• 여성건강간호학회지
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• 제28권2호
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• pp.100-111
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• 2022

Purpose: Based on the theory of unpleasant symptoms (TOUS), this study aimed to examine the direct effect of antecedent factors on health-related quality of life (HRQoL) and its indirect effect via symptoms in Korean women during the late menopausal transition (MT) and early postmenopause. Methods: This cross-sectional survey employed a descriptive correlational research design. The respondents were 152 middle-aged women 40 to 60 years with an intermenstrual interval of 60 days or more (late MT) or less than 5 years from the last menstrual period (early postmenopause). The respondents were recruited through convenience sampling in Busan, Korea, from December 1, 2020, to January 31, 2021. Based on the TOUS, self-report data were collected on perceived health status, psychological distress, social support, menopausal symptoms, and HRQoL. The collected data were analyzed using descriptive statics, independent t-test, one-way analysis of variance, Pearson's correlation coefficient, and the Hayes' PROCESS macro. Results: TOUS was supported on this sample (n=152) of Korean women during the late MT and early postmenopause. Perceived health status, psychological distress, and social support had significant direct relationships with HRQoL. Menopausal symptoms had significant indirect relationships between antecedent factors (perceived health status, psychological distress, and social support) and partially mediated HRQoL. Conclusion: The findings of this study indicate that menopausal symptoms play an important role as an intervening factor of HRQoL in women during the late MT and early postmenopause. Therefore, women need an integrated program that manages antecedent factors and menopausal symptoms to improve HRQoL in these menopausal stages.

• Biomolecules & Therapeutics
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• 제31권2호
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• pp.210-218
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• 2023

Prostate cancer is the fifth leading cause of cancer-related mortality in men, primarily because of treatment resistance, recurrence, and metastasis. In the present study, we investigated the role of paracrine interleukin-8 (IL-8) in the antagonistic expression of IL-8 and androgen receptor (AR), and the contribution of IL-8 to prostate cancer aggressiveness. In hormone-responsive LNCaP cells that do not express IL-8, recombinant IL-8 treatment significantly increased expressions of IL-8, CXC chemokine receptor 2 (CXCR2), matrix metalloproteinase (MMP)-2/9, Snail, and vimentin. IL-8 treatment significantly decreased AR and E-cadherin expression. IL-8-induced gene expression changes were suppressed by navarixin, a CXCR1/2 inhibitor, and gallein, a Gβγ inhibitor. In PC-3 androgen-refractory prostate cancer cells, IL-8 knockdown reduced expressions of CXCR2, MMP-2/9, Snail, and vimentin, and increased AR and E-cadherin expressions at the mRNA and protein levels. Co-culture with MEG-01 human megakaryocytic cells secreting high levels of IL-8 induced gene expression changes in both LNCaP and PC-3 cells, similar to those induced by IL-8 treatment. The altered gene expressions were accompanied by significant activation of transcription factor Snail in LNCaP and PC-3 cells. Treatment with the CXCR blocker navarixin inhibited the invasion of PC-3 cells but not LNCaP cells. However, invasion induced by MEG-01 was inhibited by navarixin in both LNCaP and PC-3 cells. The collective findings demonstrate that IL-8 enhances CXCR2 expression, which antagonistically regulates AR expression. More importantly, through changes in IL-8/CXCR2-regulated gene expression, IL-8 induces antiandrogen therapy resistance and epithelial-mesenchymal transition in prostate cancer.

• BMB Reports
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• 제56권4호
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• pp.258-264
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• 2023

As a high-grade soft-tissue sarcoma (STS), undifferentiated pleomorphic sarcoma (UPS) is highly recurrent and malignant. UPS is categorized as a tumor of uncertain differentiation and has few options for treatment due to its lack of targetable genetic alterations. There are also few cell lines that provide a representative model for UPS, leading to a dearth of experimental research. Here, we established and characterized new cell lines derived from two recurrent UPS tissues. Cells were obtained from UPS tissues by mincing, followed by extraction or dissociation using enzymes and culture in a standard culture environment. Cells were maintained for several months without artificial treatment, and some cell clones were found to be tumorigenic in an immunodeficient mouse model. Interestingly, some cells formed tumors in vivo when injected after aggregation in a non-adherent culture system for 24 h. The tissues from in vivo study and tissues from patients shared common histological characteristics. Pathways related to the cell cycle, such as DNA replication, were enriched in both cell clones. Pathways related to cell-cell adhesion and cell-cell signaling were also enriched, suggesting a role of the mesenchymal-to-epithelial transition for tumorigenicity in vivo. These new UPS cell lines may facilitate research to identify therapeutic strategies for UPS.

• 한국전자통신학회논문지
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• 제18권3호
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• pp.545-554
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• 2023

현대 산업에서 위성항법시스템(Global Navigation Satellite System : GNSS)은 PNT 정보(측위(P : Positioning), 항법(N : Navigation), 시각동기(T : Timing))가 항상 제공되어야 하고, 그 정보를 기반으로 정밀한 위치추정이 요구되는 다양한 분야에 활용되고 있다. 특히, 2019년부터 시작된 COVID-19 펜데믹 상황에 대한 감염 예방 및 확산 방지를 위해 정밀한 위성항법시스템 기술과 이를 보조하는 다양한 기술들이 사용되어 왔고, 전 세계의 적극적인 방역과 감염 확산 억제 노력으로 엔데믹 상황으로의 전환을 앞두고 있다. 질병, E-health 분야는 감염병의 추적 및 감시와 더불어 원격 의료 서비스 제공을 위해 이용자의 위치정보가 반드시 필요한데, 위성항법시스템이 정확한 위치정보 제공에 주도적인 역할을 하고 있다. 본 논문은 이러한 위성항법시스템 기술이 질병 및 E-health 분야에 활용된 최신 연구 동향에 대해 조사한 결과를 제시하고 그 결과를 분석한다.

• Journal of Ginseng Research
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• 제47권3호
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• pp.440-447
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• 2023

Background: The human hair follicle undergoes cyclic phases-anagen, catagen, and telogen-throughout its lifetime. This cyclic transition has been studied as a target for treating hair loss. Recently, correlation between the inhibition of autophagy and acceleration of the catagen phase in human hair follicles was investigated. However, the role of autophagy in human dermal papilla cells (hDPCs), which is involved in the development and growth of hair follicles, is not known. We hypothesized that acceleration of hair catagen phase upon inhibition of autophagy is due to the downregulation of Wnt/β-catenin signaling in hDPCs, and that components of Panax ginseng extract can increase the autophagic flux in hDPCs. Methods: We generated an autophagy-inhibited condition using 3-methyladenine (3-MA), a specific autophagy inhibitor, and investigated the regulation of Wnt/β-catenin signaling using the luciferase reporter assay, qRT-PCR, and western blot analysis. In addition, cells were cotreated with ginsenoside Re and 3-MA and their roles in inhibiting autophagosome formation were investigated. Results: We found that the unstimulated anagen phase dermal papilla region expressed the autophagy marker, LC3. Transcription of Wnt-related genes and nuclear translocation of β-catenin were reduced after treatment of hDPCs with 3-MA. In addition, treatment with the combination of ginsenoside Re and 3-MA changed the Wnt activity and hair cycle by restoring autophagy. Conclusions: Our results suggest that autophagy inhibition in hDPCs accelerates the catagen phase by downregulating Wnt/β-catenin signaling. Furthermore, ginsenoside Re, which increased autophagy in hDPCs, could be useful for reducing hair loss caused by abnormal inhibition of autophagy.

• Journal of Preventive Medicine and Public Health
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• 제56권3호
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• pp.272-281
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• 2023

Objectives: Young mothers are vulnerable to postpartum depression due to role transition-related stress. Understanding the causes underlying these stressors is essential for developing effective interventions. Methods: This study analyzed the 2018 Indonesian Basic Health Research data. The Mini International Neuropsychiatric Interview was used to assess postpartum depression symptoms in mothers aged 15-24 years with infants aged 0-6 months. In 1285 subjects, the risk factors for postpartum depression were evaluated using multivariate logistic regression. Results: The overall prevalence of depression in the 6 months postpartum was 4.0%, with a higher prevalence in urban areas (5.7%) than in rural areas (2.9%). Urban and rural young mothers showed distinct postpartum depression risk factors. In urban areas, living without a husband (odds ratio [OR], 3.82; 95% confidence interval [CI], 1.24 to 11.76), experiencing preterm birth (OR, 4.67; 95% CI, 1.50 to 14.50), having pregnancy complications (OR, 3.03; 95% CI, 1.20 to 7.66), and having postpartum complications (OR, 5.23; 95% CI, 1.98 to 13.80) were associated with a higher risk of postpartum depression. In rural areas, postpartum depression was significantly associated with a smaller household size (OR, 3.22; 95% CI, 1.00 to 10.38), unwanted pregnancy (OR, 4.40; 95% CI, 1.15 to 16.86), and pregnancy complications (OR, 3.41; 95% CI, 1.31 to 8.88). Conclusions: In both urban and rural contexts, postpartum depression relates to the availability of others to accompany young mothers throughout the postpartum period and offer support with reproductive issues. Support from the family and the healthcare system is essential to young mothers' mental health. The healthcare system needs to involve families to support young mothers' mental health from pregnancy until the postpartum period.

• 천문학회보
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• 제44권2호
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• pp.68.1-68.1
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• 2019

Turbulence plays a crucial role in controlling star formation as it produces density fluctuation as well as non-thermal pressure against gravity. Therefore, turbulence controls the mode and tempo of star formation. However, despite a plenty of previous studies, the properties of turbulence remain poorly understood. As part of the Taeduk Radio Astronomy Observatory (TRAO) Key Science Program (KSP), "mapping Turbulent properties In star-forming MolEcular clouds down to the Sonic scale (TIMES; PI: Jeong-Eun Lee)", we mapped the Orion A and the Ophiuchus clouds, in three sets of lines (13CO 1-0/C18O 1-0, HCN 1-0/HCO+ 1-0, and CS 2-1/N2H+ 1-0) with a high-velocity resolution (~0.1 km/s) using the TRAO 14-m telescope. The mean Trms for the observed maps are less than 0.25 K, and all these maps show uniform Trms values throughout the observed area. These homogeneous and high signal-to-noise ratio data provide the best chance to probe the nature of turbulence in two different star-forming clouds, the Orion A and Ophiuchus clouds. We present comparisons between the line intensities of different molecular tracers as well as the results of a Principal Component Analysis (PCA).

• 한국프랜차이즈경영연구
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• 제2권2호
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• pp.134-149
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• 2011

최근 들어 기업의 사회적 책임(CSR)에 관한 기업과 학자들의 관심이 갈수록 증대하고 있다. 기업의 사회적 책임의 속성 중 일반적으로 기업의 역할론을 집중적으로 조명하고 있다. 더욱이 국제표준화기구(ISO)가 기업의 실제적 규범으로ISO900, ISO1400을 지정한 후, 2010년 11월 ISO가 ISO26000을 기업의 사회적 책임의 새로운 가이드라인으로 선언하면서 그 중요성이 훨씬 증대되었다. 경제전환시대에 이르러, 중국에서도 기업의 사회적 책임에 관한 중요성이 날로 증가하고 있다. 2011년 중국사회과학원의 '중국기업의 사회책임에 관한 보고'에 의하면, 중국기업의 사회책임수준은 초기단계로서, 아직까지 낮은 수준에 머무르고 있다. 특히 베이징은 중국의 수도로서 정치, 문화, 국제, 중국내 교류 중심지로서, 중국에서 가장 큰 소매시장이 형성되었고, 세계 10대 소비도시로 소매기업이 꾸준히 발전하고 있다. 그러나 아직까지 베이징 소매기업에 대한 기업의 사회적 책임에 관한 관리모형에 대한 연구가 부족한 현실이다. 본 논문은 중국 및 베이징의 소매기업의 사회적책임에 관한 관리현황을 파악하였다. 그리고 정부주도하의 베이징의 소매기업의 사회적 책임 관리모형을 4개 측면에서 수립하였다. 또한 기업이 계속적인 경쟁력을 유지하기 위해 소매기업의 사회적 책임을 수행할 수 있도록 5가지 시행방안을 제안하였다.

• 문화기술의 융합
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• 제9권4호
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• pp.161-170
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• 2023

본 연구에서는 전통 판화의 디지털 전환을 위해 전통 판화의 문화적 함의와 형식적 특징 등 판화 예술만이 가진 고유한 매체 특성을 지키는데 중점을 두고 전통 판화 제작에 증강현실 기술을 적용하는 방법을 제한하고 있다. 이를 위해 디지털 전환 시대에 전통 판화 예술과 증강현실 기술의 융합 의도를 이해할 수 있도록 증강현실 작품을 4가지 유형으로 구분하고 여러 나라의 AR 작품 사례를 분석하였다. 이를 통해 증강현실 기술과 전통 판화의 결합 방식과 디자인 방향을 결정하였다. 또한 저자의 작품 "봄, 여름, 가을, 겨울"을 기반으로 한 AR 판화 작품을 완성하여 증강현실 기술이 판화 발전에 충분한 역할을 할 수 있음을 입증하였다. 우리는 이 연구를 통해 AR 판화는 보다 확장된 스토리를 제공하여 몰입감 있는 판화 예술작품으로써의 가능성과 그 가치를 확인할 수 있었다.

• Journal of Animal Science and Technology
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• 제66권2호
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• pp.279-294
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• 2024

Agriculture has played a significant role in the national economy, contributing to food security, driving economic growth, and safeguarding the dietary habits of the population. Korean agriculture has been compelled to focus on intensive farming due to its limited cultivation area, excessive input costs, and the limitations of agricultural mechanization. In the Republic of Korea (R.O.K), the concept of environmentally friendly animal agriculture began to be introduced in the early 2000s. This concept ultimately aims to cultivate sustainable animal agriculture (SAA) through environmentally friendly production practices, ensuring the healthy rearing of animals to supply safe animal products. Despite the government's efforts, there are still significant challenges in implementing environmentally friendly agriculture and SAA in the R.O.K. Therefore, the objective of this review is to establish the direction that the animal agriculture sector should take in the era of climate crisis, and to develop effective strategies for SAA tailored to the current situation in the R.O.K by examining the trends in SAA in the U.S. The animal agriculture sector in the U.S. has been working towards creating a SAA system where humans, animals, and the environment can coexist through government initiatives, industry research, technological support, and individual efforts. Efforts have been made to reduce emissions like carbon, and improve factors affecting the environment such as the carbon footprint, odor, and greenhouse gases associated with animal agriculture processes for animals such as cattle and pigs. The transition of the U.S. towards SAA appears to be driven by both external goals related to addressing climate change and the primary objectives of responding to the demand for safe animal products, expanding consumption, and securing competitiveness in overseas export markets. The demand for animal welfare, organic animal products, and processed goods has been increasing in the U.S. consumer market. A major factor in the transformation of the U.S. animal agriculture sector in terms of livestock specifications is attributed to environmentally friendly practices such as high-quality feed, heat stress reduction, improvements in reproductive ability and growth period reduction, and efforts in animal genetic enhancement.