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Prognostic Value of Serum S100 Protein by Elecsys S100 Immunoassay in Patients with Spontaneous Subarachnoid and Intracerebral Hemorrhages

  • Yoon, Seok-Mann;Choi, Young-Jin;Kim, Hwi-Jun;Shim, Jai-Joon;Bae, Hack-Gun;Yun, Il-Gyu
    • Journal of Korean Neurosurgical Society
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    • v.44 no.5
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    • pp.308-313
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    • 2008
  • Objective: The serum S100 protein has been known to reflect the severity of neuronal damage. The purpose of this study was to assess the prognostic value of the serum S100 protein by Elecsys S100 immunoassay in patients with subarachnoid hemorrhage (SAH) and intracerebral hemorrhage (ICH) and to establish reference value for this new method. Methods: Serum S100 protein value was measured at admission, day 3 and 7 after bleeding in 42 consecutive patients (SAH : 20, ICH : 22) and 74 healthy controls, prospectively. Admission Glasgow coma scale (GCS) score, Hunt & Hess grade and Fisher grade for SAH, presence of intraventricular hemorrhage, ICH volume, and outcome at discharge were evaluated. Degrees of serum S100 elevation and their effect on outcomes were compared between two groups. Results: Median S100 levels in SAH and ICH groups were elevated at admission (0.092 versus $0.283{\mu}g/L$) and at day 3 (0.110 versus $0.099{\mu}g/L$) compared to healthy controls ($0.05{\mu}g/L;$ p<0001). At day 7, however, these levels were normalized in both groups. Time course of S100 level in SAH patient was relatively steady at least during the first 3 days, whereas in ICH patient it showed abrupt S100 surge on admission and then decreased rapidly during the next 7 days, suggesting severe brain damage at the time of bleeding. In ICH patient, S100 level on admission correlated well with GCS score (r=-0.859; p=0.0001) and ICH volume (r=0.663; p=0.001). A baseline S100 level more than $0.199{\mu}g/L$ predicted poor outcome with 92% sensitivity and 90% specificity. Logistic regression analyses showed Ln (S100) on admission as the only independent predictor of poor outcome (odd ratio 36.1; 95% CI, 1.98 to 656.3) Conclusion: Brain damage in ICH patient seems to develop immediately after bleeding, whereas in SAH patients it seems to be sustained for few days. Degree of brain damage is more severe in ICH compared to SAH group based on the S100 level. S100 level is considered an independent predictor of poor outcome in patient with spontaneous ICH, but not in SAH. Further study with large population is required to confirm this result.

[ H2S ] Removal Characteristics by Combined System of Bioscrubber and Biofilter (Bioscrubber와 Biofilter 병합 시스템에 의한 H2S 제거특성)

  • Bin, Jung-In;Lee, Byung-Hun;Kam, Sang-Kyu;Lee, Min-Gyu
    • Journal of Environmental Science International
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    • v.16 no.6
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    • pp.763-769
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    • 2007
  • This study compared the performance of a bioscrubber, a biofilter, and a combined system of bioscrubber and biofilter employed being operated at the laboratory-scale. for the removal of hydrogen sulfide. The bioscrubber maintained 100% removal of hydrogen sulfide up to inlet load of $56\;g-S/m^3{\cdot}hr$, while the removal efficiency was decreased with the increase of inlet load. The biofilter showed 100% removal efficiency up to inlet load of $126\;g-S/m^3{\cdot}h$ and the maximum elimination capacity of $126\;g\;S/m^3{\cdot}h$ for the inlet load of $224\;g-S/m^3{\cdot}h$. On the other hand, the combined system of bioscrubber and biofilter showed 100% removal for an inlet hydrogen sulfide load of up to $85\;g-S/m^3{\cdot}h$ and the maximum elimination capacity of $153\;g-S/m^3{\cdot}h$ for inlet loads of $224\;g-S/m^3{\cdot}h$.

Analysis of Manganese Content in Frequently Consumed Foods by Koreans (한국인 상용 식품 중 망간 함량 분석)

  • Choi, Mi-Kyeong;Kim, Eun-Young
    • Journal of Nutrition and Health
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    • v.40 no.8
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    • pp.769-778
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    • 2007
  • Using ICP-AES, we analyzed manganese content in 366 foods consumed frequently by Koreans. For the analysis, it was included a total of 366 foods such as 51 kinds of grains, 7 kinds of potatoes and starches, 7 kinds of sugars and sweeteners, 12 kinds of legumes, 11 kinds of nuts and seeds, 68 kinds of vegetables, 7 kinds of mushrooms, 33 kinds of fruits, 13 kinds of meats, 4 kinds of eggs, 48 kinds of fishes and shellfishes, 7 kinds of seaweeds, 16 kinds of milks, 8 kinds of oils and fats, 27 kinds of beverages, 34 kinds of seasonings, 13 kinds of processed foods and others. Among the grains, starches and sugars, manganese content of rice was 0.745 mg/100g. As for legumes, the content of manganese in soybean milk was 0.033 mg/100g and in black beans was 4.075 mg/100g. In nuts and seeds, the content of manganese in gingko nuts was 0.268 mg/100g while that in pine nuts was 8.872 mg/100g. Among the vegetables, manganese contents were 0.061 mg/100g in cherry tomato and 14.017 mg/100g in ginger. In mushrooms, the highest manganese content was displayed in ear mushroom at 10.382 mg/100g. Dried jujube and shrimp were found to be the fruits and fishes with high manganese contents at 2.985 mg/100g and 3.512 mg/100g, respectively. Among dairy foods, oils and beverages, manganese content was the highest in instant coffee powder at 2.577 mg/100g. Seasonings and processed foods posted 0.010 mg/100g in Sagolgomtang, instant soup and 23.846 mg/100g in pepper. In a furture, more various food for manganese content needs to be analyzed and a reliable food database should be compiled from the findings of researches in order to estimate manganese consumption accurately.

The Effect of Feeding Houttuynia cordata Thunb on Cholesterol and Cholesterol oxides of Pork Lion's (어성초 분말의 혼합 급이가 돈육의 cholesterol 및 산화물에 미치는 영향)

  • Kang, Min-Jung;Joo, Jong-Chan;Shin, Jung-Hye;Choi, Sun-Young;Yang, Seung-Mi;Sung, Nak-Ju
    • Journal of Life Science
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    • v.16 no.6
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    • pp.1029-1035
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    • 2006
  • The study was designed to investigate the influence of feeding Eosungcho(houttutnia cordata Thunb) on the meat quality of porks. Experimental groups were divided into control group(C), 5%(T1) and 10%(T2) Eosungcho powder feeding group, and than administered for 12 weeks. And then pork's loins were storaged at $4^{\circ}C$, for 23 days after vaccum packed. TBARS was increased(P<0.05) during storage days in all samples, while it's contents were lower Eosungcho feding groups than control group. Total cholesterol contents of pork's loin, were $48.9{\pm}0.2\;mg/100\;g$ in control group, $39.1{\pm}0.2\;mg/100\;g$ in T1 group and $37.8{\pm}0.3\;mg/100\;g$ in T2 group. 4 kinds of cholesterol oxides($7{\beta}-hydroxycholesterol$, 19-hydroxycholesterol, ${\alpha}-$ and ${\beta}-epoxide$) detected in pork's loin. Cholesterol oxides concentration of pork's loin was increased during storage and lowest in T2 group.

Market and Technology Trends in 100Gb/s Optical Transceiver (100Gb/s 광트랜시버 시장 및 기술동향)

  • Lee, J.J.;Huh, J.Y.;Kang, S.K.;Lee, J.K.;Lee, J.C.;Lee, D.S.
    • Electronics and Telecommunications Trends
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    • v.30 no.1
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    • pp.65-76
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    • 2015
  • 스마트폰의 보급에 따른 대용량 멀디미디어 서비스의 폭발적인 수요 증가에 따라데이터센터의 100Gb/s 광트랜시버에 대한 수요는 2017년을 기점으로 10Gb/s를 추월하여 2018년 데이터콤 전체 시장의 50% 이상을 차지할 전망이다. 한편, 데이터센터의 소비전력 및 시스템 집적도 증가를 위해 광트랜시버의 Form-factor는 CFP(40G/100G Form-factor Pluggable)에서 QSFP28($4{\times}28G$ Quad Small Form-factor Pluggable)로 약 1/14배 소형화될 전망이며, 이에 따른 광트랜시버 구성 부품의 집적도는 높아지고 소비전력은 현재 대비 1/9로 낮아져야 한다. 본고에서는 소형화 및 저전력화를 위한 광트랜시버의 표준화 및 기술동향과 국내외 시장동향에 대해 기술한다.

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$FIXATE^{TM}$ G-100 POLYMER - A New Standard for Fixative Performance

  • F. Shuster
    • Proceedings of the SCSK Conference
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    • 2003.09b
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    • pp.462-463
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    • 2003
  • With Fixate$^{TM}$ G-100 polymer, a whole new world of styling product possibilities awaks you. Fixate$^{TM}$ G-100 polymer satisties the demand for high performance products that offer significant consumer perceptible benefits, while meeting the tormulator's needs for cost control and manufacturing efficiency.(omitted)ted)

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Selective in vitro cytotoxicity of Hypericum hookerianum towards cancer cell lines

  • P., Vijayan;S., Vinod Kumar;Badami, Shrishailappa;PK, Mukherjee;SA, Dhanaraj;B., Suresh
    • Advances in Traditional Medicine
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    • v.3 no.3
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    • pp.141-146
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    • 2003
  • The methanol extracts of the aerial parts, leaves and stem of Hypericum hookerianum were tested for in vitro cytotoxicity on selected normal and cancer cell lines and anti tumor activity using DLA cells. Cell viability and morphological changes were assessed. Among the three extracts tested, the stem extract of Hypericum hookerianum showed potent cytotoxicity against HEp-2 and RD cell lines. The $CTC_{50}$(concentration required to reduce viability by 50%) of this extract was found to be $2.02\;{\mu}g/ml$ for RD cell line, $10.25\;{\mu}g/ml$ for HEp-2 cell line and $100.06\;{\mu}g/ml$ for Vero cell line. In the clonogenic assay, no colony formation was observed up to a concentration of $100\;{\mu}g/ml$. In the short term cytotoxicity studies using DLA cells, 50% viability was observed in the concentration range of $50-100\;{\mu}g/ml$ for aerial parts, $100-200\;{\mu}g/ml$ for stem and more than $200\;{\mu}g/ml$ for leaf extracts of Hypericum hookerianum. In the long-term activity using HEp-2 cell line, no colony formation was observed over a concentration of 200 mg/ml for the stem extract. Hypericum hookerianum stem extract was fractionated into petroleum ether, chloroform, ethyl acetate and methanol soluble fractions. The petroleum ether and chloroform soluble fractions showed higher cytotoxic activity against HEp-2 cell line when compared to the other two fractions. The methanol stem extract of Hypericum hookerianum has the potential for further investigation in animal models to determine its anti-tumor activity and to identify its active principles.

A Study on Contents of Beta-Carotene in Local Agricultural Products (지역 농특산물의 베타카로틴 함량 조사)

  • Eom, Hyun-Ju;Kang, Hye Jeong;Yoon, Hyang-Sik;Kwon, Nu Ri;Kim, Youngho;Hong, Seong Taek;Park, Jinju;Lee, Joonsoo
    • The Korean Journal of Food And Nutrition
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    • v.32 no.4
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    • pp.335-341
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    • 2019
  • Beta-carotene is the most prominent member of the group of carotenoids, natural colorants that occur in the human diet. Beta-carotene is also an effective source of vitamin A in both conventional foods and vitamin supplements, and it's generally safe. In this study, we explored the beta-carotene contents in agricultural products widely and specifically grown in Korea. The beta-carotene contents were ranging from 223 to $27,908{\mu}g/100g$ in leaves, and 0 to $7,588{\mu}g/100g$ in vegetables. In leaves and vegetables, the amount of beta-carotene was the highest in green tea powder ($27,908{\mu}g/100g$), followed by pepper ($7,588{\mu}g/100g$). In fruits, the beta-carotene content was found to range from $0{\mu}g/1,011g$ to maximum of $293.66{\mu}g/100g$(plumcot). However, there beta-carotene was not detected in strawberry. In the case of cereals and specialty crops, the beta-carotene contents were $326{\mu}g/100g$ for non-glutinous rice, $313{\mu}g/100g$ for glutinous rice, $57{\mu}g/100g$ for amaranth and $15{\mu}g/100g$ for pine nut, respectively. However, the beta-carotene content was not detected in other samples. This study revealed the presence of beta-carotene content in agricultural products specifically grown in Korea for nutritional information and food composition database.

Changes in Free Sugars, Organic Acids, Free Amino Acids and Minerals by Harvest Time and Parts of Acanthopanax koreanum (섬오갈피의 수확시기와 부위에 따른 유리당, 유기산, 아미노산, 무기물의 함량 변화)

  • Jwa, Chang-Sook;Yang, Young-Tack;Koh, Jeong-Sam
    • Applied Biological Chemistry
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    • v.43 no.2
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    • pp.106-109
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    • 2000
  • In order to determine the optimum harvest time of Acanthopanax koreanum Nakai, free sugars, organic acids, amino acids and minerals were investigated. Ash, crude fat and crude protein of 4-age's tree of Acanthopanax koreanum were $2.98%{\sim}3.90%,\;1.93%{\sim}2.34%,\;3.52%{\sim}4.23%$, respectively. Minerals were 835.9 mg/100g of K, 971.3 mg/100g of Ca, 168.7 mg/100g of Mg, 38.8 mg/100g, of Na, 18.6 mg/100g of Fe, and 8.5 mg/100g of Cu on average, respectively. Calcium content was increased distinguishably as late as harvest time, especially in stem and root. Glucose, fructose and sucrose content of stem were $0.71{\sim}0.75%,\;0.31{\sim}0.03%,\;and\;0.16{\sim}0.21%$, respectively. Organic acid was $381.0\;mg/100g{\sim}504.9\;mg/100g$, and was mainly consisted of succinic acid, citric acid and malic acid. Twelve kinds of free amino acids were detected. Total amino acids was $33.56\;mg/100g{\sim}48.60\;mg/100g$, and it was the highest on samples harvested at September. Arginine, phenylalanine and glutamic acid were the main free amino acids of stems.

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Antioxidant Properties and Ubiquinone Contents in Different Parts of Several Commercial Mushrooms (시판버섯의 부위별 항산화능과 유비퀴논 함량)

  • Hong, Myung-Hee;Jin, Yoo-Jeong;Pyo, Young-Hee
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.41 no.9
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    • pp.1235-1241
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    • 2012
  • Antioxidant properties and antioxidant compound contents in different parts of 14 commercial mushrooms were evaluated. Methanolic extracts from the entire mushroom, the pileus and the stipe, separately, were screened for their DPPH and ABTS free radical scavenging activities. Total ubiquinones (Coenzyme Qs; CoQs), total phenolic, and flavonoid contents were determined, in order to assess the extract's antioxidant activity. The portion of the mushroom selected had an effect on the results, with pileus methanolic extract exhibiting the greatest antioxidant effect (p<0.05). The analyzed mushrooms contained powerful antioxidants such as phenols (144.5~536.6 mg of gallic acid equivalents, mg GAE/100 g of dried weight, dw), flavonoids (3.7~31.2 mg of quercetin equivalents, mg QE/100 g dw) and ubiquinones (65.6~485.1 ${\mu}g$/100 g dw). Content of CoQ9 and CoQ10 in the 14 commercial mushrooms varied from 23.1 to 256.2 ${\mu}g$/100 g and from 16.1 to 238.3 ${\mu}g$/100 g, respectively. Phellinus linteus showed the highest antioxidant activity among all species due to the contribution of antioxidants such as phenols (530.5 mg GAE/100 g dw) and ubiquinones (308.8 ug/100 g dw). A positive linear correlation was demonstrated between free radical scavenging activity and total phenolic ($R^2=0.79$) and ubiquinone ($R^2=0.59$) contents in the pileus of mushrooms (p<0.05). Our data indicate that commercial mushrooms have potential as dietary sources of CoQs and phenolic antioxidants.