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Comparing Quality of Life following Liver Transplantation for Cadaveric versus Living Donor Liver Transplant Recipients: A Single-Center Study (사체간이식 환자와 생체간이식 환자들의 삶의 질 비교 연구)

  • Kim, Gum Hi;Yoon, Seok-Jun;Ahn, Hyeong-Sik;Lee, Jun-Young;Park, Hyeung-Keun;Suh, Kyung-Suk
    • Quality Improvement in Health Care
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    • v.11 no.1
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    • pp.32-45
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    • 2004
  • Objective : The aim of this study were to measure quality of life(QOL) in liver transplant recipients, to compare QOL between living donor liver transplant recipients and cadaveric liver transplant recipients and to investigate whether SF-36 may be used as a disease-specific instrument in liver transplant recipients. Methods : We conducted a single-center cross-sectional study of 133 LT recipients ages 13 to 65 years, all of whom had had Liver Transplantation(LT) at least 1 months previously. QOL was assessed using a self-completion questionnaire consisting of the Bang Whal Ran(1991) instruments and the 36-Item Short-Form Health Survey(SF-36) health status profile measure. We investigated whether the SF-36 instrument may be used as a disease-specific instrument in LT recipients. Individual scale scores range from 0 to 100, with higher score reflecting better health. Data on demographics, clinical status at pre transplantation 1 day, post transplantation clinical status, and graft function were collected to identify predictors of post transplantation QOL. Results : Standard measures for test-retest reliability, internal consistency, and discriminant and concurrent validity were examined. The reliability of the SF-36, as measured by test-retest correlation(Pearson coefficients: 0.729, p=0.002) and by internal consistency(Cronbach's alpha: 0.9431) exceeded conventional acceptability criteria. The correlation between domain scores of SF-36 and the Bang Whal Ran(l991) was clear and logical in that the clinical characteristics of SF-36 strongly correlated with the clinical component summary score of the Bang Whal Ran(l991)(r = 0.8155, P<.01). SF-36 scale scores were compared between Cadaveric Liver Transplant recipients and Living Donor Liver Transplant recipients. Donor types of post LT did not influence HRQOL(p>0.05). 87% of the liver transplant recipients were satisfied to get LT. Satisfaction of post LT showed significantly greater HRQOL(p<0.001). Conclusion : SF-36 is found reliable and valid. This study indicates thet Donor Type did not influence HRQOL after LT. The information gained from this study will help us to better define expectations and the clinical course after liver transplantation to patients and their families.

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Development of Nursing Costs by Nursing Activities in Clinical Nurse Specialist (전문간호사 간호행위에 관한 간호수가체계 개발)

  • Kim, Yoon-Hee;Lee, Hyang-Yeon;Han, Sang-Sook;Shin, Hye-Sook;Lee, Myung-Hee;Kim, Sook-Neoung;Lee, Hye-Jin;Kim, Hye-Sook;Choi, Hyes-Sun
    • Journal of East-West Nursing Research
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    • v.13 no.2
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    • pp.197-207
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    • 2007
  • Purpose: This study was carried out to deveop nursing costs and to substantiate the application of appropriate activity-based nursing costs for the current clinical nurse specialists. Method: The study sample was a group of 8 home health care team of the tirtiary Hospital in Korea. The data was collected from September 2003 through December 2004. The statistical analysis was done by SPSS PC 11.0 program and calculated mean and the standard deviation. In Lee(2003)'s nursing activity analysis, nursing activities were classified into two major classification, 19 domains and 70 activities. Each activities was calculated using its work validity, physical effort, psychological effort, stress as a intensity, and the necessary time. The simple work costs was calculated the work wage per minute and the necessary time. The work load intensity was calculated using the work wage per minute and the necessary time work load intensity/100. Results: In this study, the work wage was 283 won per minute. The work validity ranged from 2.71-4.00. The highest simple work cost/work load intensity cost was 12,735won/47,374won for research activity, 10,700won/27,499won for bedsore care, and 9,727won/35,114won for deathbed care. The lowest simple work cost/work load intensity cost was 2,123won/2,038won for intramuscular injection, 2,210won/2,166won for hypodermic injection, and 2,210won/1,547won for a application of medicine(or ointment or cream). Conclusions: It revealed that the nursing cost should be considered validity, physical effort, psychological effort, stress as a intensity, and necessary time. Therefore, It is necessary to calculate nursing cost systematically based on activities.

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The Research for effect of lubricant oil aging on environmental performance (자동차 윤활유의 성상 및 열화가 환경성에 미치는 영향 연구)

  • Kim, Jeong-Hwan;Kim, Ki-Ho;Ha, Jong-Han;Jin, Dong-Young;Myung, Cha-Lee;Jang, Jin-Young
    • Journal of the Korean Applied Science and Technology
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    • v.34 no.1
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    • pp.12-24
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    • 2017
  • The main purpose of this research is for the investigation on the impact of engine oil aging on PM and DPF. It is widely known that lubricant specifications and consumption from an ICE have significantly influenced on the regulated and unregulated harmful emissions as the engine operating conditions. Considering DPF clogging phenomena with lubricant-derived soot/ash components, simulated aging mode for the DPF was newly designed for engine dynamometer testing. PM/ash accumulation cycle were developed in reflecting real-world engine operating conditions for the increment of engine oil consumption and natural DPF regeneration for the ash accumulation. The test duration for DPF aging reached around 100hrs with high- and low-SAPS engine oils, respectively. Using high SAPs engine oil made more PM/ash accumulation compared with low SAPs engine oils and it could accelerate fouling of EGR in engine. Fouling of EGR made effects on more harmful exhaust gases emissions. The test results on engine lubricant under engines operating conditions will deliver for the establishment of regulated and unregulated toxic emissions policy, lubricant quality standard.

Growth and Fruit Characteristics of Mini Watermelon in Different Cultivation Types and Plant Spacings (미니수박의 재배유형과 재식거리에 따른 생육 및 과실특성)

  • Jeong, Taek-Gu;Noh, Sol-Ji;Han, Jong-Woo;Kim, Young-Sang;Kim, Ik-Jei;Kim, Tae-Il;Hong, Sung-Taek
    • Journal of Bio-Environment Control
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    • v.27 no.2
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    • pp.117-124
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    • 2018
  • Recently, the interest and consumption of mini watermelon (Citrullus lunatus Thunb.) are increasing due to nuclear family and one person household. However, there's no research for mini watermelon. Therefore, the purpose of the study is to develop standard cultivation method of mini watermelon. The test cultivar is 'Minimi', which is a small-sized fruit, the rootstock is 'Bullojangsaeng', which is a cucurbit line. Grafted plants were transplanted on April 5, 2017, and harvested in early July. Cultivated types were 3 methods, which are ${\cap}-form$, arched, and runner type, and plant spacing were 40, 60, and 80 cm, respectively. The rowth and yield in ${\cap}-form$ was higher than that of the arched and runner types, and the sugar content was higher a bit. The yield per unit area was about 50% higher than ${\cap}-form$, which can be plant density cultivation than that of the runner type. The number of seeds per fruit of 'Minimi' was similar to that of 'Sambokggul', but seed weight was one third lower than that of 'Sambokggul'. The content of lycopene was 30% higher than that of 'Sambokggul' watermelon, and the main sugar content is similar to or slightly less. In conclusion, the ${\cap}-form$ staking cultivation was superior to the runner type or arched cultivation in terms of fruit setting ratio, yield and quality.

Field Survey on the Structure and Manure Treatment of Two-Storey and Sawdust Pig Houses in Korea (국내 2층 돈사와 톱밥돈사의 구조 및 분뇨처리 실태조사)

  • Jeong J. W.;Yoo Y. H.;Song J. I.;Kim T. I.;Jeon B. S.;Yang C. B.
    • Journal of Animal Environmental Science
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    • v.11 no.3
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    • pp.169-176
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    • 2005
  • The farm house structure, ventilation system and manure treatment of two-storey buildings and sawdust pig houses were surveyed and analyzed. Based on the data for ten selected farms in five provinces during eight months, the goal is to eventually establish a standard two-storey pig house. Manure treatments were composting, slurry and activated sludge in two-storey pig houses, while fermentation method was done in sawdust pig house. The depth of sawdust as a litter material were 10 to 60cm, with a duration of 1/2, 1, 3 and 6 months, respectively. The ventilation systems were the mechanical type in two-storey pig houses and natural system in the sawdust pig house. Side wall in the two-storey pig house was enclosed with insulation materials such as block, colored metal sheet and sandwich panels. The minimum ceiling height in the first floor of the two-storey pig house was 2.0m and the maximum was 3.0m. On the second floor, ceiling height ranged from 2.0 to 2.7m. The construction cost in the two-storey systems were $700\~140$, and sidewall curtain systems were $30\~40$ thousand Won/pyung.

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The Relationship between Total Body Fat Distribution and the Broca Index of Obese Students in High Schools (일 고등학교 비만학생의 체지방 분포양상과 브로카지수와의 관계 연구)

  • Kim, Lee-Sun
    • Research in Community and Public Health Nursing
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    • v.9 no.2
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    • pp.458-466
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    • 1998
  • The purpose of this study is to investigate the differences in body fat distribution between obese boys and girls in high school and the relationship between the precent of body fat and the Broca Index. The survey of data was conducted from November 3rd to the 11th in 1997. The data were analyzed by the use of a mean, standard deviation and a Pearson's correlation coefficient. Measurements of the percentage of body fat and lean body mass were made by a Bioelectrical Impedence while height, weigh and the Broca index were measured by a fatness measuring system. First, measurements of height, weight and the Broca index were made by a fatness measuring system on 1,125 1st year students and 1,076 2nd year students. The result of measurements, 216 obese boys and 100 obese girls appeared to have above 10% of the Broca index. The result of this study can be summarized as follows: 1) Obese boys and girls were grouped by the level of the Broca index as follows: boys, 110-less than 120 60.0%, 120-less than 130 20.8%, 130-less than 140 11.1%, above 140 7.4%. ; girls, 110-less than 120 44.4%, 120-less than 130 32.0%, 130-less than 140 13.0%, above 140 11.0%. 2) Obese boys and girls were grouped by level of the percentage of body fat by Bioelectrical Impedence as follows: boys, less than 20% 5%, 20%-less than 25% 34.7%, above 25% 33.8% ; girls. less than 25% 15.0%, 25%-less than 30% 43.0%, above 30% 42.0%. 3) In obese boys the Broca index score appeared to be positively related to body weight(r = .741, p<.001), the percent of body fat(r=.604, p<.001), lean body mass(r=.375, p<.001), body fluid(r=.445, p<.001l). On the other hand the percent of body fat was not a significant correlation of lean body mass (r= -.074), body fluid(r= -.073). 4) In obese girls, the Broca index score appeared to be positively related to body weight(r= .693, p<.001), the percent of body fat(r=.645, p<.001), lean body mass(r=.531, p<.001), body fluid(r=.532, p<.01), and the percent of body weight score appeared to be positively related to lean body mass(r=.206, p<.01), body fluid(r=.207, p<.01).

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Simultaneous Determination of Five Porphyrins in Human Urine and Plasma Using High Performance Liquid Chromatography-Tandem Mass Spectrometry

  • Hur, Yeoun;Tae, Sookil;Koh, Yun-Joo;Hong, Sung-Hyun;Yoon, Young Ho;Jang, Haejong;Kim, Sooji;Kim, Kyeong Ho;Kang, Seung Woo;Lee, Youngshin;Han, Sang Beom
    • Mass Spectrometry Letters
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    • v.5 no.2
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    • pp.42-48
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    • 2014
  • A specific and sensitive liquid chromatography-electrospray ionization tandem mass spectrometry method (LC-ESI-MS/MS) was developed and validated for the simultaneous quantification of porphyrins (coproporphyrin, pentacarboxylporphyrin, hexacarboxylporphyrin, heptacarboxylporphyrin, and uroporphyrin) in human plasma and urine. Acidified plasma samples and urine samples were prepared by using liquid-liquid extraction using ethyl acetate and protein precipitation with acetonitrile, respectively. The separation was achieved onto a Synergi Fusion RP column ($150mm{\times}2.0mm$, $4{\mu}m$) with a gradient elution of mobile phase A (0.1% formic acid in 2 mmol/L ammonium acetate, v/v) and mobile phase B (20% methanol in acetonitrile, v/v) at a flow rate of $450{\mu}L$/min. Porphyrins and the internal standard (IS), coproporphyrin I-$^{15}N_4$, were detected by a tandem mass spectrometer equipped with an electrospray ion source operating in positive ion mode. Multiple reaction monitoring (MRM) transitions of the protonated precursor ions and the related product ions were optimized to increase selectivity and sensitivity. The proposed method was validated by assessing selectivity, linearity, limit of quantification (LOQ), precision, accuracy, recovery, and stability. The calibration curves were obtained in the range of 0.1-100 nmol/L and the LOQs were estimated as 0.1 nmol/L for all porphyrins. Results obtained from the validation study of porphyrins showed good accuracy, precision, recovery, and stability. Finally, the proposed method was successfully applied to clinical studies on the autism spectrum disorder (ASD) diagnosis of 203 Korean children.

New Modified Chevron Osteotomy for Hallux Valgus (무지 외반증의 새로운 변형 Chevron 절골술)

  • Oh, In-Suk;Kim, Myung-Ku;Choi, Sung-Wook;Ban, Jun-Ho
    • Journal of Korean Foot and Ankle Society
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    • v.8 no.2
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    • pp.126-130
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    • 2004
  • Purpose: In this study, we tried to develop the technique of osteotomy for hallux valgus. The new modified technique of osteotomy was accomplished with even more greater stability, accurate correction of the deformity and more effective than 'chevron' osteotomy in terms of correction of the deformity. Materials and Methods: Between March 1998 and December 2001, 55 cases of new modified osteotomy for hallux valgus were performed for 39 patients, 16 of whom underwent operation of both feet. Operations were made for 34 women and 5 men whose average age was 46 years old (range, $20{\sim}71$ years). Average follow up period was three years (range, $2{\sim}5$ years), and during the follow up, the patients underwent physical examination and assessment with use of the American Orthpaedic Foot and Ankle Society's hallux-metatarso-phalangealinterphalangeal scale and standard foot radiographic measurements. Results: 37 patients (53 cases) out of 39 patients (55 cases) had no pain, good cosmesis, and all of the patients were satisfied with the results of the operation. Two had occasional mild discomfort. The average score according to the hallux-metatarso-phallangeal-interphalangeal scale was 93.2 points (range, $78{\sim}100$ points). The average preoperative intermetatarsal angle was $14.4^{\circ}$, which was decreased to $7.9^{\circ}$ after the osteotomy with an average correction of $6.5^{\circ}$ and The average preoperative hallux valgus angle was $34.1^{\circ}$, which was decreased to $11.1^{\circ}$ after the osteotomy with an average correction of $23^{\circ}$. This new modified technique would prevent the angulation or shortening at the osteotomy site and it was also even more stable at osteotomy site, and could do even more effective and accurate correction of the deformity than conventional Chevron osteotomy. Conclusion: New modified chevron osteotomy for the treatment of symptomatic hallux valgus was done in 55 cases, and the results were satisfactory in all cases. This method was more stable at the osteotomy site than conventional Chevron osteotomy and was also possible to do more accurate and more effective correction of the deformity. It was also easy to control the distal fragment of first metatarsal bone.

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Accelerated Life Prediction on Tensile Strength of Oil Resistance HNBR (내유성 HNBR 고무의 인장강도 성능에 대한 가속수명예측)

  • Kim, Kyung Pil;Lee, Yong Seok;Yeo, Yong Heon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.11
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    • pp.233-238
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    • 2020
  • Although the interest in NBR has been increasing due to the recent developments of the aerospace sector, there are few reports on HNBR's aeronautical oil, particularly evaluations of the accelerated life of harsh factors. In this study, the tensile strength was adopted as a performance evaluation factor to evaluate the accelerated life of HNBR used in the aviation field. The accelerated stress factor affecting the performance-aging characteristics was defined as temperature. The acceleration stress factor was determined to be temperature, and the result of measuring the tensile strength change over time. The sample for the acceleration condition was taken out of the oven for a certain period and left at room temperature for 24 hours. The dumbbell type 3 specimens were manufactured according to the standard specified in KS M 6518 and were measured the tensile strength, a factor in accelerated life evaluations. The activation energy was 0.895, and the shape parameter was 1.152 using the Arrhenius model. The characteristic life obtained from the tensile strength of the HNBR specimen immersed in aviation oil at 20℃ was 272,256 hours; the average life was 258,965 hours, and the B10 life was 38,624 hours.

Effect of Various Divalent Ions on the Calcium Current of Adrenal Medullary Chromaffin Cells in the Rat

  • Kim, Jun;Leem, Chae-Hun;Kim, Sang-Jeong
    • The Korean Journal of Physiology
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    • v.26 no.2
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    • pp.113-122
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    • 1992
  • It is well known that chromaffin cells of adrenal medulla secrete catecholamine in response to sympathetic nerve activation and the influx of $Ca^{2+}$ through the voltage dependent $Ca^{2+}$ channels (VDCC) in the cell membrane do a major role in this secretory process. In this study, we explored the effect of divalent cations on VDCC of rat chromaffin cells. Rat (Sprague-Dawley rat, 150-250 gm) chromaffin cells were isolated and cultured. Standard giga seal, whole cell recording techniques were employed to study $Ca^{2+}$ current with external and internal solutions that could effectively isolate VDCC currents $(NMG\;in\;external\;and\;TEA\;and\;Cs^{2+}\;in\;internal\;solution)$. The voltage dependence and the inactivation time course of VDCC in our cells were identical to those of bovine chromaffin cells. A persistent inward current was first activated by depolarizing step pulse from the holding potential (H.P.) of -80 mV to -40 mV, increased to maximum amplitude at around +10 mV, and became smaller with progressively higher depolarizing pulses to reverse at around +60 mV. The inactivation time constant $(\tau)$, fitted from the long duration test potential (2 sec) was $1295.2{\pm}126.8$ msec $(n=20,\;1\;day\;of\;culture,\;mean\;{\pm}S.E.M.)$ and the kinetic parameters were not altered along the culture duration. Nicardipine $(10\;{\mu}M)$ blocked the current almost completely. Among treated divalent cations such as $Cd^{2+},\;Co^{2+},\;Ni^{2+},\;Zn^{2+}\;and\;,Mn^{2+},\;Cd^{2+}$ was the most potent blocker on VDCC. When the depolarizing step pulse from -80 mV to 10 mV was applied, the equilibrium dissociation constant $(K_d)$ of $Cd^{2+}\;was\;39\;{\mu}M,\;K_d\;of\;Co^{2+}\;was\;100\;{\mu}M\;and\;K_d\;of\;Ni^{2+}];was];780{\mu}M.$ The principal findings of this study are as follows. First, the majority of $Ca^{2+}$ channels in rat chromaffin cells are well classified to L-type $Ca^{2+}$ channel in the view of kinetics and pharmacology. Second, all divalent cations tested could block the $Ca^{2+}$ current and the most potent blocker among the tested was $Cd^{2+}$.

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