• BMB Reports
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• v.36 no.1
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• pp.43-48
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• 2003

Understanding the process of carcinogenesis will involve both the accumulation of many scientific facts derived from molecular, biochemical, cellular, physiological, whole animal experiments and epidemiological studies, as well as from conceptual understanding as to how to order and integrate those facts. From decades of cancer research, a number of the "hallmarks of cancer" have been identified, as well as their attendant concepts, including oncogenes, tumor suppressor genes, cell cycle biochemistry, hypotheses of metastasis, angiogenesis, etc. While all these "hallmarks" are well known, two important concepts, with their associated scientific observations, have been generally ignored by many in the cancer research field. The objective of the short review is to highlight the concept of the role of human adult pluri-potent stem cells as "target cells" for the carcinogenic process and the concept of the role of gap junctional intercellular communication in the multi-stage, multi-mechanism process of carcinogenesis. With these two concepts, an attempt has been made to integrate the other well-known concepts, such as the multi-stage, multi-mechanisn or the "initiation/promotion/progression" hypothesis; the stem cell theory of carcinogenesis; the oncogene/tumor suppression theory and the mutation/epigenetic theories of carcinogenesis. This new "integrative" theory tries to explain the well-known "hallmarks" of cancers, including the observation that cancer cells lack either heterologous or homologous gap junctional intercellular communication whereas normal human adult stem cells do not have expressed or functional gap junctional intercellular communication. On the other hand, their normal differentiated, non-stem cell derivatives do express connexins and express gap junctional intercellular communication during their differentiation. Examination of the roles of chemical tumor promoters, oncogenes, connexin knock-out mice and roles of genetically-engineered tumor and normal cells with connexin and anti-sense connexin genes, respectively, seems to provide evidence which is consistent with the roles of both stem cells and gap junctional communication playing a major role in carcinogenesis. The integrative hypothesis provides new strategies for chemoprevention and chemotherapy which focuses on modulating connexin gene expression or gap junctional intercellular communication in the premalignant and malignant cells, respectively.

• Journal of the Korean Society of Clothing and Textiles
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• v.19 no.5
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• pp.738-746
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• 1995

The purposes of this study were 1) to find out any significant relationships among genderlogy, gender identity of clothing, and attitudes toward unisex clothing, 2) to investi- gate differences in genderlogy, gender identity of clothing, and attitudes toward unisex clothing between female and male college students, 3) to understand the structual dimension of genderlogy. The theory of this study was Bem's androgyny sex role theory which suggested an individual's masculine and feminine sex role lied on separate lines rather than on a linear line. The research design was an ex post facto survey and the subjects were 222 female college students and 179 male students in Taejeon, Chungnam and Chungbuk province. Using the SPSS program, factor analysis, 1-test, Pearson correlation coefficient, and plot were calculated for statistical analysis. The findings of this study were summarized as follows: 1) The 1.test showed significant differences in genderloy, gender identity of clothing, attitudes toward unisex clothing between female and male college students. 2) There were significant relationship among genderlogy, gender identity of clothing, attitudes toward unisex clothing. 3) The moi or dimensions of genderlogy were found to be traditional sex role and equal sex roles. There were only moderate negative relationship between traditional and equal sex roles and these two dimensions affected differently on the gender identity of clothing, as well as the attitudes toward unisex clothing, therefore traditional sex roles and equal sex roles seemed to lie on separate lines, and the androgyny sex role theory was supported.

• Convergence Security Journal
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• v.18 no.1
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• pp.69-84
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• 2018

This study examines antecedents of the intention of compliance with information security policies based on Ajzen's Theory of Planned Behavior. The study conducted the following: Verification of casual relations between role of management and protection motivation and the antecedents of planned behavior as parameters to determine the effect on the intention of compliance with information security policy, and comparative analysis between the research model and a competition model. The result of the study disclosed that, in the research model, attitude and subjective norm took an intermediary role on management beliefs, response efficacy, response cost, self-efficacy, and compliance intention, and perceived behavior control on management beliefs, self-efficacy and compliance intention.

• Korean Journal of Logic
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• v.12 no.2
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• pp.89-114
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• 2009

We have many causal beliefs, and they play an important role in our decision making. Unlike evidential decision theory, causal decision theory claims that an account of rational choice must use causal beliefs to identify the considerations that make a choice rational. I claim that evidential decision theory is refuted by the original Newcomb's problem but not by the medical Newcomb problem. The latter is taken to be the best example to point out the weakness of evidential decision theory. However, by the explicit statement about causal relations, I argue that the medical Newcomb problem loses its strength in refuting evidential decision theory. With this argument, this paper clarifies the difference between evidential decision theory and causal decision theory.

• Language and Information
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• v.2 no.2
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• pp.81-120
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• 1998

The case marking phenomenon in Korean is closely related to semantic entailment and should be studied as an interface between syntax and semantics. Assuming a direct mapping between syntactic realization and semantic information, this study investigates the role of the accusative marker ul/lul in Korean, and explores the semantic constraints working on the argument realization on the basis of proto-roles hypothesis. Specifically, I will study various types of case alternations in Korean and clarify the role of the accusative marker ul/lul, which manifests the distinction between direct object NPs and oblique NPs.

• Journal of Distribution Science
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• v.15 no.10
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• pp.93-103
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• 2017

Purpose - Sports and the media have been developed together through a close relationship. During the past decade, the media landscape and the coverage of sports events have been changed. Sports fans can use the sports content at the time they want, on the platform they prefer. Furthermore, thanks to the advanced information technology, sports fans are likely to be more engaged in sport in communication technology-friendly stadium. However, the literature on the relationship between sports and the media has heavily focused on the differences of media types, clear distinction between media suppliers and consumers, and the limited media extension. Given the limitation of prior research, therefore, it has not fully reflected the change in society and culture, the importance of media recipients or consumers, and the mediating characteristic of the media. In order to generate further insights for sport media related industry and its society, it is necessary to comprehend the contemporary phenomena of real world situation in new media and sport and to discuss how new media influence sport and how their relationship is changing in managerial context. The purpose of this study is to identify new media cases as distribution channels in sports context and is to develop insights by discussing its role and meaning of new media in sport society. Research design, data, and methodology - The study employed the theory-centered review and case analysis. In order to explain phenomena of the role of new media in contemporary sport and to generate related insights in sport context, the study reviewed the new media cases applied in sport industry and interpreted their meaning by employing medium theory, remediation theory, and new media theory. Results - The study discussed the limitation of prior sport media research and identified the characteristics of sport as new media such as remediating, extending sensory organs, reiterating physical space and electronic space. Conclusions - The study derived the characteristics of sport as new media, in a sport setting, and through sports settings. Findings would assist to comprehend the role of new media in spectating sport and provide insights for sport media study.

• Journal of the Korean Institute of Oriental Medical Informatics
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• v.21 no.2
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• pp.11-23
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• 2015

Objectives : Through a comparative study between Sasang constitutional medicine and Syndrome identification and treatment medicine about the theory of diagnosis, the theory of herbal medicine, the theory of prescription, the theory of acupuncture and constitutional medicine to put forward a complementary perfect solution which has good clinical utility. Methods : We compared and sorted out the textbook of Korean Sasang constitutional medicine which named Sasang medicine, and also the textbook of Chinese TCM which was including Basic theory of TCM, Diagnostics of TCM, Science of Chinese materia medica, Pharmacology of traditional Chinese medical formulae, Science of acupuncture and moxibustion, Constitution of TCM, and also related papers. Results : (1) Through a comparative study between Sasang constitutional medicine and Syndrome identification and treatment medicine about diagnosis, herbal medicine, prescription and acupuncture, Sasang constitutional medicine is a medical system which gives priority to balance of organs, when Syndrome identification and treatment medicine is a medical system that gives priority to improve symptom. (2) The prescriptions of Sasang constitutional medicine are used for the treatment of basic pathogenesis in the chronic stage of the disease, which can recover vital qi, when Syndrome identification and treatment medicine are used for the treatment of stage pathogenesis in the acute stage of the disease, which can get rid of pathogenic factors. (3) There are two kind of complementary perfect solution between Sasang constitutional medicine and Syndrome identification and treatment medicine. One perfect complementary medicine is that Sasang constitutional medicine plays a major role when Syndrome identification and treatment medicine plays a supporting role. The other one is that Syndrome identification and treatment medicine plays a major role when Sasang constitutional medicine plays a supporting role. It determined by the usual symptoms and the symptoms now, vital qi and pathogenic factors, symptom and the root cause, acute stage and chronic stage, and the state of pathogenesis. Conclusion : A new perfect complementary medicine can be created which is based on the setting that Sasang constitutional medicine primarily treat the usual symptoms, vital qi, the root cause, chronic stage and basic pathogenesis when Syndrome identification and treatment medicine primarily treat the symptoms now, pathogenic factors, symptom, acute stage and stage pathogenesis.

• Korean Institute of Interior Design Journal
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• v.25 no.6
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• pp.89-97
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• 2016

The aim of this study is to review Norberg-Schulz's architectural phenomenology to find out its meaning and limitations in contemporary architecture. His phenomenological trilogy, 'Existence, Space and Architecture', 'Genius Loci' and 'The Concept of Dwelling' are main texts to examine background, characteristics, meaning and limitations of his theory in relation to Structuralism and Heidegger's thoughts. Heidegger's phenomenology, especially his dwelling concept, had great impacts on forming Norberg-Schulz's architectural phenomenology. However, since his architectural phenomenology was strongly influenced by Structuralism, his theories present unstable combination of phenomenology and semiotics. And this results in instrumentalization, and overlooking body movement and socio-economical elements in his theory. In spite of these limitations, his theory also shows possibility to go beyond the theory of Modern architecture and plays important role in suggesting direction for better environment through applicability from single building to city in Postmodern architecture. Another meaning of his theory lies in presenting theoretical background for new way to interpret regionalism and specific policy tool to make town planning in Finland.

• Educational Technology International
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• v.6 no.2
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• pp.59-67
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• 2005

The primary purposes of this study are to develop a Situated Learning Support System based on an MMORPG (Massively Multiplayer Online Role Playing Game) and to investigate applications of Situated Learning theory both hypothetically and practically. In Situated Leaning theory, cognition is interpreted as a dynamic system related to situation, context and activity. According to this theory, learning context, social interaction and personal direct experience are also emphasized. A virtual reality learning system based on an MMORPG provides context, social interaction and a learning environment able to provide direct experiences. However, such a system has been difficult for teachers to develop. This study aims to develop a support system facilitating the construction of a Situated Learning System based on an MMORPG. This study proposes new research and practical applications of Situated Learning theory using educational games.

• Journal of the Korean Society of Clothing and Textiles
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• v.30 no.3 s.151
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• pp.436-446
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• 2006

The purpose of this study was to compare the influences of men's and women's sex role identities and sex role discrepancies on their appearance satisfaction and self esteem. Congruency theory, androgyny theory, masculinity theory and self discrepancy theory were used to explore the influence of sex roles on appearance satisfaction and self esteem. Theories suggest that the influence would be different by gender. Data were collected from a convenience sample of 125 men and 197 women aged between 20 and 40 years living in the Seoul metropolitan area. Structural equation modeling was employed to analyze the data. For men, both appearance satisfaction and self esteem were influenced only by their perceived masculinity. For women, however, perceived femininity, femininity discrepancy and masculinity discrepancy had an influence on appearance satisfaction. All the four sex role variables had an influence on women's self esteem. BMI had a negative effect on self esteem for women, but no effect for men. According to the results, unlike men, whose appearance satisfaction and self esteem are only determined by how masculine they are, the women's levels of appearance satisfaction and self esteem are influenced not only by how feminine they are, but also by how masculine and feminine they want to be. The results of this study have implications for body image counselors or practitioners who try to help young women increase their self esteem and satisfaction to their appearance.