• Title/Summary/Keyword: S100b

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Effects of Mixture of Citri Peticulatae Viride Pericarpium and Lycii Radicis Cortex on the Change of HPA-Axis and Catecholamic System in the Forced Swimming Test (청피(靑皮)와 지골피(地骨皮) 복합제(複合劑)가 강제수영부하실험에서 CRF, c-Fos와 TH의 변화에 미치는 영향)

  • Park, Soo-Hyun;Lee, Tae-Hee
    • The Korea Journal of Herbology
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    • v.25 no.2
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    • pp.117-128
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    • 2010
  • Objectives : In this study the antidepressant effects of mixture of Citri Peticulatae Viride Pericarpium and Lycii Radicis Cortex on the change of HPA-Axis and Catecholamic system was investigated Methods : The forced swimming test(FST) was performed. The expression of corticotropin-releasing factor(CRF), c-Fos in the paraventricular nucleus(PVN), and tyrosine hydroxylase(TH) in the ventral tegmental area(VTA) and locus coeruleus(LC) was measured with immunohistochemical method and the concentration of seum adrenocorticotropic hormone(ACTH) was measured with ELISA method. And the experimental groups were divided into the extraction after mixing(A) and mixture after extraction(B). The effects of both group were compared. Results : The duration of immobility in the forced swimming test was significantly decreased in the A400 group(P<0.01). The expression of CRF in PVN were significantly reduced in the A100, A400, B100, B400groups(P<0.001). but the expression of c-fos in PVN weren't reduced in all groups. And the concentration of ACTH in Plasma were significantly reduced in the A 100 group(P<0.01). The expression of TH in LC were significantly reduced in the A 400, B 100 and B400 groups(P<0.05~P<0.01). Conclusion : Mixture of Citri Peticulatae Viride Pericarpium and Lycii Radicis Cortex has antidepressant effects. But the difference between mixing and extracting methods was not shown.

Effect of Antioxidant, Antimutagenicity and Anticancer of Root Extract from Ixeris dentata Nakai (씀바귀 뿌리 추출물의 항산화성, 항돌연변이원성 및 항암활성 효과)

  • Kim, Myong-Jo;Kim, Ju-Sung;Jeong, Dong-Myong;Ham, Seung-Shi;Yu, Chang-Yeon
    • Korean Journal of Medicinal Crop Science
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    • v.10 no.3
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    • pp.222-229
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    • 2002
  • Ixeris dentata root were extracted with methanol and then fractionated with n-hexane, EtOAc and BuOH to get active fractions. and their antioxidant and antimicrobial activities in each fraction were determined. Ethyl acetate fraction of Ixeris dentata root showed strong antioxidant activities, but aqueous fraction did not show any activities. But in the antimicrobial test, aqueous fraction showed strong antimicrobial activities except to Escherichia coli. especially, aqueous fraction showed the strongest activities against Hypocrea nigricans. and butanol fraction showed the strongest activities against Cladosporium herbarum. This study was performed to determine the antimutagenic and cytotoxic effect of Ixeris dentata root methanol extract on Salmonella typhimurium TA98, TA100 and cancer cell lines using ames test and cytotoxicity assay, respectively. Cancer cell lines include human lung carcinoma(A549), human breast adenocarcinoma(MCF-7) and human hepatocellular carcinoma (Hep 3B). Futher fractionations with hexane, ethyl acetate, butanol and water from methanol extract of Ixeris dentata root were performed to obtain effective fraction, methanol extracts showed 79.94% inhibitory effect on the mutagenesis induced by N' -methyl- N' -nitro-N-nitrosoguanidine(MNNG) against TA100, while 89.99% inhibition was observed on the mutagenesis induced by 4-nitroquinoline-1-oxide(4NQO) against TA98. In the meanwhile, butanol fraction showed 89.92% and 71.01% inhibitory effect on the mutagenesis induced by benzo(a)pyrene(B(a)P) against TA98 and TA100, respectively. Ethyl acetate fraction showed the strongest effect against A549, MCF-7 and Hep3B at the same concentration compared to those of other fration.

Orientation and thickness dependence of magnetic levitation force and trapped magnetic field of single grain YBa2Cu3O7-y bulk superconductors

  • Jung, Y.;Go, S.J.;Joo, H.T.;Lee, Y.J.;Park, S.D.;Jun, B.H.;Kim, C.J.
    • Progress in Superconductivity and Cryogenics
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    • v.19 no.1
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    • pp.30-35
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    • 2017
  • The effects of the crystallographic orientation and sample thickness on the magnetic levitation forces (F) and trapped magnetic field (B) of single grain YBCO bulk superconductors were examined. Single grain YBCO samples with a (001), (110) or (100) surface were used as the test samples. The samples used for the force-distance (F-d) measurement were cooled at 77 K without a magnetic field (zero field cooling, ZFC), whereas the samples used for the B measurement were cooled under the external magnetic field of a Nd-B-Fe permanent magnet (field cooling, FC). It was found that F and B of the (001) surface were higher than those of the (110) or (100) surface, which is attributed to the higher critical current density ($J_c$) of the (001) surface. For the (001) samples with t=5-18 mm, the maximum magnetic levitation forces ($F_{max}s$) of the ZFC samples were larger than 40 N. About 80% of the applied magnetic field was trapped in the FC samples. However, the F and B decreased rapidly as t decreased below 5 mm. There exists a critical sample thickness (t=5 mm for the experimental condition of this study) for maintaining the large levitation/trapping properties, which is dependent on the material properties and magnitude of the external magnetic fields.

Effects of Settings in Dynamic Ranges and Frequency Modes on Ultrasonic Images (초음파 영상에서 동적영역과 주파수 방식의 설정에 따른 효과)

  • Yang, Jeong-Hwa;Kang, Gwan-Suk;Lee, Kyung-Sung;Paeng, Dong-Guk;Choi, Min-Joo
    • Journal of radiological science and technology
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    • v.32 no.3
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    • pp.277-283
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    • 2009
  • It is important to get clinical ultrasonic images of good quality for accurate diagnosis. In this study, it observed the change of ultrasonic images against setting frequency, dynamic range(DR) and type of probes on ultrasonic scanner. In the experiment it evaluated image of LCS (Low Contrast Sensitivity) targets(-15, -6, -3, +3, +6, +15 dB) of a standard ultrasonic test phantoms(539,551, ATS, USA) similar to solid and cystic lesions. Its imaged from convex (C3-7IM) and linear probe (L5-12IM) on SA-9900 (Medison Ltd, Korea) scanner. The images obtained altering the setting parameters which are frequency(gen, pen, res, harmonic) mode and DR($40{\sim}100\;dB$). The quality of images evaluated compare with the nominal LCS value of target and measured LCS value. The results show that there was no significant changing of quality images altering DR 40, 60, 80, 100 dB against frequency in Convex probe but the image being the highest in LCS target at DR 60 dB, harmonic of frequency mode in the -15 dB target close to cystic lesion. In Linear probe, DR 40 dB, harmonic mode at -15 dB LCS target close to nominal value. It discussed necessity of evaluation about ROC(Receiver Operating Characteristic) from the psychological viewpoint and limit of evaluation from quantified images.

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A Study on the Cosmetic Preservative Effects of Cornus officinalis seed Extracts (산수유 종자 추출물의 화장품 방부효능에 관한 연구)

  • Yang, Jae-Chan
    • Journal of the Korean Applied Science and Technology
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    • v.33 no.2
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    • pp.333-341
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    • 2016
  • To evaluate the possibility as a natural preservative of Cornus officinalis seed extracts, we investigated the anti-microbial activity and preservation effect of cosmetics. Cornus officinalis seed extracted with 1,3-Butylene Glycol(1,3-BG) and Ethanol(EtOH). As a result, Cornus officinalis seed extracts showed anti-microbial activity at Staphylococcus aureus, Staphylococcus epidermidis, Propionibacterium acnes and Cornus officinalis seed 1,3-BG extracts(COS-A) showed $26.7{\pm}4.0mm$ clear zone at the $1000.0{\mu}l/ml$. Minimum inhibitory concentration of S. epidermidis was observed at Cornus officinalis seed EtOH extracts(COS-B) $25.0{\mu}l/ml$. The result of challenge test for preservation effect on cosmetics, S. aureus and S. epidermidis was 100% eliminated from emulsion containing COS-A and COS-B after 7 days. These results suggest that Cornus officinalis seed extracts may have possibility as the natural preservative instead of synthetic perservative on cosmetics.

Cytyotoxicity and Anti-Malassezia Activity of Limonene (Limonene의 세포독성과 항Malassezia 활성)

  • Lee, Jeong-Hyun;Lee, Jae-Sug
    • Microbiology and Biotechnology Letters
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    • v.39 no.4
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    • pp.387-389
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    • 2011
  • A previous study of ours indicated that Citrus auranifoli oil possesses antifungal activity against Malassezia furfur and Malassezia pachydermatis. In this study, we evaluated the anti-M. furfur and M. pachydermatis activities of limonene, which is a major component of C. aurantifolia oil, using the disk diffusion method. We also examined cytotoxicity against human normal epithelial (Beas-2B) cells using the cytopathic effect reduction (CPE) method. The results revealed that the minimum fungicidal concentration (MFC) value of limonene is lower than the value for itraconazole. The MFC value of limonene was seen to be 7.81 ${\mu}g$/mL against M. furfur and 3.90 ${\mu}g$/mL against M. pachydermatis. MFC values of itraconazole against M. furfur and M. pachydermatis were 62.50 ${\mu}g$/mL and 31.25 ${\mu}g$/mL, respectively. In addition, it was noted that limonene was not toxic to Beas-2B cells with normal morphology at a concentration of 100 ${\mu}g$/mL. However, itraconazole exhibited weak toxicity at the same concentration. Therefore, our results indicate that limonene could potentially be effective at controlling M. furfur and M. pachydermatis infections with no cytotoxicity.

Pathogenicity of Entomopathogenic Nematodes to Some Agro-Forest Insect Pests (농림해충에 대한 곤충병원성 선충의 병원성)

  • 이상명;이동운;추호렬;김도완;김준범
    • The Korean Journal of Soil Zoology
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    • v.2 no.2
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    • pp.76-82
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    • 1997
  • Mortality of some agro-forest insect pests, Agrotis segetum, Blitopertha orientalis, Agerastica coerulea, Glyphodes perspectalis and Acantholyda parki caused by entomopathogenic nematodes was investigated in laboratory and in pot. Steinernema carpocapsae All and Pocheon strain were effective against 2nd of 3rd instar larvae of A. segetum showing 100% mortalities at the concentration of 10Ijs/larva but not effective against 4th inster larvae. Mortality of B. orientalis was 100% after 26 days in H. bacteriopora NC 1, H. bacteriophora Hamyang and S. glageri NC strain treatment. S. monticulum also showed 100% mortalities against A. coerulea andd G. perspectalis at the concentration of 80 and 40 Ijs/larva. However, H. bacteriophora Cheju and S. glaseri Cheju strain were not effective against A. parki, i.e., showing 23.3 and 20.0% mortalities, respectively at the concentration of 160Ijs/larva. S. glaseri Hanrim strain was more effective than H. bacteriophora Cheju strain against Pryeria sinica.

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The World's Largest 100inch TFT-LCD for HDTV and Public Display Application

  • Kang, I.B.;Jin, H.C.;Lee, S.H.;Jang, E.S.;Moon, H.M.;Oh, C.H.;Yeo, S.D.
    • 한국정보디스플레이학회:학술대회논문집
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    • 2006.08a
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    • pp.281-285
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    • 2006
  • Recently LG.Philips LCD (hereafter "LPL") has announced the development of the world's largest 100-inch TFT-LCD with Advanced Super IPS technology. This magnificent LCD achieves the feature of a full high definition resolution $1920{\times}1080(16:9)$, 600nit brightness, 3000:1 dynamic contrast ratio, 92% color gamut, 180 degree viewing angle, and 5msec response time at all grays, targeted for HDTV and public display applications. Some unique technologies such as Cu bus line, advanced wide view polarizer, and high color gamut lamp were applied. A new stitching free technology was developed to overcome the size limitation of photo mask in both the TFT and CF processes. The size of the panel (100-inch) based on the wide format (16:9) is determined by the maximum efficiency of world's $1^{st}$ seventh generation line (glass size:$1950{\times}2250mm$) in LPL's Paju display cluster. In this paper, we will discuss the issues of 100-inch TFT-LCD.

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PHYTOSOCIOLOGICAL STUDY OF MARINE ALGAE AT ODONG-DO (오동도의 해조 군락)

  • SONG Sang Ho
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.4 no.3_4
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    • pp.105-112
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    • 1971
  • The annual variation of algal vegetation at two reefs, A and 3, of Odong-do, Yeosu, was observed two times each month during the period from June 1970 to May 1971, and the results obtained are as follows : 1. The total number of the algal species occurred were 69 species, of which 12 species belong to Chlorophyceae, 17 species to Phaeophyceae and 40 species to Rhodophyceae. No significant difference was noticed in the occurrence number of algal species at the reefs observed. 2. Most species of the algal communities in each algal belt did not show seasonal variations, but the following species showed fluctuations iii cover degree : Ulva pertusa, Enteromorpha sp., Sphacelaria sp., Scytosiphon iomentaria, Colpomenia sinuosa, Sargassum thunber gii, Pterocladia tenuis, Amphiroa ephedrea, Carpopeltis affinis, Gigartina tenera, Polysiphonia yendoi, Chondria crassicaulis, Symphyocladia atiuscula. 3. The species occurred in each algal belt at all two reefs did not show much variations and the main species in each belt are as follows: $200\~150cm$ belt - Gloiopeltis complanata, G. furcata, Enteromorpha sp., etc. : $150\~100cm$ belt - Ulva pertusa, Chondria crassicaulis, Sargassum thunbergii, etc. ; $100\~50cm$ belt - Gigartina tenera, Pterocladia tenuis, Scytosiphcn lomentaria, Polysiphonia yendoi, etc ; Below 50cm- Sargassum sagamianum, Cystophyllum sisymbrioides, Gelidium amansii, Acresorium yendoi, Microcladia elegance, etc. 4. The species occurred below 100cm level were almost the same at A and B reefs, but those above 100cm level at the A leef were different from the B reef; th: species of the algal belt of reef A were composed of Gloiopeltis complanata, Corallina pilulifera, Chondria crassicaulis, Sargassum thunbergii, Polysiphonia yendoi, Ulva Pertusa, etc., and those of reef B were composed of Gloiopeltis complanata, G. furcata, Enteromurpha sp. and Ulva pertusa, thus the main composition of reef B was very simple. 5. According to Taniguti's classification of marin: algal com nunity, the reefs observed belong to the Gigartina intermedia-Sargassum sagaminnum association (Sargasseto-Gigartinetum Taniguti) of Myelophycus caespitosus alliance (Myelophycion Taniguti).

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The Calculation of Lightning Flashover rate of 345kV/154kV Transmission Tower (345kV 및 154kV 송전철탑의 뇌사고율 예측계산)

  • Shim, E.B.;Woo, J.W.;Kwak, J.S.;Min, B.W.;Hwang, J.I.
    • Proceedings of the KIEE Conference
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    • 2001.07a
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    • pp.452-454
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    • 2001
  • This paper described the calculation results of lightning flashover rate on the 345kV and 154kV transmission system of KEPCO. The back-flashover rate and shielding failure rate was calculated by FLASH(lightning flashover rate calculation program from IEEE) and KEPRI's own program which is based on the EGM(Electro Geometrical Model) method. The estimated lightning flashover late of 345kV transmission system of double circuit was 1.0 flash per 100km-year, and the lightning flashover rate of 154kV transmission line was 2.0 flash Per 100km-year approximately.

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