• Title/Summary/Keyword: S-102

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Uncertainty Analysis of BAG by GNSS Correction (해저지형 표면자료의 GNSS 보정방법에 따른 불확실도 연구)

  • OH, Che-Young;KIM, HO-Yong;LEE, Yun-Sik;CHOI, Chul-Uong
    • Journal of the Korean Association of Geographic Information Studies
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    • v.22 no.3
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    • pp.1-9
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    • 2019

  • In the recent marine sector, the development and standardization regarding S-100, which is the universal hydrographical data model standard for development of marine space information, was progressed, and for the effectiveness of marine chart production work and the multi-purpose use of water level data in S-100, S-102(Bathymetric Surface grid) standard development and various studies of BAG formats combined with water level and uncertainty, property information is being progressed. Since the water level information that is important in the operation of the ship is provided based on S-102, the calibration method of the location information when producing S-102 is an important factor in deciding the water level. In this study, the hydrographical surveying was conducted by piloting the standardized method for the production of S-102 in Korea, and have compared the accuracy of water level information according to the GNSS post treatment calibration method. As a result of comparing the water level in 2 places in the rocky terrain of the study area, the northern water level of Namu-do was shown as DL 0.79~0.83m, the eastern water level of Daeho-do was DL 12.63~12.91m, and the horizontal position errors of the intermittent sunshine water level were confirmed to be within 1m. As a result, the intermittent sunshine water level according to the location calibration method when producing the BAG was confirmed that it was in the available range for a ship's safe voyage. However, the accuracy verification for the location of the ship when conducting hydrographical surveying was judged that there is a need for a various additional study about regional characteristics and environment factor.

  • https://doi.org/10.11108/kagis.2019.22.3.001 인용 PDF KSCI

Subacute Toxicity of SP-102 (Sulbactam. Piperacilline) in Rats Administered Intraperitoneally (복합항생제 SP-102(설박탐.픽페라실린)의 랫드 복강내 투여에 의한 아급성 독성)

  • 서경원;박기숙;신동환;김창옥;한형미;박인원;김효정
    • Biomolecules & Therapeutics
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    • v.1 no.2
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    • pp.251-261
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    • 1993

  • The subacute toxicity of combined antibiotics, SP-102 (Sulbactam.Piperacilline), was examined in S.D.rats. Four groups of rats were administered intraperitoneally with 0, 512, 1280 and 3200 mg/kg/day of SP-102 for 30 days. Hain clinical sign related to the compound was soft stool. The body weight gain was slightly decreased in male rats treated with 1280, 3200 mg/kg and in female rats treated with 1280 mg/kg of SP-102. Water consumption was significantly increased in rats administered with SP-102. There were no dose-related changes of urinalysis, biochemical examination and hematological findings in all the groups treated with SP-102. Gross necropsy and histopathology revealed no evidence of specific toxicity related to SP-102. Our data indicate that no-observed effect level of SP-102 is below 512 mg/kg in male and female rats. Maximum tolerated dose of SP-102 was estimated to be above 3200 ma/kg in this study.

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Characterization of Two Self-Sufficient Monooxygenases, CYP102A15 and CYP102A170, as Long-Chain Fatty Acid Hydroxylases

  • Rimal, Hemraj;Lee, Woo-Haeng;Kim, Ki-Hwa;Park, Hyun;Oh, Tae-Jin
    • Journal of Microbiology and Biotechnology
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    • v.30 no.5
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    • pp.777-784
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    • 2020

  • Self-sufficient P450s, due to their fused nature, are the most effective tools for electron transfer to activate C-H bonds. They catalyze the oxygenation of fatty acids at different omega positions. Here, two new, self-sufficient cytochrome P450s, named 'CYP102A15 and CYP102A170,' from polar Bacillus sp. PAMC 25034 and Paenibacillus sp. PAMC 22724,respectively, were cloned and expressed in E. coli. The genes are homologues of CYP102A1 from Bacillus megaterium. They catalyzed the hydroxylation of both saturated and unsaturated fatty acids ranging in length from C12-C20, with a moderately diverse profile compared to other members of the CYP102A subfamily. CYP102A15 exhibited the highest activity toward linoleic acid with Km 15.3 μM, and CYP102A170 showed higher activity toward myristic acid with Km 17.4 μM. CYP10A170 also hydroxylated the Eicosapentaenoic acid at ω-1 position only. Various kinetic parameters of both monooxygenases were also determined.

  • https://doi.org/10.4014/jmb.1911.11048 인용 PDF KSCI