary circulation are, also, definitively influenced by a change of interest rates. Hence most of the organ of monetary circulation studied to a scientific and systematic analysis for deterministic factors which have an effect on interest rates and progress development of a forecasting model of interest rates. In this paper, we develope the forecasting system which has highly forecasting performance based on a number of time series models for interest rates and discuss practical use of this system.